Obesity and OverweightNCT06972277
A Randomized Controlled Trial Comparing the Efficacy of Commercial Weight Management Programs
A study testing Commercial weight management program in people with Obesity and Overweight, run by WW International Inc at 1 site in United States.
Trial summary
The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Obesity and Overweight
- What is being tested?
- Commercial weight management program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 459 participants
- Where
- 1 siteUnited States
- Study dates
- 14 May 2025to 9 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18 years or older
- BMI ≥27 kg/m²
- Own a bodyweight scale that they can weigh themselves with during the study
- Willing and able to comply with study protocol
- Capable of providing informed consent
- Able to read and write in English
- Willing to be randomized
- Willing to sign a Non Disclosure Agreement
Who cannot join
- Pregnant, lactating, or plans to become pregnant in the next 6 months
- Previous bariatric surgery or planned bariatric surgery during the study period
- Major surgery within the past 6 months or plans to have surgery during the study period
- Participation in the previous 3 months or current participation in a structured behavioral weight loss program
- Participation in another structured weight loss program during the study period (i.e., the next 3 months)
- Communication needs that would render them unable to understand the study and/or intervention materials
Show all 19Show fewer
- Current or previous history of anorexia or bulimia nervosa
- Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight
- Currently taking anti-obesity medications, planning to take anti-obesity medications in the next 6 months, or previously taken anti-obesity medications in the previous 3 months
- Weight loss of ≥ 5 kg (11 lb) in the previous 6 months
- Self-reported diagnosis of severe depression, bipolar disorder, substance abuse, or psychosis
- Participants who are involved in any other research studies at this time
- Untreated thyroid disease or any changes (type or dose) in thyroid medication in last 6 months
- Chronic/inflammatory gastrointestinal disorders (irritable bowel syndrome is acceptable)
- History of heart problems (e.g., angina, bypass surgery, myocardial infarction, etc.) within previous 6 months
- Diagnosis of type 1 or type 2 diabetes
- Presence of implanted cardiac defibrillator or pacemaker
- History of cancer within past 5 years or current treatment for cancer
- Hospitalization for psychiatric disorders during the last 12 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Comparative Effectiveness of Commercial Weight Management Programs in Adults Living With Overweight or Obesity: A Randomized Controlled Trial
The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks.
- Conditions
- Obesity and Overweight
- Being tested
- Commercial weight management program
- Medical subject headings
- Obesity, Overweight
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Commercial weight management programBehavioural
Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.
| Study group | Role | What they receive |
|---|---|---|
| Commercial weight management program 1 | Experimental | Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. Receives: Behavioral: Commercial weight management program |
| Commercial weight management program 2 | Experimental | Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. Receives: Behavioral: Commercial weight management program |
| Commercial weight management program 3 | Experimental | Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. Receives: Behavioral: Commercial weight management program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percent body weight lost at 12 weeks
Measurement of weight using a body weight scale
Measured: Baseline, 4 weeks, 8 weeks, 12 weeks
Change in body weight (in kg or pounds) at 12 weeks
Measurement of weight using a body weight scale
Measured: Baseline, 4 weeks, 8 weeks, 12 weeks
Secondary outcomes (9)
Physical Activity and Sedentary Behavior
Global Physical Activity Questionnaire (GPAQ)
Measured: Baseline, 12 weeks
Dietary intake
Diet ID, powered by Diet Quality Photo Navigation (DQPN®)
Measured: Baseline, 12 weeks
Hunger
Hunger VAS (Visual Analogue Scale)
Measured: Baseline, 12 weeks
Impact of Weight on Quality
Impact of Weight on Quality of Life-Lite (IWQOL-Lite)
Measured: Baseline, 12 weeks
Wellbeing
World Health Organization (WHO-5)
Measured: Baseline, 12 weeks
Body appreciation
Body Appreciation Scale (BAS-2)
Measured: Baseline, 12 weeks
Self-Compassion
Self-Compassion Scale (SCS)
Measured: Baseline, 12 weeks
Weight Bias Internalization
Weight Bias Internalization Scale (WBIS-2F)
Measured: Baseline, 12 weeks
Food cravings
Food Cravings Inventory (FCI-II)
Measured: Baseline, 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 May 2025
- Study start14 May 2025
- Primary completion9 Jan 2026
- Study completion9 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obesity and OverweightStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 459 participants (actual)
Sponsor and investigators
- Lead sponsor
- WW International Inc
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Principal investigator, Kara Marlatt, WW International Inc
- Investigators
- Kara Marlatt, PhD, MPH, Principal investigator, WW International Inc
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06972277
- Sponsor's protocol ID
- The ACE Study
- Status last verified
- Jan 2026
- First submitted
- 6 May 2025
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Comparative Effectiveness of Commercial Weight Management Programs in Adults Living With Overweight or Obesity: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT06972277
- Acronym / sponsor ID
- The ACE Study
- Conditions
- Obesity and Overweight
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 459 participants (actual)
- Lead sponsor
- WW International IncIndustry (pharma, biotech, devices)
- Study start
- 14 May 2025 (actual)
- Primary completion
- 9 Jan 2026 (actual)
- Study completion
- 9 Jan 2026 (actual)
- First posted
- 14 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Commercial weight management program 1 | Experimental | Behavioral: Commercial weight management programParticipants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. |
| Commercial weight management program 2 | Experimental | Behavioral: Commercial weight management programParticipants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. |
| Commercial weight management program 3 | Experimental | Behavioral: Commercial weight management programParticipants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- 18 years or older
- BMI ≥27 kg/m²
- Own a bodyweight scale that they can weigh themselves with during the study
- Willing and able to comply with study protocol
- Capable of providing informed consent
Key exclusion criteria (19 listed)
- Pregnant, lactating, or plans to become pregnant in the next 6 months
- Previous bariatric surgery or planned bariatric surgery during the study period
- Major surgery within the past 6 months or plans to have surgery during the study period
- Participation in the previous 3 months or current participation in a structured behavioral weight loss program
- Participation in another structured weight loss program during the study period (i.e., the next 3 months)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Commercial weight management programParticipants will receive evidence-based behavioral / lifestyle support from a commercial weight management program. | Behavioural | Commercial weight management program 1, Commercial weight management program 2, Commercial weight management program 3 |
Primary outcome
Percent body weight lost at 12 weeks
Time frame: Baseline, 4 weeks, 8 weeks, 12 weeks
Measurement of weight using a body weight scale
Change in body weight (in kg or pounds) at 12 weeks
Time frame: Baseline, 4 weeks, 8 weeks, 12 weeks
Measurement of weight using a body weight scale
9 secondary outcomes
Physical Activity and Sedentary Behavior
Time frame: Baseline, 12 weeks
Dietary intake
Time frame: Baseline, 12 weeks
Hunger
Time frame: Baseline, 12 weeks
Impact of Weight on Quality
Time frame: Baseline, 12 weeks
Wellbeing
Time frame: Baseline, 12 weeks
Body appreciation
Time frame: Baseline, 12 weeks
Self-Compassion
Time frame: Baseline, 12 weeks
Weight Bias Internalization
Time frame: Baseline, 12 weeks
Food cravings
Time frame: Baseline, 12 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kara Marlatt, PhD, MPH principal investigator
WW International Inc
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Commercial weight management program in people with Obesity and Overweight, run by WW International Inc at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Percent body weight lost at 12 weeks (time frame: Baseline, 4 weeks, 8 weeks, 12 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.