Intensive Care PatientsNCT06872697
Impact of Whole Body Vibration on Muscle Function and Respiratory Parameters in Intensive Care Patients
A study testing whole body vibration, Neuromuscular Electrical Stimulation and Conventional Physiotherapy in people with Intensive Care Patients and Whole Body Vibration, run by Istinye University at 1 site in Turkey (Türkiye).
Trial summary
Immobility and mechanical ventilation in intensive care unit (ICU) patients lead to muscle weakness and loss, particularly in antigravity and respiratory muscles. Early physiotherapy interventions are crucial to prevent complications, reduce side effects, shorten intubation time, and lower patient costs. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Intensive Care Patients, Whole Body Vibration
- What is being tested?
- whole body vibration, Neuromuscular Electrical Stimulation and Conventional Physiotherapy
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Dec 2024to 25 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged between 18 and 80 years,
- Clinically stable condition,
- Deemed suitable for physiotherapy interventions by the intensive care specialist physician,
- Willing to participate in the study or, if unconscious, authorized by a first-degree relative.
Who cannot join
- Patients with coagulation disorders (Prothrombin Time (PT); International Normalized Ratio (INR) value greater than 1.5, and platelet count less than 50,000/mm³),
- Agitated patients (Richmond Agitation and Sedation Scale (RASS) score ≥ 2)
- Patients with signs of increased intracranial pressure,
- Patients with cardiac and respiratory instability (respiratory rate above 30 breaths/min, systolic blood pressure below 80 mmHg or above 200 mmHg, diastolic blood pressure below 50 mmHg or above 100 mmHg, PaO₂ < 65 mmHg, FiO₂ > 55%),
- Patients with hemodynamic instability (requiring dopamine support > 5 mcg/kg/min),
- Patients in shock,
Show all 10Show fewer
- Patients with malignancies,
- Pregnant individuals,
- Patients using pacemakers,
- Patients with high fever.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Whole Body Vibration Application on Muscle Functional Level and Respiratory Parameters in Intensive Care Patients
Immobility and mechanical ventilation in intensive care unit (ICU) patients lead to muscle weakness and loss, particularly in antigravity and respiratory muscles. Early physiotherapy interventions are crucial to prevent complications, reduce side effects, shorten intubation time, and lower patient costs. ICU physiotherapy includes chest physiotherapy, range of motion exercises, strengthening exercises, mobilization, positioning, and inspiratory/peripheral muscle training.
Muscle training plays a key role in ICU physiotherapy. Whole Body Vibration (WBV) is a promising, side-effect-free intervention to enhance muscle strength in various populations. Its effects result from neuromuscular responses to mechanical vibrations and the tonic vibration reflex. WBV has been reported to improve muscle strength, elasticity, circulation, and balance while reducing pain and fall risk. However, its effects on ICU patients remain unclear. To date, only one study has shown increased muscle electrical activity in ICU patients after WBV, but no research has evaluated changes in muscle strength, mass, or elasticity.
Read more
Another method used in muscle training is neuromuscular electrical stimulation (NMES), which prevents muscle atrophy, strengthens muscles, and restores endurance. NMES is suitable for patients with limited cooperation, making it an alternative to active exercise. No study has compared NMES and WBV in immobile ICU patients. Given the limited non-pharmacological options in ICU care, particularly for unconscious or uncooperative patients, identifying effective alternatives is essential.
This study aims to compare the effects of WBV and NMES on respiratory muscle strength, respiratory parameters, and muscle mass, composition, elasticity, and strength in ICU patients. Participants will be divided into three groups: WBV (n=15), NMES (n=15), and conventional therapy only (n=15). All groups will receive conventional therapy five days a week for four weeks, with WBV added to the first group and NMES to the second. Functional status, muscle assessments, grip strength, respiratory muscle strength, and respiratory parameters will be evaluated at baseline and study completion.
The findings will provide objective data on the effectiveness of WBV and NMES in ICU patients, guiding future research and treatment while contributing to national and international literature.
Read the detailed description
This randomized controlled trial will investigate and compare the effects of WBV and NMES on respiratory muscle strength, respiratory parameters, and muscle mass, composition, elasticity, and strength in ICU patients. A total of 45 patients will be randomly assigned to one of three groups:
WBV Group (n=15): Conventional therapy + Whole Body Vibration NMES Group (n=15): Conventional therapy + Neuromuscular Electrical Stimulation Control Group (n=15): Conventional therapy only
- Conditions
- Intensive Care Patients, Whole Body Vibration
- Being tested
- whole body vibration, Neuromuscular Electrical Stimulation, Conventional Physiotherapy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
whole body vibrationOther
In the group receiving whole-body vibration in addition to conventional treatment, the whole-body vibration will be performed with the patient's hips and knees in approximately 20° flexion, and the bed inclined to 25-30°. The vibration platform will be fixed at the end of the bed, and the patients will apply pressure with their feet on the platform. The whole-body vibration will be administered for 3 minutes, 1-4 sets, at a frequency of 20-25 Hz, 5 days a week, for 4 weeks, depending on the protocol, in addition to conventional physiotherapy.
Neuromuscular Electrical StimulationDevice
Also called electrotherapy
In this group, neuromuscular electrical stimulation (NMES) will be applied to the targeted muscle groups. The application will be carried out with the patient in a comfortable seated or lying position. Stimulation parameters will be set as follows: a frequency of 35-50 Hz, a pulse duration of 200-400 microseconds, and an intensity adjusted to elicit visible muscle contractions without causing discomfort. NMES will be applied for 20-30 minutes per session, 3-5 times a week, for 4-6 weeks, depending on the protocol, in addition to conventional physiotherapy.
Conventional PhysiotherapyOther
The conventional treatment program will include normal range of motion, airway clearance techniques, breathing exercises, and mobilization.
| Study group | Role | What they receive |
|---|---|---|
| whole body vibration group | Experimental | In the group receiving whole-body vibration in addition to conventional treatment, the whole-body vibration will be performed with the patient's hips and knees in approximately 20° flexion, and the bed inclined to 25-30°. The vibration platform will be fixed at the end of the bed, and the patients will apply pressure with their feet on the platform. The whole-body vibration will be administered for 3 minutes, 1-4 sets, at a frequency of 20-25 Hz, 5 days a week, for 4 weeks. Receives: Other: whole body vibration; Other: Conventional Physiotherapy |
| Neuromuscular Electrical Stimulation Group | Active comparator | In addition to conventional treatment, low-frequency neuromuscular electrical stimulation with a symmetrical biphasic waveform at 50 Hz will be applied to the biceps brachii and quadriceps femoris muscles for 45 minutes per session, 5 days a week, for 4 weeks. Receives: Device: Neuromuscular Electrical Stimulation; Other: Conventional Physiotherapy |
| control group | Active comparator | As conventional treatment (CT), normal range of motion exercises, airway clearance techniques, breathing exercises, and mobilization will be applied 5 days a week for 4 weeks. Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Evaluation of Muscle Thickness
The patient's muscle thickness is evaluated with the EDAN DUS 60 ultrasonography device, and the increase in muscle thickness is measured.
Measured: at 4 weeks
Muscle Elasticity Assessment
Myoton device will be used for the assessment. How the values change according to the application will be examined.
Measured: 4 weeks
Muscle Strength Assessment
Muscle strength will be objectively measured using a myometer in conjunction with the Medical Research Council (MRC) scale. Each muscle group is assessed on a scale from 0 (no movement or complete paralysis) to 5 (full normal strength). The cumulative MRC scale score ranges from 0 to 60, with a score below 48 indicating the presence of muscle weakness.
Measured: 4 weeks
Grip Strength Assessment
Grip strength will be measured using a Jamar brand dynamometer. Hand grip strength provides information about overall body muscle strength.
Measured: 4 weeks
Measurement of Respiratory Muscle Strength
To measure respiratory muscle strength, patients connected to mechanical ventilation will be switched to the CPAP mode of the ventilator. The ventilator settings will be adjusted to PEEP: 5 cmH2O and Psup: 10 cmH2O to overcome the physiological resistance of the ventilator circuit. The pressure value displayed on the mechanical ventilator screen will be recorded as the MIB value
Measured: 4 weeks
Functional Status Assessment
The Premorbid Activity Level Scale will be used to determine the patient's functional status in daily life prior to intensive care. This scale categorizes activity levels from 0 (completely dependent) to 4 (independent in all activities). . The P-FIT is scored from 0 to 12, with higher scores indicating better physical function.
Measured: 4 weeks
Functional Status Assessment
The CPAX is scored from 0 to 50, where higher scores reflect greater independence and physical ability.
Measured: 4 weeks
Assessment of Inspiratory tidal volume
Inspiratory tidal volume (TVi) in milliliters in L/min will be recorded.
Measured: 4 weeks
Assessment of Expiratory tidal volume
Expiratory tidal volume (TVe) in milliliters in L/min will be recorded.
Measured: 4 weeks
Assessment of Minute Ventilation
Minute ventilation in L/min will be recorded.
Measured: 4 weeks
Secondary outcomes (13)
Assessment of APCAHE II
APACHE II ranges from 0 to 71, combining physiological, laboratory, and demographic data to predict severity and mortality risk.The higher the APACHE II score, the higher the patient's risk of mortality in the intensive care unit.
Measured: 4 weeks
Consciousness Level Assessment
The Glasgow Coma Scale (GCS) will be used to determine the patient's level of consciousness. The Glasgow Coma Scale (GCS) assesses consciousness by evaluating three components: eye opening (4-1), verbal response (5-1), and motor response (6-1). Scores range from 3 (deep coma) to 15 (fully alert), with lower scores indicating more severe impairment. A score of 8 or below typically suggests the need for immediate intervention.
Measured: 4 weeks
Agitation, Anxiety, and Sedation Assessment
Agitation and anxiety levels will be assessed using the Richmond Agitation and Sedation Scale (RASS).. Scores range from +4 (combative) to 0 (calm and alert) to -5 (unarousable). Positive scores indicate agitation, 0 indicates normal alertness, and negative scores reflect increasing levels of sedation.
Measured: 4 weeks
Pain Assessment-The Nonverbal Pain Scale
The Nonverbal Pain Scale (NVPS) is designed for adults who cannot communicate verbally and evaluates pain based on five categories: facial expression, body movement, muscle tension, compliance with ventilation, and vocalization, each scored from 0 to 2, with a total score ranging from 0 to 10. A score closer to 10 suggests severe pain, while a score closer to 0 indicates minimal or no pain.
Measured: 4 weeks
Dyspnea Assessment
Patients will rate their dyspnea by marking a point on a 10 cm horizontal line, where 0 represents no fatigue and 10 indicates the worst fatigue imaginable. The score is determined by measuring the distance from the 0 point to the patient's mark, providing a quantitative measure of dyspnea intensity.
Measured: 4 weeks
SOFA Assessment
SOFA evaluates dysfunction in six organ systems, with a total score ranging from 0 to 24, where higher scores indicate greater dysfunction and mortality risk
Measured: 4 weeks
Pain Assessment-The Visual Analog Scale
The Visual Analog Scale (VAS) is a self-reported measure where patients mark their pain intensity on a 10 cm line, with 0 indicating no pain and 10 representing the worst pain imaginable.
Measured: 4 weeks
General Body Fatigue Assessment
Patients will rate their fatigue by marking a point on a 10 cm horizontal line, where 0 represents no fatigue and 10 indicates the worst fatigue imaginable. The score is determined by measuring the distance from the 0 point to the patient's mark, providing a quantitative measure of fatigue intensity.
Measured: 4 weeks
Heart Rate Assessment
The heart rate will be recorded on the monitor at the beginning, end and half an hour after the session.
Measured: at 4 weeks
Systolic Pressure Assessment
Systolic pressure will be recorded on the monitor at the beginning, end and half an hour after the session.
Measured: at 4 weeks
Diastolic Pressure Assessment
Diastolic Pressure will be recorded on the monitor at the beginning, end and half an hour after the session.
Measured: at 4 weeks
Oxygen Saturation Assessment
Oxygen saturation will be recorded on the monitor at the beginning, end and half an hour after the session.
Measured: at 4 weeks
Respiratory Rate Assessment
The respiratory rate will be recorded at the beginning, end and half an hour after the session.
Measured: at 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2025
- Study start20 Dec 2024
- Primary completion15 Feb 2025
- Study completion25 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Intensive Care PatientsStudies of the same condition, open and under way.
- More trials run by Istinye UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elif Kabasakal, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06872697
- Sponsor's protocol ID
- 4/2023.K-11
- Status last verified
- Mar 2025
- First submitted
- 20 Dec 2024
- Last updated
- 3 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Tutuneken YE, Kabasakal E, Kardes K, Karabulut H, Tanriogen B, Senel O, Cagliyan Erdogan H, Isikci B, Parlak H, Yilmaz Yelvar GD, Cirak YB. Effects of whole-body vibration and neuromuscular electrical stimulation on muscle biomechanical properties and thickness in patients in the intensive care unit: a randomized controlled trial. Physiother Theory Pract. 2026 Apr 20:1-11. doi: 10.1080/09593985.2026.2660184. Online ahead of print.
PubMed 42003288
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Whole Body Vibration Application on Muscle Functional Level and Respiratory Parameters in Intensive Care Patients
- ClinicalTrials.gov ID
- NCT06872697
- Acronym / sponsor ID
- 4/2023.K-11
- Conditions
- Intensive Care Patients, Whole Body Vibration
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 20 Dec 2024 (actual)
- Primary completion
- 15 Feb 2025 (actual)
- Study completion
- 25 Mar 2025 (actual)
- First posted
- 12 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Immobility and mechanical ventilation in intensive care unit (ICU) patients lead to muscle weakness and loss, particularly in antigravity and respiratory muscles. Early physiotherapy interventions are crucial to prevent complications, reduce side effects, shorten intubation time, and lower patient costs. ICU physiotherapy includes chest physiotherapy, range of motion exercises, strengthening exercises, mobilization, positioning, and inspiratory/peripheral muscle training.
Muscle training plays a key role in ICU physiotherapy. Whole Body Vibration (WBV) is a promising, side-effect-free intervention to enhance muscle strength in various populations. Its effects result from neuromuscular responses to mechanical vibrations and the tonic vibration reflex. WBV has been reported to improve muscle strength, elasticity, circulation, and balance while reducing pain and fall risk. However, its effects on ICU patients remain unclear. To date, only one study has shown increased muscle electrical activity in ICU patients after WBV, but no research has evaluated changes in muscle strength, mass, or elasticity.
Another method used in muscle training is neuromuscular electrical stimulation (NMES), which prevents muscle atrophy, strengthens muscles, and restores endurance. NMES is suitable for patients with limited cooperation, making it an alternative to active exercise. No study has compared NMES and WBV in immobile ICU patients. Given the limited non-pharmacological options in ICU care, particularly for unconscious or uncooperative patients, identifying effective alternatives is essential.
This study aims to compare the effects of WBV and NMES on respiratory muscle strength, respiratory parameters, and muscle mass, composition, elasticity, and strength in ICU patients. Participants will be divided into three groups: WBV (n=15), NMES (n=15), and conventional therapy only (n=15). All groups will receive conventional therapy five days a week for four weeks, with WBV added to the first group and NMES to the second. Functional status, muscle assessments, grip strength, respiratory muscle strength, and respiratory parameters will be evaluated at baseline and study completion.
The findings will provide objective data on the effectiveness of WBV and NMES in ICU patients, guiding future research and treatment while contributing to national and international literature.
Detailed description
This randomized controlled trial will investigate and compare the effects of WBV and NMES on respiratory muscle strength, respiratory parameters, and muscle mass, composition, elasticity, and strength in ICU patients. A total of 45 patients will be randomly assigned to one of three groups:
WBV Group (n=15): Conventional therapy + Whole Body Vibration NMES Group (n=15): Conventional therapy + Neuromuscular Electrical Stimulation Control Group (n=15): Conventional therapy only
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| whole body vibration group | Experimental | Other: whole body vibration, Other: Conventional PhysiotherapyIn the group receiving whole-body vibration in addition to conventional treatment, the whole-body vibration will be performed with the patient's hips and knees in approximately 20° flexion, and the bed inclined to 25-30°. The vibration platform will be fixed at the end of the bed, and the patients will apply pressure with their feet on the platform. The whole-body vibration will be administered for 3 minutes, 1-4 sets, at a frequency of 20-25 Hz, 5 days a week, for 4 weeks. |
| Neuromuscular Electrical Stimulation Group | Active comparator | Device: Neuromuscular Electrical Stimulation, Other: Conventional PhysiotherapyIn addition to conventional treatment, low-frequency neuromuscular electrical stimulation with a symmetrical biphasic waveform at 50 Hz will be applied to the biceps brachii and quadriceps femoris muscles for 45 minutes per session, 5 days a week, for 4 weeks. |
| control group | Active comparator | Other: Conventional PhysiotherapyAs conventional treatment (CT), normal range of motion exercises, airway clearance techniques, breathing exercises, and mobilization will be applied 5 days a week for 4 weeks. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Aged between 18 and 80 years,
- Clinically stable condition,
- Deemed suitable for physiotherapy interventions by the intensive care specialist physician,
- Willing to participate in the study or, if unconscious, authorized by a first-degree relative.
Key exclusion criteria (10 listed)
- Patients with coagulation disorders (Prothrombin Time (PT); International Normalized Ratio (INR) value greater than 1.5, and platelet count less than 50,000/mm³),
- Agitated patients (Richmond Agitation and Sedation Scale (RASS) score ≥ 2)
- Patients with signs of increased intracranial pressure,
- Patients with cardiac and respiratory instability (respiratory rate above 30 breaths/min, systolic blood pressure below 80 mmHg or above 200 mmHg, diastolic blood pressure below 50 mmHg or above 100 mmHg, PaO₂ < 65 mmHg, FiO₂ > 55%),
- Patients with hemodynamic instability (requiring dopamine support > 5 mcg/kg/min),
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| whole body vibrationIn the group receiving whole-body vibration in addition to conventional treatment, the whole-body vibration will be performed with the patient's hips and knees in approximately 20° flexion, and the bed inclined to 25-30°. The vibration platform will be fixed at the end of the bed, and the patients will apply pressure with their feet on the platform. The whole-body vibration will be administered for 3 minutes, 1-4 sets, at a frequency of 20-25 Hz, 5 days a week, for 4 weeks, depending on the protocol, in addition to conventional physiotherapy. | Other | whole body vibration group |
| Neuromuscular Electrical StimulationAlso: electrotherapyIn this group, neuromuscular electrical stimulation (NMES) will be applied to the targeted muscle groups. The application will be carried out with the patient in a comfortable seated or lying position. Stimulation parameters will be set as follows: a frequency of 35-50 Hz, a pulse duration of 200-400 microseconds, and an intensity adjusted to elicit visible muscle contractions without causing discomfort. NMES will be applied for 20-30 minutes per session, 3-5 times a week, for 4-6 weeks, depending on the protocol, in addition to conventional physiotherapy. | Device | Neuromuscular Electrical Stimulation Group |
| Conventional PhysiotherapyThe conventional treatment program will include normal range of motion, airway clearance techniques, breathing exercises, and mobilization. | Other | Neuromuscular Electrical Stimulation Group, control group, whole body vibration group |
Primary outcome
Evaluation of Muscle Thickness
Time frame: at 4 weeks
The patient's muscle thickness is evaluated with the EDAN DUS 60 ultrasonography device, and the increase in muscle thickness is measured.
Muscle Elasticity Assessment
Time frame: 4 weeks
Myoton device will be used for the assessment. How the values change according to the application will be examined.
Muscle Strength Assessment
Time frame: 4 weeks
Muscle strength will be objectively measured using a myometer in conjunction with the Medical Research Council (MRC) scale. Each muscle group is assessed on a scale from 0 (no movement or complete paralysis) to 5 (full normal strength). The cumulative MRC scale score ranges from 0 to 60, with a score below 48 indicating the presence of muscle weakness.
Grip Strength Assessment
Time frame: 4 weeks
Grip strength will be measured using a Jamar brand dynamometer. Hand grip strength provides information about overall body muscle strength.
Measurement of Respiratory Muscle Strength
Time frame: 4 weeks
To measure respiratory muscle strength, patients connected to mechanical ventilation will be switched to the CPAP mode of the ventilator. The ventilator settings will be adjusted to PEEP: 5 cmH2O and Psup: 10 cmH2O to overcome the physiological resistance of the ventilator circuit. The pressure value displayed on the mechanical ventilator screen will be recorded as the MIB value
Functional Status Assessment
Time frame: 4 weeks
The Premorbid Activity Level Scale will be used to determine the patient's functional status in daily life prior to intensive care. This scale categorizes activity levels from 0 (completely dependent) to 4 (independent in all activities). . The P-FIT is scored from 0 to 12, with higher scores indicating better physical function.
Functional Status Assessment
Time frame: 4 weeks
The CPAX is scored from 0 to 50, where higher scores reflect greater independence and physical ability.
Assessment of Inspiratory tidal volume
Time frame: 4 weeks
Inspiratory tidal volume (TVi) in milliliters in L/min will be recorded.
Assessment of Expiratory tidal volume
Time frame: 4 weeks
Expiratory tidal volume (TVe) in milliliters in L/min will be recorded.
Assessment of Minute Ventilation
Time frame: 4 weeks
Minute ventilation in L/min will be recorded.
13 secondary outcomes
Assessment of APCAHE II
Time frame: 4 weeks
Consciousness Level Assessment
Time frame: 4 weeks
Agitation, Anxiety, and Sedation Assessment
Time frame: 4 weeks
Pain Assessment-The Nonverbal Pain Scale
Time frame: 4 weeks
Dyspnea Assessment
Time frame: 4 weeks
SOFA Assessment
Time frame: 4 weeks
Pain Assessment-The Visual Analog Scale
Time frame: 4 weeks
General Body Fatigue Assessment
Time frame: 4 weeks
Heart Rate Assessment
Time frame: at 4 weeks
Systolic Pressure Assessment
Time frame: at 4 weeks
Diastolic Pressure Assessment
Time frame: at 4 weeks
Oxygen Saturation Assessment
Time frame: at 4 weeks
Respiratory Rate Assessment
Time frame: at 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2025.
- Derived from this study: PubMed 42003288Tutuneken YE, Kabasakal E, Kardes K, Karabulut H, Tanriogen B, Senel O, Cagliyan Erdogan H, Isikci B, Parlak H, Yilmaz Yelvar GD, Cirak YB. Effects of whole-body vibration and neuromuscular electrical stimulation on muscle biomechanical properties and thickness in patients in the intensive care unit: a randomized controlled trial. Physiother Theory Pract. 2026 Apr 20:1-11. doi: 10.1080/09593985.2026.2660184. Online ahead of print.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing whole body vibration, Neuromuscular Electrical Stimulation and Conventional Physiotherapy in people with Intensive Care Patients and Whole Body Vibration, run by Istinye University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Evaluation of Muscle Thickness (time frame: at 4 weeks). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06872697, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2025.