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Gingival Recession, LocalizedPhase 2NCT06871475

The Effect Of Using Sticky Bone With Coronally Advanced Flap In Management Of Type 1 Gingival Recession

A Phase 2 study testing sticky bone with coronally advanced flap and coronally advanced flap in people with Gingival Recession, Localized, run by Minia University at 1 site in Egypt.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

the main goal of this clinical trial is to evaluate the effect of sticky bone with coronally advanced flap in management of gingival recession in comparison to coronally advanced flap alone Read more about this study

Who is it for?
Ages 25 to 45 years
Conditions the study is for
Gingival Recession, Localized
What is being tested?
sticky bone with coronally advanced flap and coronally advanced flap
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
30 participants
Where
1 siteEgypt
Study dates
1 Mar 2025to 30 Nov 2025
Phase
Phase 2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 25 to 45 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Selected patients of both sexes with age range 25-45 years old.
  • Patients are systemically healthy based on questionnaire dental modification of Cornell index.
  • O'Leary index (1972) is less than 10% (the surgical therapy is not initiated until the patient reaches the 10% level or less of plaque accumulation).
  • Buccal recession defects are classified RT1 according to Cairo's classification (2011).
  • Clinical indication and/or patient request for recession coverage.

Who cannot join

  • Pregnant female.
  • Smokers.
  • Patients with special needs or with any mental problems.
  • All patients are using any kind of medications that could interfere with healing of periodontal tissues. Such as chemotherapy and radiotherapy.
  • Teeth with carious lesions.
  • Rotated and extruded teeth.
  • Patient undergone any prior periodontal surgery in the relevant region within year.

Trial locations and contacts

1 site in 1 country.

Egypt1 site

  • Minia University

    Minya, Minya Governorate, 61511

Other trials in Egypt

About this study

the main goal of this clinical trial is to evaluate the effect of sticky bone with coronally advanced flap in management of gingival recession in comparison to coronally advanced flap alone

Being tested
sticky bone with coronally advanced flap, coronally advanced flap
Medical subject headings
Gingival Recession

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • sticky bone with coronally advanced flapBiological

    using sticky bone with coronally advanced flap in treating the gingival recession

  • coronally advanced flapProcedure or surgery

    using coronally advanced flap alone in treating gingival recession

Study groups in NCT06871475
Study groupRoleWhat they receive
study groupExperimentalparticipant will receive sticky bone with coronally advanced flap
Receives: Biological: sticky bone with coronally advanced flap
control groupActive comparatorparticipants will undergo coronally advanced flap in treating gingival recession
Receives: Procedure: coronally advanced flap

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. recession depth

    is measured from CEJ to the gingival margin in millimeters.

    Measured: changes in millimeters from base line up to 6 months

  2. thickness of keratinized gingiva

    thickness of the keratinized gingiva in the faciolingual direction (gingival biotype)

    Measured: changes in biotype in millimeters from base line to follow up after 6 months

Secondary outcomes (4)

  1. Recession Width

    the widest point from the mesial gingival margin to the distal gingival margin in millimeters

    Measured: changes in millimeters from base line to follow up after 6 months

  2. the height of keratinized gingiva

    the distance from the mucogingival junction to the gingival margin

    Measured: changes in millimeters from base line up to 6 months

  3. percentage of root coverage

    it is the [pre-operative gingival recession depth - post-operative recession depth]/ [preoperative recession depth] * 100%

    Measured: changes in percentile from base line up to 6 months

  4. Probing pocket depth

    the distance from the gingival margin to base of pocket.

    Measured: changes in millimeters from base line up to 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted12 Mar 2025
  2. Study start1 Mar 2025
  3. Primary completion25 Sep 2025
  4. Study completion30 Nov 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
30 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06871475
Sponsor's protocol ID
870
Status last verified
Mar 2025
First submitted
4 Mar 2025
Last updated
30 Jun 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Ogata Y, Bui M, Griffin TJ, Hur Y. Use of Allograft with Platelet Concentrate in the Treatment of Multiple Miller Class III Gingival Recession Defects: Report of Three Cases. Int J Periodontics Restorative Dent. 2017 May/Jun;37(3):339-344. doi: 10.11607/prd.2673.

    PubMed 28402343

  • Wang HL, Kimble K, Eber R. Use of bone grafts for the enhancement of a GTR-based root coverage procedure: a pilot case study. Int J Periodontics Restorative Dent. 2002 Apr;22(2):119-27.

    PubMed 12019707

  • Sohn, D., B, H., J, K., Park WE, & Park CC. (2015). Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix(Sticky bone) and CGF-enriched fibrin membrane in implant dentistry. Jr Implant Adv Cli Dent.

  • Mathur A, Jain M, Jain K, Samar M, Goutham B, Swamy PD, Kulkarni S. Gingival recession in school kids aged 10-15 years in Udaipur, India. J Indian Soc Periodontol. 2009 Jan;13(1):16-20. doi: 10.4103/0972-124X.51889.

    PubMed 20376235

  • Louis F. Rose, D. M. (2006). Surgical Therapies for the Treatment of Gingival Recession. Inside dentistry.

  • Kimble KM, Eber RM, Soehren S, Shyr Y, Wang HL. Treatment of gingival recession using a collagen membrane with or without the use of demineralized freeze-dried bone allograft for space maintenance. J Periodontol. 2004 Feb;75(2):210-20. doi: 10.1902/jop.2004.75.2.210.

    PubMed 15068108

  • Hadziabdic, N. (2022). PRF and Sticky Bone as Regenerative Materials in Oral Surgery. IntechOpen. doi:10.5772/intechopen.108807

  • Ghoderao D, Rathod S, Kolte AP, Bawankar P, Jadhav A. Randomized, controlled clinical trial to evaluate efficacy of sticky bone and concentrated growth factor in the management of intrabony defects: 12 months follow-up study. Dent Res J (Isfahan). 2022 Aug 16;19:67. eCollection 2022.

    PubMed 36159047

  • Kapa BP, N K S, G V G, Mehta DS. Coronally Advanced Flap Combined With Sticky Bone and i-PRF-Coated Collagen Membrane to Treat Single Maxillary Gingival Recessions: Case Series. Clin Adv Periodontics. 2022 Sep;12(3):147-151. doi: 10.1002/cap.10164. Epub 2021 May 15.

    PubMed 33938633

  • Chatterjee A, Sharma E, Gundanavar G, Subbaiah SK. Treatment of multiple gingival recessions with vista technique: A case series. J Indian Soc Periodontol. 2015 Mar-Apr;19(2):232-5. doi: 10.4103/0972-124X.145836.

    PubMed 26015680

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing sticky bone with coronally advanced flap and coronally advanced flap in people with Gingival Recession, Localized, run by Minia University at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 30 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

recession depth (time frame: changes in millimeters from base line up to 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06871475, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jun 2026.

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