Radial ArteryNCT06975566
Long-term Effects of Radial Artery Cannulation on Vessel Diameter, Blood Flow and Fine Motor Skills
An observational study of Radial Artery and Ultrasound, run by Kartal City Hospital.
Trial summary
This observational study examined changes in blood vessel diameter, blood flow, and fine motor performance after ultrasound-guided radial artery cannulation in adults undergoing elective cardiac surgery. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Radial Artery, Ultrasound, Fine Motor Skills
- What is being tested?
- radial artery catheterization
- Type of treatment
- Surgery or procedure
- How many people
- 103 participants
- Where
- No sites listed yet
- Study dates
- 22 Jul 2016to 2 Dec 2016
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults aged 18-80 years with American Society of Anesthesiologists physical status I-III who were scheduled for elective cardiac surgery and required radial arterial monitoring at Pamukkale University Faculty of Medicine, Department of Cardiovascular Surgery. Eligible patients were recruited consecutively from 22 July to 2 September 2016.
Who may be able to join
- Age 18-80 years.
- American Society of Anesthesiologists physical status I-III.
- Scheduled for elective cardiac surgery, including coronary artery bypass grafting, valve surgery, the Bentall procedure, or atrial septal defect repair.
- Requirement for radial arterial monitoring.
Who cannot join
- Emergency surgery.
- Haemodynamic instability.
- Planned femoral arterial cannulation.
- Body mass index >35 kg/m².
- Peripheral vascular disease.
- Infection at the puncture site.
- An abnormal pulse-oximetry-assisted modified Allen screening result.
About this study
This observational study examined changes in blood vessel diameter, blood flow, and fine motor performance after ultrasound-guided radial artery cannulation in adults undergoing elective cardiac surgery. Ultrasound measurements of the radial and ulnar arteries and Purdue Pegboard tests of hand performance were obtained before cannulation and during follow-up for three months. Measurements were compared over time within each participant and between the relevant arteries or hands.
Read the detailed description
This single-centre prospective longitudinal observational study was conducted in the Department of Cardiovascular Surgery at Pamukkale University Faculty of Medicine. Adults aged 18-80 years with American Society of Anesthesiologists physical status I-III who required radial arterial monitoring during elective cardiac surgery were recruited consecutively from 22 July to 2 September 2016. Baseline assessments were performed in all 103 enrolled participants. Radial and ulnar artery internal diameter, peak systolic velocity, end-diastolic velocity, resistive index, pulsatility index, and mean volume flow were assessed before cannulation and at seven subsequent time points over three months. Purdue Pegboard performance was assessed before cannulation, 10 days after baseline, and three months after baseline. Comparisons were made within participants over time, between the radial and ulnar arteries of the cannulated arm, and between the cannulated left and non-cannulated right hands; bimanual performance was assessed separately. Fifty participants completed all reported assessments and were included in the complete-case analysis. The other 53 participants did not complete follow-up because of death (7), severe postoperative morbidity (13), incomplete follow-up attendance (22), or technical or organizational reasons (11). Individual-level partial records for these 53 participants were unavailable for reanalysis. The study received ethics committee approval on 19 July 2016, and written informed consent was obtained before study procedures. The investigation originated as a medical specialty thesis completed in 2017 and was retrospectively registered in 2025.
- Conditions
- Radial Artery, Ultrasound, Fine Motor Skills
- Being tested
- radial artery catheterization
- Keywords
- Catheterization, Regional blood flow, Fine motor skills
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
radial artery catheterizationProcedure or surgery
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in radial and ulnar artery diameter and Doppler parameters over three months
Internal anteroposterior diameter (mm), peak systolic velocity (cm/s), end-diastolic velocity (cm/s), resistive index (unitless), pulsatility index (unitless), and mean volume flow (mL/min) of the radial and ulnar arteries in the cannulated arm were measured by ultrasound. Each value was the mean of three independent acquisitions. Each parameter was analysed separately for changes from baseline and differences between arteries. T1 was 1 minute after anesthesia induction following cannulation; T2 was 30 minutes after cannulation; T3 was postoperative day 1; T4 was 3 days after cannulation; T5, T6 and T7 were 10 days, 1 month and 3 months after baseline, respectively.
Measured: Before cannulation (T0); 1 minute after anesthesia induction (T1); 30 minutes after cannulation (T2); postoperative day 1 (T3); 3 days after cannulation (T4); 10 days (T5), 1 month (T6), and 3 months (T7) after T0.
Changes in Purdue Pegboard fine motor performance over three months
Fine motor performance was assessed using the Purdue Pegboard Test (Model 32020). The right hand, left hand, and both hands together were tested in separate 30-second subtests. Unilateral scores counted successfully inserted pins; bimanual scores counted completed pin pairs, with one pin placed by each hand. Each subtest was repeated three times and the mean score was analysed. Higher scores indicate better performance. The left hand was the cannulated hand and the right hand was the non-cannulated hand. Unilateral performance was compared between hands and over time; bimanual performance was analysed separately over time. The 60-second assembly subtest was not performed.
Measured: Before cannulation (T0), 10 days after T0 (T5), and 3 months after T0 (T7).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 May 2025
- Study start22 Jul 2016
- Primary completion2 Dec 2016
- Study completion2 Dec 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Radial ArteryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 103 participants (actual)
Sponsor and investigators
- Lead sponsor
- Kartal City Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, AKIN BİLİR, Kartal City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06975566
- Sponsor's protocol ID
- radial artery study
- Status last verified
- Sep 2026
- First submitted
- 1 May 2025
- Last updated
- 16 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Desrosiers J, Hebert R, Bravo G, Rochette A. Age-related changes in upper extremity performance of elderly people: a longitudinal study. Exp Gerontol. 1999 Jun;34(3):393-405. doi: 10.1016/s0531-5565(99)00018-2.
PubMed 10433393Taneja K, Jain R, Sawhney S, Rajani M. Occlusive arterial disease of the upper extremity: colour Doppler as a screening technique and for assessment of distal circulation. Australas Radiol. 1996 Aug;40(3):226-9. doi: 10.1111/j.1440-1673.1996.tb00391.x.
PubMed 8826723Numaguchi A, Adachi YU, Aoki Y, Ishii Y, Suzuki K, Obata Y, Sato S, Nishiwaki K, Matsuda N. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound. J Clin Monit Comput. 2015 Oct;29(5):653-7. doi: 10.1007/s10877-014-9648-5. Epub 2014 Dec 16.
PubMed 25516161
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Long-term Effects of Radial Artery Cannulation on Vessel Diameter, Blood Flow and Fine Motor Skills
- ClinicalTrials.gov ID
- NCT06975566
- Acronym / sponsor ID
- radial artery study
- Conditions
- Radial Artery, Ultrasound, Fine Motor Skills
- Keywords
- Catheterization, Regional blood flow, Fine motor skills
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 103 participants (actual)
- Lead sponsor
- Kartal City HospitalUniversity, hospital or other
- Study start
- 22 Jul 2016 (actual)
- Primary completion
- 2 Dec 2016 (actual)
- Study completion
- 2 Dec 2016 (actual)
- First posted
- 16 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational study examined changes in blood vessel diameter, blood flow, and fine motor performance after ultrasound-guided radial artery cannulation in adults undergoing elective cardiac surgery. Ultrasound measurements of the radial and ulnar arteries and Purdue Pegboard tests of hand performance were obtained before cannulation and during follow-up for three months. Measurements were compared over time within each participant and between the relevant arteries or hands.
Detailed description
This single-centre prospective longitudinal observational study was conducted in the Department of Cardiovascular Surgery at Pamukkale University Faculty of Medicine. Adults aged 18-80 years with American Society of Anesthesiologists physical status I-III who required radial arterial monitoring during elective cardiac surgery were recruited consecutively from 22 July to 2 September 2016. Baseline assessments were performed in all 103 enrolled participants. Radial and ulnar artery internal diameter, peak systolic velocity, end-diastolic velocity, resistive index, pulsatility index, and mean volume flow were assessed before cannulation and at seven subsequent time points over three months. Purdue Pegboard performance was assessed before cannulation, 10 days after baseline, and three months after baseline. Comparisons were made within participants over time, between the radial and ulnar arteries of the cannulated arm, and between the cannulated left and non-cannulated right hands; bimanual performance was assessed separately. Fifty participants completed all reported assessments and were included in the complete-case analysis. The other 53 participants did not complete follow-up because of death (7), severe postoperative morbidity (13), incomplete follow-up attendance (22), or technical or organizational reasons (11). Individual-level partial records for these 53 participants were unavailable for reanalysis. The study received ethics committee approval on 19 July 2016, and written informed consent was obtained before study procedures. The investigation originated as a medical specialty thesis completed in 2017 and was retrospectively registered in 2025.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults aged 18-80 years with American Society of Anesthesiologists physical status I-III who were scheduled for elective cardiac surgery and required radial arterial monitoring at Pamukkale University Faculty of Medicine, Department of Cardiovascular Surgery. Eligible patients were recruited consecutively from 22 July to 2 September 2016.
Key inclusion criteria (4 listed)
- Age 18-80 years.
- American Society of Anesthesiologists physical status I-III.
- Scheduled for elective cardiac surgery, including coronary artery bypass grafting, valve surgery, the Bentall procedure, or atrial septal defect repair.
- Requirement for radial arterial monitoring.
Key exclusion criteria (7 listed)
- Emergency surgery.
- Haemodynamic instability.
- Planned femoral arterial cannulation.
- Body mass index >35 kg/m².
- Peripheral vascular disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| radial artery catheterization | Procedure or surgery | – |
Primary outcome
Changes in radial and ulnar artery diameter and Doppler parameters over three months
Time frame: Before cannulation (T0); 1 minute after anesthesia induction (T1); 30 minutes after cannulation (T2); postoperative day 1 (T3); 3 days after cannulation (T4); 10 days (T5), 1 month (T6), and 3 months (T7) after T0.
Internal anteroposterior diameter (mm), peak systolic velocity (cm/s), end-diastolic velocity (cm/s), resistive index (unitless), pulsatility index (unitless), and mean volume flow (mL/min) of the radial and ulnar arteries in the cannulated arm were measured by ultrasound. Each value was the mean of three independent acquisitions. Each parameter was analysed separately for changes from baseline and differences between arteries. T1 was 1 minute after anesthesia induction following cannulation; T2 was 30 minutes after cannulation; T3 was postoperative day 1; T4 was 3 days after cannulation; T5, T6 and T7 were 10 days, 1 month and 3 months after baseline, respectively.
Changes in Purdue Pegboard fine motor performance over three months
Time frame: Before cannulation (T0), 10 days after T0 (T5), and 3 months after T0 (T7).
Fine motor performance was assessed using the Purdue Pegboard Test (Model 32020). The right hand, left hand, and both hands together were tested in separate 30-second subtests. Unilateral scores counted successfully inserted pins; bimanual scores counted completed pin pairs, with one pin placed by each hand. Each subtest was repeated three times and the mean score was analysed. Higher scores indicate better performance. The left hand was the cannulated hand and the right hand was the non-cannulated hand. Unilateral performance was compared between hands and over time; bimanual performance was analysed separately over time. The 60-second assembly subtest was not performed.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2026.
- Background: PubMed 10433393Desrosiers J, Hebert R, Bravo G, Rochette A. Age-related changes in upper extremity performance of elderly people: a longitudinal study. Exp Gerontol. 1999 Jun;34(3):393-405. doi: 10.1016/s0531-5565(99)00018-2.
- Background: PubMed 8826723Taneja K, Jain R, Sawhney S, Rajani M. Occlusive arterial disease of the upper extremity: colour Doppler as a screening technique and for assessment of distal circulation. Australas Radiol. 1996 Aug;40(3):226-9. doi: 10.1111/j.1440-1673.1996.tb00391.x.
- Background: PubMed 25516161Numaguchi A, Adachi YU, Aoki Y, Ishii Y, Suzuki K, Obata Y, Sato S, Nishiwaki K, Matsuda N. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound. J Clin Monit Comput. 2015 Oct;29(5):653-7. doi: 10.1007/s10877-014-9648-5. Epub 2014 Dec 16.
- Individual participant dataSharing planned: Yes
Related trials for Radial Artery
Enrolling by invitation
EDEN Intracardiac Electrogram Recording and Classifying System
Ventricular Arrhythmia
Not yet recruitingPhase 4
SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers
Healthy Volunteers, Sympathetic Activity
Active, not recruiting
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Lung Cancer, Lung; Node
Not yet recruiting
ERCG vs Intensive Lifestyle Intervention for Weight Regain After GLP-1 RA Discontinuation
Obesity & Overweight
Not yet recruitingPhase 3
Interest of Cryotherapy in Reducing Pain During Radial Arterial Blood Sampling
Chronic Respiratory Diseases
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Radial Artery and Ultrasound, run by Kartal City Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in radial and ulnar artery diameter and Doppler parameters over three months (time frame: Before cannulation (T0); 1 minute after anesthesia induction (T1); 30 minutes after cannulation (T2); postoperative day 1 (T3); 3 days after cannulation (T4); 10 days (T5), 1 month (T6), and 3 months (T7) after T0.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06975566, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2026.