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Moral InjuryMI-PRONCT06926296

Moral Injury in French Healthcare Workers

A study testing Self-Questionnaires for Healthcare Workers in people with Moral Injury, run by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer at 1 site in France.

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Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
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Trial summary

Healthcare professionals are facing an escalating crisis, with burnout rates ranging between 40% and 60% and a growing intention to leave the profession, affecting one in five physicians and one in four nurses in the coming years. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Moral Injury
What is being tested?
Self-Questionnaires for Healthcare Workers
Could I receive a placebo?
No, everyone receives an active treatment
How many people
3,073 participants
Where
1 siteFrance
Study dates
19 Nov 2025to Jan 2027
Phase
Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Healthcare workers

Who cannot join

  • Absence of consent

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

France1 site, 1 recruiting
  • Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer

    Toulon, Var, 83100

    Sophie LAFOND, 0483772062 ext. +33, sophie.lafond@ch-toulon.fr

    Laurent BOYER, Pr

    Recruiting

Other trials in France

About this study

Healthcare professionals are facing an escalating crisis, with burnout rates ranging between 40% and 60% and a growing intention to leave the profession, affecting one in five physicians and one in four nurses in the coming years. While current interventions focused on individual resilience, such as mindfulness, peer support, and workload management, have been promoted as solutions, they have failed to bring about systemic improvements. This raises the question of whether other factors, such as Moral Injury, play a key role in this crisis. Moral Injury is an emerging concept that highlights the profound misalignment between healthcare workers' professional values and the reality of their practice, often exacerbated by organizational and economic constraints.

The objective of this study is to describe the manifestations of Moral Injury among healthcare professionals in France. By establishing the first large-scale assessment of Moral Injury among healthcare professionals in France, this study aims to identify key organizational and personal risk factors contributing to this phenomenon. The use of Structural Equation Modeling will help build a robust theoretical model that clarifies the underlying mechanisms of Moral Injury and its interactions with broader health issues. The findings will support the development of targeted interventions focused on systemic organizational changes to improve healthcare workers' well-being and guide public health policies.

Read the detailed description

Healthcare professionals are facing an escalating crisis, with burnout rates ranging between 40% and 60% and a growing intention to leave the profession, affecting one in five physicians and one in four nurses in the coming years. While current interventions focused on individual resilience, such as mindfulness, peer support, and workload management, have been promoted as solutions, they have failed to bring about systemic improvements. This raises the question of whether other factors, such as Moral Injury, play a key role in this crisis. Moral Injury is an emerging concept that highlights the profound misalignment between healthcare workers' professional values and the reality of their practice, often exacerbated by organizational and economic constraints.

The primary objective of this study is to describe the manifestations of Moral Injury among healthcare professionals in France. Secondary objectives include the psychometric validation of a French-language Moral Injury scale, the analysis of organizational and individual determinants of Moral Injury, and the structural modeling of underlying mechanisms.

This nationwide cross-sectional survey will be conducted electronically, reaching participants through healthcare institutions, professional societies, social networks, and a snowball dissemination strategy. Data collection will include standardized scales such as the Moral Injury Inventory for Healthcare Professionals, the Moral Injury Events Scale (MIES), the Maslach Burnout Inventory (MBI), and the EuroQol 5-Dimensions (EQ-5D) for quality of life, as well as ad hoc questions designed to explore additional systemic and professional challenges. A rigorous psychometric validation of the Moral Injury scale will be performed, followed by Structural Equation Modeling (SEM) to analyze the complex relationships between Moral Injury and other factors such as burnout, depression, and anxiety.

By establishing the first large-scale assessment of Moral Injury among healthcare professionals in France, this study aims to identify key organizational and personal risk factors contributing to this phenomenon. The use of Structural Equation Modeling will help build a robust theoretical model that clarifies the underlying mechanisms of Moral Injury and its interactions with broader health issues. The findings will support the development of targeted interventions focused on systemic organizational changes to improve healthcare workers' well-being and guide public health policies.

Conditions
Moral Injury
Being tested
Self-Questionnaires for Healthcare Workers
Keywords
Moral injury, Burnout, Depression, Anxiety, Healthcare workers, Health services research
Medical subject headings
Stress Disorders, Post-Traumatic, Burnout, Psychological, Depression, Anxiety Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Self-Questionnaires for Healthcare WorkersOther

    Health workers will be invited to complete an online self-questionnaire.

Study groups in NCT06926296
Study groupRoleWhat they receive
Healthcare workersOtherAll health professionals working in metropolitan France and the French overseas departments and territories
Receives: Other: Self-Questionnaires for Healthcare Workers

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Moral Injury Inventory for Healthcare Professionals

    An overall score out of 100 will be created for the inventory, where a high score indicates a high level of "Moral Injury"

    Measured: One point : baseline

Secondary outcomes (3)
  1. Moral Injury Events Scale

    Minimum score = 11, Maximum score = 66 Higher average scores indicate greater intensity of experience

    Measured: One point : baseline

  2. Maslach Burnout Inventory

    3 scores calculated in this inventory Burnout : minimum score = 0, maximum score = 63, Higher average scores indicate greater intensity of burnout Depersonalization : minimum score = 0, maximum score = 35, Higher average scores indicate greater intensity of depersonalization Personal fulfillment : minimum score = 0, maximum score = 56, Higher average scores indicate greater intensity of personal fulfillment

    Measured: One point : baseline

  3. EuroQol 5-Dimensions (EQ-5D)

    Scores range from -0.59 to 1, where 1 is the best possible health status.

    Measured: One point : baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Apr 2025
  2. Study start19 Nov 2025
  3. Primary completionJul 2026 (estimated)
  4. Study completionJan 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Health services research
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
3,073 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06926296
Sponsor's protocol ID
2024-CHITS-019
Other IDs
2024-a02449-38
Acronym
MI-PRO
Status last verified
Jul 2026
First submitted
7 Apr 2025
Last updated
7 Jul 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Boyer L, Fond G, Tran B, Llorca PM, Duclos A. The hidden crisis: Moral injury among French healthcare workers. J Epidemiol Popul Health. 2024 Dec;72(6):202780. doi: 10.1016/j.jeph.2024.202780. Epub 2024 Oct 19.

    PubMed 39427511
  • Dean W, Morris D, Llorca PM, Talbot SG, Fond G, Duclos A, Boyer L. Moral Injury and the Global Health Workforce Crisis - Insights from an International Partnership. N Engl J Med. 2024 Sep 5;391(9):782-785. doi: 10.1056/NEJMp2402833. Epub 2024 Aug 31. No abstract available.

    PubMed 39216090

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