Opioid UseNCT06909851
Comparison of Pain Relief After Arthroscopic Knee Surgery: Adductor Canal Block and Genicular Nerve Block
A study testing Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) in people with Opioid Use and Pain Postoperative, run by Başakşehir Çam & Sakura City Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing arthroscopic knee surgery under spinal anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 72 yearsHealthy volunteers can take part
- Conditions the study is for
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- What is being tested?
- Adductor Canal Block (ACB) and Genicular Nerve Block (GNB)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Mar 2025to 30 Sep 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 72 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Voluntary willingness to participate in the study.
- Patients undergoing arthroscopic knee surgery (meniscus, ACL, arthroscopic intervention etc).
- ASA I-II-III classification.
- Aged between 18-72 years.
- No contraindications for regional anesthesia, and deemed suitable for regional anesthesia by the anesthesiologist.
- Undergoing surgery under spinal anesthesia.
- Fully oriented and able to cooperate.
Who cannot join
- Undergoing surgery under general anesthesia.
- Chronic analgesic use.
- Presence of an active infection at the procedure site.
- Outside the appropriate age range.
- Inability to comply with postoperative pain/NRS follow-ups.
- ASA IV-V classification.
- Non-voluntary patients.
- Pregnancy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Başakşehir Çam & Sakura City Hospital
Istanbul
SİNAN ANAŞ, +905314220762, tharkunbalrogs@gmail.com
MUZAFFER GENCER, +905059436459, dr.m.gencer07@gmail.com
About this study
Official title: Comparison of the Effectiveness of Adductor Canal Block and Genicular Nerve Block on Postoperative Pain and Analgesic Use in Arthroscopic Knee Surgeries
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing arthroscopic knee surgery under spinal anesthesia. The main question it aims to answer is:
To demonstrate whether Adductor Canal Block or Genicular Nerve Block is more effective in postoperative analgesia in patients undergoing arthroscopic knee surgery based on pain scores, opioid consumption and patient satisfaction.
Arthroscopic knee surgeries cause severe pain especially with movement in the post-operative period. After surgery, the movements of the participants are severely restricted because of pain, which increases the possibility of complications and postpones post-operative knee exercises. In this study, the participants' pain status, VAS score, opioid consumption and patient satisfaction will be measured with a simple scoring system for 24 hours at predetermined time points and then compared. Both types of blocks have pain-relieving effects. This study will only investigate which one is more effective in reducing pain, and there will be no deficiency in relieving the pain of the participants.
- Conditions
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- Being tested
- Adductor Canal Block (ACB), Genicular Nerve Block (GNB)
- Keywords
- Genicular Nerve Block, Arthroscopic Knee Surgery, Adductor Canal Block, Postoperative Analgesia
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adductor Canal Block (ACB)Procedure or surgery
Evaluation of postoperative analgesic effectiveness of ACB block in participants undergoing arthroscopic knee surgery under spinal anesthesia.
Genicular Nerve Block (GNB)Procedure or surgery
Evaluation of postoperative analgesic effectiveness of GNB block in participants undergoing arthroscopic knee surgery under spinal anesthesia.
| Study group | Role | What they receive |
|---|---|---|
| ACB Group | Active comparator | Participants undergoing arthroscopic knee surgery under spinal anestesia receiving pre operative Adductor Canal Block (ACB) Receives: Procedure: Adductor Canal Block (ACB) |
| Genicular Nerve Block | Active comparator | Participants undergoing arthroscopic knee surgery under spinal anestesia receiving pre operative Genicular Nerve Block (GNB) Receives: Procedure: Genicular Nerve Block (GNB) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effectiveness on Pain Scores (NRS)
Postoperative pain assessment is performed using the Numerical Rating Scale (NRS). Participants are asked about their rest pain at Baseline 0, postoperative 1st, 2nd, 4th, 6th, 12th, and 24th hours after applying a preoperative peripheral nerve block. With this method, participants rate their pain with a precise numerical value from 0 to 10. While zero(0) represents "no pain"; Ten (10) represents the opposite end of the pain continuum (e.g., "The most intense pain imaginable," "As intense pain as possible," "Maximum pain").
Measured: Postoperative 24 hours
Secondary outcomes (7)
Amount of rescue analgesia administration
After the surgery all patients will be given 4 times a day Paracetamol 1 gram. Patients who still have pain (NRS 4 or higher) will be given Tramadol 1 mg/kg (maximum 400 mg Tramadol daily). Postoperative 24 hours the amount of the rescue analgesic (Tramadol) will be noted.
Measured: Postoperative 24 hours.
Postoperative Blood pressure
Participants' blood pressure (mm/hg) will be monitored for 24 hours (Post op 1st, 2nd, 4th, 6th, 12th and 24th hours) postoperatively.
Measured: Postoperative 24 hours
Length of hospital stay
Length of hospital stay will be noted.
Measured: Postoperative 14 days
First Time Of Mobilisation/Exercise
First time of mobilisation/exercise will be noted.
Measured: Postoperative 24 hours
The Time of Rescue Analgesic
After the surgery all patients will be given 4 times a day Paracetamol 1 gram. Patients who still have pain (NRS 4 or higher) will be given Tramadol 1 mg/kg (maximum 400 mg Tramadol daily). Postoperative 24 hours the time of the rescue analgesic usage (Tramadol) will be noted.
Measured: Postoperative 24 hours
Postoperative heart rate
Participants' heart rate (bpm) will be monitored for 24 hours (Post op 1st, 2nd, 4th, 6th, 12th and 24th hours) postoperatively.
Measured: Postoperative 24 hours
Postoperative oxygen saturation levels
Participants' oxygen saturation levels (spO2 %) will be monitored for 24 hours (Post op 1st, 2nd, 4th, 6th, 12th and 24th hours) postoperatively.
Measured: Postoperative 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Apr 2025
- Study start10 Mar 2025
- Primary completion31 Aug 2025 (estimated)
- Study completion30 Sep 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Opioid UseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Patients who are admitted to the orthopedic and traumatology clinic and are scheduled for arthroscopic knee surgery will be informed and monitored prior to the operation under spinal anesthesia. Preoperatively, either Adductor Canal Block (ACB) (Group A) or Genicular Nerve Block (GNB) (Group B) will be applied. Randomization will be performed using a computer-based method (http://www.randomizer.org) with a 1:1 allocation.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 68 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Başakşehir Çam & Sakura City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Muzaffer GENCER, Başakşehir Çam & Sakura City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06909851
- Sponsor's protocol ID
- BSH-ANES-SA-01
- Status last verified
- Mar 2025
- First submitted
- 21 Mar 2025
- Last updated
- 4 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Vora MU, Nicholas TA, Kassel CA, Grant SA. Adductor canal block for knee surgical procedures: review article. J Clin Anesth. 2016 Dec;35:295-303. doi: 10.1016/j.jclinane.2016.08.021. Epub 2016 Oct 11.
PubMed 27871547Tamam A, Guven Kose S, Kose HC, Akkaya OT. Comparison of the Effectiveness of Ultrasound-Guided Proximal, Mid, or Distal Adductor Canal Block after Knee Arthroscopy. Turk J Anaesthesiol Reanim. 2023 Apr;51(2):135-142. doi: 10.5152/TJAR.2023.22225.
PubMed 37140579
Study at a glance
From the registry record, last updated by the sponsor on 4 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effectiveness of Adductor Canal Block and Genicular Nerve Block on Postoperative Pain and Analgesic Use in Arthroscopic Knee Surgeries
- ClinicalTrials.gov ID
- NCT06909851
- Acronym / sponsor ID
- BSH-ANES-SA-01
- Conditions
- Opioid Use, Pain Postoperative, Arthroscopic Knee Surgeries
- Keywords
- Genicular Nerve Block, Arthroscopic Knee Surgery, Adductor Canal Block, Postoperative Analgesia
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 68 participants (estimated)
- Lead sponsor
- Başakşehir Çam & Sakura City HospitalOther government
- Study start
- 10 Mar 2025 (actual)
- Primary completion
- 31 Aug 2025 (estimated)
- Study completion
- 30 Sep 2025 (estimated)
- First posted
- 4 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective randomized study aims to compare the analgesic efficacy of Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) groups to relieve postoperative pain in participants between ages of 18-72 undergoing arthroscopic knee surgery under spinal anesthesia. The main question it aims to answer is:
To demonstrate whether Adductor Canal Block or Genicular Nerve Block is more effective in postoperative analgesia in patients undergoing arthroscopic knee surgery based on pain scores, opioid consumption and patient satisfaction.
Arthroscopic knee surgeries cause severe pain especially with movement in the post-operative period. After surgery, the movements of the participants are severely restricted because of pain, which increases the possibility of complications and postpones post-operative knee exercises. In this study, the participants' pain status, VAS score, opioid consumption and patient satisfaction will be measured with a simple scoring system for 24 hours at predetermined time points and then compared. Both types of blocks have pain-relieving effects. This study will only investigate which one is more effective in reducing pain, and there will be no deficiency in relieving the pain of the participants.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Patients who are admitted to the orthopedic and traumatology clinic and are scheduled for arthroscopic knee surgery will be informed and monitored prior to the operation under spinal anesthesia. Preoperatively, either Adductor Canal Block (ACB) (Group A) or Genicular Nerve Block (GNB) (Group B) will be applied. Randomization will be performed using a computer-based method (http://www.randomizer.org) with a 1:1 allocation.
| Arm | Type | Receives |
|---|---|---|
| ACB Group | Active comparator | Procedure: Adductor Canal Block (ACB)Participants undergoing arthroscopic knee surgery under spinal anestesia receiving pre operative Adductor Canal Block (ACB) |
| Genicular Nerve Block | Active comparator | Procedure: Genicular Nerve Block (GNB)Participants undergoing arthroscopic knee surgery under spinal anestesia receiving pre operative Genicular Nerve Block (GNB) |
Who may qualify
- Ages
- 18 to 72 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Voluntary willingness to participate in the study.
- Patients undergoing arthroscopic knee surgery (meniscus, ACL, arthroscopic intervention etc).
- ASA I-II-III classification.
- Aged between 18-72 years.
- No contraindications for regional anesthesia, and deemed suitable for regional anesthesia by the anesthesiologist.
Key exclusion criteria (8 listed)
- Undergoing surgery under general anesthesia.
- Chronic analgesic use.
- Presence of an active infection at the procedure site.
- Outside the appropriate age range.
- Inability to comply with postoperative pain/NRS follow-ups.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adductor Canal Block (ACB)Evaluation of postoperative analgesic effectiveness of ACB block in participants undergoing arthroscopic knee surgery under spinal anesthesia. | Procedure or surgery | ACB Group |
| Genicular Nerve Block (GNB)Evaluation of postoperative analgesic effectiveness of GNB block in participants undergoing arthroscopic knee surgery under spinal anesthesia. | Procedure or surgery | Genicular Nerve Block |
Primary outcome
Effectiveness on Pain Scores (NRS)
Time frame: Postoperative 24 hours
Postoperative pain assessment is performed using the Numerical Rating Scale (NRS). Participants are asked about their rest pain at Baseline 0, postoperative 1st, 2nd, 4th, 6th, 12th, and 24th hours after applying a preoperative peripheral nerve block. With this method, participants rate their pain with a precise numerical value from 0 to 10. While zero(0) represents "no pain"; Ten (10) represents the opposite end of the pain continuum (e.g., "The most intense pain imaginable," "As intense pain as possible," "Maximum pain").
7 secondary outcomes
Amount of rescue analgesia administration
Time frame: Postoperative 24 hours.
Postoperative Blood pressure
Time frame: Postoperative 24 hours
Length of hospital stay
Time frame: Postoperative 14 days
First Time Of Mobilisation/Exercise
Time frame: Postoperative 24 hours
The Time of Rescue Analgesic
Time frame: Postoperative 24 hours
Postoperative heart rate
Time frame: Postoperative 24 hours
Postoperative oxygen saturation levels
Time frame: Postoperative 24 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Apr 2025.
- Background: PubMed 27871547Vora MU, Nicholas TA, Kassel CA, Grant SA. Adductor canal block for knee surgical procedures: review article. J Clin Anesth. 2016 Dec;35:295-303. doi: 10.1016/j.jclinane.2016.08.021. Epub 2016 Oct 11.
- Background: PubMed 37140579Tamam A, Guven Kose S, Kose HC, Akkaya OT. Comparison of the Effectiveness of Ultrasound-Guided Proximal, Mid, or Distal Adductor Canal Block after Knee Arthroscopy. Turk J Anaesthesiol Reanim. 2023 Apr;51(2):135-142. doi: 10.5152/TJAR.2023.22225.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adductor Canal Block (ACB) and Genicular Nerve Block (GNB) in people with Opioid Use and Pain Postoperative, run by Başakşehir Çam & Sakura City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact MUZAFFER GENCER (+905059436459, dr.m.gencer07@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effectiveness on Pain Scores (NRS) (time frame: Postoperative 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06909851, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Apr 2025.