Acute Heart Failure (AHF)EC/AHFNCT06982560
Electrical Cardiometry in Management of Acute Heart Failure
A study testing electrical cardiometry and traditonal methods in people with Acute Heart Failure (AHF), run by Alexandria University at 1 site in Egypt.
Trial summary
The goal of this clinical trial is to assess if electrical cardiometry (EC) could help in managing acute heart failure (AHF). The main questions it aims to answer are: 1. Is there effect of use of cardiometry on rate of use of vasopressors, vasodilators and inotropes? 2. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Acute Heart Failure (AHF)
- What is being tested?
- electrical cardiometry and traditonal methods
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2023to 31 Dec 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- acute heart failure
Who cannot join
- pregnant females, atrial fibrillation, severe valvular diseases, skin lesions in thoracic area, large pleural effusion
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Assessment and Management of Acute Heart Failure Patients Guided by Electrical Cardiometry
The goal of this clinical trial is to assess if electrical cardiometry (EC) could help in managing acute heart failure (AHF). The main questions it aims to answer are:
- Is there effect of use of cardiometry on rate of use of vasopressors, vasodilators and inotropes?
- is there effect of use of cardiometry on mortality and hospital length of stay?
Researchers compared cardiometry to traditional methods like clinical examination, lung ultrasound and inferior vena cava.
Participants were divided into two groups, one managed by cardiometry and the other by traditional methods, then followed till improvement or death and compared regarding use of medications, length of stay and mortality
Read the detailed description
The purpose of the research is to assess the role of electrical cardiometry in hemodynamic monitoring in studied cases with acute heart failure to guide treatment.
This is a prospective controlled research that involved fifty patients, diagnosed with acute heart failure and admitted to critical care units at Alexandria University Hospitals, patients were divided into 2 groups:
Group A: was assessed by traditional methods which include: clinical examination including chest auscultation and systolic blood pressure measurement, lung ultrasound and inferior vena cava assessment and managed according to the results of these parameters.
Group B: was assessed by electrical cardiometry parameters as cardiac output, thoracic fluid content (TFC) and systemic vascular resistance (SVR) and was managed as following: inotropes up and down titration according to cardiac output readings, use of vasopressors or vasodilators according to SVR readings, doses of diuretics were modified according to TFC readings.
- Conditions
- Acute Heart Failure (AHF)
- Being tested
- electrical cardiometry, traditonal methods
- Keywords
- cardiometry, acute heart failure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
electrical cardiometryDevice
use of cardiometry parameters as cardiac output, thoracic fluid content, systemic vascular resistance
traditonal methodsOther
clinical examination, lung ultrasound, inferior vena cava
| Study group | Role | What they receive |
|---|---|---|
| Group A: traditional group | Placebo comparator | traditional methods like clinical examination, lung ultrasound, inferior vena cava Receives: Other: traditonal methods |
| Group B: cardiometry group | Experimental | use of cardiometry parameters like cardiac output, thoracic fluid content and systemic vascular resistance Receives: Device: electrical cardiometry |
What is being measured
The primary outcome is the main question the study is designed to answer.
mortality and intensive care unit (ICU) length of stay
number of days in ICU and mortality in ICU
Measured: 7 days
Secondary outcomes (1)
use of vasopressors, vasodilators, inotropes
number of patients who needed these medications
Measured: 7 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 May 2025
- Study start1 Dec 2023
- Primary completion30 Nov 2024
- Study completion31 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Acute Heart Failure (AHF)Studies of the same condition, open and under way.
- More trials run by Alexandria UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Alexandria University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mohammed R Elsalamouny, MD, Principal investigator, Lecturer of Critical Care Medicine, Alexandria University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06982560
- Sponsor's protocol ID
- 0107959
- Acronym
- EC/AHF
- Status last verified
- May 2025
- First submitted
- 6 May 2025
- Last updated
- 21 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Shaheen, Mostafa Mohamed, Ahmed Said Elgebaly, Ghada Fouad Elbaradey, and Amira Mahfouz Alqablawi. 2022. "Fluid Management Using Cardiometry in ARDS Patients". Journal of Advances in Medicine and Medical Research 34 (11):21-27. https://doi.org/10.9734/jammr/2022/v34i1131360.
Paranjape VV, Henao-Guerrero N, Menciotti G, Saksena S, Agostinho M. Agreement between Electrical Cardiometry and Pulmonary Artery Thermodilution for Measuring Cardiac Output in Isoflurane-Anesthetized Dogs. Animals (Basel). 2023 Apr 21;13(8):1420. doi: 10.3390/ani13081420.
PubMed 37106987Abdou , Noura, Heba Elmahdy, Osama Tolba, Nihal Shihab, Asmaa Elmesiry, and Mohammed Rowisha. 2023. "Electrical Cardiometry Versus Echocardiography in Assessment of Hemodynamic Status in Preterm Neonates With Septic Shock". Journal of Advances in Medicine and Medical Research 35 (20):144-55. https://doi.org/10.9734/jammr/2023/v35i205184.
Liu YH, Dhakal BP, Keesakul C, Kacmarek RM, Lewis GD, Jiang Y. Continuous non-invasive cardiac output monitoring during exercise: validation of electrical cardiometry with Fick and thermodilution methods. Br J Anaesth. 2016 Jul;117(1):129-31. doi: 10.1093/bja/aew156. No abstract available.
PubMed 27317712
Study at a glance
From the registry record, last updated by the sponsor on 21 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment and Management of Acute Heart Failure Patients Guided by Electrical Cardiometry
- ClinicalTrials.gov ID
- NCT06982560
- Acronym / sponsor ID
- EC/AHF / 0107959
- Conditions
- Acute Heart Failure (AHF)
- Keywords
- cardiometry, acute heart failure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Alexandria UniversityUniversity, hospital or other
- Study start
- 1 Dec 2023 (actual)
- Primary completion
- 30 Nov 2024 (actual)
- Study completion
- 31 Dec 2024 (actual)
- First posted
- 21 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to assess if electrical cardiometry (EC) could help in managing acute heart failure (AHF). The main questions it aims to answer are:
- Is there effect of use of cardiometry on rate of use of vasopressors, vasodilators and inotropes?
- is there effect of use of cardiometry on mortality and hospital length of stay?
Researchers compared cardiometry to traditional methods like clinical examination, lung ultrasound and inferior vena cava.
Participants were divided into two groups, one managed by cardiometry and the other by traditional methods, then followed till improvement or death and compared regarding use of medications, length of stay and mortality
Detailed description
The purpose of the research is to assess the role of electrical cardiometry in hemodynamic monitoring in studied cases with acute heart failure to guide treatment.
This is a prospective controlled research that involved fifty patients, diagnosed with acute heart failure and admitted to critical care units at Alexandria University Hospitals, patients were divided into 2 groups:
Group A: was assessed by traditional methods which include: clinical examination including chest auscultation and systolic blood pressure measurement, lung ultrasound and inferior vena cava assessment and managed according to the results of these parameters.
Group B: was assessed by electrical cardiometry parameters as cardiac output, thoracic fluid content (TFC) and systemic vascular resistance (SVR) and was managed as following: inotropes up and down titration according to cardiac output readings, use of vasopressors or vasodilators according to SVR readings, doses of diuretics were modified according to TFC readings.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A: traditional group | Placebo comparator | Other: traditonal methodstraditional methods like clinical examination, lung ultrasound, inferior vena cava |
| Group B: cardiometry group | Experimental | Device: electrical cardiometryuse of cardiometry parameters like cardiac output, thoracic fluid content and systemic vascular resistance |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- acute heart failure
Key exclusion criteria (1 listed)
- pregnant females, atrial fibrillation, severe valvular diseases, skin lesions in thoracic area, large pleural effusion
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| electrical cardiometryuse of cardiometry parameters as cardiac output, thoracic fluid content, systemic vascular resistance | Device | Group B: cardiometry group |
| traditonal methodsclinical examination, lung ultrasound, inferior vena cava | Other | Group A: traditional group |
Primary outcome
mortality and intensive care unit (ICU) length of stay
Time frame: 7 days
number of days in ICU and mortality in ICU
1 secondary outcome
use of vasopressors, vasodilators, inotropes
Time frame: 7 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 May 2025.
- BackgroundShaheen, Mostafa Mohamed, Ahmed Said Elgebaly, Ghada Fouad Elbaradey, and Amira Mahfouz Alqablawi. 2022. "Fluid Management Using Cardiometry in ARDS Patients". Journal of Advances in Medicine and Medical Research 34 (11):21-27. https://doi.org/10.9734/jammr/2022/v34i1131360.
- Background: PubMed 37106987Paranjape VV, Henao-Guerrero N, Menciotti G, Saksena S, Agostinho M. Agreement between Electrical Cardiometry and Pulmonary Artery Thermodilution for Measuring Cardiac Output in Isoflurane-Anesthetized Dogs. Animals (Basel). 2023 Apr 21;13(8):1420. doi: 10.3390/ani13081420.
- BackgroundAbdou , Noura, Heba Elmahdy, Osama Tolba, Nihal Shihab, Asmaa Elmesiry, and Mohammed Rowisha. 2023. "Electrical Cardiometry Versus Echocardiography in Assessment of Hemodynamic Status in Preterm Neonates With Septic Shock". Journal of Advances in Medicine and Medical Research 35 (20):144-55. https://doi.org/10.9734/jammr/2023/v35i205184.
- Background: PubMed 27317712Liu YH, Dhakal BP, Keesakul C, Kacmarek RM, Lewis GD, Jiang Y. Continuous non-invasive cardiac output monitoring during exercise: validation of electrical cardiometry with Fick and thermodilution methods. Br J Anaesth. 2016 Jul;117(1):129-31. doi: 10.1093/bja/aew156. No abstract available.
- Information about cardiometryLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mohammed R Elsalamouny, MD principal investigator
Lecturer of Critical Care Medicine, Alexandria University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing electrical cardiometry and traditonal methods in people with Acute Heart Failure (AHF), run by Alexandria University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
mortality and intensive care unit (ICU) length of stay (time frame: 7 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06982560, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 May 2025.