Meniscal ExtrusionNCT06906783
Transtibial Pull Out Method Versus Suture Anchor Method for Meniscus Extrusion
A study testing Transtibial Pull Out Method and Suture Anchor Method in people with Meniscal Extrusion and Meniscus Injury, run by Ataturk University at 1 site in Turkey (Türkiye).
Trial summary
The concept of meniscal extrusion has recently been recognized as an important pathological condition associated with meniscal dysfunction. Meniscal extrusion is the medial or lateral displacement of the meniscus beyond the edges of the tibial plateau. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Meniscal Extrusion, Meniscus Injury
- What is being tested?
- Transtibial Pull Out Method and Suture Anchor Method
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Oct 2024to 1 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Presence of meniscal extrusion greater than 3 mm on MRI scans
- Symptomatic complaints in the knee with extrusion
Who cannot join
- Malalignment greater than 5 degrees
- Presence of Kellgren-Lawrence grade 3-4 osteoarthritis
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Ataturk University Hospital
Erzurum, Yakutiye, 25100
Muhammet Celik, Principal Investigator, MD, 905392087998, drcelik@outlook.com
About this study
Official title: Comparison of Transtibial Pull Out Method And Suture Anchor Method in Surgical Treatment of Meniscus Extrusion
The concept of meniscal extrusion has recently been recognized as an important pathological condition associated with meniscal dysfunction. Meniscal extrusion is the medial or lateral displacement of the meniscus beyond the edges of the tibial plateau. Some meniscal extrusions are physiologic, but large degrees of extrusion are thought to be pathologic.
Meniscal extrusion can vary in extent from minimal physiological extrusion to extrusions exceeding 10 mm. The generally accepted threshold value is considered to be 3 mm.
Read more
To date, the gold standard for measuring meniscal extrusion is T2-weighted MRI. MRI is valuable not only due to its ability to define other meniscal or knee pathologies but also because it provides good sensitivity and specificity.
Surgical treatment of meniscal extrusion is preferred in young, active, symptomatic patients and individuals with acute injuries. The treatment approach may vary depending on the underlying cause. One of these methods is centralization surgery, which aims to achieve the anatomical reduction of the extruded meniscus.
The aim of this study is to compare the functional outcomes of transtibial pull-out and suture anchor techniques used in centralization surgery and to contribute to standardization.
- Conditions
- Meniscal Extrusion, Meniscus Injury
- Being tested
- Transtibial Pull Out Method, Suture Anchor Method
- Keywords
- Meniscus Extrusion, Surgical Treatment, Transtibial Pull Out, Suture Anchor Method
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transtibial Pull Out MethodProcedure or surgery
The Transtibial Pull-Out Repair is a surgical technique used to fix posterior root tears of the meniscus, particularly in the medial meniscus. This method restores the hoop stress mechanism of the meniscus, which is essential for knee stability and function.
Suture Anchor MethodProcedure or surgery
The Suture Anchor Technique is an alternative to the Transtibial Pull-Out Method for repairing posterior meniscal root tears, especially in the medial meniscus. Instead of using a tibial tunnel, this technique fixes the meniscal root directly to the native footprint using suture anchors.
| Study group | Role | What they receive |
|---|---|---|
| Transtibial Pull Out Method | Active comparator | Not described Receives: Procedure: Transtibial Pull Out Method |
| Suture Anchor Method | Active comparator | Not described Receives: Procedure: Suture Anchor Method |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in the amount of meniscus extrusion in MR images.
determine the change in the amount of meniscus extrusion in preoperative and postoperative 12th month MR images.
Measured: From enrollment to the end of treatment at 12 months
Secondary outcomes (3)
Lysholm score
The Lysholm score is a 100-point scoring system for examining a patient's knee-specific symptoms including mechanical locking, instability, pain, swelling, stair climbing, and squatting.
Measured: From enrollment to the end of treatment at 3, 6 and 12 months.
Tegner activity score
The scale is numbered on a "0-10" format, with 10 being international soccer, and one being a person who is disabled from knee issues.
Measured: From enrollment to the end of treatment at 3, 6 and 12 months.
International Knee Documentation Committee (IKDC) Score
The IKDC is a patient-completed tool, which contains sections on knee symptoms (7 items), function (2 items), and sports activities (2 items). Scores range from 0 points (lowest level of function or highest level of symptoms) to 100 points (highest level of function and lowest level of symptoms).
Measured: From enrollment to the end of treatment at 3, 6 and 12 months.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2025
- Study start1 Oct 2024
- Primary completion1 Jan 2026 (estimated)
- Study completion1 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Meniscal ExtrusionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 46 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ataturk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muhammet Celik, Ataturk University
- Investigators
- Ahmet E Paksoy, Assoc.Prof., Study director, Ataturk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06906783
- Sponsor's protocol ID
- ATAUNIORTHO
- Status last verified
- Apr 2025
- First submitted
- 26 Mar 2025
- Last updated
- 4 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Yan X, Sahu S, Li H, Zhou W, Xiong T, Chen S, Li C, Hao L. Arthroscopic meniscal posterior root repair combined with centralization reduces medial meniscus extrusion associated with posterior root tears: One-year clinical outcomes. Knee Surg Sports Traumatol Arthrosc. 2025 Aug;33(8):2825-2832. doi: 10.1002/ksa.12533. Epub 2024 Nov 14.
PubMed 39543774Zhou Y, Yang Q, Kang J, Xu J, Chen M, Wu C. Clinical effect of medial meniscus posterior root repair combined with centralization technique in the treatment of medial meniscus posterior root tears. BMC Musculoskelet Disord. 2024 Nov 30;25(1):982. doi: 10.1186/s12891-024-08125-2.
PubMed 39616323
Study at a glance
From the registry record, last updated by the sponsor on 4 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Transtibial Pull Out Method And Suture Anchor Method in Surgical Treatment of Meniscus Extrusion
- ClinicalTrials.gov ID
- NCT06906783
- Acronym / sponsor ID
- ATAUNIORTHO
- Conditions
- Meniscal Extrusion, Meniscus Injury
- Keywords
- Meniscus Extrusion, Surgical Treatment, Transtibial Pull Out, Suture Anchor Method
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 46 participants (estimated)
- Lead sponsor
- Ataturk UniversityUniversity, hospital or other
- Study start
- 1 Oct 2024 (actual)
- Primary completion
- 1 Jan 2026 (estimated)
- Study completion
- 1 Feb 2026 (estimated)
- First posted
- 2 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The concept of meniscal extrusion has recently been recognized as an important pathological condition associated with meniscal dysfunction. Meniscal extrusion is the medial or lateral displacement of the meniscus beyond the edges of the tibial plateau. Some meniscal extrusions are physiologic, but large degrees of extrusion are thought to be pathologic.
Meniscal extrusion can vary in extent from minimal physiological extrusion to extrusions exceeding 10 mm. The generally accepted threshold value is considered to be 3 mm.
To date, the gold standard for measuring meniscal extrusion is T2-weighted MRI. MRI is valuable not only due to its ability to define other meniscal or knee pathologies but also because it provides good sensitivity and specificity.
Surgical treatment of meniscal extrusion is preferred in young, active, symptomatic patients and individuals with acute injuries. The treatment approach may vary depending on the underlying cause. One of these methods is centralization surgery, which aims to achieve the anatomical reduction of the extruded meniscus.
The aim of this study is to compare the functional outcomes of transtibial pull-out and suture anchor techniques used in centralization surgery and to contribute to standardization.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Transtibial Pull Out Method | Active comparator | Procedure: Transtibial Pull Out Method |
| Suture Anchor Method | Active comparator | Procedure: Suture Anchor Method |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Presence of meniscal extrusion greater than 3 mm on MRI scans
- Symptomatic complaints in the knee with extrusion
Key exclusion criteria (2 listed)
- Malalignment greater than 5 degrees
- Presence of Kellgren-Lawrence grade 3-4 osteoarthritis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transtibial Pull Out MethodThe Transtibial Pull-Out Repair is a surgical technique used to fix posterior root tears of the meniscus, particularly in the medial meniscus. This method restores the hoop stress mechanism of the meniscus, which is essential for knee stability and function. | Procedure or surgery | Transtibial Pull Out Method |
| Suture Anchor MethodThe Suture Anchor Technique is an alternative to the Transtibial Pull-Out Method for repairing posterior meniscal root tears, especially in the medial meniscus. Instead of using a tibial tunnel, this technique fixes the meniscal root directly to the native footprint using suture anchors. | Procedure or surgery | Suture Anchor Method |
Primary outcome
Change in the amount of meniscus extrusion in MR images.
Time frame: From enrollment to the end of treatment at 12 months
determine the change in the amount of meniscus extrusion in preoperative and postoperative 12th month MR images.
3 secondary outcomes
Lysholm score
Time frame: From enrollment to the end of treatment at 3, 6 and 12 months.
Tegner activity score
Time frame: From enrollment to the end of treatment at 3, 6 and 12 months.
International Knee Documentation Committee (IKDC) Score
Time frame: From enrollment to the end of treatment at 3, 6 and 12 months.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 May 2025.
- Results publication: PubMed 39543774Yan X, Sahu S, Li H, Zhou W, Xiong T, Chen S, Li C, Hao L. Arthroscopic meniscal posterior root repair combined with centralization reduces medial meniscus extrusion associated with posterior root tears: One-year clinical outcomes. Knee Surg Sports Traumatol Arthrosc. 2025 Aug;33(8):2825-2832. doi: 10.1002/ksa.12533. Epub 2024 Nov 14.
- Results publication: PubMed 39616323Zhou Y, Yang Q, Kang J, Xu J, Chen M, Wu C. Clinical effect of medial meniscus posterior root repair combined with centralization technique in the treatment of medial meniscus posterior root tears. BMC Musculoskelet Disord. 2024 Nov 30;25(1):982. doi: 10.1186/s12891-024-08125-2.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmet E Paksoy, Assoc.Prof. study director
Ataturk University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transtibial Pull Out Method and Suture Anchor Method in people with Meniscal Extrusion and Meniscus Injury, run by Ataturk University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammet Celik, primary investigator, MD (905392087998, drcelik@outlook.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in the amount of meniscus extrusion in MR images. (time frame: From enrollment to the end of treatment at 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06906783, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 May 2025; AzTrials last refreshed its copy on 27 Oct 2026.