Young Healthy AdultsHUMVISNCT06851923
Study of Visual Mecanisms Involved in Face Recognition
A study testing 3Tesla magnetic resonance imaging of the healthy human visual system in people with Young Healthy Adults and Healthy, run by Université Catholique de Louvain.
Trial summary
Since the 19th century, perception has been regarded as an inferential process in which sensory input is compared with prior knowledge, namely the internalised representation of the visual environment. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Young Healthy Adults, Healthy
- What is being tested?
- 3Tesla magnetic resonance imaging of the healthy human visual system
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2025to 15 Nov 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants will be screened (see annex 2) to ascertain they fit with all these inclusion criteria:
- Be between 18 and 50 years old,
- have normal eyesight or eyesight corrected with contact lenses,
- Have no neurological disorder,
- Not have had a skull fracture or head surgery,
- Have no chronic progressive illness or mental deficiency,
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- Have no metal parts in their body (dental braces or pins, metal plates, pacemakers, implanted prostheses, etc.),
- Have no tattoos containing metallic particles or implanted jewellery (e.g. piercings) that cannot be removed,
- Not to have worked with metals,
- Do not take any medicines or substances that may affect brain function (e.g. drugs, energy drinks, alcohol),
- Not to be pregnant or breastfeeding.
- Do not be claustrophobic.
Who cannot join
- Participants presenting a counter-indication (responding yes to one of the questions of the screening questionnaire, see annex 2) to participate will be excluded from participation.
- Participants will be screened to ascertain they do not present any of these counter-indications to the participation to the MRI measurement. We will exclude people with these characteristics:
- Be younger than 18 or older than 50 years old,
- have poor eyesight,
- Have neurological disorder,
- have had a skull fracture or head surgery,
Show all 13Show fewer
- Have a chronic progressive illness or mental deficiency,
- Have metal parts in their body (dental braces or pins, metal plates, pacemakers, implanted prostheses, etc.),
- Have tattoos containing metallic particles or implanted jewellery (e.g. piercings) that cannot be removed,
- have worked with metals,
- take medicines or substances that may affect brain function (e.g. drugs, energy drinks, alcohol),
- pregnant or breastfeeding.
- claustrophobic.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Since the 19th century, perception has been regarded as an inferential process in which sensory input is compared with prior knowledge, namely the internalised representation of the visual environment. This notion is central to the understanding of everyday perception and cognition in general, and is attracting much attention in various areas of psychology and cognitive neuroscience. However, it is unclear whether and how the primary visual refinement that is thought to underlie the convergence of bottom-up inputs with top-down prior knowledge applies to the processing of meaningful stimuli in our everyday lives. The investigators have shown that human face processing mechanisms are shaped by prior knowledge that the horizontal range of face information conveys the richest and most reliable cues. Furthermore, investigators' previous data suggest that the primary visual cortex is recruited during the progressive refinement of face representation. Using very high field neuroimaging, the present project proposes to follow the neural mechanisms underlying the cortical refinement of horizontal information in human face processing, and to study their contribution to behaviour.
- Conditions
- Young Healthy Adults, Healthy
- Being tested
- 3Tesla magnetic resonance imaging of the healthy human visual system
- Keywords
- face perception, Magnetic Resonance Imaging, 3 Tesla, human vision, orientation selectivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
3Tesla magnetic resonance imaging of the healthy human visual systemOther
The present project presents a series of monocentric MRI studies carried out on healthy adult human volunteers. All neuroimaging will be performed at the Cliniques Universitaires Saint-Luc (CUSL, IRM de recherche). Participants will not directly benefit from their participation. All studies will manipulate the visual properties of the experimental stimuli in a within-subject way, and therefore do not rely on any participation group assignation/randomization method. The duration of studies will vary between 3h to 6h, i.e., from 2 to 4x1h30 3Tesla magnetic resonance imaging sessions depending on the experimental design.
| Study group | Role | What they receive |
|---|---|---|
| Study of the visual mechanisms involved in face perception | Experimental | Not described Receives: Other: 3Tesla magnetic resonance imaging of the healthy human visual system |
What is being measured
The primary outcome is the main question the study is designed to answer.
Orientation tuning in the visual system
fMRI will be used to analyse brain responses along the ventral visual pathway to the visual presentation of orientation-filtered visual face and scene stimuli
Measured: 2 years
Emergence of orientation tuning over processing course in the visual system
fMRI will be used to analyse brain responses along the ventral visual pathway to the visual presentation of temporally masked orientation-filtered visual stimuli
Measured: 2 years
Receptive field mapping of the visual system
fMRI will be used to measure population receptive fields using stimuli varying in position and size randomly
Measured: 2 years
Behavioral task performance
Participants will identify famous faces presented on-screen and respond via keypress.
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Feb 2025
- Study start1 Mar 2025 (estimated)
- Primary completion15 Nov 2030 (estimated)
- Study completion15 Nov 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Young Healthy AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Université Catholique de Louvain
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Valerie Goffaux, PhD, Study director, Université Catholique de LouvainMrittika Dey, Master, Principal investigator, Université Catholique de Louvain
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06851923
- Sponsor's protocol ID
- HUMVIS
- Acronym
- HUMVIS
- Status last verified
- Feb 2025
- First submitted
- 7 Feb 2025
- Last updated
- 28 Feb 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Feb 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of Visual Mecanisms Involved in Face Recognition
- ClinicalTrials.gov ID
- NCT06851923
- Acronym / sponsor ID
- HUMVIS / HUMVIS
- Conditions
- Young Healthy Adults, Healthy
- Keywords
- face perception, Magnetic Resonance Imaging, 3 Tesla, human vision, orientation selectivity
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Université Catholique de LouvainUniversity, hospital or other
- Study start
- 1 Mar 2025 (estimated)
- Primary completion
- 15 Nov 2030 (estimated)
- Study completion
- 15 Nov 2030 (estimated)
- First posted
- 28 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Since the 19th century, perception has been regarded as an inferential process in which sensory input is compared with prior knowledge, namely the internalised representation of the visual environment. This notion is central to the understanding of everyday perception and cognition in general, and is attracting much attention in various areas of psychology and cognitive neuroscience. However, it is unclear whether and how the primary visual refinement that is thought to underlie the convergence of bottom-up inputs with top-down prior knowledge applies to the processing of meaningful stimuli in our everyday lives. The investigators have shown that human face processing mechanisms are shaped by prior knowledge that the horizontal range of face information conveys the richest and most reliable cues. Furthermore, investigators' previous data suggest that the primary visual cortex is recruited during the progressive refinement of face representation. Using very high field neuroimaging, the present project proposes to follow the neural mechanisms underlying the cortical refinement of horizontal information in human face processing, and to study their contribution to behaviour.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study of the visual mechanisms involved in face perception | Experimental | Other: 3Tesla magnetic resonance imaging of the healthy human visual system |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (12 listed)
- Participants will be screened (see annex 2) to ascertain they fit with all these inclusion criteria:
- Be between 18 and 50 years old,
- have normal eyesight or eyesight corrected with contact lenses,
- Have no neurological disorder,
- Not have had a skull fracture or head surgery,
Key exclusion criteria (13 listed)
- Participants presenting a counter-indication (responding yes to one of the questions of the screening questionnaire, see annex 2) to participate will be excluded from participation.
- Participants will be screened to ascertain they do not present any of these counter-indications to the participation to the MRI measurement. We will exclude people with these characteristics:
- Be younger than 18 or older than 50 years old,
- have poor eyesight,
- Have neurological disorder,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 3Tesla magnetic resonance imaging of the healthy human visual systemThe present project presents a series of monocentric MRI studies carried out on healthy adult human volunteers. All neuroimaging will be performed at the Cliniques Universitaires Saint-Luc (CUSL, IRM de recherche). Participants will not directly benefit from their participation. All studies will manipulate the visual properties of the experimental stimuli in a within-subject way, and therefore do not rely on any participation group assignation/randomization method. The duration of studies will vary between 3h to 6h, i.e., from 2 to 4x1h30 3Tesla magnetic resonance imaging sessions depending on the experimental design. | Other | Study of the visual mechanisms involved in face perception |
Primary outcome
Orientation tuning in the visual system
Time frame: 2 years
fMRI will be used to analyse brain responses along the ventral visual pathway to the visual presentation of orientation-filtered visual face and scene stimuli
Emergence of orientation tuning over processing course in the visual system
Time frame: 2 years
fMRI will be used to analyse brain responses along the ventral visual pathway to the visual presentation of temporally masked orientation-filtered visual stimuli
Receptive field mapping of the visual system
Time frame: 2 years
fMRI will be used to measure population receptive fields using stimuli varying in position and size randomly
Behavioral task performance
Time frame: 2 years
Participants will identify famous faces presented on-screen and respond via keypress.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Feb 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Valerie Goffaux, PhD study director
Université Catholique de Louvain
Mrittika Dey, Master principal investigator
Université Catholique de Louvain
Questions about this trial
What is this clinical trial studying?
A study testing 3Tesla magnetic resonance imaging of the healthy human visual system in people with Young Healthy Adults and Healthy, run by Université Catholique de Louvain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Feb 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Valerie Goffaux, PhD (003210473877, Valerie.goffaux@uclouvain.be), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Orientation tuning in the visual system (time frame: 2 years). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Feb 2025.