Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory TaskMOFiANCT06908863
Correlations Between Fine Manual Motor Skills and Speech Articulation
A study testing Tasks learning and MRI scan in people with Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
Trial summary
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task
- What is being tested?
- Tasks learning and MRI scan
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteFrance
- Study dates
- 13 Oct 2025to 4 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male or female between the ages of 18 and 35
- Right-handed
- Member of beneficiary of a social security insurance
- Signature of an informed consent
Who cannot join
- Disorders of fine manual motor skills and/or articulatory disorders
- A neurological history that has affected the subject's cerebral function (stroke, head injury)
- Contraindication to MRI (presence of ferromagnetic material in the body, claustrophobia)
- Pregnant women
- Taking medication that may alter the cerebral haemodynamic signal
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Cortical Correlations Between Fine Manual Motor Skills and Speech Articulation : Pilot Study
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35.
The literature reveals a well-established relationship between manual motor skills and speech from an anatomical and functional point of view. Some studies indicate a proximity between the motor cortical regions corresponding to the hand and the mouth, with a mutual interaction of the two functions from the earliest stages of life (for example, the Babkin reflex). Experimental data shows that hand movements can be influenced by mouth movements. Neurophysiological studies have demonstrated the existence of a link between these two systems in humans and monkeys.
To date, no study has identified the common cortical networks that are active during these two limb movements in a given sample of subjects. The aim of this study is to determine whether such networks exist. The results could be therapeutically relevant, particularly for stroke patients, by enabling more effective restoration of articulatory abilities through complementary limb movements.
- Conditions
- Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task
- Being tested
- Tasks learning and MRI scan
- Keywords
- Motor skills, speech, cortical
- Medical subject headings
- Speech
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tasks learning and MRI scanOther
- 2-week learning and training phase of motor tasks and oral and facial language (OLF) tasks.
Manual fine motor tasks will correspond to activities requiring increasing precision and different types of grip (crushing a ball, modelling clay with the palm of the hand, sorting round coins with thumb/index pliers).
The OLF praxis tasks will correspond to coordinated movements of different parts of the face (cheeks, lips and tongue).
- MRI (magnetic resonance imaging) exam, During this exam, the investigator will give to the subject instructions for a task to be carried out. These tasks will correspond to the motor tasks previously trained.
| Study group | Role | What they receive |
|---|---|---|
| Motor tasks and oral and facial language | Experimental | Exercises and MRI Receives: Other: Tasks learning and MRI scan |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recording of brain activity during manual motor skills and speech articulation
Detection and comparison of fMRI image sequences of brain areas based on variations in the difference between oxygenated and deoxygenated hemoglobin during manual motor tasks and silent phoneme articulation
Measured: 2 weeks after inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2025
- Study start13 Oct 2025
- Primary completion1 Jan 2026
- Study completion4 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory TaskStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de NiceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Category 2 pilot study involving healthy subjects.
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Guillaume SACCO, Principal investigator, Centre Hospitalier Universitaire de Nice
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06908863
- Sponsor's protocol ID
- 24-AOIP-03
- Acronym
- MOFiA
- Status last verified
- Mar 2026
- First submitted
- 25 Mar 2025
- Last updated
- 19 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cortical Correlations Between Fine Manual Motor Skills and Speech Articulation : Pilot Study
- ClinicalTrials.gov ID
- NCT06908863
- Acronym / sponsor ID
- MOFiA / 24-AOIP-03
- Conditions
- Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task
- Keywords
- Motor skills, speech, cortical
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NiceUniversity, hospital or other
- Study start
- 13 Oct 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 4 Feb 2026 (actual)
- First posted
- 3 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35.
The literature reveals a well-established relationship between manual motor skills and speech from an anatomical and functional point of view. Some studies indicate a proximity between the motor cortical regions corresponding to the hand and the mouth, with a mutual interaction of the two functions from the earliest stages of life (for example, the Babkin reflex). Experimental data shows that hand movements can be influenced by mouth movements. Neurophysiological studies have demonstrated the existence of a link between these two systems in humans and monkeys.
To date, no study has identified the common cortical networks that are active during these two limb movements in a given sample of subjects. The aim of this study is to determine whether such networks exist. The results could be therapeutically relevant, particularly for stroke patients, by enabling more effective restoration of articulatory abilities through complementary limb movements.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Category 2 pilot study involving healthy subjects.
| Arm | Type | Receives |
|---|---|---|
| Motor tasks and oral and facial language | Experimental | Other: Tasks learning and MRI scanExercises and MRI |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Male or female between the ages of 18 and 35
- Right-handed
- Member of beneficiary of a social security insurance
- Signature of an informed consent
Key exclusion criteria (5 listed)
- Disorders of fine manual motor skills and/or articulatory disorders
- A neurological history that has affected the subject's cerebral function (stroke, head injury)
- Contraindication to MRI (presence of ferromagnetic material in the body, claustrophobia)
- Pregnant women
- Taking medication that may alter the cerebral haemodynamic signal
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tasks learning and MRI scan- 2-week learning and training phase of motor tasks and oral and facial language (OLF) tasks. Manual fine motor tasks will correspond to activities requiring increasing precision and different types of grip (crushing a ball, modelling clay with the palm of the hand, sorting round coins with thumb/index pliers). The OLF praxis tasks will correspond to coordinated movements of different parts of the face (cheeks, lips and tongue). - MRI (magnetic resonance imaging) exam, During this exam, the investigator will give to the subject instructions for a task to be carried out. These tasks will correspond to the motor tasks previously trained. | Other | Motor tasks and oral and facial language |
Primary outcome
Recording of brain activity during manual motor skills and speech articulation
Time frame: 2 weeks after inclusion
Detection and comparison of fMRI image sequences of brain areas based on variations in the difference between oxygenated and deoxygenated hemoglobin during manual motor tasks and silent phoneme articulation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Mar 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Guillaume SACCO principal investigator
Centre Hospitalier Universitaire de Nice
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tasks learning and MRI scan in people with Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Recording of brain activity during manual motor skills and speech articulation (time frame: 2 weeks after inclusion). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Mar 2026; AzTrials last refreshed its copy on 6 Nov 2026.