COPD (Chronic Obstructive Pulmonary Disease)NCT06869720
Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life With Chronic Obstructive Pulmonary Disease
A study testing Eccentric bike and conventional group in people with COPD (Chronic Obstructive Pulmonary Disease), run by Fu Jen Catholic University at 1 site in Taiwan.
Trial summary
This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- COPD (Chronic Obstructive Pulmonary Disease)
- What is being tested?
- Eccentric bike and conventional group
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- 1 siteTaiwan
- Study dates
- 11 Mar 2025to 31 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Having undergone pulmonary rehabilitation for more than 3 months
- Sign the written informed consent form
- FEV1/FVC < 0.70
- Approval for exercise training granted by a specialist physician's assessment
- Specialist physician's approval for exercise training
Who cannot join
- Existing of tracheostomy
- Those who use oxygen therapy or ventilator at home
- Severe heart failure (NYHA III-IV)
- Neuromuscular disease
- Acute exacerbation within the past three months
- Those who are unable to cooperate with the cardiopulmonary exercise test
Trial locations and contacts
1 site in 1 country.
Taiwan1 site
Fu Jen Catholic University Hospital, Fu Jen Catholic University
New Taipei City, 24352
About this study
Official title: The Impact of Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life in Patients With Chronic Obstructive Pulmonary Disease
This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method.
Read the detailed description
Background： Chronic respiratory diseases, including COPD, are leading causes of chronic illness and mortality worldwide. However, limitations in ventilation and muscle function restrict COPD patients from engaging in higher-power exercise therapies. Compared to concentric exercise, eccentric exercise can effectively improve health-related fitness and quality of life at lower cardiopulmonary and metabolic loads. Pulmonary rehabilitation programs have been shown to effectively improve symptoms of chronic respiratory diseases, increase exercise capacity, enhance quality of life, delay disease progression, prevent and treat acute exacerbations, and reduce mortality. Therefore, it is hoped that a "safe and effective" eccentric exercise strategy can be designed for COPD patients to comprehensively improve their cardiopulmonary/muscle fitness and quality of life, thereby improving the course of their disease.
Study Design： This is a one-year, single-center, prospective randomized controlled trial. Methods： This study plans to enroll 60 participants who will be randomly assigned to control and experimental groups. The intervention will take place in the pulmonary rehabilitation room on the sixth floor of Fu Jen Hospital. Each group will undergo a functional fitness test and complete a quality of life questionnaire before and after 24 sessions (over 12 weeks) of exercise training.
Effect： It is anticipated that after 24 sessions of elliptical exercise training, there will be an improvement in the functional fitness and in quality of life related to physical activity function.
Key words： Pulmonary rehabilitation; eccentric exercise; chronic obstructive pulmonary disease; cardiopulmonary fitness; functional fitness
- Being tested
- Eccentric bike, conventional group
- Keywords
- Pulmonary rehabilitation, Eccentric exercise, Chronic obstructive pulmonary disease, Cardiopulmonary fitness, Functional fitness
- Medical subject headings
- Pulmonary Disease, Chronic Obstructive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric bikeDevice
Received eccentric cycling exercise
conventional groupOther
Received conventional treatment
| Study group | Role | What they receive |
|---|---|---|
| Intervention Group: eccentric cycling exercise | Experimental | Received eccentric cycling exercise Receives: Device: Eccentric bike |
| Control group | Active comparator | Undergoing conventional treatment Receives: Other: conventional group |
What is being measured
The primary outcome is the main question the study is designed to answer.
six minute walk test
functional performance
Measured: 12 weeks
time up and go
functional performance
Measured: 12 weeks
stairs ascending and descending walking time
functional performance
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Mar 2025
- Study start11 Mar 2025
- Primary completion31 Jul 2025
- Study completion31 Jul 2025
Why it stopped: Due to persistent challenges in participant recruitment, the study has been terminated and the protocol has been formally withdrawn.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for COPD (Chronic Obstructive Pulmonary Disease)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fu Jen Catholic University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ke-Yun, Chao, Fu Jen Catholic University
- Investigators
- Ke-Yun Chao, PhD, Principal investigator, Fu Jen Catholic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06869720
- Sponsor's protocol ID
- FJUH113384
- Status last verified
- Mar 2025
- First submitted
- 6 Mar 2025
- Last updated
- 4 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life in Patients With Chronic Obstructive Pulmonary Disease
- ClinicalTrials.gov ID
- NCT06869720
- Acronym / sponsor ID
- FJUH113384
- Keywords
- Pulmonary rehabilitation, Eccentric exercise, Chronic obstructive pulmonary disease, Cardiopulmonary fitness, Functional fitness
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Due to persistent challenges in participant recruitment, the study has been terminated and the protocol has been formally withdrawn.
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Fu Jen Catholic UniversityUniversity, hospital or other
- Study start
- 11 Mar 2025 (actual)
- Primary completion
- 31 Jul 2025 (actual)
- Study completion
- 31 Jul 2025 (actual)
- First posted
- 11 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method.
Detailed description
Background： Chronic respiratory diseases, including COPD, are leading causes of chronic illness and mortality worldwide. However, limitations in ventilation and muscle function restrict COPD patients from engaging in higher-power exercise therapies. Compared to concentric exercise, eccentric exercise can effectively improve health-related fitness and quality of life at lower cardiopulmonary and metabolic loads. Pulmonary rehabilitation programs have been shown to effectively improve symptoms of chronic respiratory diseases, increase exercise capacity, enhance quality of life, delay disease progression, prevent and treat acute exacerbations, and reduce mortality. Therefore, it is hoped that a "safe and effective" eccentric exercise strategy can be designed for COPD patients to comprehensively improve their cardiopulmonary/muscle fitness and quality of life, thereby improving the course of their disease.
Study Design： This is a one-year, single-center, prospective randomized controlled trial. Methods： This study plans to enroll 60 participants who will be randomly assigned to control and experimental groups. The intervention will take place in the pulmonary rehabilitation room on the sixth floor of Fu Jen Hospital. Each group will undergo a functional fitness test and complete a quality of life questionnaire before and after 24 sessions (over 12 weeks) of exercise training.
Effect： It is anticipated that after 24 sessions of elliptical exercise training, there will be an improvement in the functional fitness and in quality of life related to physical activity function.
Key words： Pulmonary rehabilitation; eccentric exercise; chronic obstructive pulmonary disease; cardiopulmonary fitness; functional fitness
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention Group: eccentric cycling exercise | Experimental | Device: Eccentric bikeReceived eccentric cycling exercise |
| Control group | Active comparator | Other: conventional groupUndergoing conventional treatment |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Having undergone pulmonary rehabilitation for more than 3 months
- Sign the written informed consent form
- FEV1/FVC < 0.70
- Approval for exercise training granted by a specialist physician's assessment
- Specialist physician's approval for exercise training
Key exclusion criteria (6 listed)
- Existing of tracheostomy
- Those who use oxygen therapy or ventilator at home
- Severe heart failure (NYHA III-IV)
- Neuromuscular disease
- Acute exacerbation within the past three months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric bikeReceived eccentric cycling exercise | Device | Intervention Group: eccentric cycling exercise |
| conventional groupReceived conventional treatment | Other | Control group |
Primary outcome
six minute walk test
Time frame: 12 weeks
functional performance
time up and go
Time frame: 12 weeks
functional performance
stairs ascending and descending walking time
Time frame: 12 weeks
functional performance
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ke-Yun Chao, PhD principal investigator
Fu Jen Catholic University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric bike and conventional group in people with COPD (Chronic Obstructive Pulmonary Disease), run by Fu Jen Catholic University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 4 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
six minute walk test (time frame: 12 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2026.