Cardiovascular HealthNCT06956963

Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep

A study testing Partial Sleep Deprivation in people with Cardiovascular Health and Sleep, run by Florida State University at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. Read more about this study

Who is it for?: Ages 18 to 39 yearsHealthy volunteers can take part
Conditions the study is for: Cardiovascular Health, Sleep
What is being tested?: Partial Sleep Deprivation
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 24 participants
Where: 1 siteUnited States
Study dates: 21 Jul 2025to 31 Jan 2026
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 39 years
All sexes
Healthy volunteers accepted
Adult

Who may be able to join

Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR
Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

Who cannot join

Chronic, uncontrolled disease (cardiovascular, metabolic)
Poor sleep (regularly achieving <7 hours of sleep per night)
Musculoskeletal injury in the last 6 months
Obese (grade II or higher)
Pregnant

Trial locations and contacts

1 site in 1 country.

United States1 site

Institute of Sports Sciences and Medicine
Tallahassee, Florida, 32301

Other trials in United States

About this study

To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals.
To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals.
To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals.

Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).

Conditions: Cardiovascular Health, Sleep
Being tested: Partial Sleep Deprivation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Partial Sleep DeprivationOther
Also called Reduced Sleep
30% reduction in habitual time in bed

Study groups in NCT06956963
Study group	Role	What they receive
Normal Sleep	No intervention	Not described
Acute Partial Sleep Deprivation	Experimental	30% reduction in habitual time in bed Receives: Other: Partial Sleep Deprivation

What is being measured

The primary outcome is the main question the study is designed to answer.

Arterial Stiffness
Carotid-femoral pulse wave velocity measured via applanation tonometry
Measured: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

21 Jul 202531 Jan 2026

First posted4 May 2025
Study start21 Jul 2025
Primary completion31 Jan 2026
Study completion31 Jan 2026

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Other trials for Cardiovascular HealthStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Other
Allocation: Randomised
Intervention model: Crossover
Masking: None (open label)
Enrolment: 24 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06956963
Sponsor's protocol ID: STUDY00006067
Status last verified: Jun 2026
First submitted: 10 Apr 2025
Last updated: 8 Jun 2026
Results posted: Yes, on ClinicalTrials.gov
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Undecided

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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All Cardiovascular Health trials

Study at a glance

From the registry record, last updated by the sponsor on 8 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Aerobic Exercise: A Potential Rescue From the Negative Ramifications of Poor Sleep
ClinicalTrials.gov ID: NCT06956963
Acronym / sponsor ID: STUDY00006067
Conditions: Cardiovascular Health, Sleep
Study type: Interventional
Recruitment status: Completed
Enrolment: 24 participants (actual)
Lead sponsor: Florida State UniversityUniversity, hospital or other
Study start: 21 Jul 2025 (actual)
Primary completion: 31 Jan 2026 (actual)
Study completion: 31 Jan 2026 (actual)
First posted: 4 May 2025 (actual)
Results: Posted 8 Jun 2026

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals.
To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals.
To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals.

Study design

Primary purpose: Other
Allocation: Randomised
Intervention model: Crossover
Masking: None (open label)
Number of arms: 2

Arm	Type	Receives
Normal Sleep	No intervention	–
Acute Partial Sleep Deprivation	Experimental	Other: Partial Sleep Deprivation30% reduction in habitual time in bed

Who may qualify

Ages: 18 to 39 years
Sex: All
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (2 listed)

Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months) OR
Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

Key exclusion criteria (5 listed)

Chronic, uncontrolled disease (cardiovascular, metabolic)
Poor sleep (regularly achieving <7 hours of sleep per night)
Musculoskeletal injury in the last 6 months
Obese (grade II or higher)
Pregnant

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Partial Sleep DeprivationAlso: Reduced Sleep30% reduction in habitual time in bed	Other	Acute Partial Sleep Deprivation

Primary outcome

Arterial Stiffness
Time frame: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order
Carotid-femoral pulse wave velocity measured via applanation tonometry

Results and safety

Results posted to the registry on 8 Jun 2026, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Active Group: Normal Sleep, Then Acute Sleep Deprivation	6	6
Active Group: Acute Sleep Deprivation, Then Normal Sleep	6	6
Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation	6	6
Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep	6	6

Primary outcome: Arterial Stiffness

Time frame: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order. Mean (Standard Deviation). Unit: meters per second

Measure	Active Group: Normal Sleep n = 12	Active Group: Acute Sleep Deprivation n = 12	Sedentary Group: Normal Sleep n = 12	Sedentary Group: Acute Sleep Deprivation n = 12
Value	5.7 (0.6)	5.4 (0.6)	5.5 (0.7)	5.7 (0.5)

Adverse events

Time frame: from enrollment through study completion, an average of 1 month. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Active Group: Normal Sleep	0 of 12 (0%)	0 of 12 (0%)	0 of 12
Active Group: Acute Sleep Deprivation	0 of 12 (0%)	0 of 12 (0%)	0 of 12
Sedentary Group: Normal Sleep	0 of 12 (0%)	0 of 12 (0%)	0 of 12
Sedentary Group: Acute Sleep Deprivation	0 of 12 (0%)	0 of 12 (0%)	0 of 12

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 8 Jun 2026.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Individual participant dataSharing planned: Undecided

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RecruitingPhase 1/2
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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Partial Sleep Deprivation in people with Cardiovascular Health and Sleep, run by Florida State University at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 8 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 8 Jun 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Arterial Stiffness (time frame: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06956963.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jun 2026.