Inhalation AnesthesiaWiPPULFANCT06967948
Wash-in Period in Patients Undergoing Low Flow Anesthesia
An observational study of Inhalation Anesthesia, run by Serkan Uckun at 3 sites in Turkey (Türkiye).
Trial summary
Volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Inhalation Anesthesia
- How many people
- 40 participants
- Where
- 3 sitesTurkey (Türkiye)
- Study dates
- 10 Apr 2025to Dec 2025
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Study population: Male or female Between 18-60 years of age ASA I-II risk group patients with general anesthesia Duration of surgery between 2 hours and 4 hours
Who may be able to join
- ASA I-II risk group patients Duration of surgery between 2 hours and 4 hours, cases with general anesthesia
Who cannot join
- Patient refusal to participate in the study
- Under 18 years old BMI>40
- Patients receiving invasive mechanical ventilator support in the last 1 month
- Patients who have received chemotherapy or radiotherapy in the last 2 months
- Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack)
- Known severe pulmonary hypertension
Show all 17Show fewer
- Smoke poisoning (carbon monoxide, cyanide poisoning)
- Alcohol or acetone poisoning
- Malignant hyperthermia
- Intracranial tumor
- Hemodynamic instability
- Shock
- Neuromuscular disease
- Pathologies causing increased intracranial and intraocular pressure
- Those with severe cardiac arrhythmias Those with -EF<30
- Severe peripheral arterial disease
- Patients with liver and kidney dysfunction
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)3 sites, 3 recruiting
- Recruiting
Balıkesir University Health Practice and Research Hospital Operating Room
Balıkesir
- Recruiting
Balıkesir University Health Practice and Research Hospital
Balıkesir
Ebru Duman, Research assistant doctor
Serkan Uçkun, Asist. Prof.
- Recruiting
Balıkesir University Health Practice and Research Hospital
Balıkesir
Serkan Uçkun, Assistant professor, +905353701164, serkanuckun@yahoo.com
Özlem Sağır, Prof. Dr
About this study
Official title: The Effect of Two Different Fresh Gas Flows on Inhaled Gas Consumption During Wash-in Period in Patients Undergoing Low Flow Anesthesia: An Observational Study
Volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. The value indicating the brain's response to hypnotic substances, the vapor concentration in the lung alveoli and the minimum amount of anesthesia gas used will be recorded at certain times. The aim of the researchers in the study was to observe the effect of two different fresh gas flow rates on the amount and cost of waste gas released into the atmosphere.
Read the detailed description
Anesthetic management of a patient receiving general anesthesia consists of induction, maintenance and termination periods. In the "wash in period" (saturation of the circuit between the anesthesia device and the patient), high fresh gas flows, usually 2-4 l/min fresh gas flow (50% oxygen and 50% air/nitrous oxide mixture) are used. Inhaled anesthetic agents are routinely used in resuscitation. However, the part of this inhaled agent that is not used by the patient is released into the atmosphere and environment. The higher the flow of fresh gas administered, the greater the proportion not used by the patient and discharged into the atmosphere. These waste gases contribute significantly to the greenhouse effect in the atmosphere. Occupational exposure (liver-kidney disease, neurologic disease, cancer, spontaneous abortions, etc. in healthcare workers) accounts for the portion released into the environment. The consumption and cost of inhalation agents depends on the fresh gas flow rate, vaporizer setting and duration of anesthesia. It has been observed that reducing the fresh gas flow rate significantly reduces the cost. The aim of the researchers in the study was to observe the effect of a fresh gas flow rate of 1 l/min to 4 l/min on the amount of waste gas discharged into the atmosphere and thus on the cost of inhaled agents.
- Conditions
- Inhalation Anesthesia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| 1 lt/min | ''Wash in period'' 1 lt/min fresh gas flow is used. | |
| 4 lt/min | ''Wash in period'' 4 lt/min fresh gas flow is used. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Demographic data
Demographic data such as age (years), height (cm), weight (kg) and gender (male/female) of the volunteer patients will be analyzed to see if they are similar for both study groups.
Measured: preoperative
Duration of surgery
It will be examined whether the duration of surgery (minutes) is similar for volunteer patients
Measured: During the period of operation (2-4 hours)
Duration of anesthesia
It will be examined whether the duration of anesthesia (minutes) is similar for volunteer patients
Measured: During the period of operation (2-4 hours)
Heart rate
We will examine whether there is a difference in heart rate (beats/minute) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter in volunteer patients
Measured: During the period of operation (2-4 hours)
Systolic blood pressure
The volunteer patients will be examined for differences in systolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Measured: During the period of operation (2-4 hours)
Diastolic blood pressure
The volunteer patients will be examined for differences in diastolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Measured: During the period of operation (2-4 hours)
Mean blood pressure
The volunteer patients will be examined for differences in mean blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Measured: During the period of operation (2-4 hours)
Oxygen saturation
We will examine whether there is a difference between the oxygen saturation (%) values measured at 5-minute intervals in the first half hour and then at 15-minute intervals in volunteer patients.
Measured: During the period of operation (2-4 hours)
Total inhaled gas consumption
Total inhaled gas consumption (milliliter) at the end of anesthesia will be examined whether it is similar for volunteer patients.
Measured: During the period of operation (2-4 hours)
Minimum alveolar concentration (MAC)
Minimum alveolar concentration (MAC) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.
Measured: During the period of operation (2-4 hours)
Bispectral index (BIS)
Bispectral index (BIS) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.
Measured: During the period of operation (2-4 hours)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 May 2025
- Study start10 Apr 2025
- Primary completionOct 2025 (estimated)
- Study completionDec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Inhalation AnesthesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Serkan Uckun
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Serkan Uckun, Balikesir University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06967948
- Sponsor's protocol ID
- SUckun
- Acronym
- WiPPULFA
- Status last verified
- Apr 2025
- First submitted
- 14 Apr 2025
- Last updated
- 16 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Two Different Fresh Gas Flows on Inhaled Gas Consumption During Wash-in Period in Patients Undergoing Low Flow Anesthesia: An Observational Study
- ClinicalTrials.gov ID
- NCT06967948
- Acronym / sponsor ID
- WiPPULFA / SUckun
- Conditions
- Inhalation Anesthesia
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Serkan UckunUniversity, hospital or other
- Study start
- 10 Apr 2025 (actual)
- Primary completion
- Oct 2025 (estimated)
- Study completion
- Dec 2025 (estimated)
- First posted
- 13 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. The value indicating the brain's response to hypnotic substances, the vapor concentration in the lung alveoli and the minimum amount of anesthesia gas used will be recorded at certain times. The aim of the researchers in the study was to observe the effect of two different fresh gas flow rates on the amount and cost of waste gas released into the atmosphere.
Detailed description
Anesthetic management of a patient receiving general anesthesia consists of induction, maintenance and termination periods. In the "wash in period" (saturation of the circuit between the anesthesia device and the patient), high fresh gas flows, usually 2-4 l/min fresh gas flow (50% oxygen and 50% air/nitrous oxide mixture) are used. Inhaled anesthetic agents are routinely used in resuscitation. However, the part of this inhaled agent that is not used by the patient is released into the atmosphere and environment. The higher the flow of fresh gas administered, the greater the proportion not used by the patient and discharged into the atmosphere. These waste gases contribute significantly to the greenhouse effect in the atmosphere. Occupational exposure (liver-kidney disease, neurologic disease, cancer, spontaneous abortions, etc. in healthcare workers) accounts for the portion released into the environment. The consumption and cost of inhalation agents depends on the fresh gas flow rate, vaporizer setting and duration of anesthesia. It has been observed that reducing the fresh gas flow rate significantly reduces the cost. The aim of the researchers in the study was to observe the effect of a fresh gas flow rate of 1 l/min to 4 l/min on the amount of waste gas discharged into the atmosphere and thus on the cost of inhaled agents.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 1 lt/min | – | –''Wash in period'' 1 lt/min fresh gas flow is used. |
| 4 lt/min | – | –''Wash in period'' 4 lt/min fresh gas flow is used. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Male or female Between 18-60 years of age ASA I-II risk group patients with general anesthesia Duration of surgery between 2 hours and 4 hours
Key inclusion criteria (1 listed)
- ASA I-II risk group patients Duration of surgery between 2 hours and 4 hours, cases with general anesthesia
Key exclusion criteria (17 listed)
- Patient refusal to participate in the study
- Under 18 years old BMI>40
- Patients receiving invasive mechanical ventilator support in the last 1 month
- Patients who have received chemotherapy or radiotherapy in the last 2 months
- Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Demographic data
Time frame: preoperative
Demographic data such as age (years), height (cm), weight (kg) and gender (male/female) of the volunteer patients will be analyzed to see if they are similar for both study groups.
Duration of surgery
Time frame: During the period of operation (2-4 hours)
It will be examined whether the duration of surgery (minutes) is similar for volunteer patients
Duration of anesthesia
Time frame: During the period of operation (2-4 hours)
It will be examined whether the duration of anesthesia (minutes) is similar for volunteer patients
Heart rate
Time frame: During the period of operation (2-4 hours)
We will examine whether there is a difference in heart rate (beats/minute) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter in volunteer patients
Systolic blood pressure
Time frame: During the period of operation (2-4 hours)
The volunteer patients will be examined for differences in systolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Diastolic blood pressure
Time frame: During the period of operation (2-4 hours)
The volunteer patients will be examined for differences in diastolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Mean blood pressure
Time frame: During the period of operation (2-4 hours)
The volunteer patients will be examined for differences in mean blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter
Oxygen saturation
Time frame: During the period of operation (2-4 hours)
We will examine whether there is a difference between the oxygen saturation (%) values measured at 5-minute intervals in the first half hour and then at 15-minute intervals in volunteer patients.
Total inhaled gas consumption
Time frame: During the period of operation (2-4 hours)
Total inhaled gas consumption (milliliter) at the end of anesthesia will be examined whether it is similar for volunteer patients.
Minimum alveolar concentration (MAC)
Time frame: During the period of operation (2-4 hours)
Minimum alveolar concentration (MAC) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.
Bispectral index (BIS)
Time frame: During the period of operation (2-4 hours)
Bispectral index (BIS) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 May 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Inhalation Anesthesia, run by Serkan Uckun at 3 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 17 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Serkan Uçkun, assistant professor (+90 535 370 11 64, serkanuckun@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Demographic data (time frame: preoperative). The study lists 11 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 May 2025; AzTrials last refreshed its copy on 6 Nov 2026.