Chronic Ankle InstabilityNCT06987435
Elasticity of Structures Around the Ankle in Chronic Ankle Instability
An observational study of Chronic Ankle Instability, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to examine the flexibility of the structures around the ankle in individuals with unilateral chronic ankle instability. Individuals between the ages of 18-45 who have been diagnosed with chronic ankle instability by an orthopedist and who have unilateral instability will be included in the… Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Chronic Ankle Instability
- How many people
- 75 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2025to 1 Sep 2025
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Adult
Study population: Individuals with Chronic Ankle Instability
Who may be able to join
- Ages 18 to 45
- Mini Mental State Exam (MMSE) score of 24 to 30
- Diagnosed with unilateral chronic ankle instability by a physician
Who cannot join
- Inability to communicate verbally
- Use of a walking aid
- Any history of lower extremity surgery
- People with severe visual impairment, neurological disorders and/or congestive heart failure.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Flexibility of Structures Around the Ankle in Individuals With Chronic Ankle Instability
The aim of this study is to examine the flexibility of the structures around the ankle in individuals with unilateral chronic ankle instability. Individuals between the ages of 18-45 who have been diagnosed with chronic ankle instability by an orthopedist and who have unilateral instability will be included in the study. The flexibility of the healthy and instability sides will be evaluated. Demographic information of the individuals will be recorded and clinical evaluations will be made. The severity of ankle instability will be evaluated with the Functional Ankle Identification (FABIT). The foot posture of the individuals participating in the study will be evaluated with the Foot Posture Index, and the degree of flat feet will be evaluated with the Navicular Drop Test. The flexibility of the gastrocnemius, tibialis anterior, peroneus longus, achilles tendon and plantar fascia of the individuals participating in the study will be measured with a myotonometer.
- Conditions
- Chronic Ankle Instability
What is being measured
The primary outcome is the main question the study is designed to answer.
Functional Ankle Identification
The Functional Ankle Identification method is a scale developed to evaluate the functional ankle instability of individuals.
Measured: Baseline
Foot Posture Index
Foot Posture Index will be applied in this study to evaluate the foot postures of the participants.
Measured: Baseline
Navicular Drop Test
The Navicular Drop Test will be administered to measure how much the participants' navicular bones have fallen.
Measured: Baseline
Myoton
Participants' gastrocnemius, tibialis anterior, peroneus longus, achilles tendon and plantar fascia flexibility will be evaluated using a myotonometer device.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 May 2025
- Study start1 Jun 2025
- Primary completion15 Aug 2025
- Study completion1 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Chronic Ankle InstabilityStudies of the same condition, open and under way.
- More trials run by Hacettepe UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 75 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Busra Seckinogullari Korkusuz, Hacettepe University
- Investigators
- Süleyman Korkusuz, PhD, Study chair, Atılım UniversityBüşra Seçkinoğulları Korkusuz, PhD, Principal investigator, Ankara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06987435
- Sponsor's protocol ID
- 604.01.02-423
- Status last verified
- May 2025
- First submitted
- 16 May 2025
- Last updated
- 26 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Tas S, Salkin Y. An investigation of the sex-related differences in the stiffness of the Achilles tendon and gastrocnemius muscle: Inter-observer reliability and inter-day repeatability and the effect of ankle joint motion. Foot (Edinb). 2019 Dec;41:44-50. doi: 10.1016/j.foot.2019.09.003. Epub 2019 Sep 29.
PubMed 31704588Rydahl SJ, Brouwer BJ. Ankle stiffness and tissue compliance in stroke survivors: a validation of Myotonometer measurements. Arch Phys Med Rehabil. 2004 Oct;85(10):1631-7. doi: 10.1016/j.apmr.2004.01.026.
PubMed 15468023Redmond AC, Crosbie J, Ouvrier RA. Development and validation of a novel rating system for scoring standing foot posture: the Foot Posture Index. Clin Biomech (Bristol). 2006 Jan;21(1):89-98. doi: 10.1016/j.clinbiomech.2005.08.002. Epub 2005 Sep 21.
PubMed 16182419Seckinogullari Korkusuz B, Korkusuz S. Silent mechanical adaptation: Passive mechanical properties of ankle-surrounding tissues in individuals with unilateral chronic ankle instability. J Back Musculoskelet Rehabil. 2026 Oct 27:10538127261500496. doi: 10.1177/10538127261500496. Online ahead of print.
PubMed 42935279
Study at a glance
From the registry record, last updated by the sponsor on 26 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Flexibility of Structures Around the Ankle in Individuals With Chronic Ankle Instability
- ClinicalTrials.gov ID
- NCT06987435
- Acronym / sponsor ID
- 604.01.02-423
- Conditions
- Chronic Ankle Instability
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 75 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 15 Aug 2025 (actual)
- Study completion
- 1 Sep 2025 (actual)
- First posted
- 23 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to examine the flexibility of the structures around the ankle in individuals with unilateral chronic ankle instability. Individuals between the ages of 18-45 who have been diagnosed with chronic ankle instability by an orthopedist and who have unilateral instability will be included in the study. The flexibility of the healthy and instability sides will be evaluated. Demographic information of the individuals will be recorded and clinical evaluations will be made. The severity of ankle instability will be evaluated with the Functional Ankle Identification (FABIT). The foot posture of the individuals participating in the study will be evaluated with the Foot Posture Index, and the degree of flat feet will be evaluated with the Navicular Drop Test. The flexibility of the gastrocnemius, tibialis anterior, peroneus longus, achilles tendon and plantar fascia of the individuals participating in the study will be measured with a myotonometer.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Day
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Age groups
- Adult
- Study population
- Individuals with Chronic Ankle Instability
Key inclusion criteria (3 listed)
- Ages 18 to 45
- Mini Mental State Exam (MMSE) score of 24 to 30
- Diagnosed with unilateral chronic ankle instability by a physician
Key exclusion criteria (4 listed)
- Inability to communicate verbally
- Use of a walking aid
- Any history of lower extremity surgery
- People with severe visual impairment, neurological disorders and/or congestive heart failure.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Functional Ankle Identification
Time frame: Baseline
The Functional Ankle Identification method is a scale developed to evaluate the functional ankle instability of individuals.
Foot Posture Index
Time frame: Baseline
Foot Posture Index will be applied in this study to evaluate the foot postures of the participants.
Navicular Drop Test
Time frame: Baseline
The Navicular Drop Test will be administered to measure how much the participants' navicular bones have fallen.
Myoton
Time frame: Baseline
Participants' gastrocnemius, tibialis anterior, peroneus longus, achilles tendon and plantar fascia flexibility will be evaluated using a myotonometer device.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Nov 2025.
- Background: PubMed 31704588Tas S, Salkin Y. An investigation of the sex-related differences in the stiffness of the Achilles tendon and gastrocnemius muscle: Inter-observer reliability and inter-day repeatability and the effect of ankle joint motion. Foot (Edinb). 2019 Dec;41:44-50. doi: 10.1016/j.foot.2019.09.003. Epub 2019 Sep 29.
- Background: PubMed 15468023Rydahl SJ, Brouwer BJ. Ankle stiffness and tissue compliance in stroke survivors: a validation of Myotonometer measurements. Arch Phys Med Rehabil. 2004 Oct;85(10):1631-7. doi: 10.1016/j.apmr.2004.01.026.
- Background: PubMed 16182419Redmond AC, Crosbie J, Ouvrier RA. Development and validation of a novel rating system for scoring standing foot posture: the Foot Posture Index. Clin Biomech (Bristol). 2006 Jan;21(1):89-98. doi: 10.1016/j.clinbiomech.2005.08.002. Epub 2005 Sep 21.
- Derived from this study: PubMed 42935279Seckinogullari Korkusuz B, Korkusuz S. Silent mechanical adaptation: Passive mechanical properties of ankle-surrounding tissues in individuals with unilateral chronic ankle instability. J Back Musculoskelet Rehabil. 2026 Oct 27:10538127261500496. doi: 10.1177/10538127261500496. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Süleyman Korkusuz, PhD study chair
Atılım University
Büşra Seçkinoğulları Korkusuz, PhD principal investigator
Ankara University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Ankle Instability, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Functional Ankle Identification (time frame: Baseline). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06987435, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Nov 2025.