Substance UseNCT06941181
Neurocognitive Predictors of Health Risk Behaviors
A study testing neurocognitive tasks in people with Substance Use, run by Virginia Polytechnic Institute and State University at 2 sites in United States.
Trial summary
This study proposes to extend the ongoing longitudinal study of health risk behaviors and obtain new data from former adolescents (followed previously from ages 13-22; Times 1-8) now from ages 23 to 28 (Times 9-11). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Substance Use
- What is being tested?
- neurocognitive tasks
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 117 participants
- Where
- 2 sitesUnited States
- Study dates
- 20 Jan 2014to 31 May 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adolescents (now young adults) who participated in the original longitudinal project.
Who cannot join
- standard contraindications for magnetic resonance imaging at the study onset
- history of seizures/stroke
- a head injury with > 10 min of unconsciousness or neurological sequelae
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Virginia Tech
Blacksburg, Virginia, 24061-0001
Fralin Biomedical Research Institute at VTC
Roanoke, Virginia, 24016
About this study
This study proposes to extend the ongoing longitudinal study of health risk behaviors and obtain new data from former adolescents (followed previously from ages 13-22; Times 1-8) now from ages 23 to 28 (Times 9-11). The goal of this study is to examine the contribution of developing neurocognitive markers to substance use in young adulthood by following a well-characterized longitudinal sample.
Read the detailed description
The main questions it aims to answer is: what are the long-term effects of valuation and control decision-making systems on health risk behaviors? Participants will complete online surveys assessing their substance use behaviors and perform neurocognitive tasks related to risk processing and cognitive control across three time points.
- Conditions
- Substance Use
- Being tested
- neurocognitive tasks
- Medical subject headings
- Substance-Related Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
neurocognitive tasksOther
- risk-processing: Participants choose between two choices across 72 trials of a forced choice decision-making neurocognitive task (Holt and Laury, 2002). Each trial included a high and low monetary outcome with an associated probability of occurring. Each choice option is shown as a pie with ten slices represented probabilities, in which each piece corresponded to ten percent.
- cognitive control: A multi-source interference task (MSIT; Bush et al., 2003) is used in which participants are presented with three digits and asked to identify the digit different from the others. In the neutral condition, the target's identity is congruent with its relative position. In the interference condition, the target's identity does not match its relative position. There are a total of 96 neutral trials and 96 interference trials.
| Study group | Role | What they receive |
|---|---|---|
| neurocognition | Other | Neurocognitive tasks Receives: Other: neurocognitive tasks |
What is being measured
The primary outcome is the main question the study is designed to answer.
substance use behaviors
Frequency (past year and past month use) of cigarette/tobacco, alcohol, cannabis, and other drug use will be asked.
Measured: Approximately every 18 months, 3 times across 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Apr 2025
- Study start20 Jan 2014
- Primary completion31 May 2029 (estimated)
- Study completion31 May 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Substance UseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 117 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Virginia Polytechnic Institute and State University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jungmeen Kim-Spoon, Virginia Polytechnic Institute and State University
- Investigators
- Jungmeen Kim-Spoon, PhD, Principal investigator, Virginia Polytechnic Institute and State UniversityBrooks Casas, PhD, Principal investigator, Virginia Polytechnic Institute and State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06941181
- Sponsor's protocol ID
- Predictors of Risky Behaviors
- Status last verified
- Feb 2026
- First submitted
- 14 Apr 2025
- Last updated
- 12 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurocognitive Predictors of Health Risk Behaviors
- ClinicalTrials.gov ID
- NCT06941181
- Acronym / sponsor ID
- Predictors of Risky Behaviors
- Conditions
- Substance Use
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 117 participants (estimated)
- Lead sponsor
- Virginia Polytechnic Institute and State UniversityUniversity, hospital or other
- Study start
- 20 Jan 2014 (actual)
- Primary completion
- 31 May 2029 (estimated)
- Study completion
- 31 May 2029 (estimated)
- First posted
- 23 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study proposes to extend the ongoing longitudinal study of health risk behaviors and obtain new data from former adolescents (followed previously from ages 13-22; Times 1-8) now from ages 23 to 28 (Times 9-11). The goal of this study is to examine the contribution of developing neurocognitive markers to substance use in young adulthood by following a well-characterized longitudinal sample.
Detailed description
The main questions it aims to answer is: what are the long-term effects of valuation and control decision-making systems on health risk behaviors? Participants will complete online surveys assessing their substance use behaviors and perform neurocognitive tasks related to risk processing and cognitive control across three time points.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| neurocognition | Other | Other: neurocognitive tasksNeurocognitive tasks |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adolescents (now young adults) who participated in the original longitudinal project.
Key exclusion criteria (3 listed)
- standard contraindications for magnetic resonance imaging at the study onset
- history of seizures/stroke
- a head injury with > 10 min of unconsciousness or neurological sequelae
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| neurocognitive tasks1. risk-processing: Participants choose between two choices across 72 trials of a forced choice decision-making neurocognitive task (Holt and Laury, 2002). Each trial included a high and low monetary outcome with an associated probability of occurring. Each choice option is shown as a pie with ten slices represented probabilities, in which each piece corresponded to ten percent. 2. cognitive control: A multi-source interference task (MSIT; Bush et al., 2003) is used in which participants are presented with three digits and asked to identify the digit different from the others. In the neutral condition, the target's identity is congruent with its relative position. In the interference condition, the target's identity does not match its relative position. There are a total of 96 neutral trials and 96 interference trials. | Other | neurocognition |
Primary outcome
substance use behaviors
Time frame: Approximately every 18 months, 3 times across 5 years
Frequency (past year and past month use) of cigarette/tobacco, alcohol, cannabis, and other drug use will be asked.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jungmeen Kim-Spoon, PhD principal investigator
Virginia Polytechnic Institute and State University
Brooks Casas, PhD principal investigator
Virginia Polytechnic Institute and State University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing neurocognitive tasks in people with Substance Use, run by Virginia Polytechnic Institute and State University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 12 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
substance use behaviors (time frame: Approximately every 18 months, 3 times across 5 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Feb 2026.