BronchiectasisPhase 3NCT06872892

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

A Phase 3 study testing BI 1291583 in people with Bronchiectasis, run by Boehringer Ingelheim at 478 sites in 46 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

Search all trials

Trial summary

This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations). The purpose of this study is to find out whether a medicine called BI 1291583 helps people with bronchiectasis. Read more about this study

Who is it for?: Ages 12 years and older
Conditions the study is for: Bronchiectasis
What is being tested?: BI 1291583
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 1,755 participants
Where: 478 sitesin 46 countries
Study dates: 9 Jun 2025to 20 Dec 2027
Phase: Phase 3
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 12 years and older
All sexes
No healthy volunteers
Child, Adult, Older adult

Who may be able to join

Male or female participants. Woman of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per International Council of Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1 % per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the participant information.
Signed and dated written informed consent and assent, if applicable, prior to admission to the study, in accordance with GCP and local legislation.
Age of participants when signing the informed consent/assent ≥12 years.
-- Adolescents need to weigh at least 35 kg at Visit 1.
Clinical history consistent with bronchiectasis (e.g. cough, chronic sputum production, recurrent respiratory infections) and investigator confirmed diagnosis of bronchiectasis by CT scan where bronchiectasis has been documented by a radiologist.
Participants whose past CT scan image records are not available will undergo a chest CT scan during Screening. Historical scans must not be older than five years.

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Adult participants should be able to produce sputum for Pseudomonas aeruginosa assessment during the screening period.
History of documented pulmonary exacerbations (assessed and recorded by the investigator) requiring antibiotic treatment. In the 12 months before Visit 1, participants must have had either:
at least 2 exacerbations, or
at least 1 exacerbation and an St. George's Respiratory Questionnaire (SGRQ) Symptoms score of >40 at screening Visit 1 (adults only)
at least 1 exacerbation and high symptom burden according to the investigator's judgement (adolescents only) For participants on oral or inhaled antibiotics as chronic treatment for bronchiectasis and participants on Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy (CFTR-MT), at least one exacerbation must have occurred since initiation of antibiotics or CFTR-MT.

Who cannot join

Any new or newly diagnosed condition of primary or secondary immunodeficiency within 1 year before randomisation.
Allergic bronchopulmonary aspergillosis being treated or requiring treatment.
Tuberculosis or non-tuberculosis mycobacterial infection being treated or requiring treatment
Any findings in the medical examination and/or laboratory value assessed at Screening Visit 1 or during screening period, that in the opinion of the investigator may put the participant at risk by participating in the trial.
Any clinically relevant (at the discretion of the investigator) acute respiratory infection or ongoing pulmonary exacerbation at screening visit or during the screening unless recovered in the opinion of the investigator prior to Visit 2.
Any relevant pulmonary, gastrointestinal, hepatic, renal, cardiovascular, metabolic, immunological, hormonal, or other disorder that, in the opinion of the investigator, may put the participant at risk by participating in the study.

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Major surgery (major according to the investigator's assessment) performed within 6 weeks prior to randomisation or scheduled during trial period.
Any documented active or suspected malignancy or history of malignancy within 5 years prior to screening, except appropriately treated in situ non-melanoma skin cancers or in situ carcinoma of uterine cervix.
Evidence or medical history of moderate or severe liver disease (Child-Pugh score B or C hepatic impairment).
estimated Glomerular Filtration Rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula (adults) or Chronic Kidney Disease Under 25 (CKiD-U25) (adolescents) <30 mL/min at Visit 1.
Previous treatment with a dipeptidyl peptidase-1 (DPP1) (Cathepsin C (CatC)) inhibitor. (Note: Participants that were randomised and only received placebo in studies with DPP1 (CatC) inhibitor are allowed.) Further exclusion criteria apply.

Trial locations and contacts

478 sites in 46 countries. Contact the study team or a site near you to ask about taking part.

Boehringer Ingelheim contact

1-800-243-0127

clintriage.rdg@boehringer-ingelheim.com

Country

City, postcode or hospital

Sites recruiting now only

478 sites in 46 countries

United States79 sites, 11 recruiting

Akron Children's Hospital
Akron, Ohio, 44308
Completed
Central Florida Pulmonary Group
Altamonte Springs, Florida, 32701
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Not yet recruiting
University of Michigan
Ann Arbor, Michigan, 48109
Active, not recruiting
Emory University
Atlanta, Georgia, 30342
Completed
Augusta University
Augusta, Georgia, 30912
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
Johns Hopkins Hospital
Baltimore, Maryland, 21287
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
University of Alabama at Birmingham
Birmingham, Alabama, 35233
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, 02114
Active, not recruiting
Meris Clinical Research-Brandon-69466
Brandon, Florida, 33511
Active, not recruiting
University of Vermont
Burlington, Vermont, 05401
Active, not recruiting
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514
Completed
Medical University of South Carolina
Charleston, South Carolina, 29425
Completed
The Lung Research Center, LLC
Chesterfield, Missouri, 63017
Completed
Northwestern University
Chicago, Illinois, 60611
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Not yet recruiting
University of Cincinnati
Cincinnati, Ohio, 45219
Active, not recruiting
St. Francis Medical Institute
Clearwater, Florida, 33765
Completed
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106
Active, not recruiting
Horizon Clinical Research Group
Cypress, Texas, 77429
Active, not recruiting
Baylor University Medical Center
Dallas, Texas, 75246
Active, not recruiting
University of Texas Southwestern Medical Center
Dallas, Texas, 75390
Active, not recruiting
National Jewish Health
Denver, Colorado, 80206
Active, not recruiting
Clinical Research Associates of Central PA
DuBois, Pennsylvania, 15801
Active, not recruiting
El Paso Pulmonary Association
El Paso, Texas, 79902
Active, not recruiting
Inova Fairfax Medical Campus
Falls Church, Virginia, 22042
Active, not recruiting
North Florida/South Georgia Veterans Health System
Gainesville, Florida, 32608
Completed
University of Texas Medical Branch at Galveston
Galveston, Texas, 77555
Active, not recruiting
New York Medical College - Hawthorne
Hawthorne, New York, 10532
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
Baylor College of Medicine
Houston, Texas, 77030
Active, not recruiting
Stern Research Partners, LLC
Huntersville, North Carolina, 28078
Active, not recruiting
Indiana University
Indianapolis, Indiana, 46202
Completed
University of Iowa Hospitals and Clinics
Iowa City, Iowa, 52242
Completed
University Of Mississippi Medical Center
Jackson, Mississippi, 39216
Active, not recruiting
University of Florida College of Medicine
Jacksonville, Florida, 32209
Completed
Mayo Clinic - Florida
Jacksonville, Florida, 32224
Active, not recruiting
University of Kansas Medical Center
Kansas City, Kansas, 66160
Active, not recruiting
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03766
Completed
University of Wisconsin
Madison, Wisconsin, 53792
Active, not recruiting
Metroplex Pulmonary & Sleep Center
McKinney, Texas, 75069
Active, not recruiting
University of Miami
Miami, Florida, 33136
Active, not recruiting
Froedtert and The Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Active, not recruiting
Intermountain Healthcare
Murray, Utah, 84107
Active, not recruiting
Essence MD Research
Naples, Florida, 34102
Active, not recruiting
Rutgers Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
Northwell Health
New Hyde Park, New York, 11040
Active, not recruiting
New York University Langone Medical Center
New York, New York, 10016
Completed
Icahn School of Medicine at Mount Sinai
New York, New York, 10029
Active, not recruiting
New York Presbyterian Hospital -Columbia University
New York, New York, 10032
Active, not recruiting
NewYork-Presbyterian/Weill Cornell Medical Center
New York, New York, 10065
Completed
Newport Native MD, Inc
Newport Beach, California, 92663
Active, not recruiting
Yale University School of Medicine
North Haven, Connecticut, 06473
Active, not recruiting
University of Nebraska Medical Center
Omaha, Nebraska, 68198-1230
Active, not recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
Active, not recruiting
Jefferson Health Honickman Center
Philadelphia, Pennsylvania, 19107
Active, not recruiting
Dignity Health, St. Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Not yet recruiting
Pinehurst Medical Clinic, Inc. - East
Pinehurst, North Carolina, 28374
Active, not recruiting
Oregon Health and Sciences University
Portland, Oregon, 97239
Completed
Paradigm Clinical Research - Redding
Redding, California, 96001
Active, not recruiting
Virginia Commonwealth University Health Systems
Richmond, Virginia, 23219
Active, not recruiting
Mayo Clinic, Rochester
Rochester, Minnesota, 55902
Active, not recruiting
Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732
Active, not recruiting
University of California Davis
Sacramento, California, 95817
Active, not recruiting
HealthPartners Specialty Center 401 Building
Saint Paul, Minnesota, 55130
Active, not recruiting
Methodist Heart and Lung Institute
San Antonio, Texas, 78229
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Not yet recruiting
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Recruiting
Element Research Group
San Antonio, Texas, 78258
Completed
University of California San Francisco
San Francisco, California, 94143
Active, not recruiting
University of Washington
Seattle, Washington, 98195
Active, not recruiting
Providence Medical Research Center
Spokane, Washington, 99204
Active, not recruiting
Washington University School of Medicine
St Louis, Missouri, 63110
Active, not recruiting
Washington University School of Medicine
St Louis, Missouri, 63110
Completed
Vantage Clinical Trials - Tampa
Tampa, Florida, 33614
Active, not recruiting
ProMedica Physicians Pulmonary and Sleep Medicine - Toledo
Toledo, Ohio, 43606
Boehringer Ingelheim, 833-602-2368, unitedstates@bitrialsupport.com
Not yet recruiting
University of Maryland St. Joseph Medical Group Pulmonary Care and Sleep Medicine
Towson, Maryland, 21286
Completed
University of Arizona
Tucson, Arizona, 85724
Active, not recruiting
University of Texas Health Science Center at Tyler
Tyler, Texas, 75708
Active, not recruiting
Ventura County Medical Center
Ventura, California, 93003
Completed
Georgetown University
Washington D.C., District of Columbia, 20007
Active, not recruiting
Cleveland Clinic Florida
Weston, Florida, 33331
Active, not recruiting
UMASS Memorial Medical Center
Worcester, Massachusetts, 01655
Active, not recruiting

Other trials in United States

China51 sites, 51 recruiting

China-Japan Friendship Hospital
Beijing, 100029
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Peking University People's Hospital
Beijing, 100044
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Beijing Children's Hospital, Capital Medical University
Beijing, 100045
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Peking University Third Hospital
Beijing, 100191
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Peking Union Medical College Hospital
Beijing, 100730
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Hospital of Jilin University
Changchun, 130000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Second Hospital of Jilin University
Changchun, 130000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Second Xiangya Hospital Of Central South University
Changsha, 410011
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
West China Hospital, Sichuan University
Chengdu, 610041
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Sichuan Provincial People's Hospital
Chengdu, 610072
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
First Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Guangdong Provincial People's Hospital
Guangzhou, 510080
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Guizhou Provincial People's Hospital
Guiyang, 550002
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital, Zhejiang University
Hangzhou, 310003
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Hangzhou First People's Hospital
Hangzhou, 310006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, 310009
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Zhejiang Hospital
Hangzhou, 310013
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
Hangzhou, 310016
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital of Anhui Medical University
Hefei, 230022
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Huzhou Central Hospital
Huzhou, 313000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Jiangmen Central Hospital
Jiangmen, 529030
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital of Nanchang University
Nanchang, 330006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Second Affiliated Hospital to Nanchang University
Nanchang, 330006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Nanjing First Hospital
Nanjing, 210006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Nanjing Drum Tower Hospital
Nanjing, 210008
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Affiliated Hospital of Nantong University
Nantong, 226001
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Ningbo Medical Center Lihuili Hospital
Ningbo, 315000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital of Ningbo University
Ningbo, 315010
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Pingxiang People's Hospital
Pingxiang, 337000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Qingdao Municipal Hospital
Qingdao, 266011
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Second Affiliated Hospital of Fujian Medical University
Quanzhou, 362000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, 200025
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Zhongshan Hospital Affiliated to Fudan University
Shanghai, 200032
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Huadong Hospital affiliated to Fudan University
Shanghai, 200040
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Tongji Hospital, Tongji University
Shanghai, 200065
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Shanghai General Hospital
Shanghai, 200080
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Shanghai Fifth People's Hospital affiliated to Fudan University
Shanghai, 200240
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Shanghai Pulmonary Hospital
Shanghai, 200433
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Children's Hospital of Fudan University
Shanghai, 201102
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University
Shanghai, 201700
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Shenzhen People's Hospital
Shenzhen, 518020
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital of Soochow University
Suzhou, 215006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Tianjin Medical University General Hospital
Tianjin, 30052
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Wenzhou People's Hospital
Wenzhou, 325006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430056
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Wuxi People's Hospital
Wuxi, 214043
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, 710061
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
The Affiliated Hospital of Xuzhou Medical College
Xuzhou, 221006
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Northern Jiangsu People's Hospital
Yangzhou, 225001
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting
Yixing People'S Hospital
Yixing, 214258
Boehringer Ingelheim, 4001200553, china@bitrialsupport.com
Recruiting

Other trials in China

Japan38 sites, 38 recruiting

Nagoya University Hospital
Aichi, Nagoya, 466-8560
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Hirosaki University Hospital
Aomori, Hirosaki, 036-8563
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Chiba University Hospital
Chiba, Chiba, 260-8677
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kameda Clinic
Chiba, Kamogawa, 296-0041
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Fukuoka Children's Hospital
Fukuoka, Fukuoka, 813-0017
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Fukuoka University Hospital
Fukuoka, Fukuoka, 814-0180
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Aso Co.,Ltd Iizuka Hospital
Fukuoka, Iizuka, 820-8505
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Hokkaido University Hospital
Hokkaido, Sapporo, 060-8648
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Terada Clinic, Respiratory Medicine & General practice
Hyogo, Himeji, 670-0849
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
University of Tsukuba Hospital
Ibaraki, Tsukuba, 305-8576
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kagoshima University Hospital
Kagoshima, Kagoshima, 890-8520
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, 236-0051
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Minami Kyoto Hospital
Kyoto, Joyo, 610-0113
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kyoto University Hospital
Kyoto, Kyoto, 606-8507
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Matsusaka City Hospital
Mie, Matsusaka, 515-8544
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Tohoku University Hospital
Miyagi, Sendai, 980-8574
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Nagasaki University Hospital
Nagasaki, Nagasaki, 852-8501
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Niigata University Medical and Dental Hospital
Niigata, Niigata, 951-8520
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Oita University Hospital
Oita, Yufu, 879-5593
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Kurashiki Central Hospital
Okayama, Kurashiki, 710-8602
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
National Hospital Organization Kinki-Chuo Chest Medical Center
Osaka, Sakai, 591-8555
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Osaka Toneyama Medical Center
Osaka, Toyonaka, 560-8552
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Saga University Hospital
Saga, Saga, 849-8501
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Saitama Cardiovascular and Respiratory Center
Saitama, Kumagaya, 360-0197
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Shiga University of Medical Science Hospital
Shiga, Otsu, 520-2192
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Matsue Medical Center
Shimane, Matsue, 690-8556
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Hamamatsu University Hospital
Shizuoka, Hamamatsu, 431-3192
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Tenryu Hospital
Shizuoka, Hamamatsu, 434-8511
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Tokushima University Hospital
Tokushima, Tokushima, 770-8503
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Institute of Science Tokyo Hospital
Tokyo, Bunkyo-ku, 113-8519
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Nihon University Itabashi Hospital
Tokyo, Itabashi-ku, 173-8610
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Fukujuji Hospital
Tokyo, Kiyose, 204-8522
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Toranomon Hospital
Tokyo, Minato-ku, 105-8470
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
National Center for Child Health and Development
Tokyo, Setagaya-ku, 157-8535
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Keio University Hospital
Tokyo, Shinjuku-ku, 160-8582
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Tokyo Women's Medical University Hospital
Tokyo, Shinjuku-ku, 162-8666
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting
Yamaguchi University Hospital
Yamaguchi, Ube, 755-8505
Boehringer Ingelheim, 05050508862, nippon@bitrialsupport.com
Recruiting

Other trials in Japan

Germany33 sites, 32 recruiting

Universitätsklinikum Aachen, AöR
Aachen, 52074
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Velocity Clinical Research Germany GmbH, Ahrensburg
Ahrensburg, 22926
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
CIMS Studienzentrum Bamberg GmbH
Bamberg, 96049
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Charité - Universitätsmedizin Berlin
Berlin, 10117
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Vivantes Netzwerk für Gesundheit GmbH
Berlin, 12351
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Evangelische Lungenklinik Berlin gGmbH
Berlin, 13125
Completed
Charité - Universitätsmedizin Berlin
Berlin, 13353
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Katholisches Klinikum Bochum gGmbH
Bochum, 44791
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Bonn AöR
Bonn, 53127
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Augustiner Krankenhäuser GmbH
Cologne, 50678
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Köln (AöR)
Cologne, 50937
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Caritas-Krankenhaus St. Maria gGmbH
Donaustauf, 93093
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Klinikum Dortmund gGmbH
Dortmund, 44145
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Technische Universität Dresden
Dresden, 01307
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
Essen, 45239
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Frankfurt
Frankfurt, 60590
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
IKF Pneumologie GmbH & Co. KG
Frankfurt, 60596
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Freiburg
Freiburg im Breisgau, 79106
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Asklepios Fachkliniken München-Gauting
Gauting, 82131
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Christliches Klinikum Halle (Saale) GmbH
Halle, 06120
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Martin-Luther-Universität Halle-Wittenberg
Halle, 06120
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Medizinische Hochschule Hannover
Hanover, 30625
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
Heidelberg, 69126
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Lungenfachklinik Immenhausen
Immenhausen, 34376
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Jena
Jena, 07747
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Klinikum der Universität München AÖR
München, 80336
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Pneumologisches Studienzentrum München-West
München, 81241
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Universitätsklinikum Münster
Münster, 48149
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Klinikum Ernst von Bergmann GmbH, CF-Zentrum Potsdam
Potsdam, 14467
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
Helios Hanseklinikum Stralsund
Stralstund, 18435
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting
BAG Wiesbaden
Wiesbaden, 65183
Boehringer Ingelheim, 08007234742, deutschland@bitrialsupport.com
Recruiting

Other trials in Germany

United Kingdom23 sites, 21 recruiting

Belfast City Hospital
Belfast, BT9 7AB
Completed
Heartlands Hospital
Birmingham, B9 5SS
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Blackpool Victoria Hospital
Blackpool, FY3 8NR
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Bradford Royal Infirmary
Bradford, BD9 6RJ
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Velocity Clinical Research, Bristol
Bristol, BS8 2RA
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Royal Papworth Hospital
Cambridge, CB2 0AY
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
University Hospital Llandough
Cardiff, CF64 2XX
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Ninewells Hospital & Medical School
Dundee, Scotland, DD1 9SY
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
University Hospital Hairmyres
East Kilbride, G75 8RG
Completed
Royal Infirmary of Edinburgh
Edinburgh, EH16 4SA
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Royal Hospital for Children and Young People
Edinburgh, EH16 4TJ
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Western General Hospital
Edinburgh, EH4 2XU
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Freeman Hospital
High Heaton, NE7 7DN
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Royal Lancaster Infirmary
Lancaster, LA1 4RP
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
St James's University Hospital
Leeds, LS9 7TF
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Liverpool Heart & Chest Hospital
Liverpool, L14 3PE
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
King's College Hospital
London, SE5 9RS
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Royal Brompton Hospital
London, SW3 6NP
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Craigavon Area Hospital
Portadown, BT63 5QQ
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Northern General Hospital
Sheffield, S5 7AU
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Southampton General Hospital
Southampton, SO16 6YD
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Royal Stoke University Hospital
Stoke-on-Trent, ST4 6QG
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting
Torbay Hospital
Torquay, TQ2 7AA
Boehringer Ingelheim, 08000514022, unitedkingdom@bitrialsupport.com
Recruiting

Other trials in United Kingdom

Spain21 sites, 20 recruiting

Complejo Hospitalario Universitario A Coruña
A Coruña, 15006
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Germans Trias i Pujol
Badalona, 08916
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Clínic de Barcelona
Barcelona, 08036
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitario Virgen de la Arrixaca
El Palmar, 30120
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitari de Girona Doctor Josep Trueta
Girona, 17007
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Infanta Elena
Huelva, 21080
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Jerez de la Frontera
Jerez de la Frontera, 11407
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitario La Paz
Madrid, 28046
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital de Mérida
Mérida, 06800
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Central de Asturias
Oviedo, 33011
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Son Espases
Palma de Mallorca, 07120
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitario de Navarra
Pamplona, 31008
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Quirónsalud Madrid
Pozuelo de Alarcón, 28223
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitario Puerto Real
Puerto Real, 11510
Completed
Hospital Universitario Marqués de Valdecilla
Santander, 39008
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Complexo Hospitalario Universitario De Santiago
Santiago de Compostela, 15706
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitario Virgen De La Macarena
Seville, 41009
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Virgen del Rocio
Seville, 41013
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting
Hospital Universitari i Politècnic La Fe
Valencia, 46026
Boehringer Ingelheim, 900876092, espana@bitrialsupport.com
Recruiting

Other trials in Spain

South Korea18 sites, 2 recruiting

Hallym University Sacred Heart Hospital
Anyang, 14068
Active, not recruiting
Chungbuk National University Hospital
Chungju, 28644
Active, not recruiting
Yeongnam University Hospital
Daegu, 42415
Active, not recruiting
Ulsan University Hospital
Dong-gu Ulsan, 44033
Active, not recruiting
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, 21431
Active, not recruiting
Severance Hospital
Seoul, 03722
Active, not recruiting
Hanyang University Medical Center
Seoul, 04763
Boehringer Ingelheim, 0808802084, namhan@bitrialsupport.com
Recruiting
Konkuk University Medical Center
Seoul, 05030
Active, not recruiting
Kangdong Sacred Heart Hospital
Seoul, 05355
Active, not recruiting
Asan Medical Center
Seoul, 05505
Active, not recruiting
Samsung Medical Center
Seoul, 06351
Active, not recruiting
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, 06591
Active, not recruiting
SMG-SNU Boramae Medical Center
Seoul, 07071
Active, not recruiting
Hallym University Kangnam Sacred Heart Hospital
Seoul, 07441
Boehringer Ingelheim, 0808802084, namhan@bitrialsupport.com
Recruiting
Korea University Guro Hospital
Seoul, 08308
Active, not recruiting
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, 22711
Active, not recruiting
Jeonbuk National University Hospital
Seoul, 54907
Active, not recruiting
Yonsei University Wonju Severance Christian Hospital
Wŏnju, 26426
Active, not recruiting

Other trials in South Korea

Italy16 sites, 15 recruiting

Azienda Ospedaliero Universitaria delle Marche
Ancona, 60126
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Policlinico S. Orsola-Malpighi
Bologna, 40138
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania
Catania, 95121
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Not yet recruiting
Azienda Ospedaliera San Martino
Genova, 16132
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Istituto G. Gaslini
Genova, 16147
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
A.O.U.Policlinico G.Martino
Messina, 98124
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Not yet recruiting
Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
Milan, 20122
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Azienda Socio Sanitaria Territoriale Di Monza
Monza (MB), 20900
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Azienda Ospedaliera dei Colli
Naples, 80131
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Azienda Ospedaliera Universitaria di Padova
Padova, 35128
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Policlinico "Paolo Giaccone"
Palermo, 90127
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Fondazione IRCCS Policlinico S. Matteo
Pavia, 27100
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Ospedale Pediatrico Bambino Gesù
Roma, 00165
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168
Completed
Istituto Clinico Humanitas
Rozzano (MI), 20089
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting
Azienda Ospedaliera Universitaria Integrata Verona
Verona, 37126
Boehringer Ingelheim, 800977373, italia@bitrialsupport.com
Recruiting

Other trials in Italy

Australia15 sites, 1 recruiting

Eastern Health-Box Hill Hospital
Box Hill, Victoria, 3128
Completed
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050
Active, not recruiting
Heart of Australia Research Institute
Chelmer, Queensland, 4068
Active, not recruiting
Lung Research Queensland
Chermside, Queensland, 4032
Active, not recruiting
The Prince Charles Hospital
Chermside, Queensland, 4032
Active, not recruiting
Peninsula Health
Frankston, Victoria, 3199
Active, not recruiting
Canberra Hospital
Garran, Australian Capital Territory, 2605
Active, not recruiting
Greenslopes Private Hospital
Greenslopes, Queensland, 4120
Active, not recruiting
Alfred Hospital
Melbourne, Victoria, 3004
Completed
Institute for Respiratory Health
Nedlands, Western Australia, 6009
Active, not recruiting
Macquarie University
North Ryde, New South Wales, 2109
Active, not recruiting
Mater Hospital Brisbane
South Brisbane, Queensland, 4101
Active, not recruiting
Queensland Children's Hospital
South Brisbane, Queensland, 4101
Boehringer Ingelheim, 1800271035, australia@bitrialsupport.com
Recruiting
Trialswest
Spearwood, Western Australia, 6163
Active, not recruiting
Westmead Hospital
Westmead, New South Wales, 2145
Active, not recruiting

Other trials in Australia

Argentina12 sites, 11 recruiting

Centro Dr. Lazaro Langer S.R.L
Alberdi Sur, X5003DCE
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
CEC- Centro de Especialidades Cardiovasculares
Bahía Blanca
Completed
Fundacion NIBA Neurologia Infantil Buenos Aires
CABA, 1182
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Centro de Investigacion Clinica Belgrano
CABA, 1425
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Mautalen- Salud e Investigacion
CABA, C1128AAF
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Equipo Ciencia
CABA, C1428BNF
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Hospital Aleman
Capital Federal, C1118AAT
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
APRILLUS-Asistencia e Investigacion
Ciudad Autonoma Buenos Aires, C1046AAQ
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Instituto Ave Pulmo - Fundacion Enfisema
Mar del Plata, 7600
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Centro Respiratorio de Quilmes
Quilmes, B1878FNR
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Instituto de Especialidades de la Salud Rosario
Rosario, 2000
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting
Ibamedica
Santa Fe, 3000
Boehringer Ingelheim, 08002667801, argentina@bitrialsupport.com
Recruiting

Other trials in Argentina

France11 sites, 10 recruiting

CHU Amiens-Picardie
Amiens, 80054
Completed
HOP Intercommunal
Créteil, 94000
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
INS Coeur Poumon
Lille, 59037
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
Hopital De La Croix-Rousse
Lyon, 69004
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
HOP Arnaud de Villeneuve
Montpellier, 34295
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
Hopital Pasteur
Nice, 06001
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
Hôpital Cochin
Paris, 75014
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
HOP Haut-Leveque
Pessac, 33604
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
HOP Pontchaillou
Rennes, 35000
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
HOP Nord Laennec
Saint-Herblain, 44800
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting
Hôpital Larrey - CHU de Toulouse
Tououse, 31059
Boehringer Ingelheim, 0805102354, france@bitrialsupport.com
Recruiting

Other trials in France

Canada10 sites, 10 recruiting

BLC Clinical Research
Burlington, Ontario, L7N 3V2
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
University of Calgary
Calgary, Alberta, T2N 4Z6
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 3A7
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, H2X 0A9
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)
Québec, G1V 4G5
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Royal University Hospital (Saskatoon)
Saskatoon, Saskatchewan, S7N 0W8
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Diex Recherche (Sherbrooke Est)
Sherbrooke, Quebec, J1E 0N8
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Diex Recherche (Trois-Rivieres)
Trois-Rivières, Quebec, G9A 4P3
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
St. Paul's Hospital (Vancouver)
Vancouver, British Columbia, V6Z 1Y6
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting
Cardio 1 Medical Clinic
Winnipeg, Manitoba, R3L 1Z5
Boehringer Ingelheim, 18336022346, canada@bitrialsupport.com
Recruiting

Other trials in Canada

Bulgaria9 sites

MHAT Rahila Angelova AD
Pernik, 2300
Active, not recruiting
DCC V Plovdiv St. Archbishop Luka EOOD
Plovdiv, 4023
Active, not recruiting
Specialized Hospital For Active Treatment Of Pneumo-Phthisiatric Diseases Dr. Dimitar Gramatikov-Ruse
Rousse, 7002
Active, not recruiting
Multiprofile Hospital MHATEM 'Pirogov', Sofia
Sofia, 1606
Active, not recruiting
Diagnostics And Consultation Center Convex Ltd.
Sofia, 1680
Active, not recruiting
Medical Center "Pulmovision"
Sofia, 1756
Active, not recruiting
Medical Center Tara
Veliko Tarnovo, 5000
Active, not recruiting
Medical Center "Sveti Ivan Rilski"
Vidin, 3700
Active, not recruiting
Specialized Hospital For Active Treatment Of Pneumo-Physiatiric Diseases Vraca /Sbalpfz Vratsa EOOD
Vratsa, 3001
Active, not recruiting

Other trials in Bulgaria

India8 sites

Jawahar Lal Nehru Medical College
Ajmer, 305001
Completed
M. S. Ramaiah Institute of Health Science
Bengaluru, 560054
Completed
Narayana Health - Mazumdar Shaw Medical Center
Bengaluru, 560099
Completed
B. P. Poddar Hospital and Medical Research Limited
Kolkata, 700053
Completed
Midland Healthcare & Research Center
Lucknow, 226006
Completed
Siddhi Hospital, C/o Dr. Mutha Hospital
Nashik, 422007
Completed
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
Rohtak, 124001
Completed
Government Hospital for Chest and Communicable Diseases (GHCCD)
Visakhapatnam, 530017
Completed

Other trials in India

Mexico8 sites, 3 recruiting

Centro de Investigacion Integral MEDIVEST S.C
Chihuahua City, 31203
Boehringer Ingelheim, 018000623749, mexico@bitrialsupport.com
Recruiting
Mediadvance Clinical S.A.P.I de C.V.
Chihuahua City, 31203
Completed
Centro de Investigacion Farmacologica del Bajío, S.C.
León, 37160
Boehringer Ingelheim, 018000623749, mexico@bitrialsupport.com
Recruiting
Soluciones terapeuticas medico quirurgicas S de RL de CV
Mexico City, 03650
Boehringer Ingelheim, 018000623749, mexico@bitrialsupport.com
Recruiting
Oaxaca Site Management Organization, S.C.
Oaxaca City, 68000
Completed
Asociación Mexicana para la Investigacion Clínica, A.C(AMIC)
Pachuca, 42070
Completed
Clinical Research Institute S.C.
Tlalnepantla, 54055
Completed
Arke SMO S.A. de C.V.
Veracruz de Ignacio de La Llave, 91900
Completed

Other trials in Mexico

Brazil7 sites, 7 recruiting

Serviços Medicos Respirar Sul Fluminense
Barra Mansa, 27323240
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
Faculdade de Medicina de Botucatu - UNESP
Botucatu, 18618-687
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
Chronos Pesquisa Clinica
Brasília, 72145-450
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
Goiânia, 74605-020
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, 90035-074
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
Netspiro Clinica Medica Ltda - Respsono
São Bernardo do Campo, 09750-420
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting
INCOR e Hospital das Clínicas da Universidade de São Paulo
São Paulo, 05403-000
Boehringer Ingelheim, 08008919295, brasil@bitrialsupport.com
Recruiting

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Latvia7 sites

Veselibas centru apvieniba AS
Daugavpils, 5410
Active, not recruiting
Daugavpils regionala slimnica SIA
Daugavpils, 5417
Completed
VCA Dubultu Medical center
Jūrmala, 2015
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Rigas 1. slimnica SIA
Riga, 1001
Completed
Mediciniskas pecdiploma izglitibas instituts SIA
Riga, 1011
Active, not recruiting
Pauls Stradins Clinical University Hospital
Riga, LV-1002
Active, not recruiting
Rigas Austrumu kliniska universitates slimnica SIA
Upeslejas, 2118
Active, not recruiting

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New Zealand7 sites

Momentum Clinical Research Dunedin
Central Dunedin, Dunedin, 9016
Active, not recruiting
Christchurch Hospital
Christchurch, 8011
Active, not recruiting
NZ Respiratory and Sleep Institute
Greenlane East, Auckland, 1051
Active, not recruiting
Waikato Hospital
Hamilton, Waikato Region, 3240
Active, not recruiting
Momentum Clinical Research
Mount Cook, Wellington Region, 6021
Active, not recruiting
Middlemore Clinical Trials
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Momentum clinical Research Rotorua
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Portugal7 sites

ULS da Região de Aveiro
Aveiro, 3814-501
Active, not recruiting
ULS de Braga, E.P.E
Braga, 4710-243
Active, not recruiting
CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
Coimbra, 3004-561
Active, not recruiting
ULS do Alto Ave
Guimarães, 4835-045
Active, not recruiting
ULS da Região de Leiria, E.P.E.
Leiria, 2410-197
Active, not recruiting
ULS de Santa Maria, E.P.E
Lisbon, 1649-035
Active, not recruiting
Centro Hospitalar Universitário São João,EPE
Porto, 4202-451
Active, not recruiting

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Malaysia6 sites

Hospital Sultanah Bahiyah
Alor Setar, Kedah, 05460
Completed
Hospital Sultan Idris Shah Serdang
Kajang, 43000
Active, not recruiting
Hospital Raja Perempuan Zainab II
Kelantan, 15586
Active, not recruiting
Institut Perubatan Respiratori
Kuala Lumpur, 50586
Active, not recruiting
University Malaya Medical Centre
Kuala Lumpur, 59100
Active, not recruiting
Sarawak General Hospital
Kuching, 93586
Active, not recruiting

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Netherlands6 sites

Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD
Active, not recruiting
Amsterdam UMC Locatie VUMC
Amsterdam, 1081HV
Active, not recruiting
Erasmus Medisch Centrum-ROTTERDAM-50697
Rotterdam, 3015 GD
Active, not recruiting
Haga Ziekenhuis
The Hague, 2545 AA
Active, not recruiting
UMC Utrecht
Utrecht
Active, not recruiting
Gelre Ziekenhuis Zutphen
Zutphen, 7207 AE
Active, not recruiting

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Poland6 sites

Respiratory Medicine Centre, private prac., Bialystok
Bialystok, 15044
Active, not recruiting
M2M Med. Badania Sp. z o.o.
Chorzów, 41-500
Active, not recruiting
Screenmed Sp. z o.o.
Piaseczno, 05500
Active, not recruiting
EMED, Center of Medical Services,Private Prac,Rzeszow
Rzeszów, 35205
Active, not recruiting
Altamed Specjalistyczna Praktyka Lekarska Pawel Sliwinski
Warsaw, 01-456
Active, not recruiting
Medical Center K2J2
Wołomin, 05200
Completed

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Taiwan6 sites, 6 recruiting

Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
Recruiting
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
Recruiting
Taichung Veterans General Hospital
Taichung, 40705
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
Recruiting
National Taiwan University Hospital
Taipei, 10048
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
Recruiting
Chang Gung Memorial Hospital, Linkou
Taoyuan, 333
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
Recruiting
National Taiwan University Hospital Yun-Lin Branch
Yunlin County, 632
Boehringer Ingelheim, 0809092098, taiwan@bitrialsupport.com
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Denmark5 sites

Aalborg Sygehus Syd
Aalborg, 9000
Active, not recruiting
Aarhus University Hospital
Aarhus N, 8200
Active, not recruiting
Hvidovre Hospital
Hvidovre, 2650
Active, not recruiting
Copenhagen University Hospital, Rigshospitalet
København Ø, 2100
Active, not recruiting
Vejle University Hospital
Vejle, 7100
Active, not recruiting

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Israel5 sites

Lady Davis Carmel Medical Center
Haifa, 3436212
Active, not recruiting
Hadassah Medical Center, Ein-Karem
Jerusalem, 9112001
Active, not recruiting
Hadassah Medical Center, Ein-Karem
Jerusalem, 9765422
Active, not recruiting
Rabin Medical Center Beilinson
Petah Tikva, 4941492
Active, not recruiting
Sourasky Medical Center
Tel Aviv, 6423906
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Philippines5 sites

Iloilo Doctors Hospital
Iloilo City, 5000
Active, not recruiting
West Visayas State University Medical Center
Iloilo City, 5000
Active, not recruiting
Health Cube Medical Clinics
Mandaluyong, 1552
Active, not recruiting
Quirino Memorial Medical Center
Quezon City, 1109
Active, not recruiting
Philippine General Hospital
Taft, Manila, 1000
Active, not recruiting

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South Africa5 sites, 3 recruiting

Iatros International
Bloemfontein, 9301
Boehringer Ingelheim, 0800988886, southafrica@bitrialsupport.com
Recruiting
Dr Ismail Abdullah
Cape Town, 7764
Boehringer Ingelheim, 0800988886, southafrica@bitrialsupport.com
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Addington Hospital
Durban, 4001
Completed
Enhancing Care Foundation NPC
Mount Edgecombe, 4301
Completed
CAPRISA Offices on the King DinuZulu Hospital Complex
Springfield, 4091
Boehringer Ingelheim, 0800988886, southafrica@bitrialsupport.com
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Thailand5 sites, 2 recruiting

Ramathibodi Hospital
Bangkok, 10400
Active, not recruiting
Siriraj Hospital
Bangkok, 10700
Active, not recruiting
Srinagarind Hospital
Khon Kaen, 40002
Active, not recruiting
Songklanagarind Hospital
Songkhla, 90110
Boehringer Ingelheim, 1800019059, thai@bitrialsupport.com
Recruiting
King Chulalongkorn Memorial Hospital
Thailand, 10330
Boehringer Ingelheim, 1800019059, thai@bitrialsupport.com
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Belgium4 sites

Cliniques Universitaires Saint-Luc
Brussels, 1200
Active, not recruiting
Universitair Ziekenhuis Gent
Ghent, 9000
Active, not recruiting
UZ Leuven
Leuven, 3000
Active, not recruiting
Vitaz - Campus Sint-Niklaas
Sint-Niklaas, 9100
Active, not recruiting

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Finland4 sites

Helsinki University Hospital
Helsinki, 00290 HUS
Active, not recruiting
Oulun yliopistollinen keskussairaala
Oulu, 90220
Active, not recruiting
Tampere University Hospital
Tampere, 33520
Active, not recruiting
Turku University Hospital / TYKS
Turku, 20520
Active, not recruiting

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Romania4 sites

Institutul De Pneumoftiziologie Marius Nasta
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SC Medlife S.A
Cluj-Napoca, 400003
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Spitalul Clinic De Pneumoftiziologie Leon Daniello
Cluj-Napoca, 400371
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Clinical Hospital Of Infectious Diseases And Pneumophysiology Dr.Victor Babes Timisoara
Timișoara, 300310
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Singapore4 sites

National University Hospital-Singapore-42005
Singapore, 119074
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Singapore General Hospital
Singapore, 169608
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Tan Tock Seng Hospital
Singapore, 308433
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Changi General Hospital
Singapore, 529889
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Czechia3 sites

MediTrial s.r.o.
Jindřichův Hradec, 377 01
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University Hospital Motol
Prague, 15000
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The First Pulmonary Private Practice
Prague, 19000
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Hungary3 sites, 1 recruiting

Koranyi National Institute For Pulmonolgy
Budapest, 1028
Boehringer Ingelheim, 680017725, magyarorszag@bitrialsupport.com
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BKS Research Ltd
Hatvan, H-3000
Active, not recruiting
Da Vinci Private Clinic
Pécs, 7635
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Ireland3 sites

Cork University Hospital
Cork, T12 DC4A
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St. Vincent's University Hospital
Dublin, D04 T6F4
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Connolly Hospital Blanchardstown
Dublin, D15 X40D
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Lithuania3 sites

Hospital of Lithuanian University of Health Sciences Kauno Klinikos
Kaunas, 50161
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Republic Klaipeda Hospital
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Vilnius University Hospital, Santariskiu
Vilnius, 08406
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Puerto Rico3 sites, 2 recruiting

San Juan Bautista School of Medicine
Caguas, 00726
Boehringer Ingelheim, 18336022368, unitedstates@bitrialsupport.com
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VA Caribbean Healthcare System
San Juan, 00921
Boehringer Ingelheim, 18336022368, unitedstates@bitrialsupport.com
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Puerto Rico Consortium for Clinical Investigation
San Juan, 00927
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Sweden3 sites

Universitetssjukhuset, Örebro
Örebro, 703 82
Active, not recruiting
Karolinska University Hospital
Stockholm, SE-171 64
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CTC Clinical Trial Consultants AB
Uppsala, 752 37
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Austria2 sites, 2 recruiting

Medical University of Graz
Graz, 8036
Boehringer Ingelheim, 0800017900, oesterreich@bitrialsupport.com
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Medical University of Innsbruck
Innsbruck, 6020
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Chile2 sites, 2 recruiting

Centro de Estudios Clinicos CEC
Santiago, 7750000
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Centro de Investigacion del Maule
Talca, 3465586
Boehringer Ingelheim, 800392345, chile@bitrialsupport.com
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Croatia2 sites

Clinical Hospital Centar Sestre Milosrdnice
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Hong Kong2 sites, 2 recruiting

Prince of Wales Hospital-Hong Kong-20715
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Queen Mary Hospital
Hong Kong, 999077
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Kazakhstan2 sites

Multidisciplinary City Hospital №1 of the Akimat of Astana
Astana, 010000
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Slovakia2 sites

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Switzerland2 sites, 1 recruiting

Universitätsspital Basel
Basel, 4031
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University Hospital of Lausanne
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Turkey (Türkiye)1 site

Ankara University Medical Faculty
Ankara, 06620
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About this study

Official title: A Phase III, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of BI 1291583 2.5 mg Administered Once Daily for up to 76 Weeks in Patients With Bronchiectasis (The AIRTIVITY™ Study)

This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).

The purpose of this study is to find out whether a medicine called BI 1291583 helps people with bronchiectasis. Participants are put into 2 groups randomly, which means by chance. One group takes BI 1291583 tablets and the other group takes placebo tablets. A placebo tablet looks like the BI 1291583 tablet but does not contain any medicine. Participants take 1 tablet once a day for up to 1 year and 6 months.

Participants are in the study for up to 1 year and 8 months. During this time, participants visit the study site up to 10 times and get about 13 phone calls from the site staff. Participants regularly complete a diary on a smartphone about their bronchiectasis symptoms and study doctors regularly check for any changes. The study doctors document when participants experience flare-ups. The number of flare-ups is compared between the participants who receive BI 1291583 and those who receive the placebo. The study doctors also regularly check participants' health and take note of any unwanted effects.

Conditions: Bronchiectasis
Being tested: BI 1291583, Placebo matching BI 1291583
Medical subject headings: Bronchiectasis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

BI 1291583Drug
Also called Verducatib
BI 1291583
Placebo matching BI 1291583Drug
Placebo matching BI 1291583

Study groups in NCT06872892
Study group	Role	What they receive
Treatment arm	Experimental	Not described Receives: Drug: BI 1291583
Placebo arm	Placebo comparator	Not described Receives: Drug: Placebo matching BI 1291583

What is being measured

The primary outcome is the main question the study is designed to answer.

Annualised rate of adjudicated pulmonary exacerbations (number of events per person year) up to Week 76
Measured: up to 76 weeks

Secondary outcomes (6)

Time to first adjudicated pulmonary exacerbation up to Week 76
Measured: up to 76 weeks
Absolute change from baseline in Quality of Life Questionnaire - Bronchiectasis (QOL-B) respiratory symptoms domain score at Week 52 (participants ≥ 16 years)
The QOL-B is a patient reported outcome (PRO) measure assessing symptoms, functioning and health-related quality of life of patients with bronchiectasis. It consists of 37 items covering the following domains: respiratory symptoms, physical functioning, vitality, role functioning, health perception, emotional functioning, social functioning, and treatment burden.
All items are rated on a 4-point response scale ranging from 'a lot' to 'not at all' with the recall period 'the previous week'. Domain scores are generated ranging from 0 to 100, with higher scores indicating less symptom burden, better functioning, and higher health-related quality of life respectively.
Measured: at baseline, at week 52
Absolute change from baseline in post-bronchodilator Forced Expiratory Volume in the first second (FEV1) %pred at Week 52
Measured: at baseline, at week 52
Absolute change from baseline in post-bronchodilator Forced Vital Capacity (FVC) %pred at Week 52
Measured: at baseline, at week 52
Annualised rate of severe adjudicated pulmonary exacerbations up to Week 76
Measured: up to 76 weeks
Time to first adjudicated severe pulmonary exacerbation up to Week 76
Measured: up to 76 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

9 Jun 202520 Dec 2027

First posted12 Mar 2025
Study start9 Jun 2025
Primary completion15 Jun 2027 (estimated)
Study completion20 Dec 2027 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (1)Papers the sponsor has linked to this study.
Other trials for BronchiectasisStudies of the same condition, open and under way.
More trials run by Boehringer IngelheimThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 3
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind
Who is masked: Participant, Care provider, Investigator, Outcomes assessor
Enrolment: 1,755 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06872892
Sponsor's protocol ID: 1397-0014
Other IDs: 2024-518589-29-00, U1111-1317-2315
Status last verified: Oct 2026
First submitted: 7 Mar 2025
Last updated: 28 Oct 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: Yes
FDA-regulated device: No
Individual data sharing: Yes: Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Publications

Chalmers JD, Shteinberg M, Chotirmall SH, Sauter W, Flume PA, Jain R, Morimoto K, O'Donnell AE, Ringshausen FC, Watz H, Xu JF, Rauch J, Eleftheraki A, Engel AT, Chang AB, Nielsen KG, Benitez G, Gupta A, Mall MA, McShane PJ. Phase III AIRTIVITY study design: verducatib (BI 1291583) in people with bronchiectasis. ERJ Open Res. 2026 Sep 1;12(5):01068-2025. doi: 10.1183/23120541.01068-2025. eCollection 2026 Sep.
PubMed 42820152

Interested in taking part?

Boehringer Ingelheim

1-800-243-0127

clintriage.rdg@boehringer-ingelheim.com

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

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A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Adult Study Participants With Non-Cystic Fibrosis Bronchiectasis
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All Bronchiectasis trials

Study at a glance

From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: A Phase III, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of BI 1291583 2.5 mg Administered Once Daily for up to 76 Weeks in Patients With Bronchiectasis (The AIRTIVITY™ Study)
ClinicalTrials.gov ID: NCT06872892
Acronym / sponsor ID: 1397-0014
Conditions: Bronchiectasis
Phase: Phase 3
Study type: Interventional
Recruitment status: Recruiting
Enrolment: 1,755 participants (estimated)
Lead sponsor: Boehringer IngelheimIndustry (pharma, biotech, devices)
Study start: 9 Jun 2025 (actual)
Primary completion: 15 Jun 2027 (estimated)
Study completion: 20 Dec 2027 (estimated)
First posted: 12 Mar 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind (participant, care provider, investigator, outcomes assessor)
Number of arms: 2

Arm	Type	Receives
Treatment arm	Experimental	Drug: BI 1291583
Placebo arm	Placebo comparator	Drug: Placebo matching BI 1291583

Who may qualify

Ages: 12 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Child, Adult, Older adult

Key inclusion criteria (11 listed)

Male or female participants. Woman of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per International Council of Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1 % per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the participant information.
Signed and dated written informed consent and assent, if applicable, prior to admission to the study, in accordance with GCP and local legislation.
Age of participants when signing the informed consent/assent ≥12 years.
-- Adolescents need to weigh at least 35 kg at Visit 1.
Clinical history consistent with bronchiectasis (e.g. cough, chronic sputum production, recurrent respiratory infections) and investigator confirmed diagnosis of bronchiectasis by CT scan where bronchiectasis has been documented by a radiologist.

Key exclusion criteria (11 listed)

Any new or newly diagnosed condition of primary or secondary immunodeficiency within 1 year before randomisation.
Allergic bronchopulmonary aspergillosis being treated or requiring treatment.
Tuberculosis or non-tuberculosis mycobacterial infection being treated or requiring treatment
Any findings in the medical examination and/or laboratory value assessed at Screening Visit 1 or during screening period, that in the opinion of the investigator may put the participant at risk by participating in the trial.
Any clinically relevant (at the discretion of the investigator) acute respiratory infection or ongoing pulmonary exacerbation at screening visit or during the screening unless recovered in the opinion of the investigator prior to Visit 2.

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
BI 1291583Also: VerducatibBI 1291583	Drug	Treatment arm
Placebo matching BI 1291583Placebo matching BI 1291583	Drug	Placebo arm

Primary outcome

Annualised rate of adjudicated pulmonary exacerbations (number of events per person year) up to Week 76
Time frame: up to 76 weeks

6 secondary outcomes

Time to first adjudicated pulmonary exacerbation up to Week 76
Time frame: up to 76 weeks
Absolute change from baseline in Quality of Life Questionnaire - Bronchiectasis (QOL-B) respiratory symptoms domain score at Week 52 (participants ≥ 16 years)
Time frame: at baseline, at week 52
Absolute change from baseline in post-bronchodilator Forced Expiratory Volume in the first second (FEV1) %pred at Week 52
Time frame: at baseline, at week 52
Absolute change from baseline in post-bronchodilator Forced Vital Capacity (FVC) %pred at Week 52
Time frame: at baseline, at week 52
Annualised rate of severe adjudicated pulmonary exacerbations up to Week 76
Time frame: up to 76 weeks
Time to first adjudicated severe pulmonary exacerbation up to Week 76
Time frame: up to 76 weeks

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
Derived from this study: PubMed 42820152Chalmers JD, Shteinberg M, Chotirmall SH, Sauter W, Flume PA, Jain R, Morimoto K, O'Donnell AE, Ringshausen FC, Watz H, Xu JF, Rauch J, Eleftheraki A, Engel AT, Chang AB, Nielsen KG, Benitez G, Gupta A, Mall MA, McShane PJ. Phase III AIRTIVITY study design: verducatib (BI 1291583) in people with bronchiectasis. ERJ Open Res. 2026 Sep 1;12(5):01068-2025. doi: 10.1183/23120541.01068-2025. eCollection 2026 Sep.
Related InfoLink provided by the sponsor.
Individual participant dataSharing planned: Yes. Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Related trials for Bronchiectasis

Enrolling by invitationObservational study
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
Lung Diseases
Recruiting
Diagnostic Value of Oropharyngeal Suction and Effect of Respiratory Physiotherapy on the Detection of Microorganisms in the Pediatric Patient
Cystic Fibrosis (CF), Bronchiectasis, Non-Cystic Fibrosis
Active, not recruitingObservational study
Sleep Quality in Patients With Non-cystic Fibrosis Bronchiectasis
Bronchiectasis, Sleep-Disordered Breathing
RecruitingPhase 2
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
Non-cystic Fibrosis Bronchiectasis
RecruitingPhase 2
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Adult Study Participants With Non-Cystic Fibrosis Bronchiectasis
Non-cystic Fibrosis Bronchiectasis

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.

Boehringer Ingelheim contact

1-800-243-0127

clintriage.rdg@boehringer-ingelheim.com

478 sites in 46 countries: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing BI 1291583 in people with Bronchiectasis, run by Boehringer Ingelheim at 478 sites in 46 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 11 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 478 sites in United States, China, Japan, Germany, United Kingdom and 41 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Boehringer Ingelheim (1-800-243-0127, clintriage.rdg@boehringer-ingelheim.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Annualised rate of adjudicated pulmonary exacerbations (number of events per person year) up to Week 76 (time frame: up to 76 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06872892, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.