Caffeine and Resistance ExerciseCAF+RE+OxyNCT07001176

Caffeine, Resistance Exercise and Muscle/Cerebral Oxygenation

A study testing Caffeine in people with Caffeine and Resistance Exercise, run by University of Alcala at 1 site in Spain.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, the mechanism responsible for this ergogenic effect remains to be elucidated. Read more about this study

Who is it for?: Ages 18 to 35 years, men onlyHealthy volunteers can take part
Conditions the study is for: Caffeine and Resistance Exercise
What is being tested?: Caffeine
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 12 participants
Where: 1 siteSpain
Study dates: 1 Jan 2024to 23 Dec 2024
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 35 years
Men only
Healthy volunteers accepted
Adult

Who may be able to join

Age between 18 and 35 years.
Body Mass Index (BMI) \< 25 kg/m².
Resistance-trained individuals (more than 2 years of structured training).
Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
Participants must be able to perform the tests described in the following section.

Who cannot join

History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
Sedentary habits (less than 150 minutes/week of moderate exercise).
Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
Engaging in strenuous exercise within 48 hours prior to the tests.
Failure to replicate the same food intake on both experimental days.
Consumption of caffeine or any other stimulant after 6 pm on the day before the tests, to avoid headaches, discomfort, or lethargy in regular caffeine consumers.

Trial locations and contacts

1 site in 1 country.

Spain1 site

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
Alcalá de Henares, Madrid

Other trials in Spain

About this study

Official title: Effect of Acute Caffeine Intake on Muscle and Cerebral Oxygenation During Muscular Strength, Power, and Endurance Performance

Objectives: This study aims to evaluate the acute effects of caffeine intake on muscle and cerebral oxygen during muscular strength, power, muscle endurance performance. and muscle electrical activity in young adults.

Conditions: Caffeine and Resistance Exercise
Being tested: Caffeine, Placebo

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

CaffeineDietary supplement
Acute caffeine intake (3 mg/kg)
PlaceboDietary supplement
Acute placebo intake (3 mg/kg)

Study groups in NCT07001176
Study group	Role	What they receive
Caffeine	Experimental	Acute caffeine intake (3 mg/kg) Receives: Dietary Supplement: Caffeine
Placebo	Placebo comparator	Acute placebo intake Receives: Dietary Supplement: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

Muscle Oxygenation
Measuring oxygen in the muscle before and after exercise.
Measured: Through study completion, an average of 2 weeks
Cerebral oxygenation
Measuring cerebral oxygenation before and after exercise.
Measured: Through study completion, an average of 2 weeks
Number of repetitions performed in 1 set at 65%1RM until task failure
Measured: Through study completion, an average of 2 weeks
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
In bench press and back squat exercises
Measured: Through study completion, an average of 2 weeks
Power output generated in 1 set at 65%1RM until task failure
In bench press and back squat exercise
Measured: Through study completion, an average of 2 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Jan 202423 Dec 2024

First posted3 Jun 2025
Study start1 Jan 2024
Primary completion23 Dec 2024
Study completion23 Dec 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Caffeine and Resistance ExerciseStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Other
Allocation: Randomised
Intervention model: Crossover
Masking: Double blind
Who is masked: Participant, Investigator
Enrolment: 12 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07001176
Sponsor's protocol ID: CEID/2023/3/070
Acronym: CAF+RE+Oxy
Status last verified: May 2025
First submitted: 23 May 2025
Last updated: 3 Jun 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Yes

Study at a glance

From the registry record, last updated by the sponsor on 3 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Effect of Acute Caffeine Intake on Muscle and Cerebral Oxygenation During Muscular Strength, Power, and Endurance Performance
ClinicalTrials.gov ID: NCT07001176
Acronym / sponsor ID: CAF+RE+Oxy / CEID/2023/3/070
Conditions: Caffeine and Resistance Exercise
Study type: Interventional
Recruitment status: Completed
Enrolment: 12 participants (actual)
Lead sponsor: University of AlcalaUniversity, hospital or other
Study start: 1 Jan 2024 (actual)
Primary completion: 23 Dec 2024 (actual)
Study completion: 23 Dec 2024 (actual)
First posted: 3 Jun 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Other
Allocation: Randomised
Intervention model: Crossover
Masking: Double blind (participant, investigator)
Number of arms: 2

Arm	Type	Receives
Caffeine	Experimental	Dietary Supplement: CaffeineAcute caffeine intake (3 mg/kg)
Placebo	Placebo comparator	Dietary Supplement: PlaceboAcute placebo intake

Who may qualify

Ages: 18 to 35 years
Sex: Male only
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (5 listed)

Age between 18 and 35 years.
Body Mass Index (BMI) \< 25 kg/m².
Resistance-trained individuals (more than 2 years of structured training).
Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
Participants must be able to perform the tests described in the following section.

Key exclusion criteria (7 listed)

History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
Sedentary habits (less than 150 minutes/week of moderate exercise).
Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
Engaging in strenuous exercise within 48 hours prior to the tests.

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
CaffeineAcute caffeine intake (3 mg/kg)	Dietary supplement	Caffeine
PlaceboAcute placebo intake (3 mg/kg)	Dietary supplement	Placebo

Primary outcome

Muscle Oxygenation
Time frame: Through study completion, an average of 2 weeks
Measuring oxygen in the muscle before and after exercise.
Cerebral oxygenation
Time frame: Through study completion, an average of 2 weeks
Measuring cerebral oxygenation before and after exercise.
Number of repetitions performed in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 2 weeks
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 2 weeks
In bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 2 weeks
In bench press and back squat exercise

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2025.
Individual participant dataSharing planned: Yes

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Caffeine in people with Caffeine and Resistance Exercise, run by University of Alcala at 1 site in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Muscle Oxygenation (time frame: Through study completion, an average of 2 weeks). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07001176.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2025.