Metabolic RegulationNCT06962605
Effects of Intermittent Running on Metabolic Health
A study testing Moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN) and 2-minute interval running (2MIN) in people with Metabolic Regulation and Energy Expenditure, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally… Read more about this study
- Who is it for?
- Ages 20 to 45 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Metabolic Regulation, Energy Expenditure
- What is being tested?
- Moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN) and 2-minute interval running (2MIN)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteTaiwan
- Study dates
- 21 Jun 2025to 30 Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy recreationally active men
- BMI between 18.5-27 kg/m2
- Aged between 20 to 45 years
- Regular exercise (3 times per week and longer than 3 months) with cardio exercise longer than 30 minutes at least once a week
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-shift workers and sleep at least 6.5-9 hours for the past 3 months
- Non-smoker
Who cannot join
- having any cardiovascular, metabolic or pulmonary disease (angina pectoris or uncontrolled arrhythmias)
- suffering from infectious contagious diseases,
- using medications that could affect metabolic responses (including anti-inflammatory medications)
- smoking
- heavy alcohol intake (more than 4 drinks on any day or more than 14 drinks a week).
- undergoing special diets (e.g., intermittent fasting and/or ketogenic diets)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Acute Effects of Intermittent vs. Continuous Running Exercise on Physiological and Metabolic Responses
The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally active adults.
Read the detailed description
The same procedure will be repeated for all trials: Participants will be asked to perform 3 trials in a randomized-crossover design [moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN; 50% and 70% V̇O2max), 2-minute interval running (2MIN; 50% and 70% V̇O2max)]. All trials will be separated by at least 4 days wash-out and less than 14 days between trials to ensure complete rest.
Sensors for measuring muscle oxygen (10 cm proximal to the mid-patella, and 2 cm lateral) will be placed on the rectus femoris muscle and 15 min resting metabolic rate was measured. After baseline measurements, participants warm-up for 3 minutes with fixed walking intensity (i.e., 5 km/h) followed by 40 minutes running. Immediately after the running, participants return to a seated position for 30 minutes post-exercise measurements (EPOC).
During the EPOC and resting metabolic rate (RMR) measurement participants will sit in a comfortable position and need to limit fidgeting, thus allowed only to watch TV or videos on their phone. Participants will be wheeled to the bathroom if needed.
- Conditions
- Metabolic Regulation, Energy Expenditure
- Being tested
- Moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN), 2-minute interval running (2MIN)
- Keywords
- Intermittent running, Energy expenditure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Moderate-intensity continuous running (MICE: 60% V̇O2max)Behavioural
Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max)
5-minute interval running (5MIN)Behavioural
Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%.
2-minute interval running (2MIN)Behavioural
Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%.
| Study group | Role | What they receive |
|---|---|---|
| Moderate-intensity continuous running (MICE: 60% V̇O2max) | Experimental | Exercise Receives: Behavioral: Moderate-intensity continuous running (MICE: 60% V̇O2max) |
| 5-minute interval running (5MIN) | Experimental | Exercise Receives: Behavioral: 5-minute interval running (5MIN) |
| 2-minute interval running (2MIN) | Experimental | Exercise Receives: Behavioral: 2-minute interval running (2MIN) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total energy expenditure
Changes in total energy expenditure during 40-minutes running and 30 minutes of EPOC
Measured: 70 minutes
Substrate utilisation
Changes in substrate utilisation during 40-minutes running and 30 minutes of EPOC
Measured: 70 minutes
Secondary outcomes (2)
Muscle oxygen saturation
Changes in muscle oxygen during 40 minutes running and 30 minutes EPOC
Measured: 70 minutes
Subjective appetite sensation
Changes in subjective feeling of appetite using 0-100 mm scale (e.g., hunger and satisfaction) during trials
Measured: 70 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2025
- Study start21 Jun 2025
- Primary completion30 Apr 2026 (estimated)
- Study completion30 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Metabolic RegulationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will be asked to perform 4 trials in a randomized-crossover design (1) moderate-intensity continuous running (MICE: 60% V̇O2max), (2) 5-minute interval running (5MIN; 50% and 70% V̇O2max), (3) 2-minute interval running (2MIN; 50% and 70% V̇O2max).
- Masking
- None (open label)
- Enrolment
- 16 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yung-Chih Chen, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06962605
- Sponsor's protocol ID
- 202502HM010
- Status last verified
- Jan 2026
- First submitted
- 22 Apr 2025
- Last updated
- 26 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Intermittent vs. Continuous Running Exercise on Physiological and Metabolic Responses
- ClinicalTrials.gov ID
- NCT06962605
- Acronym / sponsor ID
- 202502HM010
- Conditions
- Metabolic Regulation, Energy Expenditure
- Keywords
- Intermittent running, Energy expenditure
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 16 participants (estimated)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 21 Jun 2025 (actual)
- Primary completion
- 30 Apr 2026 (estimated)
- Study completion
- 30 Apr 2026 (estimated)
- First posted
- 8 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally active adults.
Detailed description
The same procedure will be repeated for all trials: Participants will be asked to perform 3 trials in a randomized-crossover design [moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN; 50% and 70% V̇O2max), 2-minute interval running (2MIN; 50% and 70% V̇O2max)]. All trials will be separated by at least 4 days wash-out and less than 14 days between trials to ensure complete rest.
Sensors for measuring muscle oxygen (10 cm proximal to the mid-patella, and 2 cm lateral) will be placed on the rectus femoris muscle and 15 min resting metabolic rate was measured. After baseline measurements, participants warm-up for 3 minutes with fixed walking intensity (i.e., 5 km/h) followed by 40 minutes running. Immediately after the running, participants return to a seated position for 30 minutes post-exercise measurements (EPOC).
During the EPOC and resting metabolic rate (RMR) measurement participants will sit in a comfortable position and need to limit fidgeting, thus allowed only to watch TV or videos on their phone. Participants will be wheeled to the bathroom if needed.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Participants will be asked to perform 4 trials in a randomized-crossover design (1) moderate-intensity continuous running (MICE: 60% V̇O2max), (2) 5-minute interval running (5MIN; 50% and 70% V̇O2max), (3) 2-minute interval running (2MIN; 50% and 70% V̇O2max).
| Arm | Type | Receives |
|---|---|---|
| Moderate-intensity continuous running (MICE: 60% V̇O2max) | Experimental | Behavioral: Moderate-intensity continuous running (MICE: 60% V̇O2max)Exercise |
| 5-minute interval running (5MIN) | Experimental | Behavioral: 5-minute interval running (5MIN)Exercise |
| 2-minute interval running (2MIN) | Experimental | Behavioral: 2-minute interval running (2MIN)Exercise |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Healthy recreationally active men
- BMI between 18.5-27 kg/m2
- Aged between 20 to 45 years
- Regular exercise (3 times per week and longer than 3 months) with cardio exercise longer than 30 minutes at least once a week
- Weight stable for more than 3 months (no change in weight +/- 3%)
Key exclusion criteria (6 listed)
- having any cardiovascular, metabolic or pulmonary disease (angina pectoris or uncontrolled arrhythmias)
- suffering from infectious contagious diseases,
- using medications that could affect metabolic responses (including anti-inflammatory medications)
- smoking
- heavy alcohol intake (more than 4 drinks on any day or more than 14 drinks a week).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Moderate-intensity continuous running (MICE: 60% V̇O2max)Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max) | Behavioural | Moderate-intensity continuous running (MICE: 60% V̇O2max) |
| 5-minute interval running (5MIN)Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%. | Behavioural | 5-minute interval running (5MIN) |
| 2-minute interval running (2MIN)Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%. | Behavioural | 2-minute interval running (2MIN) |
Primary outcome
Total energy expenditure
Time frame: 70 minutes
Changes in total energy expenditure during 40-minutes running and 30 minutes of EPOC
Substrate utilisation
Time frame: 70 minutes
Changes in substrate utilisation during 40-minutes running and 30 minutes of EPOC
2 secondary outcomes
Muscle oxygen saturation
Time frame: 70 minutes
Subjective appetite sensation
Time frame: 70 minutes
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN) and 2-minute interval running (2MIN) in people with Metabolic Regulation and Energy Expenditure, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yung-Chih Chen, PhD (+886277496979, yc.chen@ntnu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total energy expenditure (time frame: 70 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2026.