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Sleep Wake DisordersNCT06914167

The Effectiveness of Lavender Aromatherapy Combined With Slow Breathing Exercises in Improving Occupational Burnout and Sleep Disorders Among Nursing Staff

A study testing Slow Breathing Exercises, Lavender Essential Oil Inhalation and linalyl acetate essential oil Inhalation in people with Sleep Wake Disorders, run by Tri-Service General Hospital (TSGH) at 1 site in Taiwan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study investigates the effects of breathing exercises combined with lavender essential oil inhalation on occupational burnout and sleep disturbances in rotating shift nurses. Read more about this study

Who is it for?
Ages 20 to 65 yearsHealthy volunteers can take part
Conditions the study is for
Sleep Wake Disorders
What is being tested?
Slow Breathing Exercises, Lavender Essential Oil Inhalation and linalyl acetate essential oil Inhalation
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
70 participants
Where
1 siteTaiwan
Study dates
1 Apr 2025to 31 Dec 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 65 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Aged between 20 and 65 years Registered nurses with at least 6 months of clinical experience and currently working rotating shifts Scores ≥1 in each of the three dimensions (emotional exhaustion, reduced personal accomplishment, depersonalization) on the Nursing Burnout Scale (NBS) Willing to participate in the study and accept random assignment

Who cannot join

  • Nurses with less than 6 months of clinical experience Individuals with anosmia or reduced sense of smell Diagnosed with psychiatric disorders Allergic to lavender essential oil Not currently working rotating shifts

Trial locations and contacts

1 site in 1 country.

Taiwan1 site
  • Tri-Service General Hospital, Songshan Branch

    Taipei City, Taipei, 105

Other trials in Taiwan

About this study

This study investigates the effects of breathing exercises combined with lavender essential oil inhalation on occupational burnout and sleep disturbances in rotating shift nurses.

Read the detailed description

This study will adopt a randomized controlled trial (RCT) design targeting rotating shift nurses with at least six months of clinical experience at a regional teaching hospital in northern Taiwan. Eligible participants who consent to join the study will be randomly assigned into five groups using block randomization. The randomization process will be conducted via sealed envelopes to allocate participants into the following groups: Experimental Group 1, Experimental Group 2, Experimental Group 3, Breathing-Only Group, and Control Group.

Experimental Group 1: Participants will receive slow breathing training (6 breaths per minute) once daily before bedtime, combined with the inhalation of 3 drops of natural lavender essential oil on a towel, for 3 minutes, over a 4-week period.

Experimental Group 2: Same breathing protocol as above, with 3 drops of linalyl acetate-containing essential oil.

Experimental Group 3: Same breathing protocol, with 3 drops of linalool-containing essential oil.

Breathing-Only Group: Participants will perform slow breathing training (6 breaths per minute) for 3 minutes daily before bedtime, without any essential oil inhalation, for 4 weeks.

Control Group: Participants will maintain their usual lifestyle without any intervention.

The outcomes will be evaluated using a nurse burnout scale and a sleep quality scale. Measurements will be taken at three time points: baseline (pre-test), 4 weeks after the intervention (post-test 1), and 8 weeks after the intervention (follow-up/post-test 2).

The study is co-led by Yao-Hsiang Chen, Assistant Head Nurse at Tri-Service General Hospital Songshan Branch, and Professor Chia-Hui Lin, School of Nursing, National Defense Medical Center.

Being tested
Slow Breathing Exercises, Lavender Essential Oil Inhalation, linalyl acetate essential oil Inhalation, linalool essential oil Inhalation
Keywords
Sleep Wake Disorders
Medical subject headings
Sleep Wake Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Slow Breathing ExercisesBehavioural

    Participants will perform slow breathing (6 breaths/min) for 3 minutes daily before bedtime

  • Lavender Essential Oil InhalationBehavioural

    inhalation of 3 drops of lavender essential oil on a towel,

  • linalyl acetate essential oil InhalationBehavioural

    inhalation of 3 drops of linalyl acetate essential oil on a towel.

  • linalool essential oil InhalationBehavioural

    inhalation of 3 drops of linalool essential oil on a towel.

Study groups in NCT06914167
Study groupRoleWhat they receive
Control GroupNo interventionParticipants will maintain their usual lifestyle without any intervention.
Breathing-Only GroupPlacebo comparatorParticipants will perform slow breathing training (6 breaths per minute) for 3 minutes daily before bedtime, without any essential oil inhalation, for 4 weeks.
Receives: Behavioral: Slow Breathing Exercises
Experimental Group 1ExperimentalParticipants will receive slow breathing training (6 breaths per minute) once daily before bedtime, combined with the inhalation of 3 drops of natural lavender essential oil on a towel, for 3 minutes, over a 4-week period.
Receives: Behavioral: Slow Breathing Exercises; Behavioral: Lavender Essential Oil Inhalation
Experimental Group 2ExperimentalSame breathing protocol as above, with 3 drops of linalyl acetate-containing essential oil on a towel, for 3 minutes, over a 4-week period.
Receives: Behavioral: Slow Breathing Exercises; Behavioral: linalyl acetate essential oil Inhalation
Experimental Group 3ExperimentalSame breathing protocol, with 3 drops of linalool-containing essential oil on a towel, for 3 minutes, over a 4-week period.
Receives: Behavioral: Slow Breathing Exercises; Behavioral: linalool essential oil Inhalation

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Nursing Burnout Scale, NBS

    The Nurse Burnout Inventory is specifically developed based on nurses' clinical practice experiences. It includes items that reflect three key dimensions: emotional exhaustion resulting from the high-tension clinical work environment, reduced personal accomplishment associated with feelings of ineffectiveness in medical care, and depersonalization, characterized by indifference toward others due to prolonged burnout.

    Measured: At baseline, and at 4 and 8 weeks following the start of intervention

Secondary outcomes (1)
  1. The Chinese version of the Pittsburgh Sleep Quality Index, CPSQI

    The Pittsburgh Sleep Quality Index (PSQI) is a widely used self-reported questionnaire designed to assess sleep quality over the past month. It evaluates multiple aspects of sleep, including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. A higher score indicates poorer sleep quality.

    Measured: At baseline, and at 4 and 8 weeks following the start of intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Apr 2025
  2. Study start1 Apr 2025
  3. Primary completion28 Oct 2025
  4. Study completion31 Dec 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Care provider
Enrolment
70 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06914167
Sponsor's protocol ID
TSGH-SS_E_114015
Status last verified
Mar 2025
First submitted
30 Mar 2025
Last updated
28 Apr 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Bavarsad NH, Bagheri S, Kourosh-Arami M, Komaki A. Aromatherapy for the brain: Lavender's healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer's disease: A review article. Heliyon. 2023 Jul 20;9(8):e18492. doi: 10.1016/j.heliyon.2023.e18492. eCollection 2023 Aug.

    PubMed 37554839
  • Sugawara Y, Shigetho A, Yoneda M, Tuchiya T, Matumura T, Hirano M. Relationship between mood change, odour and its physiological effects in humans while inhaling the fragrances of essential oils as well as linalool and its enantiomers. Molecules. 2013 Mar 13;18(3):3312-38. doi: 10.3390/molecules18033312.

    PubMed 23486108
  • Zangaro GA, Dulko D, Sullivan D, Weatherspoon D, White KM, Hall VP, Squellati R, Donnelli A, James J, Wilson DR. Systematic Review of Burnout in US Nurses. Nurs Clin North Am. 2022 Mar;57(1):1-20. doi: 10.1016/j.cnur.2021.11.001.

    PubMed 35236600
  • Zaccaro A, Piarulli A, Melosini L, Menicucci D, Gemignani A. Neural Correlates of Non-ordinary States of Consciousness in Pranayama Practitioners: The Role of Slow Nasal Breathing. Front Syst Neurosci. 2022 Mar 21;16:803904. doi: 10.3389/fnsys.2022.803904. eCollection 2022.

    PubMed 35387390
  • Yang CP, Yang CC, Tsai IJ, Lin TH, Chiou YL, Wang HF, Chang CM, Yih KH. The immediate effects of lavender-based essential oil inhalation on subsequent polysomnography in people with poor sleep quality. J Chin Med Assoc. 2023 Jul 1;86(7):665-671. doi: 10.1097/JCMA.0000000000000932. Epub 2023 Apr 25.

    PubMed 37098173
  • Sullivan V, Hughes V, Wilson DR. Nursing Burnout and Its Impact on Health. Nurs Clin North Am. 2022 Mar;57(1):153-169. doi: 10.1016/j.cnur.2021.11.011. Epub 2022 Feb 9.

    PubMed 35236605
  • Moghadam ZE, Delmoradi F, Aemmi SZ, Vaghee S, Vashani HB. Effectiveness of aromatherapy with inhaled lavender essential oil and breathing exercises on ECT-related anxiety in depressed patients. Explore (NY). 2022 Nov-Dec;18(6):683-687. doi: 10.1016/j.explore.2021.12.006. Epub 2021 Dec 30.

    PubMed 35027302
  • Laborde S, Allen MS, Borges U, Dosseville F, Hosang TJ, Iskra M, Mosley E, Salvotti C, Spolverato L, Zammit N, Javelle F. Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis. Neurosci Biobehav Rev. 2022 Jul;138:104711. doi: 10.1016/j.neubiorev.2022.104711. Epub 2022 May 24.

    PubMed 35623448
  • Hedigan F, Sheridan H, Sasse A. Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting - A systematic review. Complement Ther Clin Pract. 2023 Aug;52:101750. doi: 10.1016/j.ctcp.2023.101750. Epub 2023 Apr 5.

    PubMed 37031643
  • Balban MY, Neri E, Kogon MM, Weed L, Nouriani B, Jo B, Holl G, Zeitzer JM, Spiegel D, Huberman AD. Brief structured respiration practices enhance mood and reduce physiological arousal. Cell Rep Med. 2023 Jan 17;4(1):100895. doi: 10.1016/j.xcrm.2022.100895. Epub 2023 Jan 10.

    PubMed 36630953
  • Antczak-Komoterska A, Haor B, Malinowska M, Grzelak L, Biercewicz M, Kochman D, Krajewska K, Filipska-Blejder K, Wisniewski A, Slusarz R. Analysis of the Level of Stress and Methods of Coping with Stress among the Nursing Staff. Nurs Rep. 2023 Sep 14;13(3):1318-1330. doi: 10.3390/nursrep13030111.

    PubMed 37755354

Questions about this trial

What is this clinical trial studying?

A study testing Slow Breathing Exercises, Lavender Essential Oil Inhalation and linalyl acetate essential oil Inhalation in people with Sleep Wake Disorders, run by Tri-Service General Hospital (TSGH) at 1 site in Taiwan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 28 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Nursing Burnout Scale, NBS (time frame: At baseline, and at 4 and 8 weeks following the start of intervention). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06914167, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Apr 2026.

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