Periodontal Intrabony DefectInfra-MINSTNCT06992219
Impact of Minimally Invasive Non-surgical Periodontal Treatment on Infrabony Defects
A study testing Non surgical periodontal treatment evaluated through probing pocket depth reduction in people with Periodontal Intrabony Defect, run by University of Catania at 1 site in Italy.
Trial summary
Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Periodontal Intrabony Defect
- What is being tested?
- Non surgical periodontal treatment evaluated through probing pocket depth reduction
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteItaly
- Study dates
- 1 Oct 2022to 30 Nov 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of Periodontitis
Who cannot join
- Periodontal treatment
- Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
- Pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Infrabony Defects and Analysis of Defect Morphology on the Effectiveness of Treatment
Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols.
Read the detailed description
Clinical periodontal parameters, the number of pocket sites, x-ray of the infrabony defects characteristics and a composite outcome measure (COM) on the combined assessment of intrabony defect were recorded at baseline, and -3, 6- and at 12-months after treatment
- Conditions
- Periodontal Intrabony Defect
- Being tested
- Non surgical periodontal treatment evaluated through probing pocket depth reduction
- Keywords
- periodontitis
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non surgical periodontal treatment evaluated through probing pocket depth reductionOther
Patients were treated with Minimally invasive non surgical treatment (MINST) or quadrant-subgingival instrumentation (Q-SI). The efficacy of treatment in both groups was evaluated through Probin Pocket Depth reduction in millimetres measurement before and after treatment.
| Study group | Role | What they receive |
|---|---|---|
| MINST non surgical periodontal treatment | Experimental | MINST non surgical periodontal treatment Periodontitis patients treated by means of MINST for infrabony defects. Patients were treated with non-surgical MINST periodontal treatment in a single session. Receives: Other: Non surgical periodontal treatment evaluated through probing pocket depth reduction |
| Q-SI non surgical periodontal treatment | Active comparator | Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week. Receives: Other: Non surgical periodontal treatment evaluated through probing pocket depth reduction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probing Pocket Depth Reduction
Probing Pocket Depth Reduction in Probing Pocket Depth after treatment
Measured: 1-year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 May 2025
- Study start1 Oct 2022
- Primary completion30 Nov 2024
- Study completion30 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontal Intrabony DefectStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for infrabony defects
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Catania
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gaetano Isola, University of Catania
- Investigators
- Gaetano Isola, DDS, Principal investigator, Università degli Studi di Catania
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06992219
- Sponsor's protocol ID
- 2024-3308
- Acronym
- Infra-MINST
- Status last verified
- May 2025
- First submitted
- 18 May 2025
- Last updated
- 28 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Study results
Study at a glance
From the registry record, last updated by the sponsor on 28 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Infrabony Defects and Analysis of Defect Morphology on the Effectiveness of Treatment
- ClinicalTrials.gov ID
- NCT06992219
- Acronym / sponsor ID
- Infra-MINST / 2024-3308
- Conditions
- Periodontal Intrabony Defect
- Keywords
- periodontitis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- University of CataniaUniversity, hospital or other
- Study start
- 1 Oct 2022 (actual)
- Primary completion
- 30 Nov 2024 (actual)
- Study completion
- 30 Nov 2024 (actual)
- First posted
- 28 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols.
Detailed description
Clinical periodontal parameters, the number of pocket sites, x-ray of the infrabony defects characteristics and a composite outcome measure (COM) on the combined assessment of intrabony defect were recorded at baseline, and -3, 6- and at 12-months after treatment
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for infrabony defects
| Arm | Type | Receives |
|---|---|---|
| MINST non surgical periodontal treatment | Experimental | Other: Non surgical periodontal treatment evaluated through probing pocket depth reductionMINST non surgical periodontal treatment Periodontitis patients treated by means of MINST for infrabony defects. Patients were treated with non-surgical MINST periodontal treatment in a single session. |
| Q-SI non surgical periodontal treatment | Active comparator | Other: Non surgical periodontal treatment evaluated through probing pocket depth reductionPeriodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Diagnosis of Periodontitis
Key exclusion criteria (3 listed)
- Periodontal treatment
- Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non surgical periodontal treatment evaluated through probing pocket depth reductionPatients were treated with Minimally invasive non surgical treatment (MINST) or quadrant-subgingival instrumentation (Q-SI). The efficacy of treatment in both groups was evaluated through Probin Pocket Depth reduction in millimetres measurement before and after treatment. | Other | MINST non surgical periodontal treatment, Q-SI non surgical periodontal treatment |
Primary outcome
Probing Pocket Depth Reduction
Time frame: 1-year
Probing Pocket Depth Reduction in Probing Pocket Depth after treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 May 2025.
- Individual participant dataSharing planned: Undecided. Study results
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gaetano Isola, DDS principal investigator
Università degli Studi di Catania
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Non surgical periodontal treatment evaluated through probing pocket depth reduction in people with Periodontal Intrabony Defect, run by University of Catania at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probing Pocket Depth Reduction (time frame: 1-year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2025.