Transverse Thoracic Plane BlockNCT06987110
Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block and Erector Spinae Plane Block for Analgesia in Patients Undergoing Thoracoscopic Sympathectomy
A study testing Transverse thoracic plane block, Midpoint transverse process plane to pleura block and Erector spinae plane block in people with Transverse Thoracic Plane Block and Midpoint Transverse Process Plane to Pleura Block, run by Tanta University at 1 site in Egypt.
Trial summary
This study compares the transversus thoracic muscle plane block (TTPB), midtransverse to pleura block (MTPB), and erector spinae plane block (ESPB) for postoperative analgesia in patients undergoing thoracoscopic sympathectomy. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block, Erector Spinae Plane Block
- What is being tested?
- Transverse thoracic plane block, Midpoint transverse process plane to pleura block and Erector spinae plane block
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 24 May 2025to 11 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Scheduled for thoracoscopic sympathectomy
Who cannot join
- Coagulopathy.
- History of opiate abuse.
- Pre-existing chronic pain.
- Allergy to local anesthetics or analgesics.
- Infection at the site of injection.
- Mental or neurological disorders.
- Pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Randomized Clinical Trial Comparing Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block and Erector Spinae Plane Block for Analgesia in Patients Undergoing Thoracoscopic Sympathectomy
This study compares the transversus thoracic muscle plane block (TTPB), midtransverse to pleura block (MTPB), and erector spinae plane block (ESPB) for postoperative analgesia in patients undergoing thoracoscopic sympathectomy.
Read the detailed description
Thoracoscopic sympathectomy is a well-established procedure for the treatment of various hyperhidrosis disorders and certain vascular conditions, involving the division of sympathetic nerve fibers in the thoracic cavity.
The erector spinae plane block (ESPB) is an interfascial regional anesthesia block for thoracic analgesia which can be performed by superficial or deep needle approach.
The mid-transverse to pleura block (MTPB) was first described as a modified paravertebral block.
Transversus thoracic muscle plane block (TTPB) is a newly developed technique in which LA is injected into the fascial plane between the transversus thoracic muscle and the internal intercostal muscles for blocking the anterior cutaneous branches of intercostal nerves from thoracic (Th) 2 to Th 6.
- Conditions
- Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block, Erector Spinae Plane Block, Analgesia, Thoracoscopic Sympathectomy
- Being tested
- Transverse thoracic plane block, Midpoint transverse process plane to pleura block, Erector spinae plane block
- Medical subject headings
- Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transverse thoracic plane blockOther
Patients will receive a transverse thoracic plane block.
Midpoint transverse process plane to pleura blockOther
Patients will receive a midpoint transverse process plane to pleura block.
Erector spinae plane blockOther
Patients will receive an erector spinae plane block.
| Study group | Role | What they receive |
|---|---|---|
| Transverse thoracic plane block group | Experimental | Patients will receive a transverse thoracic plane block. Receives: Other: Transverse thoracic plane block |
| Midpoint transverse process plane to pleura block group | Experimental | Patients will receive a midpoint transverse process plane to pleura block. Receives: Other: Midpoint transverse process plane to pleura block |
| Erector spinae plane block group | Experimental | Patients will receive an erector spinae plane block. Receives: Other: Erector spinae plane block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to the 1st rescue analgesia
Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated)
Measured: 24 hours postoperatively
Secondary outcomes (6)
Total morphine consumption
Rescue analgesia of morphine will be given as 3 mg bolus if the Visual Analogue Scale (VAS)> 3 to be repeated after 30 min if pain persists until the VAS < 4
Measured: 24 hours postoperatively
Degree of pain
Each patient will be instructed about postoperative pain assessment with the Visual Analogue Scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.
Measured: 24 hours postoperatively
Heart rate
Heart rate will be recorded preoperatively, before performing of block, and every 15 min till the end of surgery.
Measured: Till the end of surgery (Up to 2 hours)
Mean arterial pressure
Mean arterial pressure will be recorded preoperatively, before the block is performed, and every 15 minutes until the end of the surgery.
Measured: Till the end of surgery (Up to 2 hours)
Degree of patient satisfaction
Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied)
Measured: 24 hours postoperatively
Incidence of complications
Incidence of complications such as pneumothorax, bradycardia, hypotension, nausea, vomiting, pruritis, respiratory depression, or any other complication will be recorded.
Measured: 24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 May 2025
- Study start24 May 2025
- Primary completion11 Oct 2025
- Study completion11 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Transverse Thoracic Plane BlockStudies of the same condition, open and under way.
- More trials run by Tanta UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Abdalsattar Elmohasseb, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06987110
- Sponsor's protocol ID
- 36264PR1182/4/25.
- Status last verified
- Nov 2025
- First submitted
- 15 May 2025
- Last updated
- 25 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 25 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Clinical Trial Comparing Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block and Erector Spinae Plane Block for Analgesia in Patients Undergoing Thoracoscopic Sympathectomy
- ClinicalTrials.gov ID
- NCT06987110
- Acronym / sponsor ID
- 36264PR1182/4/25.
- Conditions
- Transverse Thoracic Plane Block, Midpoint Transverse Process Plane to Pleura Block, Erector Spinae Plane Block, Analgesia, Thoracoscopic Sympathectomy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 24 May 2025 (actual)
- Primary completion
- 11 Oct 2025 (actual)
- Study completion
- 11 Oct 2025 (actual)
- First posted
- 23 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares the transversus thoracic muscle plane block (TTPB), midtransverse to pleura block (MTPB), and erector spinae plane block (ESPB) for postoperative analgesia in patients undergoing thoracoscopic sympathectomy.
Detailed description
Thoracoscopic sympathectomy is a well-established procedure for the treatment of various hyperhidrosis disorders and certain vascular conditions, involving the division of sympathetic nerve fibers in the thoracic cavity.
The erector spinae plane block (ESPB) is an interfascial regional anesthesia block for thoracic analgesia which can be performed by superficial or deep needle approach.
The mid-transverse to pleura block (MTPB) was first described as a modified paravertebral block.
Transversus thoracic muscle plane block (TTPB) is a newly developed technique in which LA is injected into the fascial plane between the transversus thoracic muscle and the internal intercostal muscles for blocking the anterior cutaneous branches of intercostal nerves from thoracic (Th) 2 to Th 6.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Transverse thoracic plane block group | Experimental | Other: Transverse thoracic plane blockPatients will receive a transverse thoracic plane block. |
| Midpoint transverse process plane to pleura block group | Experimental | Other: Midpoint transverse process plane to pleura blockPatients will receive a midpoint transverse process plane to pleura block. |
| Erector spinae plane block group | Experimental | Other: Erector spinae plane blockPatients will receive an erector spinae plane block. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Scheduled for thoracoscopic sympathectomy
Key exclusion criteria (7 listed)
- Coagulopathy.
- History of opiate abuse.
- Pre-existing chronic pain.
- Allergy to local anesthetics or analgesics.
- Infection at the site of injection.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transverse thoracic plane blockPatients will receive a transverse thoracic plane block. | Other | Transverse thoracic plane block group |
| Midpoint transverse process plane to pleura blockPatients will receive a midpoint transverse process plane to pleura block. | Other | Midpoint transverse process plane to pleura block group |
| Erector spinae plane blockPatients will receive an erector spinae plane block. | Other | Erector spinae plane block group |
Primary outcome
Time to the 1st rescue analgesia
Time frame: 24 hours postoperatively
Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated)
6 secondary outcomes
Total morphine consumption
Time frame: 24 hours postoperatively
Degree of pain
Time frame: 24 hours postoperatively
Heart rate
Time frame: Till the end of surgery (Up to 2 hours)
Mean arterial pressure
Time frame: Till the end of surgery (Up to 2 hours)
Degree of patient satisfaction
Time frame: 24 hours postoperatively
Incidence of complications
Time frame: 24 hours postoperatively
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Nov 2025.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Related trials for Transverse Thoracic Plane Block
Recruiting
Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block
Lung Cancer
Recruiting
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
Ultrasound, Pectoral Nerve Block
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transverse thoracic plane block, Midpoint transverse process plane to pleura block and Erector spinae plane block in people with Transverse Thoracic Plane Block and Midpoint Transverse Process Plane to Pleura Block, run by Tanta University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to the 1st rescue analgesia (time frame: 24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Nov 2025.