Accelerate Tooth MovementNCT06975358
Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection
A study testing Alveolar decortication plus CGF injection and canine retraction without acceleration in people with Accelerate Tooth Movement, run by Safa Basiouny Alawy at 1 site in Egypt.
Trial summary
The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration Read more about this study
- Who is it for?
- Ages 16 to 22 years
- Conditions the study is for
- Accelerate Tooth Movement
- What is being tested?
- Alveolar decortication plus CGF injection and canine retraction without acceleration
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 20 May 2025to 1 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 22 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Age of the patients ranged from 16: 22 years old.
- Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
- Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
- Good oral hygiene and periodontal condition.
Who cannot join
- Medically compromised patients.
- Severe crowding in the maxillary arch.
- Chronic intake of NSAIDs or any medication that interfere with OTM.
- Previous orthodontic treatment.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Tanta University
Tanta, Tanta, 6624033
Safa B Alawy, PhD, +201009088252, safa_basyouny@dent.tanta.edu.eg
About this study
Official title: Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial
The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration
- Conditions
- Accelerate Tooth Movement
- Being tested
- Alveolar decortication plus CGF injection, canine retraction without acceleration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Alveolar decortication plus CGF injectionProcedure or surgery
Experimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured.
canine retraction without accelerationProcedure or surgery
in the control side, the maxillary canine will be retracted without any acceleration procedure
| Study group | Role | What they receive |
|---|---|---|
| Alveolar decortication plus CGF | Experimental | Alveolar decortication followed by submucosal CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine will be randomly assigned to one side of the maxillary arch (experimental) while the other side serve as (control) receiving orthodontic treatment without any additional intervention Receives: Procedure: Alveolar decortication plus CGF injection |
| Control | Active comparator | the other side of the maxillary arch will receive the usual orthodontic treatment without any additional intervention Receives: Procedure: canine retraction without acceleration |
What is being measured
The primary outcome is the main question the study is designed to answer.
rate of canine retraction
Measured: 4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 May 2025
- Study start20 May 2025
- Primary completion1 Feb 2027 (estimated)
- Study completion1 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Accelerate Tooth MovementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Safa Basiouny Alawy
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Safa Basiouny Alawy, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06975358
- Sponsor's protocol ID
- #R-OS-12-24-3158
- Status last verified
- Sep 2026
- First submitted
- 8 May 2025
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT06975358
- Acronym / sponsor ID
- #R-OS-12-24-3158
- Conditions
- Accelerate Tooth Movement
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Safa Basiouny AlawyUniversity, hospital or other
- Study start
- 20 May 2025 (actual)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 1 Mar 2027 (estimated)
- First posted
- 16 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Alveolar decortication plus CGF | Experimental | Procedure: Alveolar decortication plus CGF injectionAlveolar decortication followed by submucosal CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine will be randomly assigned to one side of the maxillary arch (experimental) while the other side serve as (control) receiving orthodontic treatment without any additional intervention |
| Control | Active comparator | Procedure: canine retraction without accelerationthe other side of the maxillary arch will receive the usual orthodontic treatment without any additional intervention |
Who may qualify
- Ages
- 16 to 22 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Age of the patients ranged from 16: 22 years old.
- Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
- Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
- Good oral hygiene and periodontal condition.
Key exclusion criteria (4 listed)
- Medically compromised patients.
- Severe crowding in the maxillary arch.
- Chronic intake of NSAIDs or any medication that interfere with OTM.
- Previous orthodontic treatment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Alveolar decortication plus CGF injectionExperimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured. | Procedure or surgery | Alveolar decortication plus CGF |
| canine retraction without accelerationin the control side, the maxillary canine will be retracted without any acceleration procedure | Procedure or surgery | Control |
Primary outcome
rate of canine retraction
Time frame: 4 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Alveolar decortication plus CGF injection and canine retraction without acceleration in people with Accelerate Tooth Movement, run by Safa Basiouny Alawy at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Safa B Alawy, PhD (0201009088252, safa_basyouny@dent.tanta.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
rate of canine retraction (time frame: 4 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.