Muscle FatigueNCT06949566

Post-Fatigue Vibration: Impact on Grip and Reaction Time

A study testing 100 Hz Local Vibration and 50 Hz Local Vibration in people with Muscle Fatigue, run by Bitlis Eren University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

Search all trials

Trial summary

This study aims to investigate the acute effects of local vibration applied after induced fatigue of the wrist flexor muscles on grip strength and upper extremity reaction time. Read more about this study

Who is it for?: Ages 18 to 25 years, women onlyHealthy volunteers can take part
Conditions the study is for: Muscle Fatigue
What is being tested?: 100 Hz Local Vibration and 50 Hz Local Vibration
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 42 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 8 May 2025to 26 Jun 2025
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 25 years
Women only
Healthy volunteers accepted
Adult

Who may be able to join

1. Female individuals aged 18-25

Who cannot join

Having an open wound in the area where local vibration is applied
A history of previous or current upper extremity injury
Use of anti-inflammatory drugs
Having a diagnosis of epilepsy

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University
Bitlis, 13100

Other trials in Turkey (Türkiye)

About this study

Official title: Evaluation of Grip Strength and Reaction Time Following Induced Fatigue of the Wrist Flexors: The Acute Effects of Local Vibration

This study aims to investigate the acute effects of local vibration applied after induced fatigue of the wrist flexor muscles on grip strength and upper extremity reaction time.

Read the detailed description

This randomized controlled study will be conducted with a minimum of 42 participants who meet the inclusion and exclusion criteria. Participants will be randomly assigned to one of three groups: control, 50 Hz local vibration, or 100 Hz local vibration.

Conditions: Muscle Fatigue
Being tested: 100 Hz Local Vibration, 50 Hz Local Vibration, Sham Local Vibration
Keywords: Local Vibration, Upper Extremity Function, Wrist Flexors, Neuromuscular Performance

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

100 Hz Local VibrationOther
Participants in this group will receive 100 Hz local vibration along the flexor carpi ulnaris muscle for a duration of 10 minutes.
50 Hz Local VibrationOther
Participants in this group will receive 50 Hz local vibration along the flexor carpi ulnaris muscle for a duration of 10 minutes.
Sham Local VibrationOther
Participants in this group will receive sham vibration following the muscle fatigue protocol. The vibration device will be turned on but held near the muscle without making contact for 10 minutes. Participants will be informed that they are being treated with an electromagnetic vibration device.

Study groups in NCT06949566
Study group	Role	What they receive
Sham Vibration Group	Sham comparator	In this group, sham vibration will be administered following the muscle fatigue protocol. The vibration device will be activated but positioned close to the muscle without direct contact for a duration of 10 minutes. Participants will be told that they are receiving treatment with an electromagnetic vibration device. Receives: Other: Sham Local Vibration
50 Hz Local Vibration Intervention Group	Experimental	Participants in this group will receive 50 Hz local vibration following the muscle fatigue protocol. The local vibration will be applied along the flexor carpi ulnaris muscle for a duration of 10 minutes. Receives: Other: 50 Hz Local Vibration
100 Hz Local Vibration Intervention Group	Experimental	Participants in this group will receive 100 Hz local vibration following the muscle fatigue protocol. The local vibration will be applied along the flexor carpi ulnaris muscle for a duration of 10 minutes. Receives: Other: 100 Hz Local Vibration

What is being measured

The primary outcome is the main question the study is designed to answer.

Hand Grip Strength Measurement
Grip strength will be assessed using a JAMAR® hydraulic hand dynamometer, which has five grip positions. The test will follow American Society of Hand Therapists guidelines, with the elbow at 90° flexion.
Measurements will be taken on the dominant hand. Participants will sit with their head facing forward, shoulders slightly abducted (10-20°), elbows at 90°, and wrists and hands in a neutral position. Both upper extremities will remain relaxed, and feet will be flat on the floor.
Fingers will be fully extended and adducted. Participants will be instructed not to allow their hands or forearms to touch the body. The dynamometer will be adjusted to fit the participant's hand size, typically set at the second handle position.
Measured: Change in hand grip strength from baseline following intervention or rest
Upper Extremity Reaction Time Measurement
Upper extremity reaction times will be recorded using the BlazePod system (Play Coyotta Ltd., Tel Aviv, Israel). Participants will begin the reaction time test while seated, with both hands placed on a table, palms facing downward, and elbows flexed at 90°, with hands positioned 40 cm apart.
The BlazePod unit will be placed centrally, approximately 20 cm away from each hand. When the BlazePod lights up, participants will be instructed to respond as quickly as possible by tapping the light to turn it off. As the lights will activate randomly, participants will be required to react unpredictably and respond accordingly each time the light appears.
The total test duration will be recorded at the end of the trial.
Measured: Change in upper extremity reaction time from baseline following following intervention or rest

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

8 May 202526 Jun 2025

First posted29 Apr 2025
Study start8 May 2025
Primary completion26 Jun 2025
Study completion26 Jun 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (14)Papers the sponsor has linked to this study.
Other trials for Muscle FatigueStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Double blind
Who is masked: Participant, Investigator
Enrolment: 42 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06949566
Sponsor's protocol ID: BEUFTR-8
Status last verified: Jul 2025
First submitted: 22 Apr 2025
Last updated: 11 Jul 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

Publications

Ferreira RM, Silva R, Vigario P, Martins PN, Casanova F, Fernandes RJ, Sampaio AR. The Effects of Massage Guns on Performance and Recovery: A Systematic Review. J Funct Morphol Kinesiol. 2023 Sep 18;8(3):138. doi: 10.3390/jfmk8030138.
PubMed 37754971
Jones GC, Blotter JD, Smallwood CD, Eggett DL, Cochrane DJ, Feland JB. Effect of Resonant Frequency Vibration on Delayed Onset Muscle Soreness and Resulting Stiffness as Measured by Shear-Wave Elastography. Int J Environ Res Public Health. 2021 Jul 24;18(15):7853. doi: 10.3390/ijerph18157853.
PubMed 34360146
Alam MM, Khan AA, Farooq M. Effects of vibratory massage therapy on grip strength, endurance time and forearm muscle performance. Work. 2021;68(3):619-632. doi: 10.3233/WOR-203397.
PubMed 33612507
Chwala W, Pogwizd P, Rydzik L, Ambrozy T. Effect of Vibration Massage and Passive Rest on Recovery of Muscle Strength after Short-Term Exercise. Int J Environ Res Public Health. 2021 Nov 7;18(21):11680. doi: 10.3390/ijerph182111680.
PubMed 34770194
Alam MM, Khan AA, Farooq M. Effect of whole-body vibration on neuromuscular performance: A literature review. Work. 2018;59(4):571-583. doi: 10.3233/WOR-182699.
PubMed 29733043
Percival S, Sims DT, Stebbings GK. Local Vibration Therapy, Oxygen Resaturation Rate, and Muscle Strength After Exercise-Induced Muscle Damage. J Athl Train. 2022 May 1;57(5):502-509. doi: 10.4085/1062-6050-0064.21.
PubMed 35696601
Liepert J, Binder C. Vibration-induced effects in stroke patients with spastic hemiparesis--a pilot study. Restor Neurol Neurosci. 2010;28(6):729-35. doi: 10.3233/RNN-2010-0541.
PubMed 21209488
Kerschan-Schindl K, Grampp S, Henk C, Resch H, Preisinger E, Fialka-Moser V, Imhof H. Whole-body vibration exercise leads to alterations in muscle blood volume. Clin Physiol. 2001 May;21(3):377-82. doi: 10.1046/j.1365-2281.2001.00335.x.
PubMed 11380538
Otadi K, Ghasemi M, Jalaie S, Bagheri H, Azizian M, Emamdoost S, Sarafraz H, Sepahvand M. A prophylactic effect of local vibration on quadriceps muscle fatigue in non-athletic males: a randomized controlled trial study. J Phys Ther Sci. 2019 Mar;31(3):223-226. doi: 10.1589/jpts.31.223. Epub 2019 Mar 19.
PubMed 30936635
Ishikura H. Effects of local vibration stimulation on muscle recovery and hypertrophy. J Phys Ther Sci. 2024 Aug;36(8):441-446. doi: 10.1589/jpts.36.441. Epub 2024 Aug 1.
PubMed 39092417
Rosenkranz K, Rothwell JC. Differential effect of muscle vibration on intracortical inhibitory circuits in humans. J Physiol. 2003 Sep 1;551(Pt 2):649-60. doi: 10.1113/jphysiol.2003.043752. Epub 2003 Jun 23.
PubMed 12821723
Timon R, Tejero J, Brazo-Sayavera J, Crespo C, Olcina G. Effects of whole-body vibration after eccentric exercise on muscle soreness and muscle strength recovery. J Phys Ther Sci. 2016 Jun;28(6):1781-5. doi: 10.1589/jpts.28.1781. Epub 2016 Jun 28.
PubMed 27390415
Fuller JT, Thomson RL, Howe PR, Buckley JD. Effect of vibration on muscle perfusion: a systematic review. Clin Physiol Funct Imaging. 2013 Jan;33(1):1-10. doi: 10.1111/j.1475-097X.2012.01161.x. Epub 2012 Aug 2.
PubMed 23216759
Hogan MC, Richardson RS, Kurdak SS. Initial fall in skeletal muscle force development during ischemia is related to oxygen availability. J Appl Physiol (1985). 1994 Nov;77(5):2380-4. doi: 10.1152/jappl.1994.77.5.2380.
PubMed 7868458

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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All Muscle Fatigue trials

Study at a glance

From the registry record, last updated by the sponsor on 11 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Evaluation of Grip Strength and Reaction Time Following Induced Fatigue of the Wrist Flexors: The Acute Effects of Local Vibration
ClinicalTrials.gov ID: NCT06949566
Acronym / sponsor ID: BEUFTR-8
Conditions: Muscle Fatigue
Keywords: Local Vibration, Upper Extremity Function, Wrist Flexors, Neuromuscular Performance
Study type: Interventional
Recruitment status: Completed
Enrolment: 42 participants (actual)
Lead sponsor: Bitlis Eren UniversityUniversity, hospital or other
Study start: 8 May 2025 (actual)
Primary completion: 26 Jun 2025 (actual)
Study completion: 26 Jun 2025 (actual)
First posted: 29 Apr 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

This study aims to investigate the acute effects of local vibration applied after induced fatigue of the wrist flexor muscles on grip strength and upper extremity reaction time.

Detailed description

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Double blind (participant, investigator)
Number of arms: 3

Arm	Type	Receives
Sham Vibration Group	Sham comparator	Other: Sham Local VibrationIn this group, sham vibration will be administered following the muscle fatigue protocol. The vibration device will be activated but positioned close to the muscle without direct contact for a duration of 10 minutes. Participants will be told that they are receiving treatment with an electromagnetic vibration device.
50 Hz Local Vibration Intervention Group	Experimental	Other: 50 Hz Local VibrationParticipants in this group will receive 50 Hz local vibration following the muscle fatigue protocol. The local vibration will be applied along the flexor carpi ulnaris muscle for a duration of 10 minutes.
100 Hz Local Vibration Intervention Group	Experimental	Other: 100 Hz Local VibrationParticipants in this group will receive 100 Hz local vibration following the muscle fatigue protocol. The local vibration will be applied along the flexor carpi ulnaris muscle for a duration of 10 minutes.

Who may qualify

Ages: 18 to 25 years
Sex: Female only
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (1 listed)

1. Female individuals aged 18-25

Key exclusion criteria (4 listed)

Having an open wound in the area where local vibration is applied
A history of previous or current upper extremity injury
Use of anti-inflammatory drugs
Having a diagnosis of epilepsy

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
100 Hz Local VibrationParticipants in this group will receive 100 Hz local vibration along the flexor carpi ulnaris muscle for a duration of 10 minutes.	Other	100 Hz Local Vibration Intervention Group
50 Hz Local VibrationParticipants in this group will receive 50 Hz local vibration along the flexor carpi ulnaris muscle for a duration of 10 minutes.	Other	50 Hz Local Vibration Intervention Group
Sham Local VibrationParticipants in this group will receive sham vibration following the muscle fatigue protocol. The vibration device will be turned on but held near the muscle without making contact for 10 minutes. Participants will be informed that they are being treated with an electromagnetic vibration device.	Other	Sham Vibration Group

Primary outcome

Hand Grip Strength Measurement
Time frame: Change in hand grip strength from baseline following intervention or rest
Grip strength will be assessed using a JAMAR® hydraulic hand dynamometer, which has five grip positions. The test will follow American Society of Hand Therapists guidelines, with the elbow at 90° flexion. Measurements will be taken on the dominant hand. Participants will sit with their head facing forward, shoulders slightly abducted (10-20°), elbows at 90°, and wrists and hands in a neutral position. Both upper extremities will remain relaxed, and feet will be flat on the floor. Fingers will be fully extended and adducted. Participants will be instructed not to allow their hands or forearms to touch the body. The dynamometer will be adjusted to fit the participant's hand size, typically set at the second handle position.
Upper Extremity Reaction Time Measurement
Time frame: Change in upper extremity reaction time from baseline following following intervention or rest
Upper extremity reaction times will be recorded using the BlazePod system (Play Coyotta Ltd., Tel Aviv, Israel). Participants will begin the reaction time test while seated, with both hands placed on a table, palms facing downward, and elbows flexed at 90°, with hands positioned 40 cm apart. The BlazePod unit will be placed centrally, approximately 20 cm away from each hand. When the BlazePod lights up, participants will be instructed to respond as quickly as possible by tapping the light to turn it off. As the lights will activate randomly, participants will be required to react unpredictably and respond accordingly each time the light appears. The total test duration will be recorded at the end of the trial.

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 11 Jul 2025.
Background: PubMed 37754971Ferreira RM, Silva R, Vigario P, Martins PN, Casanova F, Fernandes RJ, Sampaio AR. The Effects of Massage Guns on Performance and Recovery: A Systematic Review. J Funct Morphol Kinesiol. 2023 Sep 18;8(3):138. doi: 10.3390/jfmk8030138.
Background: PubMed 34360146Jones GC, Blotter JD, Smallwood CD, Eggett DL, Cochrane DJ, Feland JB. Effect of Resonant Frequency Vibration on Delayed Onset Muscle Soreness and Resulting Stiffness as Measured by Shear-Wave Elastography. Int J Environ Res Public Health. 2021 Jul 24;18(15):7853. doi: 10.3390/ijerph18157853.
Background: PubMed 33612507Alam MM, Khan AA, Farooq M. Effects of vibratory massage therapy on grip strength, endurance time and forearm muscle performance. Work. 2021;68(3):619-632. doi: 10.3233/WOR-203397.
Background: PubMed 34770194Chwala W, Pogwizd P, Rydzik L, Ambrozy T. Effect of Vibration Massage and Passive Rest on Recovery of Muscle Strength after Short-Term Exercise. Int J Environ Res Public Health. 2021 Nov 7;18(21):11680. doi: 10.3390/ijerph182111680.
Background: PubMed 29733043Alam MM, Khan AA, Farooq M. Effect of whole-body vibration on neuromuscular performance: A literature review. Work. 2018;59(4):571-583. doi: 10.3233/WOR-182699.
Background: PubMed 35696601Percival S, Sims DT, Stebbings GK. Local Vibration Therapy, Oxygen Resaturation Rate, and Muscle Strength After Exercise-Induced Muscle Damage. J Athl Train. 2022 May 1;57(5):502-509. doi: 10.4085/1062-6050-0064.21.
Background: PubMed 21209488Liepert J, Binder C. Vibration-induced effects in stroke patients with spastic hemiparesis--a pilot study. Restor Neurol Neurosci. 2010;28(6):729-35. doi: 10.3233/RNN-2010-0541.
Background: PubMed 11380538Kerschan-Schindl K, Grampp S, Henk C, Resch H, Preisinger E, Fialka-Moser V, Imhof H. Whole-body vibration exercise leads to alterations in muscle blood volume. Clin Physiol. 2001 May;21(3):377-82. doi: 10.1046/j.1365-2281.2001.00335.x.
Background: PubMed 30936635Otadi K, Ghasemi M, Jalaie S, Bagheri H, Azizian M, Emamdoost S, Sarafraz H, Sepahvand M. A prophylactic effect of local vibration on quadriceps muscle fatigue in non-athletic males: a randomized controlled trial study. J Phys Ther Sci. 2019 Mar;31(3):223-226. doi: 10.1589/jpts.31.223. Epub 2019 Mar 19.
Background: PubMed 39092417Ishikura H. Effects of local vibration stimulation on muscle recovery and hypertrophy. J Phys Ther Sci. 2024 Aug;36(8):441-446. doi: 10.1589/jpts.36.441. Epub 2024 Aug 1.
Background: PubMed 12821723Rosenkranz K, Rothwell JC. Differential effect of muscle vibration on intracortical inhibitory circuits in humans. J Physiol. 2003 Sep 1;551(Pt 2):649-60. doi: 10.1113/jphysiol.2003.043752. Epub 2003 Jun 23.
Background: PubMed 27390415Timon R, Tejero J, Brazo-Sayavera J, Crespo C, Olcina G. Effects of whole-body vibration after eccentric exercise on muscle soreness and muscle strength recovery. J Phys Ther Sci. 2016 Jun;28(6):1781-5. doi: 10.1589/jpts.28.1781. Epub 2016 Jun 28.

Related trials for Muscle Fatigue

Not yet recruiting
ACUTE EFFECTS OF HIGH-INTENSITY LASER THERAPY ON PAIN, MUSCLE STIFFNESS, AND GRIP STRENGTH IN HEALTHY ADULTS
Exercise-Induced Muscle Fatigue, Fatigue Recovery
Recruiting
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis
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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

ömer dursun, Asst. Prof. principal investigator

Bitlis Eren University

merve tunçdemir, Asst. Prof. principal investigator

Bitlis Eren University

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing 100 Hz Local Vibration and 50 Hz Local Vibration in people with Muscle Fatigue, run by Bitlis Eren University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 11 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Hand Grip Strength Measurement (time frame: Change in hand grip strength from baseline following intervention or rest). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06949566, which also lists 14 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jul 2025.