Wound HealingNCT06891846
Relationship Between Magnesium Depletion Score and Extraction Socket Healing
An observational study of Wound Healing and Magnesium Level, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
Trial summary
The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH). SH is a complex and highly regulated biological process. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Wound Healing, Magnesium Level, Wisdom Tooth Removal
- How many people
- 111 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Sep 2025to 22 Oct 2025
- How long will I take part?
- 6 Weeks
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Systemically healthy adult participants from both sexes, who were scheduled to undergo surgical extraction of lower impacted third molars, with a physical status classified as ASA I according to the American Society of Anesthesiologists (ASA).
Who may be able to join
- Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.
Who cannot join
- Refusal to consent
- Presence of chronic diseases
- Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
- Prior radiotherapy in the head and neck area
- Pregnancy
- Inability to self-evaluate, and inability to communicate verbally or in writing.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Sağlık Bilimleri Üniversitesi Tacirler Eğitim Vakfı Sultanbeyli Ağız ve Diş Sağlığı Hastanesi
Istanbul, Sultanbeyli, 34920
About this study
Official title: Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction
The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH).
SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.
Read the detailed description
The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves "the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone." Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.
- Conditions
- Wound Healing, Magnesium Level, Wisdom Tooth Removal
- Keywords
- blood magnesium level, oral surgery, wound healing
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Participants aged between 18-75 from both sexes | Systemically healthy participants, aged between 18-75 from both sexes |
What is being measured
The primary outcome is the main question the study is designed to answer.
Magnesium depletion score (MDS)
The MDS is calculated by aggregating four factors:
- Diuretic use: Current use of diuretics is assigned 1 point.
- PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point.
- Kidney function:
- If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned.
- If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned.
The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors.
Measured: 6 weeks
Assessment of Wound healing (WH)
Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling.
The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing.
Measured: 6 weeks
Secondary outcomes (1)
Post-operative pain
Post-operative pain will be assessed using the Visual Analog Scale (VAS). Patients will be asked to rate their pain on a scale from 0 to 10, where 0 indicates no pain and 10 represents the worst imaginable pain.
Measured: 3 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Mar 2025
- Study start10 Sep 2025
- Primary completion22 Oct 2025
- Study completion22 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Wound HealingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 111 participants (actual)
- Target duration
- 6 Weeks
Sponsor and investigators
- Lead sponsor
- Saglik Bilimleri Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06891846
- Sponsor's protocol ID
- 24/738
- Status last verified
- Sep 2025
- First submitted
- 4 Feb 2025
- Last updated
- 24 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ye L, Zhang C, Duan Q, Shao Y, Zhou J. Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease. J Am Heart Assoc. 2023 Sep 19;12(18):e030077. doi: 10.1161/JAHA.123.030077. Epub 2023 Sep 8.
PubMed 37681518Xu Y, Qin Y, Lu H, Liu L, Huang W, Huang A, Ye Y, Shen H, Guo Z, Chen W. The magnesium depletion score is associated with increased likelihood of kidney stone disease among female adults. J Trace Elem Med Biol. 2024 Jul;84:127432. doi: 10.1016/j.jtemb.2024.127432. Epub 2024 Mar 12.
PubMed 38489922Wang J, Xing F, Sheng N, Xiang Z. Associations of the Dietary Magnesium Intake and Magnesium Depletion Score With Osteoporosis Among American Adults: Data From the National Health and Nutrition Examination Survey. Front Nutr. 2022 May 31;9:883264. doi: 10.3389/fnut.2022.883264. eCollection 2022.
PubMed 35711538Fan L, Zhu X, Rosanoff A, Costello RB, Yu C, Ness R, Seidner DL, Murff HJ, Roumie CL, Shrubsole MJ, Dai Q. Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults. J Nutr. 2021 Aug 7;151(8):2226-2235. doi: 10.1093/jn/nxab138.
PubMed 34038556Chen Y, Xiang X, Wu Y, Han S, Huang Z, Wu M. Magnesium Depletion Score Predicts Diabetic Retinopathy Risk among Diabetes: Findings from NHANES 2005-2018. Biol Trace Elem Res. 2023 Jun;201(6):2750-2756. doi: 10.1007/s12011-022-03384-3. Epub 2022 Aug 22.
PubMed 35989402Sisman AC, Sis O, Erdem NF. Evaluation of the association between magnesium depletion score and wound healing following the extraction of lower impacted third molars: a prospective observational cohort study. BMC Oral Health. 2026 Jul 17. doi: 10.1186/s12903-026-09328-w. Online ahead of print.
PubMed 42464072
Study at a glance
From the registry record, last updated by the sponsor on 24 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction
- ClinicalTrials.gov ID
- NCT06891846
- Acronym / sponsor ID
- 24/738
- Conditions
- Wound Healing, Magnesium Level, Wisdom Tooth Removal
- Keywords
- blood magnesium level, oral surgery, wound healing
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 111 participants (actual)
- Lead sponsor
- Saglik Bilimleri UniversitesiUniversity, hospital or other
- Study start
- 10 Sep 2025 (actual)
- Primary completion
- 22 Oct 2025 (actual)
- Study completion
- 22 Oct 2025 (actual)
- First posted
- 24 Mar 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH).
SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.
Detailed description
The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves "the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone." Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 6 Weeks
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Participants aged between 18-75 from both sexes | – | –Systemically healthy participants, aged between 18-75 from both sexes |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Systemically healthy adult participants from both sexes, who were scheduled to undergo surgical extraction of lower impacted third molars, with a physical status classified as ASA I according to the American Society of Anesthesiologists (ASA).
Key inclusion criteria (1 listed)
- Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.
Key exclusion criteria (6 listed)
- Refusal to consent
- Presence of chronic diseases
- Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
- Prior radiotherapy in the head and neck area
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Magnesium depletion score (MDS)
Time frame: 6 weeks
The MDS is calculated by aggregating four factors: 1. Diuretic use: Current use of diuretics is assigned 1 point. 2. PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point. 3. Kidney function: * If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned. * If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned. The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors.
Assessment of Wound healing (WH)
Time frame: 6 weeks
Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling. The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing.
1 secondary outcome
Post-operative pain
Time frame: 3 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Nov 2025.
- Results publication: PubMed 37681518Ye L, Zhang C, Duan Q, Shao Y, Zhou J. Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease. J Am Heart Assoc. 2023 Sep 19;12(18):e030077. doi: 10.1161/JAHA.123.030077. Epub 2023 Sep 8.
- Results publication: PubMed 38489922Xu Y, Qin Y, Lu H, Liu L, Huang W, Huang A, Ye Y, Shen H, Guo Z, Chen W. The magnesium depletion score is associated with increased likelihood of kidney stone disease among female adults. J Trace Elem Med Biol. 2024 Jul;84:127432. doi: 10.1016/j.jtemb.2024.127432. Epub 2024 Mar 12.
- Results publication: PubMed 35711538Wang J, Xing F, Sheng N, Xiang Z. Associations of the Dietary Magnesium Intake and Magnesium Depletion Score With Osteoporosis Among American Adults: Data From the National Health and Nutrition Examination Survey. Front Nutr. 2022 May 31;9:883264. doi: 10.3389/fnut.2022.883264. eCollection 2022.
- Results publication: PubMed 34038556Fan L, Zhu X, Rosanoff A, Costello RB, Yu C, Ness R, Seidner DL, Murff HJ, Roumie CL, Shrubsole MJ, Dai Q. Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults. J Nutr. 2021 Aug 7;151(8):2226-2235. doi: 10.1093/jn/nxab138.
- Results publication: PubMed 35989402Chen Y, Xiang X, Wu Y, Han S, Huang Z, Wu M. Magnesium Depletion Score Predicts Diabetic Retinopathy Risk among Diabetes: Findings from NHANES 2005-2018. Biol Trace Elem Res. 2023 Jun;201(6):2750-2756. doi: 10.1007/s12011-022-03384-3. Epub 2022 Aug 22.
- Derived from this study: PubMed 42464072Sisman AC, Sis O, Erdem NF. Evaluation of the association between magnesium depletion score and wound healing following the extraction of lower impacted third molars: a prospective observational cohort study. BMC Oral Health. 2026 Jul 17. doi: 10.1186/s12903-026-09328-w. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Wound Healing and Magnesium Level, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Magnesium depletion score (MDS) (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06891846, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2025.