Healthy ParticipantsNCT06836297
Neural and Behavioural Bases of Action Simulation
A study of Healthy Participants, run by Université Catholique de Louvain.
Trial summary
The goal of this interventional study is to understand the neural and behavioural bases of action simulation and its links with action execution in healthy volunteers. Hypotheses: Action simulation recruits neural networks that are largely similar to those activated by action execution, with some differences to avoid… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy Participants
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 300 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2025to 1 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- healthy adult volunteers (more than 18 years old)
Who cannot join
- Participants taking anti-epileptic drugs
- pregnant or breastfeeding women cannot participate in this study
- people with a pacemaker
- people with a cochlear implant
- people with a metal part in the brain or any other medical implant in their body (pump, neurostimulator, valve,) cannot take part in this study.
About this study
The goal of this interventional study is to understand the neural and behavioural bases of action simulation and its links with action execution in healthy volunteers.
Hypotheses: Action simulation recruits neural networks that are largely similar to those activated by action execution, with some differences to avoid executing a movement while observing/imagining it.
Participants will be tested with TMS while doing motor imagery or action observation.
- Conditions
- Healthy Participants
- Being tested
- Transcranial Magnetic Stimulation Sham
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transcranial Magnetic Stimulation ShamDevice
Participants will be asked to perform various behavioral tasks involving the use of action observation or motor imagery. During these tasks, transcranial magnetic stimulation will be used.
| Study group | Role | What they receive |
|---|---|---|
| Transcranial Magnetic Stimulation | Experimental | For some experiments, all participants will take part in all experimental conditions. For other experiments, participants will be randomly assigned to different groups with different conditions (e.g. TMS sham vs. TMS test). Receives: Device: Transcranial Magnetic Stimulation Sham |
What is being measured
The primary outcome is the main question the study is designed to answer.
Motor Evoked Potential (MEP)
Evoked motor potentials will be measured throughout the experiment using surface electrodes on different muscles to measure changes in corticospinal excitability.
Measured: For the duration of the participants' visit to the laboratory (max 2h30)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2025
- Study start1 Mar 2025 (estimated)
- Primary completion1 Feb 2028 (estimated)
- Study completion1 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy ParticipantsStudies of the same condition, open and under way.
- More trials run by Université Catholique de LouvainThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Université Catholique de Louvain
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06836297
- Sponsor's protocol ID
- NBBAS
- Status last verified
- Feb 2025
- First submitted
- 10 Feb 2025
- Last updated
- 20 Feb 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural and Behavioural Bases of Action Simulation
- ClinicalTrials.gov ID
- NCT06836297
- Acronym / sponsor ID
- NBBAS
- Conditions
- Healthy Participants
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Université Catholique de LouvainUniversity, hospital or other
- Study start
- 1 Mar 2025 (estimated)
- Primary completion
- 1 Feb 2028 (estimated)
- Study completion
- 1 Feb 2028 (estimated)
- First posted
- 20 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this interventional study is to understand the neural and behavioural bases of action simulation and its links with action execution in healthy volunteers.
Hypotheses: Action simulation recruits neural networks that are largely similar to those activated by action execution, with some differences to avoid executing a movement while observing/imagining it.
Participants will be tested with TMS while doing motor imagery or action observation.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Transcranial Magnetic Stimulation | Experimental | Device: Transcranial Magnetic Stimulation ShamFor some experiments, all participants will take part in all experimental conditions. For other experiments, participants will be randomly assigned to different groups with different conditions (e.g. TMS sham vs. TMS test). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- healthy adult volunteers (more than 18 years old)
Key exclusion criteria (5 listed)
- Participants taking anti-epileptic drugs
- pregnant or breastfeeding women cannot participate in this study
- people with a pacemaker
- people with a cochlear implant
- people with a metal part in the brain or any other medical implant in their body (pump, neurostimulator, valve,) cannot take part in this study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transcranial Magnetic Stimulation ShamParticipants will be asked to perform various behavioral tasks involving the use of action observation or motor imagery. During these tasks, transcranial magnetic stimulation will be used. | Device | Transcranial Magnetic Stimulation |
Primary outcome
Motor Evoked Potential (MEP)
Time frame: For the duration of the participants' visit to the laboratory (max 2h30)
Evoked motor potentials will be measured throughout the experiment using surface electrodes on different muscles to measure changes in corticospinal excitability.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study of Healthy Participants, run by Université Catholique de Louvain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Motor Evoked Potential (MEP) (time frame: For the duration of the participants' visit to the laboratory (max 2h30)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2025.