Goiter, NodularNCT06924242
Thyroid Cancer in Surgical Treated Multinodular Goiter
An observational study of Goiter, Nodular and Total Thyroidectomy, run by University of Foggia at 1 site in Italy.
Trial summary
This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Goiter, Nodular, Total Thyroidectomy, Thyroid Cancer
- What is being tested?
- total or partial thyroidectomy
- Type of treatment
- Surgery or procedure
- How many people
- 223 participants
- Where
- 1 siteItaly
- Study dates
- 1 Jan 2018to 31 Jul 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Patients of both sex with cancer incidence in multinodular thyroid goiter who underwent surgery in the same center
Who may be able to join
- patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology.
- patients who underwent surgery.
- availability of complete clinical data
Who cannot join
- history of thyroid carcinoma or other thyroid neoplasms.
- not completed postoperative follow up.
- patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Thyroid Cancer in Surgically Treated Multinodular Goiter: Incidence and Histopatological Outcomes
This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.
Read the detailed description
This retrospective study included patients with a preoperative diagnosis of multinodular goiter who underwent total or partial thyroidectomy from January 2018 to May 2024 at the Department of Medical and Surgical Sciences at the University Hospital "Ospedali Riuniti" in Foggia. The study's objective was to investigate the incidence of thyroid carcinoma in patients undergoing thyroidectomy for MNG, also analyzing associated demographic and clinical variables.
- Conditions
- Goiter, Nodular, Total Thyroidectomy, Thyroid Cancer
- Being tested
- total or partial thyroidectomy
- Medical subject headings
- Goiter, Nodular, Thyroid Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
total or partial thyroidectomyProcedure or surgery
Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.
| Study group | Role | What they receive |
|---|---|---|
| Patient with multinodular goiter who underwent total or partial thyroidectomy | Not described Receives: Procedure: total or partial thyroidectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
incidence of occult thyroid carcinoma
Incidence of occult thyroid carcinoma in a cohort of patients with multinodular goiter, providing new insights into the prevalence and characteristics of thyroid malignancies.
Measured: 6 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Apr 2025
- Study start1 Jan 2018
- Primary completion30 May 2024
- Study completion31 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Goiter, NodularStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 223 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Foggia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Giovanna Pavone, University of Foggia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06924242
- Sponsor's protocol ID
- 10
- Status last verified
- Apr 2025
- First submitted
- 28 Mar 2025
- Last updated
- 11 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Pavone G, Lamanna E, Pacilli M, Khoury E, Ambrosi A, Tartaglia N. Incidental thyroid carcinoma in surgically treated multinodular goiter: a retrospective study. Front Surg. 2026 Jul 2;13:1825352. doi: 10.3389/fsurg.2026.1825352. eCollection 2026.
PubMed 42465863
Study at a glance
From the registry record, last updated by the sponsor on 11 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Thyroid Cancer in Surgically Treated Multinodular Goiter: Incidence and Histopatological Outcomes
- ClinicalTrials.gov ID
- NCT06924242
- Acronym / sponsor ID
- 10
- Conditions
- Goiter, Nodular, Total Thyroidectomy, Thyroid Cancer
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 223 participants (actual)
- Lead sponsor
- University of FoggiaUniversity, hospital or other
- Study start
- 1 Jan 2018 (actual)
- Primary completion
- 30 May 2024 (actual)
- Study completion
- 31 Jul 2024 (actual)
- First posted
- 11 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.
Detailed description
This retrospective study included patients with a preoperative diagnosis of multinodular goiter who underwent total or partial thyroidectomy from January 2018 to May 2024 at the Department of Medical and Surgical Sciences at the University Hospital "Ospedali Riuniti" in Foggia. The study's objective was to investigate the incidence of thyroid carcinoma in patients undergoing thyroidectomy for MNG, also analyzing associated demographic and clinical variables.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patient with multinodular goiter who underwent total or partial thyroidectomy | – | Procedure: total or partial thyroidectomy |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients of both sex with cancer incidence in multinodular thyroid goiter who underwent surgery in the same center
Key inclusion criteria (3 listed)
- patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology.
- patients who underwent surgery.
- availability of complete clinical data
Key exclusion criteria (3 listed)
- history of thyroid carcinoma or other thyroid neoplasms.
- not completed postoperative follow up.
- patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| total or partial thyroidectomyTotal thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage. | Procedure or surgery | Patient with multinodular goiter who underwent total or partial thyroidectomy |
Primary outcome
incidence of occult thyroid carcinoma
Time frame: 6 years
Incidence of occult thyroid carcinoma in a cohort of patients with multinodular goiter, providing new insights into the prevalence and characteristics of thyroid malignancies.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Apr 2025.
- Derived from this study: PubMed 42465863Pavone G, Lamanna E, Pacilli M, Khoury E, Ambrosi A, Tartaglia N. Incidental thyroid carcinoma in surgically treated multinodular goiter: a retrospective study. Front Surg. 2026 Jul 2;13:1825352. doi: 10.3389/fsurg.2026.1825352. eCollection 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Goiter, Nodular and Total Thyroidectomy, run by University of Foggia at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
incidence of occult thyroid carcinoma (time frame: 6 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06924242, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Apr 2025.