Methanol PoisoningNCT06931587
Methanol Poisoning
An observational study of Methanol Poisoning, run by Kartal City Hospital at 1 site in Turkey (Türkiye).
Trial summary
This study addresses methyl alcohol intoxications with profound acidosis requiring intensive care treatment. The goal is to contribute both to the improvement of diagnosis and follow-up processes and to the development of management strategies under the highlight of existing literature. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Methanol Poisoning
- How many people
- 54 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Feb 2025to 1 Apr 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study includes patients admitted to the ICU between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication.
Who may be able to join
- Clinical diagnosis of methyl alcohol intoxication.
Who cannot join
- Other toxic alcohol intoxications
- Pregnant women
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Kartal Dr. Lütfi Kırdar City Hospital
Kartal, Istanbul, 34870
About this study
Official title: Methyl Alcohol Intoxication as a Public Health Issue: A 3-Year Retrospective Analysis
This study addresses methyl alcohol intoxications with profound acidosis requiring intensive care treatment. The goal is to contribute both to the improvement of diagnosis and follow-up processes and to the development of management strategies under the highlight of existing literature.
This study is a single-center, retrospective, observational cohort study conducted on patients admitted to the ICU between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication. The investigators analyzed patients' demographic characteristics, prognostic clinical and laboratory parameters, treatment approaches and outcomes
Read the detailed description
This study addresses methyl alcohol intoxications with profound acidosis requiring intensive care treatment. The objective is to contribute to the improvement of diagnostic and follow-up processes, as well as to the development of management strategies, in light of the existing literature.
The study is a single-center, retrospective, observational cohort analysis conducted on patients admitted to the intensive care unit (ICU) between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication.
Data collection was performed in three steps. Initially, the hospital's electronic medical database was searched using the ICD code T51.1 to identify relevant cases. Subsequently, detailed medical records were reviewed to assess clinical progress and treatment interventions. Finally, laboratory findings were obtained through the hospital's patient record system.
Demographic characteristics-including age and gender-reasons for ICU admission, pre-existing conditions, presenting symptoms, and disease severity based on Acute Physiology and Chronic Health Evaluation II (APACHE II), Glasgow Coma Scale (GCS), Sequential Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score (SAPS) evaluated during the first 24 hours of ICU stay were retrospectively analyzed. Treatment interventions, including ethanol or fomepizole administration, the need for hemodialysis (intermittent hemodialysis [IHD] or continuous venovenous hemodialysis [CVVHD]), supportive therapies, ICU length of stay, and clinical outcomes were also documented.
Laboratory evaluations included arterial blood gas analysis, anion gap, osmolality, complete blood count, glucose, urea, creatinine, electrolytes (sodium, potassium, chloride), C-reactive protein (CRP), and organ function tests such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Demographic data, prognostic clinical and laboratory parameters, treatment modalities, and clinical outcomes were analyzed by the investigators.
- Conditions
- Methanol Poisoning
- Keywords
- methanol, intoxication, Intensive care, mortality
What is being measured
The primary outcome is the main question the study is designed to answer.
ICU Mortality Among Patients With Methyl Alcohol Intoxication
Mortality was defined as death occurring during ICU stay among patients admitted with laboratory-confirmed or suspected methyl alcohol intoxication.
Measured: Up to 30 days (during ICU follow-up)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2025
- Study start3 Feb 2025
- Primary completion23 Mar 2025
- Study completion1 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Methanol PoisoningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Kartal City Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, AKIN BİLİR, Kartal City Hospital
- Investigators
- banu çevik, professor doctor, Study chair, Dr. Lutfi Kirdar Kartal Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06931587
- Sponsor's protocol ID
- Kartal City Hospital
- Status last verified
- Apr 2025
- First submitted
- 3 Apr 2025
- Last updated
- 17 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: all
Publications
Alhusain F, Alshalhoub M, Homaid MB, Esba LCA, Alghafees M, Al Deeb M. Clinical presentation and management of methanol poisoning outbreaks in Riyadh, Saudi Arabia: a retrospective analysis. BMC Emerg Med. 2024 Apr 16;24(1):64. doi: 10.1186/s12873-024-00976-1.
PubMed 38627622
Study at a glance
From the registry record, last updated by the sponsor on 17 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Methyl Alcohol Intoxication as a Public Health Issue: A 3-Year Retrospective Analysis
- ClinicalTrials.gov ID
- NCT06931587
- Acronym / sponsor ID
- Kartal City Hospital
- Conditions
- Methanol Poisoning
- Keywords
- methanol, intoxication, Intensive care, mortality
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Kartal City HospitalUniversity, hospital or other
- Study start
- 3 Feb 2025 (actual)
- Primary completion
- 23 Mar 2025 (actual)
- Study completion
- 1 Apr 2025 (actual)
- First posted
- 17 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study addresses methyl alcohol intoxications with profound acidosis requiring intensive care treatment. The goal is to contribute both to the improvement of diagnosis and follow-up processes and to the development of management strategies under the highlight of existing literature.
This study is a single-center, retrospective, observational cohort study conducted on patients admitted to the ICU between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication. The investigators analyzed patients' demographic characteristics, prognostic clinical and laboratory parameters, treatment approaches and outcomes
Detailed description
This study addresses methyl alcohol intoxications with profound acidosis requiring intensive care treatment. The objective is to contribute to the improvement of diagnostic and follow-up processes, as well as to the development of management strategies, in light of the existing literature.
The study is a single-center, retrospective, observational cohort analysis conducted on patients admitted to the intensive care unit (ICU) between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication.
Data collection was performed in three steps. Initially, the hospital's electronic medical database was searched using the ICD code T51.1 to identify relevant cases. Subsequently, detailed medical records were reviewed to assess clinical progress and treatment interventions. Finally, laboratory findings were obtained through the hospital's patient record system.
Demographic characteristics-including age and gender-reasons for ICU admission, pre-existing conditions, presenting symptoms, and disease severity based on Acute Physiology and Chronic Health Evaluation II (APACHE II), Glasgow Coma Scale (GCS), Sequential Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score (SAPS) evaluated during the first 24 hours of ICU stay were retrospectively analyzed. Treatment interventions, including ethanol or fomepizole administration, the need for hemodialysis (intermittent hemodialysis [IHD] or continuous venovenous hemodialysis [CVVHD]), supportive therapies, ICU length of stay, and clinical outcomes were also documented.
Laboratory evaluations included arterial blood gas analysis, anion gap, osmolality, complete blood count, glucose, urea, creatinine, electrolytes (sodium, potassium, chloride), C-reactive protein (CRP), and organ function tests such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Demographic data, prognostic clinical and laboratory parameters, treatment modalities, and clinical outcomes were analyzed by the investigators.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study includes patients admitted to the ICU between January 2022 and March 2025 with suspected or laboratory-confirmed methyl alcohol intoxication.
Key inclusion criteria (1 listed)
- Clinical diagnosis of methyl alcohol intoxication.
Key exclusion criteria (2 listed)
- Other toxic alcohol intoxications
- Pregnant women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
ICU Mortality Among Patients With Methyl Alcohol Intoxication
Time frame: Up to 30 days (during ICU follow-up)
Mortality was defined as death occurring during ICU stay among patients admitted with laboratory-confirmed or suspected methyl alcohol intoxication.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Apr 2025.
- Background: PubMed 38627622Alhusain F, Alshalhoub M, Homaid MB, Esba LCA, Alghafees M, Al Deeb M. Clinical presentation and management of methanol poisoning outbreaks in Riyadh, Saudi Arabia: a retrospective analysis. BMC Emerg Med. 2024 Apr 16;24(1):64. doi: 10.1186/s12873-024-00976-1.
- Individual participant dataSharing planned: Yes. all
Related trials for Methanol Poisoning
RecruitingObservational study
A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning
Metabolic Acidosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
banu çevik, professor doctor study chair
Dr. Lutfi Kirdar Kartal Training and Research Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Methanol Poisoning, run by Kartal City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ICU Mortality Among Patients With Methyl Alcohol Intoxication (time frame: Up to 30 days (during ICU follow-up)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06931587, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Apr 2025.