Bladder CancerQLB-CYSNCT06851520
Retrospective Analysis of Different Quadratus Lumborum Block Techniques on Recovery Quality and Analgesic Consumption in Radical Cystectomy Patients
An observational study of Bladder Cancer and Postoperative Pain Management, run by Namik Kemal University at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study evaluates the effects of different Quadratus Lumborum Block (QLB) techniques on postoperative recovery and total opioid consumption in patients undergoing radical cystectomy under general anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Bladder Cancer, Postoperative Pain Management, Opioid Consumption
- What is being tested?
- Anterior Quadratus Lumborum Block (QLB) and Posterior Quadratus Lumborum Block (QLB)
- Type of treatment
- Surgery or procedure
- How many people
- 32 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Oct 2023to 15 Dec 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This study includes adult patients (18-65 years old) who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. Patients were retrospectively selected based on the administration of anterior or posterior Quadratus Lumborum Block (QLB) for postoperative analgesia. Patients with complete medical records were included, while those with missing data, coagulopathy, chronic opioid use, or unplanned open surgery conversion were excluded.
Who may be able to join
- Patients who underwent radical cystectomy under general anesthesia between October 15, 2023, and October 15, 2024.
- Patients who received anterior or posterior quadratus lumborum block (QLB) for postoperative analgesia.
- Age: 18-65 years.
- ASA Physical Status Classification: I-III.
- BMI < 35 kg/m².
- Complete medical records available for retrospective review.
Who cannot join
- Patients who received a different postoperative analgesia technique (e.g., epidural, TAP block).
- Incomplete or missing medical records.
- Psychiatric disorders that could affect pain perception and reporting.
- Coagulopathy or bleeding disorders.
- Hepatic or renal failure.
- Chronic opioid use before surgery.
- Patients who required unplanned conversion to open surgery.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Tekirdağ Namık Kemal University Hospital
Tekirdağ
About this study
This retrospective observational study evaluates the effects of different Quadratus Lumborum Block (QLB) techniques on postoperative recovery and total opioid consumption in patients undergoing radical cystectomy under general anesthesia. The study will analyze intraoperative and postoperative patient records from October 15, 2023, to October 15, 2024, at Tekirdağ Namık Kemal University Hospital.
Patients who received anterior or posterior QLB for postoperative analgesia will be included. Data collection will involve demographic information, total opioid consumption (morphine milligram equivalents), recovery quality scores (QoR-15), postoperative pain scores (Visual Analog Scale, VAS), time to first rescue analgesic administration, frequency of rescue analgesic use, and incidence of postoperative nausea and vomiting (PONV).
The retrospective analysis will compare the two QLB techniques to determine if there is a significant difference in postoperative opioid consumption and recovery quality. Statistical methods will be used to assess pain scores over time, opioid consumption, and overall recovery quality.
Read the detailed description
Postoperative pain management plays a crucial role in optimizing recovery after radical cystectomy, as inadequate pain control can lead to increased opioid consumption and delayed rehabilitation. This retrospective observational study examines the effects of two different Quadratus Lumborum Block (QLB) techniques-anterior and posterior approaches-on postoperative pain and opioid consumption.
The study includes patients who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. The primary focus is to compare total opioid consumption (morphine milligram equivalents) within the first 24 hours after surgery between the two groups.
Secondary outcomes include:
- Pain scores at multiple time points (0, 2, 6, 12, 24 hours), measured using the Visual Analog Scale (VAS)
- Postoperative recovery quality scores (QoR-15)
- Time to first rescue analgesic administration
- Frequency of rescue analgesic use
- Incidence of postoperative nausea and vomiting (PONV)
Data will be collected from intraoperative and postoperative patient records. Statistical analysis will compare anterior vs. posterior QLB techniques, evaluating differences in postoperative opioid consumption, pain relief efficacy, and recovery quality (QoR-15 scores).
This study aims to provide evidence-based insights into the use of regional anesthesia techniques for radical cystectomy patients, supporting the refinement of multimodal analgesia strategies to optimize pain management and minimize opioid exposure.
- Being tested
- Anterior Quadratus Lumborum Block (QLB), Posterior Quadratus Lumborum Block (QLB)
- Medical subject headings
- Urinary Bladder Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anterior Quadratus Lumborum Block (QLB)Procedure or surgery
A regional anesthesia technique where local anesthetic is injected anterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.
Posterior Quadratus Lumborum Block (QLB)Procedure or surgery
A regional anesthesia technique where local anesthetic is injected posterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.
| Study group | Role | What they receive |
|---|---|---|
| Anterior QLB Group | Patients who underwent radical cystectomy under general anesthesia and received anterior quadratus lumborum block (QLB) for postoperative analgesia. Receives: Procedure: Anterior Quadratus Lumborum Block (QLB) | |
| Posterior QLB Group | Patients who underwent radical cystectomy under general anesthesia and received posterior quadratus lumborum block (QLB) for postoperative analgesia. Receives: Procedure: Posterior Quadratus Lumborum Block (QLB) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total Opioid Consumption (Morphine Milligram Equivalents) in the First 24 Hours
The total amount of opioids (converted to morphine milligram equivalents) administered postoperatively within the first 24 hours following radical cystectomy.
Continuous variable (mg of morphine equivalent)
Measured: 0-24 hours postoperatively
Secondary outcomes (5)
Pain Scores Using Visual Analog Scale (VAS) at Multiple Time Points
Postoperative pain levels measured using the Visual Analog Scale (VAS) at predetermined time points: 0, 2, 6, 12, and 24 hours.
Ordinal variable (0-10 VAS score, higher scores indicate more pain)
Measured: 0, 2, 6, 12, and 24 hours postoperatively
Postoperative Recovery Quality (QoR-15 Score)
Recovery quality assessed using the QoR-15 questionnaire, a validated patient-reported outcome measure.
Continuous variable (QoR-15 total score, higher scores indicate better recovery quality)
Measured: 24 hours postoperatively
Time to First Rescue Analgesic Administration
The duration (in minutes) from the end of surgery until the first administration of rescue analgesia.
Continuous variable (minutes)
Measured: 0-24 hours postoperatively
Frequency of Rescue Analgesic Use
The number of times rescue analgesics were administered during the first 24 hours postoperatively.
Count variable (number of doses)
Measured: 0-24 hours postoperatively
Incidence of Postoperative Nausea and Vomiting (PONV)
The proportion of patients who experience postoperative nausea and vomiting within the first 24 hours.
Binary variable (Yes/No; presence of PONV)
Measured: 0-24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Feb 2025
- Study start15 Oct 2023
- Primary completion15 Oct 2024
- Study completion15 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Bladder CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Namik Kemal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Onur Baran, Namik Kemal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06851520
- Sponsor's protocol ID
- 2024.297.11.04
- Acronym
- QLB-CYS
- Status last verified
- Feb 2025
- First submitted
- 24 Feb 2025
- Last updated
- 28 Feb 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Korgvee A, Veskimae E, Huhtala H, Koskinen H, Tammela T, Junttila E, Kalliomaki ML. Posterior quadratus lumborum block versus epidural analgesia for postoperative pain management after open radical cystectomy: A randomized clinical trial. Acta Anaesthesiol Scand. 2023 Mar;67(3):347-355. doi: 10.1111/aas.14188. Epub 2023 Jan 3.
PubMed 36547262
Study at a glance
From the registry record, last updated by the sponsor on 28 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Retrospective Analysis of Different Quadratus Lumborum Block Techniques on Recovery Quality and Analgesic Consumption in Radical Cystectomy Patients
- ClinicalTrials.gov ID
- NCT06851520
- Acronym / sponsor ID
- QLB-CYS / 2024.297.11.04
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Namik Kemal UniversityUniversity, hospital or other
- Study start
- 15 Oct 2023 (actual)
- Primary completion
- 15 Oct 2024 (actual)
- Study completion
- 15 Dec 2024 (actual)
- First posted
- 28 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study evaluates the effects of different Quadratus Lumborum Block (QLB) techniques on postoperative recovery and total opioid consumption in patients undergoing radical cystectomy under general anesthesia. The study will analyze intraoperative and postoperative patient records from October 15, 2023, to October 15, 2024, at Tekirdağ Namık Kemal University Hospital.
Patients who received anterior or posterior QLB for postoperative analgesia will be included. Data collection will involve demographic information, total opioid consumption (morphine milligram equivalents), recovery quality scores (QoR-15), postoperative pain scores (Visual Analog Scale, VAS), time to first rescue analgesic administration, frequency of rescue analgesic use, and incidence of postoperative nausea and vomiting (PONV).
The retrospective analysis will compare the two QLB techniques to determine if there is a significant difference in postoperative opioid consumption and recovery quality. Statistical methods will be used to assess pain scores over time, opioid consumption, and overall recovery quality.
Detailed description
Postoperative pain management plays a crucial role in optimizing recovery after radical cystectomy, as inadequate pain control can lead to increased opioid consumption and delayed rehabilitation. This retrospective observational study examines the effects of two different Quadratus Lumborum Block (QLB) techniques-anterior and posterior approaches-on postoperative pain and opioid consumption.
The study includes patients who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. The primary focus is to compare total opioid consumption (morphine milligram equivalents) within the first 24 hours after surgery between the two groups.
Secondary outcomes include:
- Pain scores at multiple time points (0, 2, 6, 12, 24 hours), measured using the Visual Analog Scale (VAS)
- Postoperative recovery quality scores (QoR-15)
- Time to first rescue analgesic administration
- Frequency of rescue analgesic use
- Incidence of postoperative nausea and vomiting (PONV)
Data will be collected from intraoperative and postoperative patient records. Statistical analysis will compare anterior vs. posterior QLB techniques, evaluating differences in postoperative opioid consumption, pain relief efficacy, and recovery quality (QoR-15 scores).
This study aims to provide evidence-based insights into the use of regional anesthesia techniques for radical cystectomy patients, supporting the refinement of multimodal analgesia strategies to optimize pain management and minimize opioid exposure.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Anterior QLB Group | – | Procedure: Anterior Quadratus Lumborum Block (QLB)Patients who underwent radical cystectomy under general anesthesia and received anterior quadratus lumborum block (QLB) for postoperative analgesia. |
| Posterior QLB Group | – | Procedure: Posterior Quadratus Lumborum Block (QLB)Patients who underwent radical cystectomy under general anesthesia and received posterior quadratus lumborum block (QLB) for postoperative analgesia. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This study includes adult patients (18-65 years old) who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. Patients were retrospectively selected based on the administration of anterior or posterior Quadratus Lumborum Block (QLB) for postoperative analgesia. Patients with complete medical records were included, while those with missing data, coagulopathy, chronic opioid use, or unplanned open surgery conversion were excluded.
Key inclusion criteria (6 listed)
- Patients who underwent radical cystectomy under general anesthesia between October 15, 2023, and October 15, 2024.
- Patients who received anterior or posterior quadratus lumborum block (QLB) for postoperative analgesia.
- Age: 18-65 years.
- ASA Physical Status Classification: I-III.
- BMI < 35 kg/m².
Key exclusion criteria (7 listed)
- Patients who received a different postoperative analgesia technique (e.g., epidural, TAP block).
- Incomplete or missing medical records.
- Psychiatric disorders that could affect pain perception and reporting.
- Coagulopathy or bleeding disorders.
- Hepatic or renal failure.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anterior Quadratus Lumborum Block (QLB)A regional anesthesia technique where local anesthetic is injected anterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management. | Procedure or surgery | Anterior QLB Group |
| Posterior Quadratus Lumborum Block (QLB)A regional anesthesia technique where local anesthetic is injected posterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management. | Procedure or surgery | Posterior QLB Group |
Primary outcome
Total Opioid Consumption (Morphine Milligram Equivalents) in the First 24 Hours
Time frame: 0-24 hours postoperatively
The total amount of opioids (converted to morphine milligram equivalents) administered postoperatively within the first 24 hours following radical cystectomy. Continuous variable (mg of morphine equivalent)
5 secondary outcomes
Pain Scores Using Visual Analog Scale (VAS) at Multiple Time Points
Time frame: 0, 2, 6, 12, and 24 hours postoperatively
Postoperative Recovery Quality (QoR-15 Score)
Time frame: 24 hours postoperatively
Time to First Rescue Analgesic Administration
Time frame: 0-24 hours postoperatively
Frequency of Rescue Analgesic Use
Time frame: 0-24 hours postoperatively
Incidence of Postoperative Nausea and Vomiting (PONV)
Time frame: 0-24 hours postoperatively
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Feb 2025.
- Background: PubMed 36547262Korgvee A, Veskimae E, Huhtala H, Koskinen H, Tammela T, Junttila E, Kalliomaki ML. Posterior quadratus lumborum block versus epidural analgesia for postoperative pain management after open radical cystectomy: A randomized clinical trial. Acta Anaesthesiol Scand. 2023 Mar;67(3):347-355. doi: 10.1111/aas.14188. Epub 2023 Jan 3.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Bladder Cancer and Postoperative Pain Management, run by Namik Kemal University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total Opioid Consumption (Morphine Milligram Equivalents) in the First 24 Hours (time frame: 0-24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06851520, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Feb 2025.