Obesity and OverweightPhase 2/3NCT06921486
The Efficacy and Safety of Efsubaglutide Alfa Injection in Overweight and Obese Subjects (ENLIGHT)
A Phase 2/3 study testing Phase IIb:Efsubaglutide Alfa 5 mg QW, Phase IIb:Efsubaglutide Alfa 10 mg QW and Phase IIb:Efsubaglutide Alfa 20 mg QW in people with Obesity and Overweight, run by Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. at 41 sites in China.
Trial summary
This study is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III clinical trial aimed at evaluating the efficacy, safety, pharmacokinetics (PK), and immunogenicity profile of Efsubaglutide Alfa injection in overweight and obese subjects. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Obesity and Overweight
- What is being tested?
- Phase IIb:Efsubaglutide Alfa 5 mg QW, Phase IIb:Efsubaglutide Alfa 10 mg QW and Phase IIb:Efsubaglutide Alfa 20 mg QW
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1,003 participants
- Where
- 41 sitesChina
- Study dates
- 31 Mar 2025to 31 Dec 2026
- Phase
- Phase 2/3
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Voluntarily participate in the clinical study; fully understand and be informed about the study, and sign the informed consent form (ICF); willing to follow and capable of completing all study procedures.
- Age ≥ 18 years (including the cutoff value, based on the time of signing the ICF), regardless of gender.
- History of poor weight control through diet and exercise [defined as weight control failure if the subject has attempted at least 3 months of diet and exercise alone prior to screening without achieving a weight loss of ≥ 5.0% (based on subject self-report)].
- Willing to follow the recommendations of the investigator regarding medication, diet, and exercise.
- Stable weight within 3 months prior to screening (defined as a weight change < 5%, based on subject self-report).
- Obesity: Body Mass Index (BMI) ≥ 28 kg/m² (including the cutoff value) with or without comorbidities; or overweight: BMI ≥ 24 and < 28 kg/m² with at least one weight-related comorbidity, including but not limited to prediabetes (impaired fasting glucose [FPG] and/or abnormal glucose tolerance), hypertension, dyslipidemia, non-alcoholic fatty liver disease, or obstructive sleep apnea syndrome.
- Women of childbearing potential must have a negative blood pregnancy test during the screening period. Women of childbearing potential or male subjects and their partners must agree not to plan for pregnancy from the time of signing the ICF until 3 months after the last dose of the investigational drug, and voluntarily agree to use effective contraception, with no plans for sperm or egg donation.
Who cannot join
- Allergic constitution or allergic to any component of the investigational drug.
- Previously treated with Efsubaglutide Alfa injection.
- Received glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose co-transporter-2 (SGLT-2) inhibitors, insulin, metformin, insulin secretagogues, or thiazolidinediones (TZD) or any other weight-affecting anti-diabetic medication within the past 3 months before screening.
- HbA1c ≥ 6.5% at screening, or previously diagnosed with Type 1 or Type 2 diabetes (based on the World Health Organization [WHO] 2020 diabetes diagnosis and classification standards).
- History of severe hypoglycemia or recurrent symptomatic hypoglycemia (≥ 2 times in the past 6 months).
- Known single-gene mutations, other diseases, or drug-induced obesity, including but not limited to hypothalamic obesity, pituitary obesity, hypothyroid obesity, Cushing's syndrome, insulinoma, growth hormone deficiency, acromegaly, pseudohypoparathyroidism, gonadal dysfunction, etc.
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- Clinically significant gastric emptying abnormalities (e.g., gastric outlet obstruction), severe chronic gastrointestinal diseases (e.g., active ulcers in the past 6 months), long-term use of drugs directly affecting gastrointestinal motility (including but not limited to mosapride, cisapride, etc.), or having undergone gastrointestinal surgery within the past 6 months and deemed unsuitable for participation by the investigator.
- Use of weight-affecting medications within 3 months prior to screening, including tricyclic antidepressants, psychiatric medications, or sedative drugs (such as imipramine, amitriptyline, mirtazapine, paroxetine, phenelzine, chlorpromazine, sulpiride, clozapine, olanzapine, valproic acid, valproic acid derivatives, lithium salts, etc.). Note: Excluded if cumulative or continuous systemic steroid use is less than 14 days.
- Use of non-prescription weight loss medications or appetite suppressants (including traditional Chinese medicine weight loss drugs) within 1 month prior to screening, or use of prescription weight loss medications (e.g., phentermine, sibutramine, orlistat) or lipid-dissolving injectables (e.g., lipolytic injections) within 3 months prior to screening.
- Previously underwent weight-loss surgery (excluding acupuncture, liposuction, and abdominal fat removal within 1 year before screening), or plans to undergo surgery for obesity during the study period, such as gastric bypass surgery or gastric band surgery.
- Currently on a weight loss plan and not in the maintenance phase.
- History of hyperthyroidism or hypothyroidism, or thyroid-stimulating hormone (TSH) < 1×LLN (lower limit of normal) or TSH > 1.5×ULN (upper limit of normal).
- Screening serum calcitonin ≥ 50 ng/L (or ≥ 50 pg/mL), or history of medullary thyroid cancer, multiple endocrine neoplasia (MEN) syndrome type 2A or 2B, or related family history (family history defined as a first-degree relative with the disease).
- History of acute or chronic pancreatitis, cholecystectomy, or symptomatic gallbladder disease (patients with post-surgery resolved gallstones or cholecystectomy without sequelae can be enrolled), or known history of pancreatic injury or high-risk factors for pancreatitis, or screening with serum amylase or lipase > 2×ULN.
- Any disease that could affect HbA1c measurement, such as hemolytic anemia, sickle cell disease, etc.
- Currently receiving or have received chronic (> 14 days) systemic corticosteroid treatment in the past 3 months (excluding local, intraocular, intranasal, intra-articular, or inhaled formulations), or have evidence of severe, active autoimmune disorders (e.g., lupus or rheumatoid arthritis), and, in the opinion of the investigator, require or may require systemic corticosteroid treatment within the next 12 months.
- History of malignancy within 5 years prior to screening, excluding clinically cured cervical carcinoma in situ, squamous cell carcinoma of the skin, or basal cell carcinoma within the past 5 years.
- History of major surgery (e.g., thoracic, intracranial, or abdominal surgery) within 6 months prior to screening, or plans to undergo surgery that may affect study completion or adherence.
- Meets any of the following cardiac function criteria: clinically significant arrhythmias or conduction abnormalities requiring clinical intervention; hereditary long QT syndrome or QTcF > 450 msec or currently taking medications that may prolong the QT interval or cause torsades de pointes; clinically significant cardiovascular diseases, including acute myocardial infarction, unstable angina, coronary artery bypass graft surgery, New York Heart Association (NYHA) class III or higher congestive heart failure, left ventricular ejection fraction (LVEF) < 50%, or uncontrolled hypertension (systolic blood pressure > 160 mmHg or diastolic blood pressure > 100 mmHg); other clinically significant cardiac abnormalities judged by the investigator.
- History of hemorrhagic or ischemic stroke or transient ischemic attack within 6 months prior to screening.
- Known infectious diseases: hepatitis B surface antigen (HBsAg) positive; hepatitis C virus (HCV) antibody positive and HCV RNA above the detection limit; human immunodeficiency virus (HIV) antibody positive; Treponema pallidum antibody positive.
- Laboratory findings meeting any of the following: alanine aminotransferase (ALT) ≥ 3.0×ULN (subjects diagnosed with non-alcoholic fatty liver disease during screening and within the past 6 months with ALT ≤ 5.0×ULN may be enrolled); aspartate aminotransferase (AST) ≥ 3.0×ULN; total bilirubin (TBIL) ≥ 2.0×ULN; estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² (CKD-EPI formula); fasting triglycerides (TG) > 5.65 mmol/L.
- Known or suspected alcohol abuse within 1 year prior to screening (defined as male subjects consuming > 24 g alcohol per day, female subjects consuming > 12 g alcohol per day; 12 g alcohol is approximately equivalent to 300 mL beer, 100 mL wine, or 25 mL spirits).
- Known or suspected drug abuse at screening.
- Pregnant or breastfeeding women.
- History of moderate to severe depression, anxiety, or serious mental disorders, such as schizophrenia, bipolar disorder, etc., or screening PHQ-9 score ≥ 15.
- History of suicidal tendencies or suicide attempts.
- Participation in a clinical trial involving vaccines, medical devices, or other drugs within 3 months prior to screening (except for observational studies).
- The investigator or treating physician considers that the subject has any factors that may affect the evaluation of the efficacy or safety of the study, and is deemed unsuitable for participation in the study.
Trial locations and contacts
41 sites in 1 country.
41 sites in 1 country
China41 sites
Beijing Friendship Hospital, Capital Medical University
Beijing
Beijing Tsinghua Changgung Hospital
Beijing
Peking University First Hospital
Beijing
Changzhou First People's Hospital
Changzhou
Sichuan Academy of Medical Sciences &Sichuan Provincial People's Hospital
Chengdu
Nanfang Hospital Southern Medical University
Guangzhou
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou
The First Affiliateo Hospital of Jinan University
Guangzhou
Zhujiang Hospital of Southern Medical University
Guangzhusi
The First People'S Hospital of Zunyi
Guizhou
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou
The Fourth Affiliated Hospital of Harbin Medical University
Harbin
Anhui Provincial Hospital
Hefei
The First Affiliated Hospital of Henan University of Science and Technology
Henan
The First Affiliated Hospital of Nanyang Medical College
Henan
Pingxiang People's Hospital
Jiangxi
Jincheng General Hospital
Jincheng
The Third Affiliated Hospital
Jinzhou
The First People's Hospital of Yunnan Province
Kunming
Luan City People's Hospital
Lu'an
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Nanjing
Nan Jing First Hospital
Nanjing
The Second Hospital of Nanjing Medical University
Nanjing
The Affiliated Qingyuan Hospital ,Guangzhou Medical University(Qingyuan People's Hospital)
Qingyuan
The First Hospital of Qinhuangdao
Qinhuangdao
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Shandong
Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University
Shanghai, 200030
Shanghai General Hospital
Shanghai
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai
The First Hospital Of China Medical University
Shenyang
Shenzhen Second People's Hospital
Shenzhen
The First Hospital of Hebei Medical University
Shijiazhuang
The Second Hospital of Hebei Medical University
Shijiazhuang
Suzhou Municipal Hospital
Suzhou
The Second Affiliated Hospital of Soochow University
Suzhou
General Hospital of Tianjin Medical University
Tianjin
Tianjin Medical University Chu Hsien-I Memorial Hospital
Tianjin
Tenth People's Hospital Of Tongji University
Wuhan
Wuhan Third Hospital Tongren Hospital of Wuhan University
Wuhan
The First Affiliated Hospital of Xi'an Jiao Tong University
Xianian
Yueyang Central Hospital
Yueyang
About this study
Official title: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase IIb/III Clinical Trial to Evaluate the Efficacy and Safety of Efsubaglutide Alfa Injection in Overweight and Obese Subjects
This study is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III clinical trial aimed at evaluating the efficacy, safety, pharmacokinetics (PK), and immunogenicity profile of Efsubaglutide Alfa injection in overweight and obese subjects. The primary endpoint of the Phase IIb is the percentage change in body weight from baseline after 18 weeks of treatment. The primary endpoint of the Phase III is the percentage change in body weight from baseline after 30 weeks of treatment, the secondary endpoint is the percentage change in body weight from baseline after a cumulative 48 weeks of treatment.
- Conditions
- Obesity and Overweight
- Being tested
- Phase IIb:Efsubaglutide Alfa 5 mg QW, Phase IIb:Efsubaglutide Alfa 10 mg QW, Phase IIb:Efsubaglutide Alfa 20 mg QW, Phase IIb:Efsubaglutide Alfa 20 mg Q2W, Phase IIb:Placebo
- Medical subject headings
- Obesity, Overweight
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Phase IIb:Efsubaglutide Alfa 5 mg QWDrug
IIb:Efsubaglutide Alfa 5 mg QW
Phase IIb:Efsubaglutide Alfa 10 mg QWDrug
Efsubaglutide Alfa 10 mg QW
Phase IIb:Efsubaglutide Alfa 20 mg QWDrug
Efsubaglutide Alfa 20 mg QW
Phase IIb:Efsubaglutide Alfa 20 mg Q2WDrug
Efsubaglutide Alfa 20 mg Q2W
Phase IIb:PlaceboDrug
Placebo
Phase III:Recommended Phase 3 Dose High DoseDrug
The Recommended Phase 3 Dose High Dose confirmed by the IDMC (Independent Data Monitoring Committee) based on the safety and efficacy data results from the 18-week Phase IIb.
Phase III:Recommended Phase 3 Dose Low DoseDrug
The Recommended Phase 3 Dose Low Dose confirmed by the IDMC (Independent Data Monitoring Committee) based on the safety and efficacy data results from the 18-week Phase IIb.
Phase III:PlaceboDrug
Placebo
| Study group | Role | What they receive |
|---|---|---|
| Phase IIb:Efsubaglutide Alfa 5 mg QW | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg, reaching the target dose of 5 mg at Week 3 (W3). From W3 to W18, the treatment is maintained at a 5 mg dose. Receives: Drug: Phase IIb:Efsubaglutide Alfa 5 mg QW |
| Phase IIb:Efsubaglutide Alfa 10 mg QW | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg, reaching the target dose of 10 mg at Week 5 (W5). From W5 to W18, the treatment is maintained at a 10 mg dose. Receives: Drug: Phase IIb:Efsubaglutide Alfa 10 mg QW |
| Phase IIb:Efsubaglutide Alfa 20 mg QW | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, reaching the target dose of 20 mg at Week 7 (W7). From W7 to W18, the treatment is maintained at a 20 mg dose. Receives: Drug: Phase IIb:Efsubaglutide Alfa 20 mg QW |
| Phase IIb:Efsubaglutide Alfa 20 mg Q2W | Experimental | From Week 1 (W1) to Week 6 (W6), the drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, reaching the target dose of 20 mg at Week 7 (W7). From W7 to W18, the drug is administered every two weeks and maintained at a 20 mg dose. Receives: Drug: Phase IIb:Efsubaglutide Alfa 20 mg Q2W |
| Phase IIb:Placebo | Placebo comparator | Once weekly Receives: Drug: Phase IIb:Placebo |
| Phase III:Recommended Phase 3 Dose (RP3D) Low Dose QW | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, The dose escalation continues until reaching the RP3D Low Dose, and then the RP3D is maintained. The total cumulative duration of drug administration (from the first dose to the end of maintenance) is 48 weeks, with the once-weekly administration frequency retained throughout the entire period. Receives: Drug: Phase III:Recommended Phase 3 Dose Low Dose |
| Phase III:Recommended Phase 3 Dose (RP3D) High Dose QW | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, The dose escalation continues until reaching the RP3D High Dose, and then the RP3D is maintained. The total cumulative duration of drug administration (from the first dose to the end of maintenance) is 48 weeks, with the once-weekly administration frequency retained throughout the entire period. Receives: Drug: Phase III:Recommended Phase 3 Dose High Dose |
| Phase III:Recommended Phase 3 Dose (RP3D) High Dose Q2W | Experimental | The drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence: 1 mg → 5 mg → 10 mg → 20 mg. Dose escalation continues until reaching the RP3D High Dose. Once the RP3D High Dose is achieved, the treatment regimen transitions to alternating weekly between RP3D High Dose and placebo for the remainder of the study. The total cumulative duration of drug administration (from the first dose to the end of the maintenance phase) remains 48 weeks, with the once-weekly administration frequency retained throughout. Blinding is maintained across all treatment groups to ensure unbiased evaluation of efficacy and safety. Receives: Drug: Phase III:Recommended Phase 3 Dose High Dose; Drug: Phase III:Placebo |
| Phase III:Placebo | Placebo comparator | Once weekly Receives: Drug: Phase III:Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percentage change in body weight from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks)
Proportion of subjects with ≥5% reduction in body weight from baseline
Measured: Phase III (30 weeks)
Secondary outcomes (15)
Proportion of subjects with ≥5% reduction in body weight from baseline
Measured: Phase IIb (18 weeks) , Phase III (48 weeks)
Proportion of subjects with ≥10%, and ≥15% reduction in body weight from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Percentage change in body weight from baseline
Measured: Phase III (48 weeks)
Change in body weight from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in BMI from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in waist circumference from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in hip circumference from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood pressure (diastolic and systolic) from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in lipid levels (triglycerides, total cholesterol, low-density lipoprotein cholesterol) from baseline, percentage change from baseline, and ratio to baseline.
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (FPG) from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (HbA1c) from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (fasting insulin) from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (insulin resistance index [HOMA-IR]) from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood uric acid levels from baseline
Measured: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in IWQOL-lite-CT (Impact of Weight on Quality of Life-Lite-Clinical Trial Version) Questionnaire Score from Baseline
Measured: Phase III (30 weeks and 48 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Apr 2025
- Study start31 Mar 2025
- Primary completion31 Aug 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obesity and OverweightStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2/3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 1,003 participants (actual)
Sponsor and investigators
- Lead sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Weiping Jia, M.D,Ph. D, Principal investigator, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06921486
- Sponsor's protocol ID
- YN011-W303
- Other IDs
- YN011-W202, YN011-W303
- Status last verified
- Jan 2026
- First submitted
- 28 Mar 2025
- Last updated
- 30 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multicenter, Randomized, Double-blind, Placebo-controlled Phase IIb/III Clinical Trial to Evaluate the Efficacy and Safety of Efsubaglutide Alfa Injection in Overweight and Obese Subjects
- ClinicalTrials.gov ID
- NCT06921486
- Acronym / sponsor ID
- YN011-W303
- Conditions
- Obesity and Overweight
- Phase
- Phase 2/3
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 1,003 participants (actual)
- Lead sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.University, hospital or other
- Study start
- 31 Mar 2025 (actual)
- Primary completion
- 31 Aug 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 10 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III clinical trial aimed at evaluating the efficacy, safety, pharmacokinetics (PK), and immunogenicity profile of Efsubaglutide Alfa injection in overweight and obese subjects. The primary endpoint of the Phase IIb is the percentage change in body weight from baseline after 18 weeks of treatment. The primary endpoint of the Phase III is the percentage change in body weight from baseline after 30 weeks of treatment, the secondary endpoint is the percentage change in body weight from baseline after a cumulative 48 weeks of treatment.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 9
| Arm | Type | Receives |
|---|---|---|
| Phase IIb:Efsubaglutide Alfa 5 mg QW | Experimental | Drug: Phase IIb:Efsubaglutide Alfa 5 mg QWThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg, reaching the target dose of 5 mg at Week 3 (W3). From W3 to W18, the treatment is maintained at a 5 mg dose. |
| Phase IIb:Efsubaglutide Alfa 10 mg QW | Experimental | Drug: Phase IIb:Efsubaglutide Alfa 10 mg QWThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg, reaching the target dose of 10 mg at Week 5 (W5). From W5 to W18, the treatment is maintained at a 10 mg dose. |
| Phase IIb:Efsubaglutide Alfa 20 mg QW | Experimental | Drug: Phase IIb:Efsubaglutide Alfa 20 mg QWThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, reaching the target dose of 20 mg at Week 7 (W7). From W7 to W18, the treatment is maintained at a 20 mg dose. |
| Phase IIb:Efsubaglutide Alfa 20 mg Q2W | Experimental | Drug: Phase IIb:Efsubaglutide Alfa 20 mg Q2WFrom Week 1 (W1) to Week 6 (W6), the drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, reaching the target dose of 20 mg at Week 7 (W7). From W7 to W18, the drug is administered every two weeks and maintained at a 20 mg dose. |
| Phase IIb:Placebo | Placebo comparator | Drug: Phase IIb:PlaceboOnce weekly |
| Phase III:Recommended Phase 3 Dose (RP3D) Low Dose QW | Experimental | Drug: Phase III:Recommended Phase 3 Dose Low DoseThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, The dose escalation continues until reaching the RP3D Low Dose, and then the RP3D is maintained. The total cumulative duration of drug administration (from the first dose to the end of maintenance) is 48 weeks, with the once-weekly administration frequency retained throughout the entire period. |
| Phase III:Recommended Phase 3 Dose (RP3D) High Dose QW | Experimental | Drug: Phase III:Recommended Phase 3 Dose High DoseThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence of 1 mg → 5 mg → 10 mg → 20 mg, The dose escalation continues until reaching the RP3D High Dose, and then the RP3D is maintained. The total cumulative duration of drug administration (from the first dose to the end of maintenance) is 48 weeks, with the once-weekly administration frequency retained throughout the entire period. |
| Phase III:Recommended Phase 3 Dose (RP3D) High Dose Q2W | Experimental | Drug: Phase III:Recommended Phase 3 Dose High Dose, Drug: Phase III:PlaceboThe drug is administered once weekly, starting with a titration dose of 1 mg. The dose is up-titrated every 2 weeks in the sequence: 1 mg → 5 mg → 10 mg → 20 mg. Dose escalation continues until reaching the RP3D High Dose. Once the RP3D High Dose is achieved, the treatment regimen transitions to alternating weekly between RP3D High Dose and placebo for the remainder of the study. The total cumulative duration of drug administration (from the first dose to the end of the maintenance phase) remains 48 weeks, with the once-weekly administration frequency retained throughout. Blinding is maintained across all treatment groups to ensure unbiased evaluation of efficacy and safety. |
| Phase III:Placebo | Placebo comparator | Drug: Phase III:PlaceboOnce weekly |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Voluntarily participate in the clinical study; fully understand and be informed about the study, and sign the informed consent form (ICF); willing to follow and capable of completing all study procedures.
- Age ≥ 18 years (including the cutoff value, based on the time of signing the ICF), regardless of gender.
- History of poor weight control through diet and exercise [defined as weight control failure if the subject has attempted at least 3 months of diet and exercise alone prior to screening without achieving a weight loss of ≥ 5.0% (based on subject self-report)].
- Willing to follow the recommendations of the investigator regarding medication, diet, and exercise.
- Stable weight within 3 months prior to screening (defined as a weight change < 5%, based on subject self-report).
Key exclusion criteria (29 listed)
- Allergic constitution or allergic to any component of the investigational drug.
- Previously treated with Efsubaglutide Alfa injection.
- Received glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose co-transporter-2 (SGLT-2) inhibitors, insulin, metformin, insulin secretagogues, or thiazolidinediones (TZD) or any other weight-affecting anti-diabetic medication within the past 3 months before screening.
- HbA1c ≥ 6.5% at screening, or previously diagnosed with Type 1 or Type 2 diabetes (based on the World Health Organization [WHO] 2020 diabetes diagnosis and classification standards).
- History of severe hypoglycemia or recurrent symptomatic hypoglycemia (≥ 2 times in the past 6 months).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Phase IIb:Efsubaglutide Alfa 5 mg QWIIb:Efsubaglutide Alfa 5 mg QW | Drug | Phase IIb:Efsubaglutide Alfa 5 mg QW |
| Phase IIb:Efsubaglutide Alfa 10 mg QWEfsubaglutide Alfa 10 mg QW | Drug | Phase IIb:Efsubaglutide Alfa 10 mg QW |
| Phase IIb:Efsubaglutide Alfa 20 mg QWEfsubaglutide Alfa 20 mg QW | Drug | Phase IIb:Efsubaglutide Alfa 20 mg QW |
| Phase IIb:Efsubaglutide Alfa 20 mg Q2WEfsubaglutide Alfa 20 mg Q2W | Drug | Phase IIb:Efsubaglutide Alfa 20 mg Q2W |
| Phase IIb:PlaceboPlacebo | Drug | Phase IIb:Placebo |
| Phase III:Recommended Phase 3 Dose High DoseThe Recommended Phase 3 Dose High Dose confirmed by the IDMC (Independent Data Monitoring Committee) based on the safety and efficacy data results from the 18-week Phase IIb. | Drug | Phase III:Recommended Phase 3 Dose (RP3D) High Dose Q2W, Phase III:Recommended Phase 3 Dose (RP3D) High Dose QW |
| Phase III:Recommended Phase 3 Dose Low DoseThe Recommended Phase 3 Dose Low Dose confirmed by the IDMC (Independent Data Monitoring Committee) based on the safety and efficacy data results from the 18-week Phase IIb. | Drug | Phase III:Recommended Phase 3 Dose (RP3D) Low Dose QW |
| Phase III:PlaceboPlacebo | Drug | Phase III:Placebo, Phase III:Recommended Phase 3 Dose (RP3D) High Dose Q2W |
Primary outcome
Percentage change in body weight from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks)
Proportion of subjects with ≥5% reduction in body weight from baseline
Time frame: Phase III (30 weeks)
15 secondary outcomes
Proportion of subjects with ≥5% reduction in body weight from baseline
Time frame: Phase IIb (18 weeks) , Phase III (48 weeks)
Proportion of subjects with ≥10%, and ≥15% reduction in body weight from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Percentage change in body weight from baseline
Time frame: Phase III (48 weeks)
Change in body weight from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in BMI from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in waist circumference from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in hip circumference from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood pressure (diastolic and systolic) from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in lipid levels (triglycerides, total cholesterol, low-density lipoprotein cholesterol) from baseline, percentage change from baseline, and ratio to baseline.
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (FPG) from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (HbA1c) from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (fasting insulin) from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood glucose levels (insulin resistance index [HOMA-IR]) from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in blood uric acid levels from baseline
Time frame: Phase IIb (18 weeks) , Phase III (30 weeks and 48 weeks)
Change in IWQOL-lite-CT (Impact of Weight on Quality of Life-Lite-Clinical Trial Version) Questionnaire Score from Baseline
Time frame: Phase III (30 weeks and 48 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Weiping Jia, M.D,Ph. D principal investigator
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
41 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2/3 study testing Phase IIb:Efsubaglutide Alfa 5 mg QW, Phase IIb:Efsubaglutide Alfa 10 mg QW and Phase IIb:Efsubaglutide Alfa 20 mg QW in people with Obesity and Overweight, run by Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. at 41 sites in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 29 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 30 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 41 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this combined phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Percentage change in body weight from baseline (time frame: Phase IIb (18 weeks) , Phase III (30 weeks)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jan 2026.