De Quervain SyndromeNCT06839690
Comparison of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis
A study testing Isometric training of thumb muscles, Eccentric training for thumb muscles and Ultrasound in people with De Quervain Syndrome, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
This study is a randomised control trial and the purpose of this study is to compare the effects of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis Read more about this study
- Who is it for?
- Ages 21 to 50 years
- Conditions the study is for
- De Quervain Syndrome
- What is being tested?
- Isometric training of thumb muscles, Eccentric training for thumb muscles and Ultrasound
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 58 participants
- Where
- 1 sitePakistan
- Study dates
- 18 Jul 2024to 20 Jun 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients having history of pain, tenderness in thumb region from 3 weeks or more
- Age 21-50
- Both genders
- Individuals meeting the diagnostic criteria i.e.
- A score of 3 or more out of 7 on De Quervain screening tool.
- Positive Wrist hyperflexion and abduction of thumb (WHAT) test
- Positive Finkelstein's / Eichhoff's test
Who cannot join
- Diagnosed cases of Osteoarthritis of 1st CMC joint and Rheumatoid arthritis
- C6 cervical radiculopathy
- Any systemic inflammatory condition like septic arthritis
- Carpal Tunnel Syndrome
- Complex regional pain syndrome
- Previous surgery impacting the first extensor compartment of the wrist
- Corticosteroid injection in the radial wrist region within 3 months of enrolment into the study
- If patient had undergone isometric thumb exercises or any strengthening protocol lasting greater than 2 weeks for the management of their current episode of de Quervain's syndrome
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physcial Therapy
Rawalpindi, Punjab Province, 46000
Furqan Hassan, OMPT,PHD*, 03334056768, furqan.hassan@fui.edu.pk
About this study
This study is a randomised control trial and the purpose of this study is to compare the effects of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis
Read the detailed description
Participants will be recruited into their respective groups using a coin toss method. De Quervain Tenosynovitis will be assessed using the following tests:
- Wrist hyperflexion and abduction of thumb (WHAT) test
- Finkelstein's / Eichhoff's test
- De Quervain Screening Tool
- Conditions
- De Quervain Syndrome
- Being tested
- Isometric training of thumb muscles, Eccentric training for thumb muscles, Ultrasound
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isometric training of thumb musclesProcedure or surgery
Isometric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using manual resistance and progress with training against resistance of elastic band and theraband.I
Eccentric training for thumb musclesProcedure or surgery
In Group B, eccentric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using unweighted and weighted hammer curls and progress with training using elastic band, dumbbell and theraband.
UltrasoundProcedure or surgery
Therapeutic ultrasound for symptom management
| Study group | Role | What they receive |
|---|---|---|
| Sub-maximal Voluntary Isometric training Group | Active comparator | Group A will recieve ultrasound therapy for symptoms management and isometric training of thumb muscles (abducttor pollices longus and extensor pollices brevis) to gain improvement in range of motion and strength Receives: Procedure: Isometric training of thumb muscles; Procedure: Ultrasound |
| Eccentric training Group | Experimental | Group B will receive the ultrasound therapy similar to group A for symptoms management and eccentric training of thumb muscles to gain improvement in range of motion and strength of thumb Receives: Procedure: Eccentric training for thumb muscles; Procedure: Ultrasound |
What is being measured
The primary outcome is the main question the study is designed to answer.
Grip Strength measurement
Power grip strength will be measured using hand held dynamometer and pinch grip strength will be measured using Modified sphygmomanometer
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2025
- Study start18 Jul 2024
- Primary completion1 Jun 2025 (estimated)
- Study completion20 Jun 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for De Quervain SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized Control Trial
- Masking
- None (open label)
- Enrolment
- 58 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06839690
- Sponsor's protocol ID
- FUI/CTR/2025/1
- Status last verified
- Feb 2025
- First submitted
- 17 Feb 2025
- Last updated
- 21 Feb 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis
- ClinicalTrials.gov ID
- NCT06839690
- Acronym / sponsor ID
- FUI/CTR/2025/1
- Conditions
- De Quervain Syndrome
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 58 participants (estimated)
- Lead sponsor
- Foundation University IslamabadUniversity, hospital or other
- Study start
- 18 Jul 2024 (actual)
- Primary completion
- 1 Jun 2025 (estimated)
- Study completion
- 20 Jun 2025 (estimated)
- First posted
- 21 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a randomised control trial and the purpose of this study is to compare the effects of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis
Detailed description
Participants will be recruited into their respective groups using a coin toss method. De Quervain Tenosynovitis will be assessed using the following tests:
- Wrist hyperflexion and abduction of thumb (WHAT) test
- Finkelstein's / Eichhoff's test
- De Quervain Screening Tool
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Randomized Control Trial
| Arm | Type | Receives |
|---|---|---|
| Sub-maximal Voluntary Isometric training Group | Active comparator | Procedure: Isometric training of thumb muscles, Procedure: UltrasoundGroup A will recieve ultrasound therapy for symptoms management and isometric training of thumb muscles (abducttor pollices longus and extensor pollices brevis) to gain improvement in range of motion and strength |
| Eccentric training Group | Experimental | Procedure: Eccentric training for thumb muscles, Procedure: UltrasoundGroup B will receive the ultrasound therapy similar to group A for symptoms management and eccentric training of thumb muscles to gain improvement in range of motion and strength of thumb |
Who may qualify
- Ages
- 21 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Patients having history of pain, tenderness in thumb region from 3 weeks or more
- Age 21-50
- Both genders
- Individuals meeting the diagnostic criteria i.e.
- A score of 3 or more out of 7 on De Quervain screening tool.
Key exclusion criteria (8 listed)
- Diagnosed cases of Osteoarthritis of 1st CMC joint and Rheumatoid arthritis
- C6 cervical radiculopathy
- Any systemic inflammatory condition like septic arthritis
- Carpal Tunnel Syndrome
- Complex regional pain syndrome
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isometric training of thumb musclesIsometric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using manual resistance and progress with training against resistance of elastic band and theraband.I | Procedure or surgery | Sub-maximal Voluntary Isometric training Group |
| Eccentric training for thumb musclesIn Group B, eccentric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using unweighted and weighted hammer curls and progress with training using elastic band, dumbbell and theraband. | Procedure or surgery | Eccentric training Group |
| UltrasoundTherapeutic ultrasound for symptom management | Procedure or surgery | Eccentric training Group, Sub-maximal Voluntary Isometric training Group |
Primary outcome
Grip Strength measurement
Time frame: 4 weeks
Power grip strength will be measured using hand held dynamometer and pinch grip strength will be measured using Modified sphygmomanometer
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Feb 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isometric training of thumb muscles, Eccentric training for thumb muscles and Ultrasound in people with De Quervain Syndrome, run by Foundation University Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zahra Nayyer, MS-MSKPT* (0349-8219386, zahranayyar727@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Grip Strength measurement (time frame: 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Feb 2025.