Aedes-borne DiseasesNCT06981442
Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes
A study testing Community-based environmental management in people with Aedes-borne Diseases, run by Institute of Tropical Medicine, Belgium at 1 site in Democratic Republic of the Congo.
Trial summary
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aedes-borne Diseases
- What is being tested?
- Community-based environmental management
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,050 participants
- Where
- 1 siteDemocratic Republic of the Congo
- Study dates
- 26 Mar 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Belong to a household in one of the 4 health areas selected as study arms
- From 18 years of age to consent for household enrollment and participation in the serosurvey
- Consenting
- From 18 years of age
- Resident of the health zone of Mont Ngafula 1
- Consenting
Who cannot join
- Not belong to a household in one of the 4 health areas selected as study arms
- Under 18 years of age
- Non-consenting
- At health facility level:
- Under 18 years of age
- Not resident in the health zone of Mont Ngafula 1
- Seriously ill and hospitalized, requiring transfusion, presence of blood clotting disorders, allergies resulting from injections, adverse events associated with previous blood sampling, pregnancy
- Non-consenting
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Democratic Republic of the Congo1 site, 1 recruiting
- Recruiting
Institut National de Recherche Biomédicale, INRB
Kinshasa, République Démocratique Du Congo
Emery Metelo Matubi, +243 812695030, pathymetelo@googlemail.com
Emery Metelo Matubi
About this study
Official title: Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes, Vectors of Arboviruses.
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health.
In Africa, there is very little data on the epidemiological situation of Aedes-borne diseases and programs for monitoring these diseases are very limited. In the Democratic Republic of the Congo (DRC), several epidemics of yellow fever, dengue fever, chikungunya and Zika cases have been reported. In particular, in Kinshasa, the dengue and chikungunya viruses have previously been detected in patients with undifferentiated fevers and several studies have shown entomological transmission indices above the criteria and standards of the World Health Organization (WHO).
Read more
The aim of our study is to implement and evaluate different strategies to control Aedes mosquitoes at different stages of their life cycle in the city of Kinshasa.
In particular, a before-and-after interventional study will be piloted and tested in the health zone of Kinshasa, with the aim of providing preliminary evidence of the impact of vector control tools.
Interventions will be implemented in 400 households for each arm for 12 months. Before, after and during the interventions, entomological surveys will be conducted in 160 households in each arm to define the density of the vectors. Mosquitoes will be tested for the possible presence of arbovirus RNA (dengue, chikungunya, Zika, yellow fever). During the pre-intervention period, a serological survey for the same diseases transmitted by the Aedes mosquito will be conducted on a sample of 450 people included in two health centers of reference for the health zone of Mont Ngafula 1. A questionnaire will also be administered before and after the intervention implementation to assess the community's knowledge, attitudes and practices towards Aedes mosquito vector control and Aedes-borne diseases.
The integration of the data collected within the scope of this study will provide an assessment of the feasibility and impact of the tested methods on entomological indicators, as well as determining the exposure and knowledge of Aedes-borne diseases in the Mont Ngafula 1 area.
Read the detailed description
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health. In the last 30 years, the frequency and extent of Aedes-borne epidemics have increased significantly and the main vectors, Aedes aegypti and Aedes albopictus, have expanded their geographical distribution worldwide.
In Africa, there is very little data on the epidemiological situation of Aedes-borne diseases and programs for monitoring these diseases are very limited. In the Democratic Republic of the Congo (DRC), several epidemics of yellow fever, dengue fever, chikungunya and Zika cases have been reported. In particular, in Kinshasa, the dengue and chikungunya viruses have previously been detected in patients with undifferentiated fevers and several studies have shown entomological transmission indices above the criteria and standards of the World Health Organization (WHO). However, vector control activities for Aedes are not carried out regularly outside of epidemic periods and the need for targeted strategies remains essential.
The aim of our study is to implement and evaluate different strategies to control Aedes mosquitoes at different stages of their life cycle in the city of Kinshasa. Furthermore, the integration of a serological survey on diseases transmitted by the Aedes vector will strengthen our knowledge on the circulation of these diseases in the area, for which the data in the literature remain fragmentary until now.
In particular, a before-and-after interventional study will be piloted and tested in the health zone of Mont Ngafula 1, Kinshasa, which is characterized by ecological diversity and a known history of arbovirus circulation. In this pilot study, with the aim of providing preliminary evidence of the impact of vector control tools, there are four arms: i) community-based environmental management approach, ii) community-based environmental management and vector control against immature stages of Aedes (pyriproxifen-based autodissemination stations), iii) community-based environmental management and vector control against the mature stages of Aedes aegypti (mass trapping using BG-GAT - Gravid Aedes Traps), iv) control arm without implementation of vector control interventions. These interventions will be implemented in 400 households for each arm for 12 months. Before, after and during the interventions, entomological surveys will be conducted in 160 households in each arm to define the density of the vectors. Mosquitoes will be tested for the possible presence of arbovirus RNA (dengue, chikungunya, Zika, yellow fever). During the pre-intervention period, a serological survey for the same diseases transmitted by the Aedes mosquito will be conducted on a sample of 450 people included in two health centers of reference for the health zone of Mont Ngafula 1. The knowledge, attitudes and practices of the subjects belonging to the households enrolled in the study will be collected using an electronic questionnaire before and after the intervention. The integration of the data collected within the scope of this study will provide an assessment of the feasibility and impact of the tested methods on entomological indicators, as well as determining the exposure and knowledge of Aedes-borne diseases in the Mont Ngafula 1 area, for a better definition of the next measures to be adopted in the fight against vectors, tailored to the specific context of the the DRC.
- Conditions
- Aedes-borne Diseases
- Being tested
- Community-based environmental management, Vector control against immature stages of Aedes, Vector control against the mature stages of Aedes
- Keywords
- Vector control, Aedes mosquitoes, Democratic Republic of the Congo
- Medical subject headings
- Mosquito-Borne Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Community-based environmental managementBehavioural
This intervention will be performed by the local community, who will have been previously informed and trained on the appropriate environmental management methods for the control of the Aedes mosquito. It will be based on the following elements: i) identification and removal of all artificial sources of reproduction of the Aedes mosquito inside and around the house (i.e. covering abandoned containers and/or storage containers to avoid water accumulation); ii) regular collection and disposal of household waste; iii) identification and resolution of all artificial sources of reproduction of the Aedes vector in or around the house (i.e. natural cavities such as tree holes will be filled to prevent water accumulation). This intervention will be carried out as a single intervention in Arm 1, in combination with a larvicidal intervention in Arm 2 and in combination with the intervention against the adult stage of the Aedes mosquito in Arm 3.
Vector control against immature stages of AedesOther
Larvicidal control will be carried out through pyriproxifen-based autodissemination stations combined with Beauveria bassiana, implemented according to the manufacturer's recommended procedures.
Vector control against the mature stages of AedesOther
The control of the adult Aedes mosquitoes will be carried out through mass trapping using BG-GAT traps implemented according to the manufacturer's recommended procedures. In each household, three traps will be deployed.
| Study group | Role | What they receive |
|---|---|---|
| ARM 1_Community-based environmental management | Experimental | This intervention will be carried out by the community, who will have received training and information on the environmental management measures suitable for controlling the Aedes mosquito. It will involve a cluster of 400 households randomly assigned to this intervention. Receives: Behavioral: Community-based environmental management |
| ARM 2_Community-based environmental management AND vector control against immature stages of Aedes | Experimental | This intervention combines community-based environmental management (specified in the first study arm) with vector control against immature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention. Receives: Behavioral: Community-based environmental management; Other: Vector control against immature stages of Aedes |
| ARM 3_Community-based environmental management AND vector control against mature stages of Aedes | Experimental | This intervention combines community-based environmental management (specified in the first arm of the study) with vector control against the mature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention. Receives: Behavioral: Community-based environmental management; Other: Vector control against the mature stages of Aedes |
| ARM 4_Control arm | No intervention | No control interventions will be implemented. It will involve a cluster of 400 households randomly assigned to this arm. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adult mosquito collection - Entomological Indicator
Adult mosquitoes will be collected outdoor using Prokopack mosquito aspirator in 50 households at the center of each of the 4 study arms and using BG-Sentinel traps in 10 households at the center of each of the 4 study arms. Adult mosquitoes obtained through BG-GAT traps in Arm 3 will also be collected.
Measured: Six collections in total: 1 at baseline, 4 during the intervention (one per trimester), 1 three months after completion of the intervention.
Mosquito larval survey - Entomological Indicator
Larval surveys will be carried out in 100 households at the center of each of the 4 study arms. Immature mosquitoes obtained through the auto-dissemination stations in Arm 2 will also be collected.
Measured: Six collections in total: 1 at baseline, 4 during the intervention (one per trimester), 1 three months after completion of the intervention.
Epidemiological indicator
A sero-survey prospectively including 450 consenting subjects will be carried out in two hospitals in the health zone of Mont Ngafula 1, Kinshasa. The blood sample will be tested for antibodies against the main arboviruses (Yellow Fever, Dengue, Chikungunya, Zika). De-identified socio-demographic data will be collected.
Measured: Once : before/at beginning of intervention
Secondary outcomes (1)
Knowledge, attitudes, and practices.
A survey on knowledge, practices and behaviors regarding Aedes-borne diseases, Aedes mosquitoes and vector control will be proposed to 100 subjects for each study arm, for a total of 400 participants.
Measured: Twice in total: at the beginning of the study and three months after completion of the intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 May 2025
- Study start26 Mar 2025
- Primary completion30 Sep 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Aedes-borne DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 2,050 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Institute of Tropical Medicine, Belgium
- Sponsor type
- University, hospital or other
- Collaborators
- Institut National de Recherche Biomedicale (INRB)
- Responsible party
- Sponsor
- Investigators
- Veerle Vanlerberghe, Principal investigator, Institute of Tropical Medicine Antwerp
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06981442
- Sponsor's protocol ID
- 1778/24
- Status last verified
- Aug 2026
- First submitted
- 8 Apr 2025
- Last updated
- 19 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mbanzulu KM, Wumba R, Mukendi JK, Zanga JK, Shija F, Bobanga TL, Aloni MN, Misinzo G. Mosquito-borne viruses circulating in Kinshasa, Democratic Republic of the Congo. Int J Infect Dis. 2017 Apr;57:32-37. doi: 10.1016/j.ijid.2017.01.016. Epub 2017 Jan 30.
PubMed 28153792Proesmans S, Katshongo F, Milambu J, Fungula B, Muhindo Mavoko H, Ahuka-Mundeke S, Inocencio da Luz R, Van Esbroeck M, Arien KK, Cnops L, De Smet B, Lutumba P, Van Geertruyden JP, Vanlerberghe V. Dengue and chikungunya among outpatients with acute undifferentiated fever in Kinshasa, Democratic Republic of Congo: A cross-sectional study. PLoS Negl Trop Dis. 2019 Sep 5;13(9):e0007047. doi: 10.1371/journal.pntd.0007047. eCollection 2019 Sep.
PubMed 31487279Selhorst P, Makiala-Mandanda S, De Smet B, Marien J, Anthony C, Binene-Mbuka G, De Weggheleire A, Ilombe G, Kinganda-Lusamaki E, Pukuta-Simbu E, Lubula L, Mbala-Kingebeni P, Nkuba-Ndaye A, Vogt F, Watsenga F, Van Bortel W, Vanlerberghe V, Arien KK, Ahuka-Mundeke S. Molecular characterization of chikungunya virus during the 2019 outbreak in the Democratic Republic of the Congo. Emerg Microbes Infect. 2020 Dec;9(1):1912-1918. doi: 10.1080/22221751.2020.1810135.
PubMed 32787529Willcox AC, Collins MH, Jadi R, Keeler C, Parr JB, Mumba D, Kashamuka M, Tshefu A, de Silva AM, Meshnick SR. Seroepidemiology of Dengue, Zika, and Yellow Fever Viruses among Children in the Democratic Republic of the Congo. Am J Trop Med Hyg. 2018 Sep;99(3):756-763. doi: 10.4269/ajtmh.18-0156. Epub 2018 Jul 5.
PubMed 29988000Weetman D, Kamgang B, Badolo A, Moyes CL, Shearer FM, Coulibaly M, Pinto J, Lambrechts L, McCall PJ. Aedes Mosquitoes and Aedes-Borne Arboviruses in Africa: Current and Future Threats. Int J Environ Res Public Health. 2018 Jan 28;15(2):220. doi: 10.3390/ijerph15020220.
PubMed 29382107
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes, Vectors of Arboviruses.
- ClinicalTrials.gov ID
- NCT06981442
- Acronym / sponsor ID
- 1778/24
- Conditions
- Aedes-borne Diseases
- Keywords
- Vector control, Aedes mosquitoes, Democratic Republic of the Congo
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 2,050 participants (estimated)
- Lead sponsor
- Institute of Tropical Medicine, BelgiumUniversity, hospital or other
- Collaborators
- Institut National de Recherche Biomedicale (INRB)
- Study start
- 26 Mar 2025 (actual)
- Primary completion
- 30 Sep 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 20 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health.
In Africa, there is very little data on the epidemiological situation of Aedes-borne diseases and programs for monitoring these diseases are very limited. In the Democratic Republic of the Congo (DRC), several epidemics of yellow fever, dengue fever, chikungunya and Zika cases have been reported. In particular, in Kinshasa, the dengue and chikungunya viruses have previously been detected in patients with undifferentiated fevers and several studies have shown entomological transmission indices above the criteria and standards of the World Health Organization (WHO).
The aim of our study is to implement and evaluate different strategies to control Aedes mosquitoes at different stages of their life cycle in the city of Kinshasa.
In particular, a before-and-after interventional study will be piloted and tested in the health zone of Kinshasa, with the aim of providing preliminary evidence of the impact of vector control tools.
Interventions will be implemented in 400 households for each arm for 12 months. Before, after and during the interventions, entomological surveys will be conducted in 160 households in each arm to define the density of the vectors. Mosquitoes will be tested for the possible presence of arbovirus RNA (dengue, chikungunya, Zika, yellow fever). During the pre-intervention period, a serological survey for the same diseases transmitted by the Aedes mosquito will be conducted on a sample of 450 people included in two health centers of reference for the health zone of Mont Ngafula 1. A questionnaire will also be administered before and after the intervention implementation to assess the community's knowledge, attitudes and practices towards Aedes mosquito vector control and Aedes-borne diseases.
The integration of the data collected within the scope of this study will provide an assessment of the feasibility and impact of the tested methods on entomological indicators, as well as determining the exposure and knowledge of Aedes-borne diseases in the Mont Ngafula 1 area.
Detailed description
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health. In the last 30 years, the frequency and extent of Aedes-borne epidemics have increased significantly and the main vectors, Aedes aegypti and Aedes albopictus, have expanded their geographical distribution worldwide.
In Africa, there is very little data on the epidemiological situation of Aedes-borne diseases and programs for monitoring these diseases are very limited. In the Democratic Republic of the Congo (DRC), several epidemics of yellow fever, dengue fever, chikungunya and Zika cases have been reported. In particular, in Kinshasa, the dengue and chikungunya viruses have previously been detected in patients with undifferentiated fevers and several studies have shown entomological transmission indices above the criteria and standards of the World Health Organization (WHO). However, vector control activities for Aedes are not carried out regularly outside of epidemic periods and the need for targeted strategies remains essential.
The aim of our study is to implement and evaluate different strategies to control Aedes mosquitoes at different stages of their life cycle in the city of Kinshasa. Furthermore, the integration of a serological survey on diseases transmitted by the Aedes vector will strengthen our knowledge on the circulation of these diseases in the area, for which the data in the literature remain fragmentary until now.
In particular, a before-and-after interventional study will be piloted and tested in the health zone of Mont Ngafula 1, Kinshasa, which is characterized by ecological diversity and a known history of arbovirus circulation. In this pilot study, with the aim of providing preliminary evidence of the impact of vector control tools, there are four arms: i) community-based environmental management approach, ii) community-based environmental management and vector control against immature stages of Aedes (pyriproxifen-based autodissemination stations), iii) community-based environmental management and vector control against the mature stages of Aedes aegypti (mass trapping using BG-GAT - Gravid Aedes Traps), iv) control arm without implementation of vector control interventions. These interventions will be implemented in 400 households for each arm for 12 months. Before, after and during the interventions, entomological surveys will be conducted in 160 households in each arm to define the density of the vectors. Mosquitoes will be tested for the possible presence of arbovirus RNA (dengue, chikungunya, Zika, yellow fever). During the pre-intervention period, a serological survey for the same diseases transmitted by the Aedes mosquito will be conducted on a sample of 450 people included in two health centers of reference for the health zone of Mont Ngafula 1. The knowledge, attitudes and practices of the subjects belonging to the households enrolled in the study will be collected using an electronic questionnaire before and after the intervention. The integration of the data collected within the scope of this study will provide an assessment of the feasibility and impact of the tested methods on entomological indicators, as well as determining the exposure and knowledge of Aedes-borne diseases in the Mont Ngafula 1 area, for a better definition of the next measures to be adopted in the fight against vectors, tailored to the specific context of the the DRC.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| ARM 1_Community-based environmental management | Experimental | Behavioral: Community-based environmental managementThis intervention will be carried out by the community, who will have received training and information on the environmental management measures suitable for controlling the Aedes mosquito. It will involve a cluster of 400 households randomly assigned to this intervention. |
| ARM 2_Community-based environmental management AND vector control against immature stages of Aedes | Experimental | Behavioral: Community-based environmental management, Other: Vector control against immature stages of AedesThis intervention combines community-based environmental management (specified in the first study arm) with vector control against immature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention. |
| ARM 3_Community-based environmental management AND vector control against mature stages of Aedes | Experimental | Behavioral: Community-based environmental management, Other: Vector control against the mature stages of AedesThis intervention combines community-based environmental management (specified in the first arm of the study) with vector control against the mature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention. |
| ARM 4_Control arm | No intervention | –No control interventions will be implemented. It will involve a cluster of 400 households randomly assigned to this arm. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Belong to a household in one of the 4 health areas selected as study arms
- From 18 years of age to consent for household enrollment and participation in the serosurvey
- Consenting
- From 18 years of age
- Resident of the health zone of Mont Ngafula 1
Key exclusion criteria (8 listed)
- Not belong to a household in one of the 4 health areas selected as study arms
- Under 18 years of age
- Non-consenting
- Under 18 years of age
- Not resident in the health zone of Mont Ngafula 1
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Community-based environmental managementThis intervention will be performed by the local community, who will have been previously informed and trained on the appropriate environmental management methods for the control of the Aedes mosquito. It will be based on the following elements: i) identification and removal of all artificial sources of reproduction of the Aedes mosquito inside and around the house (i.e. covering abandoned containers and/or storage containers to avoid water accumulation); ii) regular collection and disposal of household waste; iii) identification and resolution of all artificial sources of reproduction of the Aedes vector in or around the house (i.e. natural cavities such as tree holes will be filled to prevent water accumulation). This intervention will be carried out as a single intervention in Arm 1, in combination with a larvicidal intervention in Arm 2 and in combination with the intervention against the adult stage of the Aedes mosquito in Arm 3. | Behavioural | ARM 1_Community-based environmental management, ARM 2_Community-based environmental management AND vector control against immature stages of Aedes, ARM 3_Community-based environmental management AND vector control against mature stages of Aedes |
| Vector control against immature stages of AedesLarvicidal control will be carried out through pyriproxifen-based autodissemination stations combined with Beauveria bassiana, implemented according to the manufacturer's recommended procedures. | Other | ARM 2_Community-based environmental management AND vector control against immature stages of Aedes |
| Vector control against the mature stages of AedesThe control of the adult Aedes mosquitoes will be carried out through mass trapping using BG-GAT traps implemented according to the manufacturer's recommended procedures. In each household, three traps will be deployed. | Other | ARM 3_Community-based environmental management AND vector control against mature stages of Aedes |
Primary outcome
Adult mosquito collection - Entomological Indicator
Time frame: Six collections in total: 1 at baseline, 4 during the intervention (one per trimester), 1 three months after completion of the intervention.
Adult mosquitoes will be collected outdoor using Prokopack mosquito aspirator in 50 households at the center of each of the 4 study arms and using BG-Sentinel traps in 10 households at the center of each of the 4 study arms. Adult mosquitoes obtained through BG-GAT traps in Arm 3 will also be collected.
Mosquito larval survey - Entomological Indicator
Time frame: Six collections in total: 1 at baseline, 4 during the intervention (one per trimester), 1 three months after completion of the intervention.
Larval surveys will be carried out in 100 households at the center of each of the 4 study arms. Immature mosquitoes obtained through the auto-dissemination stations in Arm 2 will also be collected.
Epidemiological indicator
Time frame: Once : before/at beginning of intervention
A sero-survey prospectively including 450 consenting subjects will be carried out in two hospitals in the health zone of Mont Ngafula 1, Kinshasa. The blood sample will be tested for antibodies against the main arboviruses (Yellow Fever, Dengue, Chikungunya, Zika). De-identified socio-demographic data will be collected.
1 secondary outcome
Knowledge, attitudes, and practices.
Time frame: Twice in total: at the beginning of the study and three months after completion of the intervention.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
- Background: PubMed 28153792Mbanzulu KM, Wumba R, Mukendi JK, Zanga JK, Shija F, Bobanga TL, Aloni MN, Misinzo G. Mosquito-borne viruses circulating in Kinshasa, Democratic Republic of the Congo. Int J Infect Dis. 2017 Apr;57:32-37. doi: 10.1016/j.ijid.2017.01.016. Epub 2017 Jan 30.
- Background: PubMed 31487279Proesmans S, Katshongo F, Milambu J, Fungula B, Muhindo Mavoko H, Ahuka-Mundeke S, Inocencio da Luz R, Van Esbroeck M, Arien KK, Cnops L, De Smet B, Lutumba P, Van Geertruyden JP, Vanlerberghe V. Dengue and chikungunya among outpatients with acute undifferentiated fever in Kinshasa, Democratic Republic of Congo: A cross-sectional study. PLoS Negl Trop Dis. 2019 Sep 5;13(9):e0007047. doi: 10.1371/journal.pntd.0007047. eCollection 2019 Sep.
- Background: PubMed 32787529Selhorst P, Makiala-Mandanda S, De Smet B, Marien J, Anthony C, Binene-Mbuka G, De Weggheleire A, Ilombe G, Kinganda-Lusamaki E, Pukuta-Simbu E, Lubula L, Mbala-Kingebeni P, Nkuba-Ndaye A, Vogt F, Watsenga F, Van Bortel W, Vanlerberghe V, Arien KK, Ahuka-Mundeke S. Molecular characterization of chikungunya virus during the 2019 outbreak in the Democratic Republic of the Congo. Emerg Microbes Infect. 2020 Dec;9(1):1912-1918. doi: 10.1080/22221751.2020.1810135.
- Background: PubMed 29988000Willcox AC, Collins MH, Jadi R, Keeler C, Parr JB, Mumba D, Kashamuka M, Tshefu A, de Silva AM, Meshnick SR. Seroepidemiology of Dengue, Zika, and Yellow Fever Viruses among Children in the Democratic Republic of the Congo. Am J Trop Med Hyg. 2018 Sep;99(3):756-763. doi: 10.4269/ajtmh.18-0156. Epub 2018 Jul 5.
- Background: PubMed 29382107Weetman D, Kamgang B, Badolo A, Moyes CL, Shearer FM, Coulibaly M, Pinto J, Lambrechts L, McCall PJ. Aedes Mosquitoes and Aedes-Borne Arboviruses in Africa: Current and Future Threats. Int J Environ Res Public Health. 2018 Jan 28;15(2):220. doi: 10.3390/ijerph15020220.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Veerle Vanlerberghe principal investigator
Institute of Tropical Medicine Antwerp
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Community-based environmental management in people with Aedes-borne Diseases, run by Institute of Tropical Medicine, Belgium at 1 site in Democratic Republic of the Congo.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Democratic Republic of the Congo. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Luciana Lepore (+32(0)32476666, llepore@itg.be), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Adult mosquito collection - Entomological Indicator (time frame: Six collections in total: 1 at baseline, 4 during the intervention (one per trimester), 1 three months after completion of the intervention.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06981442, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.