AzTrials
AzTrials

Carcinoma, Non-Small-Cell LungPhase 3NCT06875310

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

A Phase 3 study testing Adagrasib, Pembrolizumab and Carboplatin in people with Carcinoma, Non-Small-Cell Lung, run by Mirati Therapeutics Inc. at 317 sites in 35 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Carcinoma, Non-Small-Cell Lung
What is being tested?
Adagrasib, Pembrolizumab and Carboplatin
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
630 participants
Where
317 sitesin 35 countries
Study dates
24 Apr 2025to 30 Apr 2032
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor sample and/or circulating tumor deoxyribonucleic acid (ctDNA).
  • Locally advanced or metastatic disease.
  • Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion.
  • No prior systemic anti-cancer therapy given for advanced or metastatic disease.
  • Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection).
  • Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter.
  • Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx.

Who cannot join

  • Participants with an active autoimmune or inflammatory disease requiring systemic treatment within 2 years.
  • Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment that are ongoing or with risk of recurrence.
  • Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities.
  • Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry.
  • Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting.
  • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration.
  • Other protocol-defined Inclusion/Exclusion criteria apply.

Trial locations and contacts

317 sites in 35 countries. Contact the study team or a site near you to ask about taking part.

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com contact

855-907-3286

Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #. contact

317 sites in 35 countries

United States46 sites, 46 recruiting

  • Velocity Clinical Research, Annapolis

    Annapolis, Maryland, 21401

    Fayez Estephan, Site 0702

    Recruiting

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005

    David Hakimian, Site 0665, 847-827-9060

    Recruiting

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294

    Maya Khalil, Site 0347, 205-975-2833

    Recruiting

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215

    Pasi Janne, Site 0019, 617-632-6036

    Recruiting

  • Mercy Medical Center

    Cedar Rapids, Iowa, 52403

    Ann Stroh, Site 0691

    Recruiting

  • University of Illinois at Chicago

    Chicago, Illinois, 60612

    Frank Weinberg, Site 0676

    Recruiting

  • Morton Plant Hospital - BayCare Health System

    Clearwater, Florida, 33756

    Vijayakrishna Gadiyaram, Site 0694, 727-462-3692

    Recruiting

  • Maryland Oncology Hematology - Columbia

    Columbia, Maryland, 21044

    Mohit Narang, Site 0385, 817-837-8660

    Recruiting

  • Local Institution - 0678

    Cooperstown, New York, 13326

    Site 0678

    Not yet recruiting

  • Texas Oncology Sammons Cancer Center

    Dallas, Texas, 75246

    Kartik Konduri, Site 0034, 214-370-1000

    Recruiting

  • National Jewish Health Medical Center

    Denver, Colorado, 80206

    Laurie Carr, Site 0442, 303-388-4461

    Recruiting

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201

    Hirva Mamdani, Site 0293, 909-525-0093

    Recruiting

  • Northwest Cancer Centers, P.C.

    Dyer, Indiana, 46311

    Shruti Singh, Site 0454, 219-924-8178

    Recruiting

  • Saint Elizabeth Medical Center Edgewood

    Edgewood, Kentucky, 41017

    Colleen Darnell, Site 0366, 859-301-4000

    Recruiting

  • SSM Health Cancer Care - Fenton

    Fenton, Missouri, 63026

    Mudresh Mehta, Site 0685

    Recruiting

  • Parkview Research Center at Parkview Regional Medical Center

    Fort Wayne, Indiana, 46845

    patricia Rich, Site 0684, 260-266-7100

    Recruiting

  • Providence Medical Foundation

    Fullerton, California, 92835

    David Park, Site 0581, 714-446-5900

    Recruiting

  • University Of Texas Medical Branch At Galveston

    Galveston, Texas, 77555

    Maurice Willis, Site 0692, 409-772-1164

    Recruiting

  • St Francis Cancer Center

    Greenville, South Carolina, 29607

    Stephen Dyar, Site 0658, 864-603-6327

    Recruiting

  • Cancer Specialists of North Florida

    Jacksonville, Florida, 32256

    Laura Lourdes, Site 0052, 904-538-4488

    Recruiting

  • Oncology & Hematology of South Texas

    Laredo, Texas, 78041

    Eduardo Miranda, Site 0652, 956-724-8543

    Recruiting

  • Local Institution - 0682

    Loma Linda, California, 92354

    Site 0682

    Not yet recruiting

  • Helios Clinical Research

    Long Beach, California, 90805

    Omkar Marathe, Site 0202, 562-693-4477

    Recruiting

  • The University of Louisville, James Graham Brown Cancer Center

    Louisville, Kentucky, 40202

    Phuong Ngo, Site 0566, 502-562-4358

    Recruiting

  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital

    Marietta, Georgia, 30060

    Walid Shaib, Site 0031, 770-281-5124

    Recruiting

  • Local Institution - 0696

    Miami, Florida, 33176

    Site 0696

    Not yet recruiting

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203

    David Spigel, Site 0020, 615-320-5090

    Recruiting

  • Local Institution - 0697

    Nashville, Tennessee, 37212

    Site 0697

    Not yet recruiting

  • Medical Oncology Hematology Consultants, PA

    Newark, Delaware, 19713

    Jamal Misleh, Site 0701, 302-366-1200

    Recruiting

  • Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala

    Ocala, Florida, 34474

    Ketan Doshi, Site 0680, 352-732-4938

    Recruiting

  • Mid Florida Hematology and Oncology Center

    Orange City, Florida, 32763

    Santosh Nair, Site 0679, 407-353-1915

    Recruiting

  • Owensboro Medical Health System

    Owensboro, Kentucky, 42303

    Jewraj Maheshwari, Site 0693

    Recruiting

  • Mercy Health-Paducah Medical Oncology and Hematology

    Paducah, Kentucky, 42003

    Wederson Claudino, Site 0698, 000-000-0000

    Recruiting

  • Cancer Care Centers of Brevard, Inc.

    Palm Bay, Florida, 32901

    Venkat Pavan Kancharla, Site 0621, 111-111-1111

    Recruiting

  • Florida Clinical Trials Group.

    Plantation, Florida, 33322

    Harshad Amin, Site 0365, 561-447-0614

    Recruiting

  • Texas Oncology - San Antonio

    San Antonio, Texas, 78217

    Krishna Alluri, Site 0622, 210-656-7177

    Recruiting

  • Ellis Hospital

    Schenectady, New York, 12308

    Tallat Mahmood, Site 0634, 517-331-4405

    Recruiting

  • Louisiana State University Health Sciences Shreveport

    Shreveport, Louisiana, 71103

    Kavitha Beedupalli, Site 0644, 318-813-3061

    Recruiting

  • Highlands Oncology Group - Springdale

    Springdale, Arkansas, 72762

    Eric Schaefer, Site 0686, 479-872-8130

    Recruiting

  • Springfield Clinic Main Campus

    Springfield, Illinois, 62703

    Preet Singh, Site 0683, 205-919-3812

    Recruiting

  • St. Anthony's Hospital

    St. Petersburg, Florida, 33705

    Ahmad Shaker, Site 0695

    Recruiting

  • Florida Clinical Trials Group.

    Tamarac, Florida, 33321

    Chintan Gandhi, Site 0377, 561-447-0614

    Recruiting

  • H. Lee Moffitt Cancer Center & Research Institute

    Tampa, Florida, 33612

    Andreas Saltos, Site 0699, 813-745-6895

    Recruiting

  • Texas Oncology - Northeast Texas

    Tyler, Texas, 75702

    Shail Dalal, Site 0700, 903-727-2200

    Recruiting

  • White Plains Hospital

    White Plains, New York, 10601

    Daniel Sammartino, Site 0618, 914-849-7600

    Recruiting

  • WellSpan Oncology Research

    York, Pennsylvania, 17403

    Ikechukwu Akunyili, Site 0657, 717-339-2560

    Recruiting

Other trials in United States

China40 sites, 40 recruiting

  • Beijing Cancer hospital

    Beijing, Beijing Municipality, 100142

    Jian Fang, Site 0355, 861088196479

    Recruiting

  • Beijing Peking Union Medical College Hospital

    Beijing, Beijing Municipality, 100730

    mengzhao wang, Site 0491, 13911235467

    Recruiting

  • Beijing Chest Hospital,Capital Medical University

    Beijing, Beijing Municipality, 101149

    Zhe Liu, Site 0397, 010-8909303

    Recruiting

  • The First Afflilated Hospital of Bengbu Medical College

    Bengbu, Anhui, 233017

    Chengling Zhao, Site 0482, +8618105527755

    Recruiting

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021

    Kewei Ma, Site 0483, 8613756060506

    Recruiting

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013

    Lin Wu, Site 0398, 8613170419973

    Recruiting

  • Sichuan Cancer hospital

    Chengdu, Sichuan, 610041

    Wenxiu Yao, Site 0667, 18908178836

    Recruiting

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041

    Yongsheng Wang, Site 0384, 8618980602258

    Recruiting

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, 400030

    Dan Yang, Site 0490, +8613983895620

    Recruiting

  • Fujian Medical University Union Hospital

    Fuzhou Fujian, Fujian, 350001

    Xiaoyan Lin, Site 0362, 8613950482366

    Recruiting

  • The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 0

    Kejing Tang, Site 0469, 8613802946566

    Recruiting

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510140

    Chengzhi Zhou, Site 0625, 13560351176

    Recruiting

  • The first Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003

    Yihong Shen, Site 0462, 13958106605

    Recruiting

  • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310016

    Yong Fang, Site 0492, 8613588491264

    Recruiting

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022

    Yun Fan, Site 0463, 8657188122188

    Recruiting

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang, 150081

    Yan Yu, Site 0465, 13904505825

    Recruiting

  • Anhui Provincial Hospital

    Hefei, Anhui, 230001

    Junqiang Zhang, Site 0475, 8618955142161

    Recruiting

  • Shandong Cancer Hospital

    Jinan, Shandong, 250117

    Haiyong Wang, Site 0474, 15665878316

    Recruiting

  • LinYi Cancer Hospital

    Linyi, Shandong, 276001

    Jianhua Shi, Site 0359, +8615963998868

    Recruiting

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006

    Anwen Liu, Site 0467, 8613767120022

    Recruiting

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    Nanjing, Jiangsu, 210000

    Lifeng Wang, Site 0371, 13951699955

    Recruiting

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530021

    Aiping Zeng, Site 0464, 13367816089

    Recruiting

  • Nanyang City Center Hospital

    Nanyang, Henan, 473009

    Lixin Wan, Site 0626, +8613838708656

    Recruiting

  • Shanghai Chest Hospital

    Shanghai, Shanghai Municipality, 200030

    Hua Zhong, Site 0470, 13818200560

    Recruiting

  • Shanghai East Hospital

    Shanghai, Shanghai Municipality, 200120

    Caicun Zhou, Site 0354, 8613301825532

    Recruiting

  • Cancer Hospital of Shantou University Medical College

    Shantou, Guangdong, 515041

    Wen Lin, Site 0356, 13612388011

    Recruiting

  • The First Hospital of China Medical University

    Shenyang, Liaoning, 110001

    Bo Jin, Site 0473, 13604923020

    Recruiting

  • Shengjing Hospital of China Medical University

    Shenyang, Liaoning, 110004

    Xiaoye Zhang, Site 0479, 18940259600

    Recruiting

  • Liaoning Cancer Hospital

    Shenyang, Liaoning, 110042

    Rui Ma, Site 0493, 13304006343

    Recruiting

  • Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center

    Shenzhen, Guangdong, 0

    Jianhua Chang, Site 0461, 8618017312689

    Recruiting

  • ShenZhen People's Hospital

    Shenzhen, Guangdong, 518020

    Di Wu, Site 0352, 8613662589160

    Recruiting

  • Fourth Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050035

    Ping Wang, Site 0472, 13931130696

    Recruiting

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215006

    Chuanyong Mu, Site 0382, 18912615299

    Recruiting

  • Shanxi Cancer Hospital

    Taiyuan, Shanxi, 030000

    Jianchun Duan, Site 0353, 86+13811259820

    Recruiting

  • Taizhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, 317000

    Dongqing LV, Site 0374, 13867622009

    Recruiting

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, 300052

    Diansheng Zhong, Site 0460, 13821377353

    Recruiting

  • Tongji Hospital Tongji Medical,Science & Technology

    Wuhan, Hubei, 430030

    Qian Chu, Site 0373, 8613212760751

    Recruiting

  • The First Affiliated hospital of Xiamen University

    Xiamen, Fujian, 361003

    Feng Ye, Site 0383, 8613860458889

    Recruiting

  • The First Affiliated Hospital of Henan Medical University

    Xinxiang, Henan, 453100

    Yinghua Ji, Site 0494, 8613663030446

    Recruiting

  • Northern Jiangsu People's Hospital

    Yangzhou, Jiangsu, 225001

    Buhai Wang, Site 0378, 8613813194298

    Recruiting

Other trials in China

Germany18 sites, 18 recruiting

  • Vivantes Klinikum Neukölln

    Berlin, 12351

    Maike De Wit, Site 0526, 0000000000

    Recruiting

  • Evangelische Lungenklinik Berlin

    Berlin, 13125

    Christian Grohe, Site 0537, +493094802112

    Recruiting

  • Klinikum Köln-Merheim

    Cologne, North Rhine-Westphalia, 51109

    Carolin Groß-Ophoff-Müller, Site 0523, +49 221 8907-13962

    Recruiting

  • Klinikum Esslingen

    Esslingen am Neckar, Baden-Wurttemberg, 73730

    Martin Faehling, Site 0534, +4971131032402

    Recruiting

  • Malteser Krankenhaus St. Franziskus-Hospital

    Flensburg, Schleswig-Holstein, 24939

    Nicolai Faber, Site 0521, 04618162782

    Recruiting

  • Centrum für Hämatologie und Onkologie Bethanien

    Frankfurt am Main, Hesse, 60389

    Oliver Waidmann, Site 0518, 06956005626

    Recruiting

  • SRH Wald-Klinikum Gera GmbH

    Gera, Thuringia, 07548

    Dagmar Täuscher, Site 0524, 493658287758

    Recruiting

  • UKGM Gießen/Marburg

    Giessen, Hesse, 35392

    Thomas Wehler, Site 0535, 0049064198558544

    Recruiting

  • Universitätsklinikum Halle

    Halle, Saxony-Anhalt, 06120

    Stephan Eisenmann, Site 0522, +4903455591429

    Recruiting

  • Praxis Onkologie am Raschplatz

    Hanover, Lower Saxony, 30161

    Eyck von der Heyde, Site 0520, 0177-6506614

    Recruiting

  • Lungenklinik Hemer

    Hemer, 58675

    Karsten Schulmann, Site 0528, 02372-9082560

    Recruiting

  • Evangelisches Krankenhaus Herne - Eickel

    Herne, North Rhine-Westphalia, 44651

    Daniel Christoph, Site 0603, +49232349892793

    Recruiting

  • Universitätsklinikum Jena

    Jena, Thuringia, 07747

    Jakob Hammersen, Site 0551, 4936419396622

    Recruiting

  • Klinikum der Ludwig-Maximilians-Universitaet Muenchen

    München, Bavaria, 81377

    Amanda Tufman, Site 0557, 4989440057545

    Recruiting

  • Pius Hospital Oldenburg

    Oldenburg, Lower Saxony, 26121

    Frank Griesinger, Site 0527, 494412291611

    Recruiting

  • Klinikum Stuttgart - Katharinenhospital

    Stuttgart, 70174

    Cornelia Kropf-Sanchen, Site 0517, +4973150045230

    Recruiting

  • Bundeswehrkrankenhaus Ulm

    Ulm, Baden-Wurttemberg, 89081

    Matthias Mueller, Site 0670, +490731171031253

    Recruiting

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97080

    Horst Dieter Hummel, Site 0525, + 49 931 201-40916

    Recruiting

Other trials in Germany

France16 sites, 16 recruiting

  • CHU d'Amiens-Picardie - Hôpital Sud

    Amiens, Somme, 80054

    Claire Poulet, Site 0552, 0322087990

    Recruiting

  • Centre Hospitalier Universitaire d'Angers

    Angers, Maine-et-Loire, 49933

    Youssef Oulkhouir, Site 0560, 33231064676

    Recruiting

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, 92100

    Etienne Giroux-Leprieur, Site 0513

    Recruiting

  • CHRU de Brest

    Brest, Finistère, 29200

    Jessica NGUYEN, Site 0512, 0230338534

    Recruiting

  • Centre François Baclesse

    Caen, Calvados, 14076

    Hubert CURCIO, Site 0296, 0231455050

    Recruiting

  • Chu Gabriel Montpied

    Clermont-Ferrand, 63000

    Patrick MERLE, Site 0134, 0473751649

    Recruiting

  • Centre Georges François Leclerc

    Dijon, Côte-d'Or, 21079

    Coureche Kaderbhai, Site 0605, 33380737504

    Recruiting

  • Chu Grenoble Alpes

    La Tronche, Isère, 38700

    Denis Moro-Sibilot, Site 0220, 33476765467

    Recruiting

  • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren

    Limoges, 87042

    Thomas Egenod, Site 0604, 33555056892

    Recruiting

  • Institut Paoli-Calmettes

    Marseille, Provence-Alpes-Côte d'Azur Region, 13273

    Anne Madroszyk, Site 0636, 33491223789

    Recruiting

  • Assistance Publique Hôpitaux de Marseille - Hôpital Nord

    Marseille, 13915

    Laurent Greillier, Site 0164, 33491324400

    Recruiting

  • Institut Régional du Cancer Montpellier

    Montpellier, Hérault, 34298

    Xavier Quantin, Site 0558, 33467614533

    Recruiting

  • Hopitaux Universitaires Paris Centre-Hopital Cochin

    Paris, 75679

    Marie Wislez, Site 0158, 33158413091

    Recruiting

  • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

    Saint-Herblain, 44800

    Elvire Pons-Tostivint, Site 0139, +33676133810

    Recruiting

  • Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511

    Bertrand Mennecier, Site 0589, 33383154653

    Recruiting

  • Gustave Roussy

    Villejuif, Val-de-Marne, 94800

    Fabrice Barlesi, Site 0213, 33142114211

    Recruiting

Other trials in France

Brazil15 sites, 15 recruiting

  • Fundação Pio XII - Hospital de Câncer de Barretos

    Barretos, São Paulo, 14784400

    Gustavo Dix Junqueira Pinto, Site 0240, 551733216637

    Recruiting

  • Cetus Oncologia - Unidade Belo Horizonte

    Belo Horizonte, Minas Gerais, 30110-022

    Elisa Ramos, Site 0244, 5531998619660

    Recruiting

  • Clínica de Oncologia Reichow

    Blumenau, Santa Catarina, 89010-340

    Sandro Reichow, Site 0237, 554733805890

    Recruiting

  • ONCOSITE - Centro de Pesquisa Clinica em Oncologia

    Ijuí, Rio Grande do Sul, 98700-000

    Fabio Franke, Site 0235, +5555991592101

    Recruiting

  • Clínica de Neoplasias Litoral

    Itajaí, Santa Catarina, 88301-220

    Giuliano Borges, Site 0245, 5547984046243

    Recruiting

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000

    Ana Caroline Gelatti, Site 0233, (51)3320-3039

    Recruiting

  • Hospital de Amor Amazônia

    Porto Velho, Rondônia, 76834-899

    Jéssica Câmara, Site 0243, 38999986193

    Recruiting

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, 20230-130

    Luiz Henrique Araujo, Site 0236, 552132076585

    Recruiting

  • Nucleo de Oncologia da Bahia

    Salvador, Estado de Bahia, 40170-110

    Filipe Visani, Site 0257, +5571983140522

    Recruiting

  • Instituto de Oncologia Saint Gallen

    Santa Cruz do Sul, Rio Grande do Sul, 96830-180

    Bianca Correa Tabajara Weiss, Site 0238, 5551991898942

    Recruiting

  • Advanze Pesquisa

    São Carlos, São Paulo, 13561-130

    Luiz Agenor Gazzi, Site 0241, 551633711320

    Recruiting

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

    JOÃO SOLER, Site 0239, 551732015054

    Recruiting

  • A. C. Camargo Cancer Center

    São Paulo, São Paulo, 01509-010

    Vladmir Cordeiro de Lima, Site 0254, +5511976470332

    Recruiting

  • Icesp - Instituto Do Câncer Do Estado de São Paulo

    São Paulo, 01246-000

    Milena Perez Mak, Site 0258, 551138932632

    Recruiting

  • CEDOES

    Vitória, Espírito Santo, 29055450

    Mauricio Pereira, Site 0242, +5521998795727

    Recruiting

Other trials in Brazil

India15 sites, 15 recruiting

  • Hemato Oncology Clinic

    Ahmedabad, Gujarat, 380054

    Chirag Desai, Site 0136, 919824047561

    Recruiting

  • Marengo CIMS Hospital

    Ahmedabad, Gujarat, 380060

    Bhavesh Parekh, Site 0230, 9825034353

    Recruiting

  • Institute of Medical Sciences and Sum Hospital

    Bhubaneswar, Odisha, 751003

    Lalatendu Moharana, Site 0226, 9538752579

    Recruiting

  • Narayana Superspecialty Hospital

    Howrah, West Bengal, 711103

    Chandrakanth MV, Site 0161, 7738519198

    Recruiting

  • Yashoda Hospitals - Hitech City

    Hyderabad, Telangana, 500084

    Naidu Norman Bethune, Site 0663, 9989489877

    Recruiting

  • Basavatarakam Indo American Cancer Hospital & Research Institute

    Hyderabad, 500034

    Senthil Rajappa, Site 0661, 9849213102

    Recruiting

  • Netaji Subhas Chandra Bose Cancer Hospital

    Kolkata, West Bengal, 700094

    Poulami Basu, Site 0221, 6290073778

    Recruiting

  • Meenakshi Mission Hospital and Research Centre

    Madurai, Tamil Nadu, 625107

    Saju SV, Site 0224, 8891810070

    Recruiting

  • Local Institution - 0154

    Mumbai, Maharashtra, 400012

    Site 0154

    Not yet recruiting

  • All India Institute of Medical Sciences

    New Delhi, National Capital Territory of Delhi, 110029

    SACHIN KHURANA, Site 0312, 9769030180

    Recruiting

  • Vardhman Mahavir Medical College and Safdarjung Hospital

    New Delhi, National Capital Territory of Delhi, 110029

    Kaushal Kalra, Site 0511, 9968663394

    Recruiting

  • Rajiv Gandhi Cancer Institute And Research Centre

    New Delhi, National Capital Territory of Delhi, 110085

    Ullas Batra, Site 0135, 919711080001

    Recruiting

  • Local Institution - 0155

    Thiruvananthapuram, Kerala, 695011

    Site 0155

    Not yet recruiting

  • Mahamana Pandit Madan Mohan Malviya Cancer Centre

    Varanasi, Uttar Pradesh, 221005

    Akhil Kapoor, Site 0153, +915422517699

    Recruiting

  • Apollo Hospitals - Visakhapatnam - Health City

    Visakhapatnam, Andhra Pradesh, 530040

    Rakesh Reddy Boya, Site 0222, 555-555-55

    Recruiting

Other trials in India

Japan15 sites, 15 recruiting

  • Aomori Prefectural Central Hospital

    Aomori, 030-8553

    Takeshi Morimoto, Site 0346, 017-726-8111

    Recruiting

  • Tokyo Metropolitan Komagome Hospital

    Bunkyo Ku, Tokyo, 113-8677

    Yukio Hosomi, Site 0674, 81338232101

    Recruiting

  • Kyushu University Hospital

    Fukuoka, 812-8582

    Isamu Okamoto, Site 0310, +81926425378

    Recruiting

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka, 431-3192

    Naoki Inui, Site 0606, 81534352356

    Recruiting

  • Saitama Medical University International Medical Center

    Hidaka, Saitama, 350-1298

    Hiroshi Kagamu, Site 0303, 819014217189

    Recruiting

  • Kansai Medical University Hospital

    Hirakata, Osaka, 573-1191

    Takayasu Kurata, Site 0642, 81728042503

    Recruiting

  • Nagasaki University Hospital

    Nagasaki, 852-8501

    Takemoto Shinnosuke, Site 0687, 8195-819-7273

    Recruiting

  • Local Institution - 0607

    Nagoya, Aichi-ken, 457-8510

    Site 0607

    Recruiting

  • National Hospital Organization Nagoya Medical Center

    Nagoya, Aichi-ken, 460-0001

    Masahide Oki, Site 0305, 81529511111

    Recruiting

  • Osaka City General Hospital

    Osaka, 534-0021

    Yuki Nakatani, Site 0297, +81-6-6929-1221

    Recruiting

  • Osaka International Cancer Institute

    Osaka, 541-8567

    Motohiro Tamiya, Site 0309, +81-6-6945-1181

    Recruiting

  • Kitasato University Hospital

    Sagamihara, Kanagawa, 252-0375

    Katsuhiko Naoki, Site 0302, +81-80-5057-3533

    Recruiting

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 0608648

    Jun Sakakibara, Site 0298, +81-11-716-1161

    Recruiting

  • Sendai Kousei Hospital

    Sendai, Miyagi, 9810914

    Shunichi Sugawara, Site 0301, 81227288000

    Recruiting

  • Toyama University Hospital

    Toyoma, Toyama, 930-0194

    Ryuji Hayashi, Site 0343, +81763437808

    Recruiting

Other trials in Japan

Romania13 sites, 10 recruiting

  • SC Memorial Healthcare International SRL

    Bucharest, Bucharest, 013812

    Ingrid Iordan, Site 0272, 40721298677

    Recruiting

  • Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"

    Bucharest, Bucharest, 022338

    Aurelia Alexandru, Site 0261, 40723289606

    Recruiting

  • Local Institution - 0276

    Cluj-Napoca, Cluj, 400015

    Completed

  • Institutul Oncologic Cluj

    Cluj-Napoca, 400015

    Tudor Ciuleanu, Site 0273, 40745646368

    Recruiting

  • Institutul Oncologic Cluj

    Cluj-Napoca, 400015

    Cristina Cebotaru, Site 0270, 40745976913

    Recruiting

  • Local Institution - 0590

    Constanța, 900591

    Completed

  • Centrul de Oncologie "Sfântul Nectarie"

    Craiova, Dolj, 200542

    Michael Schenker, Site 0271, 40727774974

    Recruiting

  • SC Radiotherapy Center Cluj SRL

    Florești, Cluj, 407280

    Andrei Ungureanu, Site 0268, 40742206212

    Recruiting

  • S.C. Centrul de Oncologie Euroclinic S.R.L.

    Iași, 700106

    Constantin Volovat, Site 0266, 40746110096

    Recruiting

  • Institutul Regional de Oncologie

    Iași, 700483

    Dana Clement, Site 0260, 40744692062

    Recruiting

  • Local Institution - 0275

    Ovidiu, Constanța County, 905900

    Completed

  • Spitalul Municipal Schuller Ploiești

    Ploieşti, 100337

    Nita Amedeia, Site 0269, +40728121201

    Recruiting

  • Oncohelp Medical Center

    Timișoara, Timiș County, 300239

    Daniela Sirbu, Site 0592, 40744571617

    Recruiting

Other trials in Romania

Spain13 sites, 13 recruiting

  • CHUAC-Hospital Teresa Herrera

    A Coruña, A Coruña [La Coruña], 15006

    Maria Garcia Campelo, Site 0499, 34981178353

    Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [Barcelona], 08035

    Enriqueta Felip Font, Site 0501, 34932746077

    Recruiting

  • Hospital General Universitario Gregorio Marañon

    Madrid, Madrid, Comunidad de, 28009

    Antonio Calles Blanco, Site 0500, +34915868115

    Recruiting

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, Comunidad de, 28034

    Maria Eugenia Olmedo Garcia, Site 0503, 34913368263

    Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, Comunidad de, 28041

    Luis Paz-Ares Rodriguez, Site 0496, 0034913908922

    Recruiting

  • Hospital Clinico San Carlos

    Madrid, 28040

    Carlos Aguado de la Rosa, Site 0504, +34913307552

    Recruiting

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, Comunidad de, 28222

    Mariano Provencio Pulla, Site 0498, 34911917759

    Recruiting

  • H.R.U Málaga - Hospital General

    Málaga, 29011

    Manuel Cobo-Dols, Site 0502, 00349422033350000

    Recruiting

  • Hospital Son Llàtzer

    Palma, Illes Balears [Islas Baleares], 07198

    Juan Coves Sarto, Site 0508, 348712020001629

    Recruiting

  • CHUVI- Hospital Alvaro Cunqueiro

    Pontevedra, Pontevedra [Pontevedra], 36312

    Martin Lazaro Quintela, Site 0669, 34986825801

    Recruiting

  • CHUS - Hospital Clinico Universitario

    Santiago de Compostela, A Coruña [La Coruña], 15706

    Jorge Garcia Gonzalez, Site 0506, 34981950511

    Recruiting

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013

    Miriam Alonso Garcia, Site 0507, 34955013068

    Recruiting

  • Hospital Arnau de Vilanova

    Valencia, València, 46015

    Jose Garcia Sanchez, Site 0640, +34963987700

    Recruiting

Other trials in Spain

Italy11 sites, 10 recruiting

  • Instituto Tumori Giovanni Paolo II

    Bari, Apulia, 70124

    Domenico Galetta, Site 0071, 390805555442

    Recruiting

  • Azienda Ospedaliera Universitaria Careggi

    Florence, Tuscany, 50134

    Lorenzo Antonuzzo, Site 0069, 00390557947298

    Recruiting

  • IRCCS AOM Azienda Ospedaliera Metropolitana

    Genova, 16132

    Carlo Genova, Site 0588, 393397231066

    Recruiting

  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

    Meldola, Emilia-Romagna, 47014

    Angelo Delmonte, Site 0067, +393487469100

    Recruiting

  • Local Institution - 0066

    Naples, Napoli, 80131

    Active, not recruiting

  • Azienda Ospedaliero-Universitaria San Luigi Gonzaga

    Orbassano, Piedmont, 10043

    Silvia Novello, Site 0070, 390119026322

    Recruiting

  • Istituto Oncologico Veneto IRCCS

    Padova, 35128

    Valentina Guarneri, Site 0073, 00390498215931

    Recruiting

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43126

    Marcello Tiseo, Site 0156, 390521702682

    Recruiting

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100

    Francesco Agustoni, Site 0543, 0382503938

    Recruiting

  • Istituto Nazionale Tumori Regina Elena

    Rome, Roma, 00144

    Federico Capuzzo, Site 0068, +390516225126

    Recruiting

  • Ospedale di Circolo e Fondazione Macchi Varese

    Varese, 21100

    Veronica Crespi, Site 0556, 390332278558

    Recruiting

Other trials in Italy

Australia9 sites, 9 recruiting

  • Princess Alexandra Hospital

    Brisbane, Queensland, 4102

    Kenneth O'Byrne, Site 0127, 0731766505

    Recruiting

  • Canberra Hospital

    Canberra, Australian Capital Territory, 2605

    Geoffrey Peters, Site 0126, 610251242220

    Recruiting

  • Lyell McEwin Hospital

    Elizabeth Vale, South Australia, 5112

    Dainik Patel, Site 0129, 0433217127

    Recruiting

  • Frankston Hospital

    Frankston, Victoria, 3199

    Emma Beardsley, Site 0122, 61397847777

    Recruiting

  • Joondalup Health Campus

    Joondalup, Western Australia, 6027

    Arman Hasani, Site 0229, 61863889681

    Recruiting

  • Northern Hospital

    Melbourne, Victoria, 3076

    Vishal Boolell, Site 0121, 0434 479 184

    Recruiting

  • Tamworth Hospital

    North Tamworth, New South Wales, 2340

    Sunil Rai, Site 0212, 0267677760

    Recruiting

  • Orange Hospital

    Orange, New South Wales, 2800

    Robert Zielinski, Site 0128, 61263693380

    Recruiting

  • Latrobe Regional Health

    Traralgon, Victoria, 3844

    Evangeline Samuel, Site 0160, 03 5173 8000

    Recruiting

Other trials in Australia

Poland8 sites, 6 recruiting

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka

    Bydgoszcz, 85796

    Bogdan Zurawski, Site 0076, 48501446778

    Recruiting

  • Local Institution - 0206

    Gorlice, Lesser Poland Voivodeship, 38-300

    Completed

  • Pratia Onkologia Katowice

    Katowice, 40-519

    Agata Kachel-Flis, Site 0078, +48501714019

    Recruiting

  • Local Institution - 0079

    Krakow, Lesser Poland Voivodeship, 30-727

    Completed

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

    Lublin, Lublin Voivodeship, 20-090

    Izabela Chmielewska, Site 0080, +504051512

    Recruiting

  • Med-Polonia Sp. z o. o.

    Poznan, Greater Poland Voivodeship, 60-693

    Rodryg Ramlau, Site 0209, 48618549040

    Recruiting

  • Szpital Specjalistyczny w Prabutach Spolka z o.o.

    Prabuty, 82-550

    Anna Lowczak, Site 0077, +48503022396

    Recruiting

  • Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii

    Wroclaw, Lower Silesian Voivodeship, 53-439

    Krzysztof Rogoziewicz, Site 0205, 48693997463

    Recruiting

Other trials in Poland

South Korea8 sites, 7 recruiting

  • Pusan National University Hospital

    Busan, Pusan-Kwangyǒkshi, 49241

    Jung Seop Eom, Site 0186, +82512407889

    Recruiting

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644

    Ki Hyeong Lee, Site 0163, 82432696015

    Recruiting

  • Gachon University Gil Medical Center

    Namdong-gu, Incheon-gwangyeoksi [Incheon], 21565

    Eun Kyung Cho, Site 0227, 82324603383

    Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul-teukbyeolsi [Seoul], 03722

    Min Hee Hong, Site 0165, 821071541554

    Recruiting

  • Konkuk University Medical Center

    Seoul, Seoul-teukbyeolsi [Seoul], 05030

    Hee Joung Kim, Site 0228, 82220307525

    Recruiting

  • Local Institution - 0248

    Seoul, Seoul-teukbyeolsi [Seoul], 06591

    Completed

  • Korea University Guro Hospital

    Seoul, Seoul-teukbyeolsi [Seoul], 08308

    Sung Yong Lee, Site 0146, 821022179216

    Recruiting

  • Pusan National University Yangsan Hospital

    Yangsan, Kyǒngsangnam-do, 50612

    Seong Hoon Yoon, Site 0211, 82-10-2870-9389

    Recruiting

Other trials in South Korea

Mexico7 sites, 7 recruiting

  • Hospital Civil Fray Antonio Alcalde

    Guadalajara, Jalisco, 44280

    Juan Vazquez Limon, Site 0178, 523316063096

    Recruiting

  • Gefarma (Atrys)

    Mexico City, DIF, 11510

    Patricia Sánchez Valencia, Site 0176, 5514743371

    Recruiting

  • Axis Heilsa S. de R.L. de C.V.

    Monterrey, Nuevo León, 64040

    Jorge Rodriguez Olivo, Site 0591, 8115545104

    Recruiting

  • Grupo Ollin Care

    Pachuca, Hidalgo, 42000

    Juan Salinas Garcia, Site 0579, 7711996481

    Recruiting

  • Unidad Médica Onco-hematológica

    Puebla City, 72424

    MIRIAM ESCAMILLA, Site 0181, +522222154940

    Recruiting

  • Centro de Infusion E Investigacion Oncologia de Saltillo S.C.

    Saltillo, Coahuila, 25279

    Eva Willars, Site 0583, 8446887477

    Recruiting

  • FAICIC S. de R.L. de C.V.

    Veracruz, 91900

    Erika Castillo, Site 0180, 522292071578

    Recruiting

Other trials in Mexico

Turkey (Türkiye)7 sites, 7 recruiting

  • Baskent University Dr. Turgut Noyan Research and Training Center

    Adana, 01250

    Ozgur Ozyilkan, Site 0197, +905353067506

    Recruiting

  • Hacettepe Universite Hastaneleri

    Ankara, 06230

    Mustafa Erman, Site 0201, +905334318506

    Recruiting

  • Ankara University Health Practice and Research Hospitals

    Ankara, 06620

    Yuksel Urun, Site 0194, 05337483275

    Recruiting

  • Ankara Bilkent Şehir Hastanesi

    Ankara, 06800

    Mehmet Ali Nahit Sendur, Site 0198, 905555306271

    Recruiting

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, 34722

    Mahmut Gumus, Site 0549, 00905063509061

    Recruiting

  • Ege Universitesi Hastanesi

    Izmir, 35100

    Pinar Gursoy, Site 0200, 905053693004

    Recruiting

  • I.E.U. Medical Point Hastanesi

    Izmir, Karsiyaka, İzmir, 009035575

    Cagatay Arslan, Site 0199, +905052642353

    Recruiting

Other trials in Turkey (Türkiye)

Argentina6 sites, 6 recruiting

  • Hospital Italiano de Buenos Aires

    ABB, Buenos Aires F.D., C1199ABB

    Lorena Lupinacci, Site 0576, 5411495902008159

    Recruiting

  • Clinica Adventista Belgrano

    CABA, Buenos Aires F.D., C1430EGF

    Aldo Perfetti, Site 0573, 5491132682903

    Recruiting

  • Instituto Alexander Fleming

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ

    Claudio Martin, Site 0575, 5491166936669

    Recruiting

  • IDIM - Instituto de Investigaciones Metabólicas

    Ciudad de Buenos Aires, Buenos Aires, C1012AAR

    Mara Rapaccioli, Site 0570, 1124870006

    Recruiting

  • Hospital Universitario Austral

    Pilar, Buenos Aires, 1629

    Nicolas Minatta, Site 0584, 5491138018573

    Recruiting

  • Sanatorio Plaza

    Rosario, Santa Fe Province, 2000

    Miriam Raimondo, Site 0595, +549341644-8821

    Recruiting

Other trials in Argentina

Belgium6 sites, 6 recruiting

  • UZ Brussel

    Brussels, Bruxelles-Capitale, Région de, 1090

    Lore Decoster, Site 0114, 3224775457

    Recruiting

  • Cliniques universitaires Saint-Luc

    Brussels, Bruxelles-Capitale, Région de, 1200

    Frank Nana Aboubakar, Site 0113, 3227648519

    Recruiting

  • AZ Maria Middelares

    Ghent, Oost-Vlaanderen, 9000

    Paul Germonpre, Site 0216, 3292468400

    Recruiting

  • Jessa Ziekenhuis

    Hasselt, Limburg, 3500

    Kristof Cuppens, Site 0215, +32472565987

    Recruiting

  • UZ Leuven

    Leuven, Vlaams-Brabant, 3000

    christophe Dooms, Site 0107, 003216340961

    Recruiting

  • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

    Liège, 4000

    Anne Sibille, Site 0109, 003243237400

    Recruiting

Other trials in Belgium

Colombia6 sites, 6 recruiting

  • Fundación Valle del Lili

    Cali, Valle del Cauca Department, 760032

    Alvaro Osorio Franco, Site 0173, 573012895296

    Recruiting

  • Fundación Cardiovascular de Colombia

    Floridablanca, Santander Department, 681004

    Martha Alarcon, Site 0170, 3187148911

    Recruiting

  • Clinica Medellin S.A

    Medellín, 0

    Andres Yepes, Site 0580, 573002608134

    Recruiting

  • Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S

    Montería, COR, 230002

    José Lobatón Ramirez, Site 0167, 47854344

    Recruiting

  • Clinica Somer

    Rionegro, Antioquia, 054040

    Camilo Vallejo, Site 0171, +573116349000

    Recruiting

  • Sociedad De Oncología y Hematología Del Cesar SAS

    Valledupar, Cesar Department, 200001

    Raimundo Manneh, Site 0253, 573157411877

    Recruiting

Other trials in Colombia

Austria5 sites, 5 recruiting

  • Medizinische Universität Graz

    Graz, Styria, 8036

    Gudrun Absenger, Site 0539, 4331638581318

    Recruiting

  • Kepler Universitätsklinikum

    Linz, 4021

    David Lang, Site 0530, 4373278066910

    Recruiting

  • Medizinische Universität Wien

    Vienna, 1090

    Thorsten Fuereder, Site 0533, 4314040044450

    Recruiting

  • Klinik Floridsdorf

    Vienna, 1210

    Maximilian Hochmair, Site 0673, +4319106041242

    Recruiting

  • Klinikum Wels-Grieskirchen GmbH

    Wels, Upper Austria, 4600

    Christian Trockenbacher, Site 0532, 4372424152382

    Recruiting

Other trials in Austria

Croatia5 sites, 5 recruiting

  • Opća bolnica Dubrovnik

    Dubrovnik, Dubrovnik-Neretva County, 20000

    Tihana Boraska Jelavic, Site 0619, +385913458470

    Recruiting

  • Klinički bolnički centar Osijek

    Osijek, 31000

    Ivana Canjko, Site 0567, 385917223985

    Recruiting

  • Poliklinika MEDICO - Rijeka

    Rijeka, Primorje-Gorski Kotar County, 51000

    Dragan Trivanovic, Site 0664, 38598335797

    Recruiting

  • Klinički Bolnički Centar Split

    Split, Split-Dalmatia County, 21000

    Suzana Mladinov, Site 0639, +38521556434

    Recruiting

  • Clinic for lung diseases

    Zagreb, 10000

    Miroslav Samarzija, Site 0585, 012385251

    Recruiting

Other trials in Croatia

Hungary5 sites, 5 recruiting

  • Semmelweis Egyetem

    Budapest, 1083

    Veronika Muller, Site 0151, 36208259181

    Recruiting

  • Országos Korányi Pulmonológiai Intézet

    Budapest, 1121

    Gyula Ostoros, Site 0140, 3613913213

    Recruiting

  • Farkasgyepui Tudogyogyintezet

    Farkasgyepű, Veszprém megye, 8582

    Zsolt Kiraly, Site 0143, 36209264476

    Recruiting

  • Mátrai Gyógyintézet

    Gyöngyös - Mátraháza, Heves County, 3233

    Istvan Albert, Site 0144, 36202708215

    Recruiting

  • Petz Aladar Egyetemi Oktato Korhaz

    Győr, 9024

    Zsuzsanna Szalai, Site 0601, +36309758356

    Recruiting

Other trials in Hungary

Ireland5 sites, 5 recruiting

  • Cork University Hospital

    Cork, T12 E8YV

    Sinéad Noonan, Site 0102, +353879680182

    Recruiting

  • Mater Private Hospital - Dublin

    Dublin, D07 WKW8

    Jane Sui, Site 0476, +353(1)8034831

    Recruiting

  • St. James's Hospital

    Dublin, D08 E9P6

    Sinead Cuffe, Site 0101, 35314103756

    Recruiting

  • UCD School of Medicine Beacon Hospital

    Dublin, D18 AK68

    Lisa Prior, Site 0100, +35312935666

    Recruiting

  • Beaumont Hospital, Dublin

    Dublin, D9

    Jarushka Naidoo, Site 0106, 01-8092010

    Recruiting

Other trials in Ireland

Israel5 sites, 5 recruiting

  • Carmel Hospital

    Haifa, Ḥeifā, 3436212

    Ekaterina Shulman, Site 0613

    Recruiting

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001

    Hovav Nechushtan, Site 0544, 97226777836

    Recruiting

  • Rabin Medical Center

    Petah Tikva, Central District, 4941492

    Ofer Rotem, Site 0597, 9729378146

    Recruiting

  • Sheba Medical Center

    Ramat Gan, Central District, 5265601

    Jair Bar, Site 0596, 97235307096

    Recruiting

  • Yitzhak Shamir Medical Center

    Tsrifin, Central District, 70300

    Carmell Fink, Site 0600, +97289779713

    Recruiting

Other trials in Israel

Taiwan5 sites, 5 recruiting

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 235

    Kang-Yun Lee, Site 0337, 8862224900882714

    Recruiting

  • Chi Mei Hospital - Liouying Branch

    Tainan, Tainan, 73657

    Sheng-Yen Hsiao, Site 0341, 88666226999

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704

    Chun-Hui Lee, Site 0335, 886-912777918

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    Jin-Yuan Shih, Site 0331, 88622312345662905

    Recruiting

  • Tri-Service General Hospital

    Taipei City, Taipei, 114

    Chen-Liang Tsai, Site 0631, 886287923311

    Recruiting

Other trials in Taiwan

Bulgaria4 sites, 3 recruiting

  • MBAL Uni Hospital

    Panagyurishte, Pazardzhik, 4500

    Rossitza Krasteva, Site 0629, +359888938571

    Recruiting

  • Complex Oncology Center - Ruse EOOD

    Rousse, 7002

    Nikolay Nikolaev, Site 0627, 0887098616

    Recruiting

  • Local Institution - 0628

    Sofia, Sofia (stolitsa), 1632

    Completed

  • Trakia Hospital

    Stara Zagora, 6000

    Rumyana Ilieva, Site 0635, 00359888431354

    Recruiting

Other trials in Bulgaria

United Kingdom4 sites, 4 recruiting

  • Heartlands Hospital

    Birmingham, B9 5SS

    Shobhit Baijal, Site 0092, +(44)01214247456

    Recruiting

  • The Royal Surrey County Hospital

    Guildford, GU2 7XX

    Ajay Mehta, Site 0090, 441483571122

    Recruiting

  • University College London Hospital

    London, London, City of, NW1 2PG

    Siow Lee, Site 0088, 442034479091

    Recruiting

  • Guy's & St Thomas' NHS Foundation Trust

    London, London, City of, SE1 9RT

    Alexandros Georgiou, Site 0091, 00442071882006

    Recruiting

Other trials in United Kingdom

Greece3 sites, 3 recruiting

  • Errikos Dunant Hospital Center

    Athens, Attikí, 115 26

    IOANNIS MOUNTZIOS, Site 0608, +306983519989

    Recruiting

  • Thoracic General Hospital of Athens "I Sotiria"

    Athens, Attikí, 115 27

    Konstantinos Syrigos, Site 0612, +302107700220

    Recruiting

  • University General Hospital of Larissa

    Larissa, Thessalía, 41110

    Athanasios Kotsakis, Site 0609, 302413502124

    Recruiting

Other trials in Greece

Portugal3 sites, 3 recruiting

  • Instituto Portugês de Oncologia de Coimbra Francisco Gentil

    Coimbra, 3000-075

    Sara Povoa, Site 0510

    Recruiting

  • Instituto Português de Oncologia de Lisboa Francisco Gentil

    Lisbon, Lisbon District, 1099-023

    Telma Sequeira, Site 0509, +351 21 722 98 92

    Recruiting

  • Centro Hospitalar do Porto - Hospital de Santo António

    Porto, 4099-001

    Antonio Araujo, Site 0553, 351222077500x1729

    Recruiting

Other trials in Portugal

Saudi Arabia3 sites, 3 recruiting

  • King Faisal Specialist Hospital

    Jeddah, Makkah Al Mukarramah, 23433

    Ahmed Allehebi, Site 0614, +966555558414

    Recruiting

  • King Abdulaziz Medical City - National Guard Hospital

    Riyadh, 11426

    Turki Fayae, Site 0602, +966568559996

    Recruiting

  • King Faisal Specialist Hospital and Research Center

    Riyadh, 12713

    Hamed Alhusaini, Site 0562, +9664647272-49769

    Recruiting

Other trials in Saudi Arabia

Thailand3 sites, 3 recruiting

  • Chulalongkorn University

    Bangkok, Bangkok, 10330

    Virote Sriuranpong, Site 0563, 6622564533

    Recruiting

  • Songklanagarind hospital

    Hat Yai, Changwat Songkhla, 90110

    Patrapim Sunpaweravong, Site 0564, 6674451469

    Recruiting

  • Faculty of Medicine - Khon Kaen University

    Muang, Changwat Khon Kaen, 40002

    Aumkhae Sookprasert, Site 0565, 66840292822

    Recruiting

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Chile2 sites, 2 recruiting

  • Bradfordhill

    Recoleta, Santiago Metropolitan, 8420391

    Carlos Rojas, Site 0574, +56998744662

    Recruiting

  • FALP

    Santiago, Santiago Metropolitan, 7500921

    Christian Caglevic, Site 0577, 56224457254

    Recruiting

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Hong Kong2 sites, 2 recruiting

  • Queen Mary Hospital

    Hksar, 0

    Dennis Leung, Site 0466, 85222554095

    Recruiting

  • Queen Mary Hospital

    Hksar, 0

    Chung Man James Ho, Site 0379, 85222554999

    Recruiting

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Netherlands2 sites, 2 recruiting

  • Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)

    Amsterdam, North Holland, 1066 CX

    Willemijn Theelen, Site 0594, 06-xxxxxxxx

    Recruiting

  • Maastricht UMC+

    Maastricht, Limburg, 6229 HX

    Lizza Hendriks, Site 0615, 31433875051

    Recruiting

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Canada1 site, 1 recruiting

  • St. Marys Hospital Center

    Montreal, Quebec, H3T 1M5

    Adrian Langleben, Site 0559, 0000000000

    Recruiting

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Switzerland1 site, 1 recruiting

  • Kantonsspital Münsterlingen - Spital Thurgau AG

    Münsterlingen, 8596

    Ioannis Metaxas, Site 0536, +41581447850

    Recruiting

Other trials in Switzerland

About this study

Official title: A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Being tested
Adagrasib, Pembrolizumab, Carboplatin, Pemetrexed, Placebo
Keywords
Immunotherapy, KRAS, KRAS G12C, Targeted therapy
Medical subject headings
Carcinoma, Non-Small-Cell Lung

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • AdagrasibDrug

    Also called BMS-986503; KRAZATI®

    Specified dose on specified days

  • PembrolizumabDrug

    Also called KEYTRUDA®

    Specified dose on specified days

  • CarboplatinDrug

    Specified dose on specified days

  • PemetrexedDrug

    Specified dose on specified days

  • PlaceboDrug

    Specified dose on specified days

  • CisplatinDrug

    Specified dose on specified days

Study groups in NCT06875310
Study groupRoleWhat they receive
AdagrasibExperimentalNot described
Receives: Drug: Adagrasib; Drug: Pembrolizumab; Drug: Carboplatin; Drug: Pemetrexed; Drug: Cisplatin
PlaceboPlacebo comparatorNot described
Receives: Drug: Pembrolizumab; Drug: Carboplatin; Drug: Pemetrexed; Drug: Placebo; Drug: Cisplatin

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Progression Free Survival (PFS) as Assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Blinded Independent Central Review (BICR)

    Measured: Up to 7 years

  2. Overall Survival (OS)

    Measured: Up to 7 years

Secondary outcomes (11)

  1. Overall Response (OR) as Assessed per RECIST v1.1 by BICR

    Measured: Up to 7 years

  2. Duration of Response (DOR) as Assessed per RECIST 1.1 by BICR

    Measured: Up to 7 years

  3. PFS as Assessed per RECIST v1.1 by Investigator

    Measured: Up to 7 years

  4. Number of Participants With Adverse Events (AEs)

    Measured: Up to 90 days from last dose

  5. Number of Participants With Serious Adverse Events (SAEs)

    Measured: Up to 90 days from last dose

  6. Number of Participants With AEs Leading to Dose Interruption

    Measured: Up to 90 days from last dose

  7. Number of Participants With AEs Leading to Dose Reduction

    Measured: Up to 90 days from last dose

  8. Number of Participants With AEs Leading to Treatment Discontinuation

    Measured: Up to 90 days from last dose

  9. Number of Deaths

    Measured: Up to 90 days from last dose

  10. Time to Definitive Deterioration by Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ) Total Score

    Measured: Up to 7 years

  11. Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30) Scale/item Score

    Measured: Up to 90 days from last dose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Mar 2025
  2. Study start24 Apr 2025
  3. Primary completion7 Sep 2029 (estimated)
  4. Study completion30 Apr 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
630 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06875310
Sponsor's protocol ID
CA239-0004
Other IDs
2024-515698-85, U1111-1309-5596, CA2390004
Status last verified
Oct 2026
First submitted
7 Mar 2025
Last updated
27 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Adagrasib, Pembrolizumab and Carboplatin in people with Carcinoma, Non-Small-Cell Lung, run by Mirati Therapeutics Inc. at 317 sites in 35 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 317 sites in United States, China, Germany, France, Brazil and 30 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact BMS Clinical Trials Contact Center www.BMSClinicalTrials.com (855-907-3286, Clinical.Trials@bms.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Progression Free Survival (PFS) as Assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Blinded Independent Central Review (BICR) (time frame: Up to 7 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06875310.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.

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