Discrimination, RacialDOPED-SCDNCT06835335
Opioid Prescribing in the Emergency Department for Sickle Cell Disease
An observational study of Discrimination, Racial and Pain Management, run by Centre Hospitalier Universitaire de Nīmes at 2 sites in 2 countries.
Trial summary
This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Discrimination, Racial, Pain Management, Emergency Medicine
- What is being tested?
- opioid prescription
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 1,063 participants
- Where
- 2 sitesin 2 countries
- Study dates
- 17 Feb 2025to 19 Mar 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Population will consist in emergency medicine resident and physician, speaking French or English, in European countries. The population will be recruited with the use of professional networks and social medias
Who may be able to join
- Being a emergency physician
Who cannot join
- Working outside of Europe.
Trial locations and contacts
2 sites in 2 countries.
2 sites in 2 countries
United Kingdom1 site
Manchester University NHS FT
Manchester, Manchester, M139WL
About this study
Official title: Differential Opioid Prescribing in the Emergency Department for Patients With Sickle Cell Disease: a Vignette-based International Randomised Trial.
This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.
- Being tested
- opioid prescription
- Medical subject headings
- Racism, Agnosia, Anemia, Sickle Cell
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
opioid prescriptionBehavioural
The intervention consisted of a randomized questionnaire presenting a clinical case of a patient suffering from severe abdominal pain. The control case was "As an emergency physician in an adult emergency department, you are presented with the following patient: The patient is a 39-year-old non-smoking male/female with a history of Meniere's disease and an allergy to Bactrim. He/she presents with abdominal pain that began abruptly 2 hours ago and has persisted despite taking NEFOPAM 45 minutes ago. This is his first episode. His/her vital signs are blood pressure 140/66, heart rate 91, pulse ox 97%, temperature 36.8°C. He/she rates his/her pain as 8/10 without any analgesic position. On clinical examination he/she presents with localized epigastric tenderness. The rest of the abdomen is soft, painless and depressed. There are hydro-aeriform noises. No diarrhea or vomiting. The rest of the clinical examination showed no abnormalities.". In the intervention case, patient had history of S
| Study group | Role | What they receive |
|---|---|---|
| Non-black man | the case will present a non black man Receives: Behavioral: opioid prescription | |
| Black man | the case will present a non black man Receives: Behavioral: opioid prescription | |
| non-black woman | the case will present a non black woman Receives: Behavioral: opioid prescription | |
| black woman | the case will present a black woman Receives: Behavioral: opioid prescription |
What is being measured
The primary outcome is the main question the study is designed to answer.
Morphine prescription
The proportion of patient for which physician would have prescribed morphine
Measured: through study completion, an average of 1 year
Secondary outcomes (3)
Analgesic prescription between groups
To compare analgesic prescription between groups
Measured: through study completion, an average of 1 year
factors associated with differences in management between groups
identify factors associated with differences in management (urgency level, morphine prescription and computed tomography scan ordering)
Measured: through study completion, an average of 1 year
Differences according to patient and practitioner gender
analyze the difference in morphine treatment prescribed according to patient and practitioner gender
Measured: through study completion, an average of 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Feb 2025
- Study start17 Feb 2025
- Primary completion19 Mar 2025
- Study completion19 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Discrimination, RacialStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de NīmesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 1,063 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nīmes
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06835335
- Sponsor's protocol ID
- 25.02.01
- Acronym
- DOPED-SCD
- Status last verified
- Jan 2026
- First submitted
- 10 Feb 2025
- Last updated
- 23 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Coisy F, Simon A, Occelli C, Dupriez F, Ageron FX, N'Diaye L, Feral-Pierssens AL, Yates G, Bobbia X. Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians. BMJ Open. 2025 Dec 24;15(12):e108836. doi: 10.1136/bmjopen-2025-108836.
PubMed 41448706
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differential Opioid Prescribing in the Emergency Department for Patients With Sickle Cell Disease: a Vignette-based International Randomised Trial.
- ClinicalTrials.gov ID
- NCT06835335
- Acronym / sponsor ID
- DOPED-SCD / 25.02.01
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 1,063 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NīmesUniversity, hospital or other
- Study start
- 17 Feb 2025 (actual)
- Primary completion
- 19 Mar 2025 (actual)
- Study completion
- 19 Mar 2025 (actual)
- First posted
- 19 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Non-black man | – | Behavioral: opioid prescriptionthe case will present a non black man |
| Black man | – | Behavioral: opioid prescriptionthe case will present a non black man |
| non-black woman | – | Behavioral: opioid prescriptionthe case will present a non black woman |
| black woman | – | Behavioral: opioid prescriptionthe case will present a black woman |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Population will consist in emergency medicine resident and physician, speaking French or English, in European countries. The population will be recruited with the use of professional networks and social medias
Key inclusion criteria (1 listed)
- Being a emergency physician
Key exclusion criteria (1 listed)
- Working outside of Europe.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| opioid prescriptionThe intervention consisted of a randomized questionnaire presenting a clinical case of a patient suffering from severe abdominal pain. The control case was "As an emergency physician in an adult emergency department, you are presented with the following patient: The patient is a 39-year-old non-smoking male/female with a history of Meniere's disease and an allergy to Bactrim. He/she presents with abdominal pain that began abruptly 2 hours ago and has persisted despite taking NEFOPAM 45 minutes ago. This is his first episode. His/her vital signs are blood pressure 140/66, heart rate 91, pulse ox 97%, temperature 36.8°C. He/she rates his/her pain as 8/10 without any analgesic position. On clinical examination he/she presents with localized epigastric tenderness. The rest of the abdomen is soft, painless and depressed. There are hydro-aeriform noises. No diarrhea or vomiting. The rest of the clinical examination showed no abnormalities.". In the intervention case, patient had history of S | Behavioural | Black man, Non-black man, black woman, non-black woman |
Primary outcome
Morphine prescription
Time frame: through study completion, an average of 1 year
The proportion of patient for which physician would have prescribed morphine
3 secondary outcomes
Analgesic prescription between groups
Time frame: through study completion, an average of 1 year
factors associated with differences in management between groups
Time frame: through study completion, an average of 1 year
Differences according to patient and practitioner gender
Time frame: through study completion, an average of 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2026.
- Results publication: PubMed 41448706Coisy F, Simon A, Occelli C, Dupriez F, Ageron FX, N'Diaye L, Feral-Pierssens AL, Yates G, Bobbia X. Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians. BMJ Open. 2025 Dec 24;15(12):e108836. doi: 10.1136/bmjopen-2025-108836.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Discrimination, Racial and Pain Management, run by Centre Hospitalier Universitaire de Nīmes at 2 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France, United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Morphine prescription (time frame: through study completion, an average of 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06835335, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2026.