Effects of Breathing Therapy and Benson Relaxation Technique on Caregivers of Alzheimer's Patients

The intervention in this study consists of two evidence-based non-pharmacological techniques: the 4-7-8 relaxing breathing technique and the Benson Relaxation Technique. These methods were delivered in a structured format over six weeks to support caregivers of individuals diagnosed with Alzheimer's disease. The 4-7-8 breathing technique is a rhythmic breathing practice designed to induce physiological calm by modulating the autonomic nervous system. The specific procedure followed was:

• Participants were seated comfortably with a straight posture and used provided eye masks to minimize visual distractions.
• The tongue was placed behind the upper front teeth and maintained in this position throughout the exercise.
• A full exhalation was performed through the mouth while producing a soft whooshing sound.
• This was followed by a quiet nasal inhalation for 4 seconds, breath-holding for 7 seconds, and a controlled exhalation through the mouth over 8 seconds.
• This cycle was repeated approximately three times per minute, totaling 30 cycles in a 10-minute session.

The Benson Relaxation Technique, widely used in mind-body therapy, aims to elicit the relaxation response through passive focus and muscular relaxation. The steps included:

• Selecting a personal word or phrase (e.g., "peace," "health," "love") to silently repeat during exhalation.
• Sitting quietly with eyes closed, participants gradually relaxed all major muscle groups from feet to head.
• While breathing naturally, they repeated the chosen word silently on each exhalation.
• A passive attitude was encouraged; distracting thoughts were acknowledged and released without judgment, redirecting attention to the breath and word.
• Sessions concluded with a quiet reorientation period before standing. Inclusion criteria: Adults aged 18-65 who were the primary caregivers of individuals diagnosed with Alzheimer's disease for at least six months; at least primary school graduates; cognitively and physically able to perform the exercises and complete forms; and provided informed consent.

Exclusion criteria: Individuals with psychological disorders (e.g., anxiety, depression), advanced cardiac, pulmonary (e.g., COPD, asthma), or oncological conditions; communication impairments (vision, hearing, or speech); those undergoing hospitalization or surgery during the study period; or those already engaged in other structured relaxation methods such as yoga or meditation.

Rationale: Caregivers of Alzheimer's patients frequently experience chronic stress and burden, leading to emotional exhaustion, physical health issues, and reduced quality of life. Breathing-based and meditative interventions offer accessible, cost-effective strategies to counteract these effects and improve psychological resilience.

Study Design Notes:

• This is a randomized, controlled.
• Participants were assigned to groups using a computer-based randomization tool.
• All sessions were held face-to-face in groups of ≤10 participants, and all interventions were delivered by the same researcher to ensure standardization.

This structured intervention model was designed to provide both physiological relaxation (via controlled breathing) and psychological relief (via cognitive disengagement and passive awareness), aiming to support caregiver well-being through an integrative mind-body approach.

Statistical Analysis: Data were analyzed using SPSS version 23.0. Groups were anonymized as "A" and "B". Normality was evaluated via Shapiro-Wilk test, skewness-kurtosis values, and Q-Q plots. Parametric tests (Student's t-test, paired samples t-test, ANOVA) were used for normally distributed data, while non-parametric tests (Mann-Whitney U, Friedman) were applied otherwise. Categorical variables were analyzed using chi-square tests. Descriptive statistics included means ± SD or medians (min-max). Cronbach's alpha was calculated for scale reliability. A p-value <0.05 was considered statistically significant.

This study received ethical approval from the Hacettepe University Clinical Research Ethics Committee under approval numbers 2024/12-01 and 2024/23-11, dated June 26, 2024, and December 3, 2024, respectively. Additionally, regulatory approval was obtained from the Turkey Medicines and Medical Devices Agency with decision number E-85521274-000-3587573 dated January 16, 2025. All participants provided written informed consent prior to participation. Confidentiality and data security were strictly maintained throughout the study to protect participant privacy.