Breast CancerNCT06936241
Effect of Circuit Weight Training on Functional Capacity and Quality of Life in Breast Cancer Patients
A study testing Circuit weight training and Traditional physical therapy program in people with Breast Cancer, run by Cairo University at 1 site in Egypt.
Trial summary
The study is aimed at studying the effects of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients. Read more about this study
- Who is it for?
- Ages 35 to 45 years
- Conditions the study is for
- Breast Cancer
- What is being tested?
- Circuit weight training and Traditional physical therapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteEgypt
- Study dates
- 11 Sep 2024to 31 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Female with age between 35-45.
- Body Mass Index (BMI) < 25.
- Patients diagnosed with non-metastatic (Stage 0-III) breast cancer.
- All patients who are treated by neoadjuvant chemotherapy before surgery.
Who cannot join
- Patients diagnosed with cancer metastasis.
- Patients diagnosed with diseases of the nervous system (Parkinson's disease, peripheral nerve palsy) skeletal system (inflammatory diseases, scoliosis >10 Cobb angle), or rheumatic diseases.
- Patients with any current visual impairment that affected their daily living, vestibular disorder, neurological disorder, cognitive disorder, and any further medical condition that would prohibit them from participating safely.
Trial locations and contacts
1 site in 1 country.
About this study
The study is aimed at studying the effects of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.
Read the detailed description
Breast Cancer is the most common cancer among women in Egypt causing 22 percent of all cancer-related female deaths. It is the most commonly diagnosed cancer, accounting for nearly a quarter of all cancer cases globally.
With improvements in early detection, surgery, and adjuvant therapy for breast cancer, long-term survival and cure are becoming possible. Despite providing longer survival with early diagnosis of breast cancer, the treatment leaves sequelae with adverse effects such as influence on functional capacity, fatigue, depression, neuropathic lymphoedema, low immunity, and loss of flexibility. All of these effects end up affecting the quality of life (QoL), Imbalance, gait dysfunction, and falls may have particularly severe consequences in breast cancer survivors due to comorbidities increasing the risk of fall-related injury, secondary decline in physical activity, and subsequent functional decline.
Given the profound effects that imbalance, gait dysfunction, and falls have on functional independence, QOL, and long-term health and survivorship, the treatment or prevention of these symptoms is an essential component of cancer rehabilitation for all survivors.
Furthermore, the need for this study is developed from the lack of quantitative knowledge and information in the published studies about the effect of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.
- Conditions
- Breast Cancer
- Being tested
- Circuit weight training, Traditional physical therapy program
- Medical subject headings
- Breast Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Circuit weight trainingOther
The Circuit Training protocol will be performed as follows:
wall push-up, bridge on floor, single leg bridge, bird dog, windshield wiper, march in place, ball squat, squat with an overhead press, reverse pendulum, jumping rope, and spinal twist, 30-35 minutes, 3 times a week for 8 weeks
Traditional physical therapy programOther
The participants will receive traditional physical therapy program in the form of therapeutic exercises to keep daily living activity by restoring the strength of flexors and abductors of the shoulder joint using the shoulder wheel and ladder. It will be performed 3 times per week for eight weeks
| Study group | Role | What they receive |
|---|---|---|
| Circuit weight training and traditional physical therapy program | Experimental | The participants will do Circuit Weight Training in addition to traditional physical therapy program for 8 weeks Receives: Other: Circuit weight training; Other: Traditional physical therapy program |
| Traditional physical therapy program | Active comparator | The participants will receive traditional physical therapy program only for 8 weeks Receives: Other: Traditional physical therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of quality of life
The 12-Item Short Form Survey (SF-12) is the abridged practical form of the SF-36. It is a widely used screening device for measuring physical, mental, and social well-being to assess quality of life. it consists of 2 components: Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12). Its score ranges between 0-100. Higher score indicates better health.
Measured: 8 weeks
Assessment of functional capacity
The 2-minute step test (TMST) will be used to measure exercise capacity for all participants in the study before and after treatment.
The test simply requires that participants march in place as fast as possible for 2 minutes while lifting the knees to a height midway between their patella and iliac crest when standing. Performance on the test is defined as the number of right-side steps of the criterion height completed in 2 minutes.
Measured: 8 weeks
Secondary outcomes (4)
Postural stability test
It will be used to measure static balance by measuring posture sway by using the Biodex balance system. the overall stability index will be measured; lower score of overall stability index indicates better balance.
Measured: 8 weeks
Limits of stability test
t will be used to measure dynamic balance by using the Biodex balance system. Higher directional control and excursion scores with lower reaction time indicate better voluntary balance control.
Measured: 8 weeks
Single leg stability test
It will be used to assess unilateral balance with progressive instability. Lower stability indexes represent better single-leg balance and neuromuscular control.
Measured: 8 weeks
Assessment of muscle strength
A hand-held dynamometer will be used to assess muscular strength of specific muscles of upper and lower limbs by quantifying the maximum force exerted during specific movement, with higher values indicating greater strength.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2025
- Study start11 Sep 2024
- Primary completion10 Mar 2025
- Study completion31 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Breast CancerStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alhasnaa Sayed Farouk Helal, Cairo University
- Investigators
- Maher H Ibrahim, Professor, Study director, Cairo UniversityHeba A. Abdulghafar, Professor, Study chair, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06936241
- Sponsor's protocol ID
- P.T.REC/012/005445
- Status last verified
- Jul 2025
- First submitted
- 12 Apr 2025
- Last updated
- 30 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Circuit Weight Training on Functional Capacity and Quality of Life in Breast Cancer Patients
- ClinicalTrials.gov ID
- NCT06936241
- Acronym / sponsor ID
- P.T.REC/012/005445
- Conditions
- Breast Cancer
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 11 Sep 2024 (actual)
- Primary completion
- 10 Mar 2025 (actual)
- Study completion
- 31 Mar 2025 (actual)
- First posted
- 20 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study is aimed at studying the effects of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.
Detailed description
Breast Cancer is the most common cancer among women in Egypt causing 22 percent of all cancer-related female deaths. It is the most commonly diagnosed cancer, accounting for nearly a quarter of all cancer cases globally.
With improvements in early detection, surgery, and adjuvant therapy for breast cancer, long-term survival and cure are becoming possible. Despite providing longer survival with early diagnosis of breast cancer, the treatment leaves sequelae with adverse effects such as influence on functional capacity, fatigue, depression, neuropathic lymphoedema, low immunity, and loss of flexibility. All of these effects end up affecting the quality of life (QoL), Imbalance, gait dysfunction, and falls may have particularly severe consequences in breast cancer survivors due to comorbidities increasing the risk of fall-related injury, secondary decline in physical activity, and subsequent functional decline.
Given the profound effects that imbalance, gait dysfunction, and falls have on functional independence, QOL, and long-term health and survivorship, the treatment or prevention of these symptoms is an essential component of cancer rehabilitation for all survivors.
Furthermore, the need for this study is developed from the lack of quantitative knowledge and information in the published studies about the effect of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Circuit weight training and traditional physical therapy program | Experimental | Other: Circuit weight training, Other: Traditional physical therapy programThe participants will do Circuit Weight Training in addition to traditional physical therapy program for 8 weeks |
| Traditional physical therapy program | Active comparator | Other: Traditional physical therapy programThe participants will receive traditional physical therapy program only for 8 weeks |
Who may qualify
- Ages
- 35 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Female with age between 35-45.
- Body Mass Index (BMI) < 25.
- Patients diagnosed with non-metastatic (Stage 0-III) breast cancer.
- All patients who are treated by neoadjuvant chemotherapy before surgery.
Key exclusion criteria (3 listed)
- Patients diagnosed with cancer metastasis.
- Patients diagnosed with diseases of the nervous system (Parkinson's disease, peripheral nerve palsy) skeletal system (inflammatory diseases, scoliosis >10 Cobb angle), or rheumatic diseases.
- Patients with any current visual impairment that affected their daily living, vestibular disorder, neurological disorder, cognitive disorder, and any further medical condition that would prohibit them from participating safely.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Circuit weight trainingThe Circuit Training protocol will be performed as follows: wall push-up, bridge on floor, single leg bridge, bird dog, windshield wiper, march in place, ball squat, squat with an overhead press, reverse pendulum, jumping rope, and spinal twist, 30-35 minutes, 3 times a week for 8 weeks | Other | Circuit weight training and traditional physical therapy program |
| Traditional physical therapy programThe participants will receive traditional physical therapy program in the form of therapeutic exercises to keep daily living activity by restoring the strength of flexors and abductors of the shoulder joint using the shoulder wheel and ladder. It will be performed 3 times per week for eight weeks | Other | Circuit weight training and traditional physical therapy program, Traditional physical therapy program |
Primary outcome
Assessment of quality of life
Time frame: 8 weeks
The 12-Item Short Form Survey (SF-12) is the abridged practical form of the SF-36. It is a widely used screening device for measuring physical, mental, and social well-being to assess quality of life. it consists of 2 components: Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12). Its score ranges between 0-100. Higher score indicates better health.
Assessment of functional capacity
Time frame: 8 weeks
The 2-minute step test (TMST) will be used to measure exercise capacity for all participants in the study before and after treatment. The test simply requires that participants march in place as fast as possible for 2 minutes while lifting the knees to a height midway between their patella and iliac crest when standing. Performance on the test is defined as the number of right-side steps of the criterion height completed in 2 minutes.
4 secondary outcomes
Postural stability test
Time frame: 8 weeks
Limits of stability test
Time frame: 8 weeks
Single leg stability test
Time frame: 8 weeks
Assessment of muscle strength
Time frame: 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Maher H Ibrahim, Professor study director
Cairo University
Heba A. Abdulghafar, Professor study chair
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Circuit weight training and Traditional physical therapy program in people with Breast Cancer, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of quality of life (time frame: 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2025.