HealthyE-BFRNCT06856629
The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading
A study testing Eccentric blood-flow restriction training and Eccentric free-flow training in people with Healthy, run by Dario Kohlbrenner at 1 site in Switzerland.
Trial summary
Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Eccentric blood-flow restriction training and Eccentric free-flow training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 siteSwitzerland
- Study dates
- 31 Jan 2025to 28 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Clinically Healthy
Who cannot join
- Physical or intellectual impairment precluding informed consent or protocol adherence
- Pain during exercise of any origin
- History of thromboembolic event in the lower extremity
- Known pregnancy (no testing is carried out)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading (E-BFR): a Randomised Crossover Study in Healthy Subjects
Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli.
This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.
- Conditions
- Healthy
- Being tested
- Eccentric blood-flow restriction training, Eccentric free-flow training
- Keywords
- Blood-flow restriction training, acute physiological response, eccentric training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric blood-flow restriction trainingOther
Eccentric blood-flow restriction training
Eccentric free-flow trainingOther
Eccentric free-flow training
| Study group | Role | What they receive |
|---|---|---|
| Eccentric blood-flow restriction trainig | Experimental | Not described Receives: Other: Eccentric blood-flow restriction training |
| Eccentric free-flow training | Active comparator | Not described Receives: Other: Eccentric free-flow training |
What is being measured
The primary outcome is the main question the study is designed to answer.
minute ventilation
recorded with breath-by-breath analysis
Measured: During the intervention (i.e., exercise) for 10 minutes
Secondary outcomes (5)
Other variables from breath-by-breath analysis
VO2, VCO2, RER, breath rate, heart rate
Measured: During the intervention (i.e., exercise) for 10 minutes
Rate of perceived exertion
Numeric rating scale from 0-10. Participants rate perceived leg exertion and perceived respiratory exertion
Measured: Immediately after the intervention (i.e., exercise)
Near-infrared spectroscopy of the vastus lateralis
Tissue saturation
Measured: During the intervention (i.e., exercise) for 10 minutes
Delayed onset muscle soreness
Numeric rating scale 0-10 rating intensity of DOMS symptoms
Measured: 24, 48, and 72 hours after each of the intervention (i.e., exercise)
Feasibility and tolerability
Custom-made questionnaire
Measured: After study completion (i.e., after the second study visit, up to 2 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2025
- Study start31 Jan 2025
- Primary completion28 Jul 2025
- Study completion28 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- With random sequence allocation
- Masking
- None (open label)
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dario Kohlbrenner
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Dario Kohlbrenner, University of Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06856629
- Sponsor's protocol ID
- BASEC2024-02223
- Other IDs
- SNCTP000006261
- Acronym
- E-BFR
- Status last verified
- Jul 2025
- First submitted
- 6 Feb 2025
- Last updated
- 31 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Upon reasonable request
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading (E-BFR): a Randomised Crossover Study in Healthy Subjects
- ClinicalTrials.gov ID
- NCT06856629
- Acronym / sponsor ID
- E-BFR / BASEC2024-02223
- Conditions
- Healthy
- Keywords
- Blood-flow restriction training, acute physiological response, eccentric training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Dario KohlbrennerUniversity, hospital or other
- Study start
- 31 Jan 2025 (actual)
- Primary completion
- 28 Jul 2025 (actual)
- Study completion
- 28 Jul 2025 (actual)
- First posted
- 4 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli.
This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- With random sequence allocation
| Arm | Type | Receives |
|---|---|---|
| Eccentric blood-flow restriction trainig | Experimental | Other: Eccentric blood-flow restriction training |
| Eccentric free-flow training | Active comparator | Other: Eccentric free-flow training |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Clinically Healthy
Key exclusion criteria (4 listed)
- Physical or intellectual impairment precluding informed consent or protocol adherence
- Pain during exercise of any origin
- History of thromboembolic event in the lower extremity
- Known pregnancy (no testing is carried out)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric blood-flow restriction trainingEccentric blood-flow restriction training | Other | Eccentric blood-flow restriction trainig |
| Eccentric free-flow trainingEccentric free-flow training | Other | Eccentric free-flow training |
Primary outcome
minute ventilation
Time frame: During the intervention (i.e., exercise) for 10 minutes
recorded with breath-by-breath analysis
5 secondary outcomes
Other variables from breath-by-breath analysis
Time frame: During the intervention (i.e., exercise) for 10 minutes
Rate of perceived exertion
Time frame: Immediately after the intervention (i.e., exercise)
Near-infrared spectroscopy of the vastus lateralis
Time frame: During the intervention (i.e., exercise) for 10 minutes
Delayed onset muscle soreness
Time frame: 24, 48, and 72 hours after each of the intervention (i.e., exercise)
Feasibility and tolerability
Time frame: After study completion (i.e., after the second study visit, up to 2 weeks)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2025.
- Individual participant dataSharing planned: Undecided. Upon reasonable request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric blood-flow restriction training and Eccentric free-flow training in people with Healthy, run by Dario Kohlbrenner at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
minute ventilation (time frame: During the intervention (i.e., exercise) for 10 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2025.