StrokeNCT06980181
Comparison of Graded Motor Imagery and Mirror Therapy in Chronic Stroke Rehabilitation
A study testing Graded Motor Imagery and Mirror Therapy in people with Stroke, run by Elite College of Management Sciences, Gujranwala, Pakistan at 1 site in Pakistan.
Trial summary
The study is conducted to assess whether the GMI or MT reduce the level of spasticity. Also to compare the level of independence in GMI and MT in the chronic stroke patients. Read more about this study
- Who is it for?
- Ages 45 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Stroke
- What is being tested?
- Graded Motor Imagery and Mirror Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Jun 2025to 1 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age:45 to 65 years
- First ever unilateral stroke and over 3 months since onset.
- Both ischemic and hemorrhagic stroke individuals were included.
Who cannot join
- Patients suffering from psychological problems.
- Visual Impairments.
- Fractures.
- Any other Neurological disorder
- Inflammatory joint diseases
- Medical instability e.g Uncontrolled HTN
- Any systemic disease
Trial locations and contacts
1 site in 1 country.
About this study
The study is conducted to assess whether the GMI or MT reduce the level of spasticity. Also to compare the level of independence in GMI and MT in the chronic stroke patients.
Read the detailed description
A stroke is a medical condition that occurs when inadequate blood flow to a part of the brain leads to cell death. There are two primary types of strokes: ischemic, caused by reduced blood flow, and hemorrhagic, caused by bleeding. Both types result in impaired brain function in the affected areas.
A systemic review was conducted on the effectiveness of mirror therapy on lower extremities, stal and walk in early stage and long term stroke. Results shown better results with using mirror the than control group.
Non-randomized controlled trial study was conducted on stroke patients treated by graded n imagery. It consisted of 28 subjects and the experimental group included 14 and other 14 included in the control group. Graded motor imagery showed better results than the convent therapy as 10 patients showed better outcomes in the intervention group and only 4 patients sho improvement in the control group.
- Conditions
- Stroke
- Being tested
- Graded Motor Imagery, Mirror Therapy
- Keywords
- Stroke, Speech Disorder, Stroke Rehabilitation, Hypertension
- Medical subject headings
- Stroke, Speech Disorders, Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Graded Motor ImageryOther
Graded Motor Imagery typically 1 to 3 times per day for 5 to 10 minutes for each phase. No physical movement at first only cognitive task, mental rehearsal and visual motor.
Mirror TherapyOther
Mirror Therapy typically involves 1 to 3 sessions per day for 10 to 15 minutes gradually increases as tolerated.Visual and motor training using a mirror placed at the midline.
| Study group | Role | What they receive |
|---|---|---|
| Graded Motor Imagery | Experimental | GMI uses visual cues and mental exercises to retain the brain in steps. Receives: Other: Graded Motor Imagery |
| Mirror Therapy | Active comparator | Mirror Therapy uses a mirror to make the brain think the weak side is moving Receives: Other: Mirror Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Modified Ashworth Scale
Changes from baseline Modified Ashworth SCale is a clinical tool used to measure the spasticity.It comprises 4 grades.0 No increase in muscle tone, 1 Slight increase in muscle tone, manifested by a catch and release or by minimal resistance at the end of the range of motion (ROM), 1+ Slight increase in muscle tone, manifested by a catch, followed by minimal resistance throughout the remainder (less than half) of the ROM, 2 More marked increase in muscle tone through most of the ROM, but affected parts) easily moved, 3 Considerable increase in muscle tone, passive movement difficult, 4 Affected parts rigid in flexion or extension.
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 May 2025
- Study start15 Jun 2025
- Primary completion15 Jun 2025
- Study completion1 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Model Description
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Elite College of Management Sciences, Gujranwala, Pakistan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Usman Iqbal Janjua, Phd, Principal investigator, Elite College of Management Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06980181
- Sponsor's protocol ID
- 2020-079262
- Status last verified
- May 2026
- First submitted
- 12 May 2025
- Last updated
- 11 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gandhi DB, Sterba A, Khatter H, Pandian JD. Mirror Therapy in Stroke Rehabilitation: Current Perspectives. Ther Clin Risk Manag. 2020 Feb 7;16:75-85. doi: 10.2147/TCRM.S206883. eCollection 2020.
PubMed 32103968Gallanagh S, Quinn TJ, Alexander J, Walters MR. Physical activity in the prevention and treatment of stroke. ISRN Neurol. 2011;2011:953818. doi: 10.5402/2011/953818. Epub 2011 Oct 1.
PubMed 22389836
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Graded Motor Imagery and Mirror Therapy in Chronic Stroke Rehabilitation
- ClinicalTrials.gov ID
- NCT06980181
- Acronym / sponsor ID
- 2020-079262
- Conditions
- Stroke
- Keywords
- Stroke, Speech Disorder, Stroke Rehabilitation, Hypertension
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Elite College of Management Sciences, Gujranwala, PakistanUniversity, hospital or other
- Study start
- 15 Jun 2025 (actual)
- Primary completion
- 15 Jun 2025 (actual)
- Study completion
- 1 Jul 2025 (actual)
- First posted
- 20 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study is conducted to assess whether the GMI or MT reduce the level of spasticity. Also to compare the level of independence in GMI and MT in the chronic stroke patients.
Detailed description
A stroke is a medical condition that occurs when inadequate blood flow to a part of the brain leads to cell death. There are two primary types of strokes: ischemic, caused by reduced blood flow, and hemorrhagic, caused by bleeding. Both types result in impaired brain function in the affected areas.
A systemic review was conducted on the effectiveness of mirror therapy on lower extremities, stal and walk in early stage and long term stroke. Results shown better results with using mirror the than control group.
Non-randomized controlled trial study was conducted on stroke patients treated by graded n imagery. It consisted of 28 subjects and the experimental group included 14 and other 14 included in the control group. Graded motor imagery showed better results than the convent therapy as 10 patients showed better outcomes in the intervention group and only 4 patients sho improvement in the control group.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- Model Description
| Arm | Type | Receives |
|---|---|---|
| Graded Motor Imagery | Experimental | Other: Graded Motor ImageryGMI uses visual cues and mental exercises to retain the brain in steps. |
| Mirror Therapy | Active comparator | Other: Mirror TherapyMirror Therapy uses a mirror to make the brain think the weak side is moving |
Who may qualify
- Ages
- 45 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age:45 to 65 years
- First ever unilateral stroke and over 3 months since onset.
- Both ischemic and hemorrhagic stroke individuals were included.
Key exclusion criteria (7 listed)
- Patients suffering from psychological problems.
- Visual Impairments.
- Fractures.
- Any other Neurological disorder
- Inflammatory joint diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Graded Motor ImageryGraded Motor Imagery typically 1 to 3 times per day for 5 to 10 minutes for each phase. No physical movement at first only cognitive task, mental rehearsal and visual motor. | Other | Graded Motor Imagery |
| Mirror TherapyMirror Therapy typically involves 1 to 3 sessions per day for 10 to 15 minutes gradually increases as tolerated.Visual and motor training using a mirror placed at the midline. | Other | Mirror Therapy |
Primary outcome
Modified Ashworth Scale
Time frame: 4 weeks
Changes from baseline Modified Ashworth SCale is a clinical tool used to measure the spasticity.It comprises 4 grades.0 No increase in muscle tone, 1 Slight increase in muscle tone, manifested by a catch and release or by minimal resistance at the end of the range of motion (ROM), 1+ Slight increase in muscle tone, manifested by a catch, followed by minimal resistance throughout the remainder (less than half) of the ROM, 2 More marked increase in muscle tone through most of the ROM, but affected parts) easily moved, 3 Considerable increase in muscle tone, passive movement difficult, 4 Affected parts rigid in flexion or extension.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2026.
- Background: PubMed 32103968Gandhi DB, Sterba A, Khatter H, Pandian JD. Mirror Therapy in Stroke Rehabilitation: Current Perspectives. Ther Clin Risk Manag. 2020 Feb 7;16:75-85. doi: 10.2147/TCRM.S206883. eCollection 2020.
- Background: PubMed 22389836Gallanagh S, Quinn TJ, Alexander J, Walters MR. Physical activity in the prevention and treatment of stroke. ISRN Neurol. 2011;2011:953818. doi: 10.5402/2011/953818. Epub 2011 Oct 1.
- Individual participant dataSharing planned: No
Related trials for Stroke
Not yet recruiting
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
Acute Ischemic Stroke
RecruitingObservational study
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
Acute Ichemic Stroke
Recruiting
Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
Stroke, Upper Extremity Paresis
Recruiting
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Subarachnoid Aneurysm Hemorrhage
Not yet recruiting
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Usman Iqbal Janjua, Phd principal investigator
Elite College of Management Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Graded Motor Imagery and Mirror Therapy in people with Stroke, run by Elite College of Management Sciences, Gujranwala, Pakistan at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Modified Ashworth Scale (time frame: 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06980181, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2026.