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Postoperative PeriodNCT07001670

Investigation of the Effects of Tele-Yoga Training in Individuals With Lung Cancer Undergoing Lung Resection Surgery

A study testing Tele-Yoga Training in people with Postoperative Period and Lung Cancer (Diagnosis), run by Istanbul University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This randomized controlled clinical trial aims to evaluate the effects of an 8-week tele-yoga intervention in individuals with lung cancer who have undergone lung resection surgery. Read more about this study

Who is it for?
Ages 18 to 65 years
Conditions the study is for
Postoperative Period, Lung Cancer (Diagnosis)
What is being tested?
Tele-Yoga Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
1 siteTurkey (Türkiye)
Study dates
10 Jun 2025to 10 Sep 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Aged between 18 and 65 years,
  • Histologically confirmed diagnosis of Stage I-IIIA lung cancer according to the 9th edition of the AJCC Cancer Staging Manual,
  • Underwent lobectomy, pneumonectomy, segmentectomy, or wedge resection via video-assisted thoracoscopic surgery (VATS) or robot-assisted thoracoscopic surgery (RATS),
  • An estimated life expectancy of ≥6 months,
  • Karnofsky Performance Status score greater than 80% at study entry,
  • Possession of the necessary equipment and access to a stable internet connection to enable participation in online interventions.

Who cannot join

  • History of receiving radiotherapy or chemotherapy prior to surgery,
  • Presence of severe dysfunction in vital organs such as the heart, brain, kidneys, or others,
  • Having any comorbid condition that contraindicates participation in an exercise training program,
  • Presence of serious postoperative complications,
  • Cognitive impairments that hinder effective communication,
  • Current participation in a structured and regular exercise program,
  • Missing three consecutive weeks of sessions or completing less than 75% of the prescribed exercises,
  • Voluntary withdrawal from the study by the participant.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Department of Thoracic Surgery, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa

    Istanbul

Other trials in Turkey (Türkiye)

About this study

Official title: The Effects of an 8-Week Tele-Yoga Program on Postoperative Recovery in Patients With Lung Cancer Undergoing Lung Resection

This randomized controlled clinical trial aims to evaluate the effects of an 8-week tele-yoga intervention in individuals with lung cancer who have undergone lung resection surgery. The intervention group will receive supervised yoga sessions via online synchronous video conferencing, while the control group will continue with standard post-operative care. The primary outcome is exercise capacity (6-minute walk test), with secondary outcomes including pulmonary function, respiratory and peripheral muscle strength, physical activity level, dyspnea, fatigue, sleep quality, anxiety and depression, and quality of life. It is hypothesized that tele-yoga will improve physical and psychological recovery post-surgery and may serve as a feasible home-based pulmonary rehabilitation alternative.

Read the detailed description

Lung carcinoma, also referred to as pulmonary carcinoma, is a malignant tumor characterized by uncontrolled cell proliferation in the lung tissue, originating from epithelial cells. It is the most commonly diagnosed cancer type globally. Histopathologically, lung cancer is classified into two main categories: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC constitutes approximately 85% of all lung cancer cases and is associated with high morbidity and mortality. According to the Tumor-Node-Metastasis (TNM) staging system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC), NSCLC is staged from I to IV. While SCLC has a lower prognostic value within the TNM system and is rarely operable, NSCLC is typically treated surgically in early stages.

Surgical treatment for early state of lung cancer includes lobectomy, pneumonectomy, segmentectomy, or wedge resection, depending on tumor location, lung function, and disease stage. The most commonly employed surgical approaches are thoracotomy, video-assisted thoracoscopic surgery (VATS), and robot-assisted thoracoscopic surgery (RATS). Although techniques such as VATS are associated with less postoperative pain, faster recovery, and better preservation of pulmonary function compared to thoracotomy, surgery still significantly reduces exercise capacity and contributes to long-term physical and psychological limitations.

Following lung resection, patients often experience a decline in exercise capacity, attributed to loss of lung parenchyma, ventilatory limitations, increased cardiac workload, thoracic pain, and muscle weakness. Dyspnea is prevalent in up to 60% of postoperative patients, many of whom did not experience dyspnea prior to surgery. Additionally, adjuvant chemotherapy and/or radiotherapy may cause pulmonary inflammation and fibrosis, further reducing lung function and quality of life. Sleep disturbances and psychological disorders such as anxiety and depression are also common during this period.

Exercise training is a non-pharmacological intervention that improves immune function and quality of life in cancer patients; however, traditional pulmonary rehabilitation programs are often underutilized postoperatively. There is increasing interest in mind-body exercise (MBE) modalities such as yoga, tai chi, and qigong, which integrate physical postures, breath control, and meditation. Among these, yoga has shown potential to improve exercise capacity, pulmonary function, muscle strength, fatigue, anxiety, depression, and sleep quality. Despite promising findings, there is a lack of evidence regarding the efficacy of structured yoga interventions specifically tailored for lung cancer patients post-surgery.

Furthermore, the transition from hospital to home poses challenges in ensuring the continuity and accessibility of rehabilitation services. Telehealth, defined as the provision of healthcare services via digital communication technologies, has emerged as a feasible platform for delivering home-based interventions. Tele-yoga, a form of remote supervised yoga practice, has shown benefits in various populations, including those with chronic obstructive pulmonary disease (COPD), heart failure, sleep apnea, and ankylosing spondylitis. However, no study has yet examined its application in post-surgical lung cancer patients.

Based on this gap in the literature, the present study aims to investigate the effects of an 8-week synchronized tele-yoga intervention on exercise capacity, pulmonary function, respiratory and peripheral muscle strength, physical activity level, dyspnea, fatigue, sleep quality, anxiety, depression, and health-related quality of life in patients who have undergone lung resection surgery for lung cancer. This will be the first randomized controlled trial to assess a comprehensive yoga-based telerehabilitation approach in this population. The findings may provide a cost-effective and practical home-based rehabilitation strategy to enhance physical and psychological recovery in lung cancer survivors.

Being tested
Tele-Yoga Training
Keywords
Exercise capacity, Pulmonary function, Muscle Strength, Dyspnea, Fatigue, Anxiety, Depression, Quality of Life, Exercise Therapy, Telemedicine, Rehabilitation
Medical subject headings
Lung Neoplasms, Disease, Dyspnea, Fatigue, Anxiety Disorders, Depression

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Tele-Yoga TrainingOther

    The Tele-yoga group will participate in real-time yoga sessions three times a week for eight weeks, including individual sessions for the first two weeks and small group sessions for the remaining six weeks, with all sessions supervised by a certified instructor. Each session will last approximately 45-60 minutes and include a 5-10 minute warm-up, 15-20 minutes of yoga postures, 15-20 minutes of yogic breathing exercises, and 5-10 minutes of relaxation and meditation.

Study groups in NCT07001670
Study groupRoleWhat they receive
Tele-Yoga GroupExperimentalParticipants in this arm will receive an 8-week supervised tele-yoga program delivered via real-time video conferencing.
Receives: Other: Tele-Yoga Training
Control GroupNo interventionThe control group continued to receive standard postoperative care without any additional exercise intervention.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. The Six-Minute Walk Test (6MWT)

    Distance walked in six minutes will be recorded. Test will be conducted according to the guideline of American Thoracic Society. Functional exercise capacity will be evaluated with the six-minute walk test. Patients will be walked in a 30-meter-long corridor for 6 minutes and the maximum walking distance will be measured. Before and after the test, heart rate, blood pressure and O2 saturation will be measured with pulse oximetry, and dyspnea and fatigue levels will be determined according to the Modified Borg scale.

    Measured: Change from Baseline at 8 weeks

Secondary outcomes (12)
  1. Incremental Shuttle Walk Test (ISWT)

    The Incremental Shuttle Walk Test (ISWT) The Incremental Shuttle Walk Test adapted for chronic obstructive pulmonary disease (COPD) patients consists of 12 levels with progressively increasing walking speeds over a 10-meter course. The participant walks between two cones in response to auditory beeps from a laptop. The test continues until the participant is unable to maintain the required pace due to breathlessness or fatigue. The number of shuttles completed and total distance walked are recorded. VO₂max is calculated using the formula: VO₂max (ml/min/kg) = 4.19 + (0.025 × distance).

    Measured: Change from Baseline at 8 weeks

  2. 6-Minute Pegboard and Ring Test (6PBRT)

    The 6PBRT evaluates upper extremity functional capacity by requiring participants to transfer rings from lower to upper pegs and back for 6 minutes. Participants may rest as needed, and the score is the total number of rings moved.

    Measured: Change from Baseline at 8 weeks

  3. Pulmonary Function Tests (PFT)

    Pulmonary function tests will be conducted using a portable spirometer, following the American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria.

    Measured: Change from Baseline at 8 weeks

  4. Respiratory Muscle Strength Test (MIP/MEP)

    Using a portable electronic oral pressure measurement device, maximal inspiratory pressure (MIP) and expiratory pressure (MEP) are measured per ATS/ERS recommendations. The highest value from three reproducible efforts is recorded in centimetres of water (cmH2O) and as a percentage of the expected value.

    Measured: Change from Baseline at 8 weeks

  5. Peripheral Muscle Strength (Handgrip Strength Test)

    Handgrip strength is measured using a dynamometer. Participants perform three trials with each hand, and the highest score is recorded in kg.

    Measured: Change from Baseline at 8 weeks

  6. Physical Activity Level (IPAQ-SF)

    Physical activity level is assessed using the Turkish-validated version of the International Physical Activity Questionnaire - Short Form (IPAQ-SF). This self-reported questionnaire evaluates physical activity performed in the last 7 days across different intensity levels (walking, moderate, and vigorous activity). Results are expressed in Metabolic Equivalent of Task (MET)-minutes/week.

    Scores range from 0 to an open-ended maximum depending on the amount and intensity of physical activity reported.

    Higher scores indicate a better outcome, reflecting a higher level of physical activity.

    Measured: Change from Baseline at 8 weeks

  7. Dyspnea Assessment (Cancer Dyspnea Scale - CDS)

    Dyspnea severity is measured using the validated Turkish version of the Cancer Dyspnea Scale (CDS). This self-reported scale evaluates dyspnea in cancer patients through three subscales: effort, discomfort, and anxiety related to breathing.

    The total CDS score ranges from 0 to 27, with each subscale consisting of items rated on a 4-point Likert scale (0-3).

    Higher scores indicate worse outcomes, reflecting greater severity of dyspnea and its associated components.

    Measured: Change from Baseline at 8 weeks

  8. Fatigue Assessment (Fatigue Severity Scale - FSS)

    Fatigue is assessed using the 9-item Fatigue Severity Scale, scored on a 7-point Likert scale. A mean score ≥4 indicates severe fatigue.

    Measured: Change from Baseline at 8 weeks

  9. Sleep Quality (Pittsburgh Sleep Quality Index - PSQI)

    Sleep quality is measured using the Pittsburgh Sleep Quality Index (PSQI), a validated self-reported questionnaire that assesses sleep quality over the past month. It includes seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction.

    The total PSQI score ranges from 0 to 21. Higher scores indicate worse sleep quality, with a score greater than 5 suggesting poor sleep quality.

    Measured: Change from Baseline at 8 weeks

  10. Anxiety and Depression (Hospital Anxiety and Depression Scale - HADS)

    Anxiety and depression are assessed using the HADS, with subscale cutoff scores of 10 for anxiety and 7 for depression.

    Measured: Change from Baseline at 8 weeks

  11. Quality of Life (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30):

    Cancer-specific quality of life is assessed using the validated Turkish version of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30). This instrument includes functional subscales (physical, role, emotional, cognitive, and social functioning), symptom subscales (e.g., fatigue, pain, nausea/vomiting), and a global health status/quality of life scale.

    Each item is scored on a Likert-type scale, and scores are linearly transformed to a 0-100 scale according to the EORTC scoring manual.

    For functional and global health status subscales, higher scores indicate better quality of life.

    For symptom subscales, higher scores indicate worse symptom burden.

    Measured: Change from Baseline at 8 weeks

  12. Verbal Feedback

    At the end of the 8-week intervention, participants in the intervention group will be asked to provide verbal feedback regarding safety, satisfaction, challenging poses, pros and cons of online sessions, and perceived effects of yoga.

    Measured: Post-intervention (Week 8)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Jun 2025
  2. Study start10 Jun 2025
  3. Primary completion10 Sep 2026
  4. Study completion10 Sep 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
40 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07001670
Sponsor's protocol ID
IUC-FTR-RK-01
Status last verified
Oct 2026
First submitted
23 May 2025
Last updated
21 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Tele-Yoga Training in people with Postoperative Period and Lung Cancer (Diagnosis), run by Istanbul University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

The Six-Minute Walk Test (6MWT) (time frame: Change from Baseline at 8 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.

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