Gut -MicrobiotaNCT06828159
Dietary Wild Blueberries and Joint Health
A study testing Wild blueberry in people with Gut -Microbiota and Inflammation Biomarkers, run by University of Nevada, Las Vegas at 1 site in United States.
Trial summary
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between. Read more about this study
- Who is it for?
- Ages 40 to 75 years
- Conditions the study is for
- Gut -Microbiota, Inflammation Biomarkers, Pain Assessment
- What is being tested?
- Wild blueberry
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Sep 2025to Mar 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults with documented multi-joint/knee arthritis
Who cannot join
- inability to give informed consent
- pregnancy or lactation
- planned knee replacement surgery
- allergy or contraindication to berries
- recent trauma of the knee responsible of the symptomatic knee
- intra-articular injection in the target knee/hip in the last 3 months
Show all 11Show fewer
- oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
- use of berry extracts in the last 3 months
- special diets
- cancer treatment
- bone diseases
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
OMRF
Oklahoma City, Oklahoma, 73104
Judy Goodman, 405- 271-3007, judy-goodman@omrf.org
About this study
Official title: Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
- Conditions
- Gut -Microbiota, Inflammation Biomarkers, Pain Assessment, Joint Pain
- Being tested
- Wild blueberry, Placebo
- Medical subject headings
- Arthralgia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Wild blueberryDietary supplement
Freeze-dried wild blueberry powder 25g/day
PlaceboDietary supplement
Placebo powder matched for calories and no polyphenols
| Study group | Role | What they receive |
|---|---|---|
| Wild blueberries | Experimental | 25g freeze-dried wild blueberries daily for 12 weeks Receives: Dietary Supplement: Wild blueberry |
| Placebo | Placebo comparator | Placebo powder free from polyphenols matched for calories Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Serum biomarkers of joint function
Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.
Measured: 12 weeks
Secondary outcomes (1)
Gut microbiome
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Feb 2025
- Study start1 Sep 2025
- Primary completionDec 2027 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Gut -MicrobiotaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Nevada, Las Vegas
- Sponsor type
- University, hospital or other
- Collaborators
- Oklahoma Medical Research Foundation
- Responsible party
- Principal investigator, Arpita Basu, University of Nevada, Las Vegas
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06828159
- Sponsor's protocol ID
- OMRF WB01
- Other IDs
- WBANA01
- Status last verified
- Sep 2025
- First submitted
- 10 Feb 2025
- Last updated
- 5 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
- ClinicalTrials.gov ID
- NCT06828159
- Acronym / sponsor ID
- OMRF WB01
- Conditions
- Gut -Microbiota, Inflammation Biomarkers, Pain Assessment, Joint Pain
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- University of Nevada, Las VegasUniversity, hospital or other
- Collaborators
- Oklahoma Medical Research Foundation
- Study start
- 1 Sep 2025 (actual)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- Mar 2028 (estimated)
- First posted
- 14 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Wild blueberries | Experimental | Dietary Supplement: Wild blueberry25g freeze-dried wild blueberries daily for 12 weeks |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboPlacebo powder free from polyphenols matched for calories |
Who may qualify
- Ages
- 40 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adults with documented multi-joint/knee arthritis
Key exclusion criteria (11 listed)
- inability to give informed consent
- pregnancy or lactation
- planned knee replacement surgery
- allergy or contraindication to berries
- recent trauma of the knee responsible of the symptomatic knee
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Wild blueberryFreeze-dried wild blueberry powder 25g/day | Dietary supplement | Wild blueberries |
| PlaceboPlacebo powder matched for calories and no polyphenols | Dietary supplement | Placebo |
Primary outcome
Serum biomarkers of joint function
Time frame: 12 weeks
Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.
1 secondary outcome
Gut microbiome
Time frame: 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Wild blueberry in people with Gut -Microbiota and Inflammation Biomarkers, run by University of Nevada, Las Vegas at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Arpita Basu (702-895-4576, arpita.basu@unlv.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Serum biomarkers of joint function (time frame: 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2025.