Pediatric UveitisNCT06920017
Demographic Data and Clinical Presentation of Pediatric Uveitis
An observational study of Pediatric Uveitis, run by Assiut University.
Trial summary
To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital. Read more about this study
- Who is it for?
- Ages Up to 18 years
- Conditions the study is for
- Pediatric Uveitis
- How many people
- 40 participants
- Where
- No sites listed yet
- Study dates
- 1 Apr 2025to May 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: pediatric patients
Who may be able to join
- Uveitis patients <18 years old
- must be able to participate in the study.
Who cannot join
- Age over 18 years.
- Patients with post pentrating ocular trauma.
- Patients whose legal guardians are unwilling to participate in the study.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Demographic Data and Clinical Presentation of Pediatric Uveitis Patients in Upper Egypt.
To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital.
Read the detailed description
Uveitis is a form of eye inflammation that affects the middle layer of tissue in the eye wall (uvea).
It is the third leading cause of blindness worldwide .Uveitis is more common in adults; however, children comprise 2.2% to 21.6% of patients in various studies.Despite a lower incidence of uveitis in children, the rate of visual loss may be worse than that of adults . The onset of uveitis in children is often insidious and is only discovered during routine screening.The lack of significant symptoms and delayed presentation to an ophthalmologist leads to morbidity and a decrease in visual acuity . The length of time between the diagnosis of uveitis and the referral to a tertiary eye center is strongly correlated with the complications rate and degree of visual impairment.
Uveitis is classified according to the International Uveitis Study Group criteria based on the anatomical location of the inflammation and is categorized as anterior, intermediate, Posterior or panuveitis. It is also described based on clinical onset, duration and course.
Some uveitis syndromes are unique to children, such as juvenile idiopathic arthritis (JIA), Kawasaki syndrome, Familial Juvenile Systemic Granulomatosis and Tubulointerstitial Nephritis-Uveitis syndrome. Other conditions are more prevalent in the pediatric population due to environmental factors such as trematode induced uveitis.
Due to the lack of epidemiological studies on the demographic and Clinical Characteristics of pediatric uveitis in Upper Egypt. This study aims to improve diagnosis, management, and treatment strategies tailored to the population.
- Conditions
- Pediatric Uveitis
What is being measured
The primary outcome is the main question the study is designed to answer.
Distribution of uveitis subtypes.
Measured: Baseline
Differences by age, gender, or ethnicity.
Measured: Baseline
Prevalence of systemic associations.
Measured: Baseline
Prevalence of Visual outcomes.
Measured: Baseline
Prevalence of complications rate.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2025
- Study start1 Apr 2025 (estimated)
- Primary completionApr 2026 (estimated)
- Study completionMay 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for Pediatric UveitisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hasnaa Salah Ebrahim Abo Elyuon, Assiut University
- Investigators
- Mohamed Sharaf El Din Abd El Rahim, professor, Study director, Assiut UniversityMohmed Gamal Ahmed Saleh, Assistant Professor, Study director, Assiut UniversityEslam Mohamed Mohamed Goda, Lecturer, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06920017
- Sponsor's protocol ID
- Pediatric Uveitis
- Status last verified
- Mar 2025
- First submitted
- 13 Mar 2025
- Last updated
- 9 Apr 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
American Academy of Ophthalmology meeting (Uveitis and Ocular Inflammation section), October 25, 2004; New Orleans, Louisiana
Rahimi M, Oustad M, Ashrafi A. Demographic and Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in Iran. Middle East Afr J Ophthalmol. 2016 Jul-Sep;23(3):237-40. doi: 10.4103/0974-9233.186096.
PubMed 27555706Chan NS, Choi J, Cheung CMG. Pediatric Uveitis. Asia Pac J Ophthalmol (Phila). 2018 May-Jun;7(3):192-199. doi: 10.22608/APO.2018116. Epub 2018 Apr 23.
PubMed 29682916Cunningham ET Jr. Uveitis in children. Ocul Immunol Inflamm. 2000 Dec;8(4):251-61. doi: 10.1076/ocii.8.4.251.6459.
PubMed 11262655Rosenberg KD, Feuer WJ, Davis JL. Ocular complications of pediatric uveitis. Ophthalmology. 2004 Dec;111(12):2299-306. doi: 10.1016/j.ophtha.2004.06.014.
PubMed 15582090Edelsten C, Reddy MA, Stanford MR, Graham EM. Visual loss associated with pediatric uveitis in english primary and referral centers. Am J Ophthalmol. 2003 May;135(5):676-80. doi: 10.1016/s0002-9394(02)02148-7.
PubMed 12719076Azar D, Martin F. Paediatric uveitis: a Sydney clinic experience. Clin Exp Ophthalmol. 2004 Oct;32(5):468-71. doi: 10.1111/j.1442-9071.2004.00864.x.
PubMed 15498056Kump LI, Cervantes-Castaneda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005 Jul;112(7):1287-92. doi: 10.1016/j.ophtha.2005.01.044.
PubMed 15921752Benezra D, Cohen E, Maftzir G. Patterns of intraocular inflammation in children. Bull Soc Belge Ophtalmol. 2001;(279):35-8.
PubMed 11344713.Nussenblatt RB, Whitcup SM. Uveitis: Fundamentals and Clinical Practice, 4th edition. Mosby, 2010
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057.
PubMed 16196117
Study at a glance
From the registry record, last updated by the sponsor on 9 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Demographic Data and Clinical Presentation of Pediatric Uveitis Patients in Upper Egypt.
- ClinicalTrials.gov ID
- NCT06920017
- Acronym / sponsor ID
- Pediatric Uveitis
- Conditions
- Pediatric Uveitis
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Apr 2025 (estimated)
- Primary completion
- Apr 2026 (estimated)
- Study completion
- May 2026 (estimated)
- First posted
- 9 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital.
Detailed description
Uveitis is a form of eye inflammation that affects the middle layer of tissue in the eye wall (uvea).
It is the third leading cause of blindness worldwide .Uveitis is more common in adults; however, children comprise 2.2% to 21.6% of patients in various studies.Despite a lower incidence of uveitis in children, the rate of visual loss may be worse than that of adults . The onset of uveitis in children is often insidious and is only discovered during routine screening.The lack of significant symptoms and delayed presentation to an ophthalmologist leads to morbidity and a decrease in visual acuity . The length of time between the diagnosis of uveitis and the referral to a tertiary eye center is strongly correlated with the complications rate and degree of visual impairment.
Uveitis is classified according to the International Uveitis Study Group criteria based on the anatomical location of the inflammation and is categorized as anterior, intermediate, Posterior or panuveitis. It is also described based on clinical onset, duration and course.
Some uveitis syndromes are unique to children, such as juvenile idiopathic arthritis (JIA), Kawasaki syndrome, Familial Juvenile Systemic Granulomatosis and Tubulointerstitial Nephritis-Uveitis syndrome. Other conditions are more prevalent in the pediatric population due to environmental factors such as trematode induced uveitis.
Due to the lack of epidemiological studies on the demographic and Clinical Characteristics of pediatric uveitis in Upper Egypt. This study aims to improve diagnosis, management, and treatment strategies tailored to the population.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- Up to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- pediatric patients
Key inclusion criteria (2 listed)
- Uveitis patients <18 years old
- must be able to participate in the study.
Key exclusion criteria (3 listed)
- Age over 18 years.
- Patients with post pentrating ocular trauma.
- Patients whose legal guardians are unwilling to participate in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Distribution of uveitis subtypes.
Time frame: Baseline
Differences by age, gender, or ethnicity.
Time frame: Baseline
Prevalence of systemic associations.
Time frame: Baseline
Prevalence of Visual outcomes.
Time frame: Baseline
Prevalence of complications rate.
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Apr 2025.
- BackgroundAmerican Academy of Ophthalmology meeting (Uveitis and Ocular Inflammation section), October 25, 2004; New Orleans, Louisiana
- Background: PubMed 27555706Rahimi M, Oustad M, Ashrafi A. Demographic and Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in Iran. Middle East Afr J Ophthalmol. 2016 Jul-Sep;23(3):237-40. doi: 10.4103/0974-9233.186096.
- Background: PubMed 29682916Chan NS, Choi J, Cheung CMG. Pediatric Uveitis. Asia Pac J Ophthalmol (Phila). 2018 May-Jun;7(3):192-199. doi: 10.22608/APO.2018116. Epub 2018 Apr 23.
- Background: PubMed 11262655Cunningham ET Jr. Uveitis in children. Ocul Immunol Inflamm. 2000 Dec;8(4):251-61. doi: 10.1076/ocii.8.4.251.6459.
- Background: PubMed 15582090Rosenberg KD, Feuer WJ, Davis JL. Ocular complications of pediatric uveitis. Ophthalmology. 2004 Dec;111(12):2299-306. doi: 10.1016/j.ophtha.2004.06.014.
- Background: PubMed 12719076Edelsten C, Reddy MA, Stanford MR, Graham EM. Visual loss associated with pediatric uveitis in english primary and referral centers. Am J Ophthalmol. 2003 May;135(5):676-80. doi: 10.1016/s0002-9394(02)02148-7.
- Background: PubMed 15498056Azar D, Martin F. Paediatric uveitis: a Sydney clinic experience. Clin Exp Ophthalmol. 2004 Oct;32(5):468-71. doi: 10.1111/j.1442-9071.2004.00864.x.
- Background: PubMed 15921752Kump LI, Cervantes-Castaneda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005 Jul;112(7):1287-92. doi: 10.1016/j.ophtha.2005.01.044.
- Background: PubMed 11344713Benezra D, Cohen E, Maftzir G. Patterns of intraocular inflammation in children. Bull Soc Belge Ophtalmol. 2001;(279):35-8.
- Results publication.Nussenblatt RB, Whitcup SM. Uveitis: Fundamentals and Clinical Practice, 4th edition. Mosby, 2010
- Results publication: PubMed 16196117Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed Sharaf El Din Abd El Rahim, professor study director
Assiut University
Mohmed Gamal Ahmed Saleh, Assistant Professor study director
Assiut University
Eslam Mohamed Mohamed Goda, Lecturer study director
Assiut University
Questions about this trial
What is this clinical trial studying?
An observational study of Pediatric Uveitis, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hasnaa Salah Ebrahim Abo Elyuon, master (+201090793398, Hassnaa.16266153@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Distribution of uveitis subtypes. (time frame: Baseline). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06920017, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Apr 2025.