Relapsing-remitting Multiple SclerosisNCT07002151
Educational Kinesiology Program's Effect on Cognition, Manual Dexterity and Bimanual Coordination in MS Patients
A study testing educational kinesiology training program intervention for study group in people with Relapsing-remitting Multiple Sclerosis, run by Cairo University at 1 site in Egypt.
Trial summary
the purpose of this study was to evaluate the usefulness of educational kinesiology program to improve cognitive impairement, manual dexterity and bimanual coordination in patients with relapsing remitting multiple sclerosis. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Relapsing-remitting Multiple Sclerosis
- What is being tested?
- educational kinesiology training program intervention for study group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Jan 2024to 10 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Male or female aged from 18-50 years.
- Patients with relapsing remitting MS (RRMS).
- EDSS scores for (RRMS) is ranging from 2.5 to 5.5 with a pyramid function score less than 2.
- Gave their oral and written consent to participate in the training.
- Adequate vision and hearing for completion of the study protocol, as indicated by the ability to follow written and oral instructions during screening.
- Stable medical condition.
Who cannot join
- Patients with communication problems.
- Patients with a history of previous neurologic diseases or disorders.
- Patients with other types of MS.
- In co-operative patients.
- Unhealed fracture, contracture, pressure sores that might interfere with training.
- Untreated psychiatric disorders or ongoing drug abuse.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Educational Kinesiology Program on Cognition, Manual Dexterity and Bimanual Coordination in Patients With Multiple Sclerosis
the purpose of this study was to evaluate the usefulness of educational kinesiology program to improve cognitive impairement, manual dexterity and bimanual coordination in patients with relapsing remitting multiple sclerosis. the study evaluated some domain of cognition as (attention \& concentration, figural memory, reaction behavior and logical reasoning) manual dexterity and bimanual coordination were also evaluated of individuals with multiple sclerosis who went through the traditional as compared to others who used educational kinesiology training as part of their therapy.
Read the detailed description
Multiple sclerosis (MS) is a chronic non-curative immune inflammatory demyelinating disease mainly affects the Central Nervous System. Cognitive deficits are common in MS and affect patients at all stages of the disease-including the early stage. There was a negative correlation between the employment of MS patients and their cognitive impairment assessed by information processing speed, memory, and executive function. Currently, the recommended treatments for cognitive dysfunction and depression in people with MS are cognitive retraining and cognitive behavioural therapy, respectively. Both of these approaches are time-consuming and are often unavailable away from major treatment centres. The common clinical signs of the disease include motor and sensory deficits, cerebellar symptoms, fatigue, and/or vision problems, which can impact manipulative dexterity in 76% of the population with MS. Often, patients also present bilateral impairments.Educational kinesiology program is the original 26 movements. The movements which are naturally done during the first years of life when learning coordinated the eyes, ears, hands and whole body are recalled by these activities. The principle behind Educational kinesiology program is that moving with intention leads to optimal learning. Educational kinesiology program has a beneficial effect on cognitive function and combines movement of the feet, hands in the optimization of left and right brain functions so as to improve cognitive function that were damaged or decrease.
- Conditions
- Relapsing-remitting Multiple Sclerosis
- Being tested
- educational kinesiology training program intervention for study group, conventional upper extremities coordination training for both arms experimental and comparator (study and control) groups
- Keywords
- RRMS, cognitive impairment, manual dexterity, bimanual coordination, educational kinesiology program
- Medical subject headings
- Multiple Sclerosis, Relapsing-Remitting, Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
educational kinesiology training program intervention for study groupOther
Also called brain gym exercises
The Educational kinesiology program were included : (Cross crawl) Sit or stand and with the right-hand elbow touch the left knee and vice versa. (The owl) Bring one hand up to the opposite shoulder and hold a pinch around the trapezius muscle between the neck and shoulder. the thumb should be on one side of the muscle and the other fingers clasping around the other side. Turn the head to the same side as thehand is gripping and take a deep breath. Slowly exhale as bringing the head gently around to the other side. Repeat this movement one more time. (The arm activation) Hold one arm next to the ear. Exhale gently while activating the muscles by pushing the arm against the other hand in four directions (front, back, in and away). (The Energizer) Place the head on the desk in front exhale and inhale while coming up and try to hyperextend the neck carefully. (cook's hook-up) put the left ankle over your right knee. Next, hook the right hand around the left ankle.
conventional upper extremities coordination training for both arms experimental and comparator (study and control) groupsOther
Bimanual coordination,Hand-arm coordination ,Drinking \& Strength training
| Study group | Role | What they receive |
|---|---|---|
| study group | Experimental | experimental arm was recieved educational kinesiology program and conventional upper extremity coordination exercises as intervention.Respondents were explained about the Educational kinesiology program.by the therapist. The exercise program was given three times weekly for four weeks. Duration of the session was15 min ), the patients did 5 exercises, each exercise was done for 3 minutes,when patient felt fatigue during performing the exercise he or she stopped then continued after relaxation till reaching 3 min for each one . All exercises were done from sitting position. Receives: Other: educational kinesiology training program intervention for study group; Other: conventional upper extremities coordination training for both arms experimental and comparator (study and control) groups |
| control group | Active comparator | received conventional physical therapy program in form of upper extremities coordination training Receives: Other: conventional upper extremities coordination training for both arms experimental and comparator (study and control) groups |
What is being measured
The primary outcome is the main question the study is designed to answer.
cognition
the rate of improvement in cognition assessed by Rehacom system V 6.10.2.0 software.
Measured: baseline assessment and after 12 sessions of educational kinesiology program training and conventional upper extremity coordination exercise training 3 sessions per week for 4 weaks
Secondary outcomes (1)
manual dexterity and bimanual coordination
manual dexterity and bimanual coordination were assessed by purdue pegboard test model 32107 for purdue pegboard model 32020. assessed the rate of improvement in manual dexterity and bimanual coordination.
Measured: baseline assessment and after 12 sessions of educational kinesiology training and conventional upper extremities coordination exercises training 3 sessions per week for 4 weaks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2025
- Study start10 Jan 2024
- Primary completion10 May 2025
- Study completion10 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Relapsing-remitting Multiple SclerosisStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- randomized control trial
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, mona abo-elabbas ahmed, Cairo University
- Investigators
- eman s fayez, doctorate, Study director
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07002151
- Sponsor's protocol ID
- effect of EKP on cognition
- Status last verified
- May 2025
- First submitted
- 18 May 2025
- Last updated
- 3 Jun 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Alharthi HM, Almurdi MM. Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study. Eur J Med Res. 2023 Mar 2;28(1):110. doi: 10.1186/s40001-023-01079-6.
PubMed 36864515Lyle KB, Dombroski BA, Faul L, Hopkins RF, Naaz F, Switala AE, Depue BE. Bimanual coordination positively predicts episodic memory: A combined behavioral and MRI investigation. Brain Cogn. 2017 Nov;118:71-79. doi: 10.1016/j.bandc.2017.07.009. Epub 2017 Aug 9.
PubMed 28800429
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Educational Kinesiology Program on Cognition, Manual Dexterity and Bimanual Coordination in Patients With Multiple Sclerosis
- ClinicalTrials.gov ID
- NCT07002151
- Acronym / sponsor ID
- effect of EKP on cognition
- Conditions
- Relapsing-remitting Multiple Sclerosis
- Keywords
- RRMS, cognitive impairment, manual dexterity, bimanual coordination, educational kinesiology program
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 10 Jan 2024 (actual)
- Primary completion
- 10 May 2025 (actual)
- Study completion
- 10 May 2025 (actual)
- First posted
- 3 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the purpose of this study was to evaluate the usefulness of educational kinesiology program to improve cognitive impairement, manual dexterity and bimanual coordination in patients with relapsing remitting multiple sclerosis. the study evaluated some domain of cognition as (attention \& concentration, figural memory, reaction behavior and logical reasoning) manual dexterity and bimanual coordination were also evaluated of individuals with multiple sclerosis who went through the traditional as compared to others who used educational kinesiology training as part of their therapy.
Detailed description
Multiple sclerosis (MS) is a chronic non-curative immune inflammatory demyelinating disease mainly affects the Central Nervous System. Cognitive deficits are common in MS and affect patients at all stages of the disease-including the early stage. There was a negative correlation between the employment of MS patients and their cognitive impairment assessed by information processing speed, memory, and executive function. Currently, the recommended treatments for cognitive dysfunction and depression in people with MS are cognitive retraining and cognitive behavioural therapy, respectively. Both of these approaches are time-consuming and are often unavailable away from major treatment centres. The common clinical signs of the disease include motor and sensory deficits, cerebellar symptoms, fatigue, and/or vision problems, which can impact manipulative dexterity in 76% of the population with MS. Often, patients also present bilateral impairments.Educational kinesiology program is the original 26 movements. The movements which are naturally done during the first years of life when learning coordinated the eyes, ears, hands and whole body are recalled by these activities. The principle behind Educational kinesiology program is that moving with intention leads to optimal learning. Educational kinesiology program has a beneficial effect on cognitive function and combines movement of the feet, hands in the optimization of left and right brain functions so as to improve cognitive function that were damaged or decrease.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- randomized control trial
| Arm | Type | Receives |
|---|---|---|
| study group | Experimental | Other: educational kinesiology training program intervention for study group, Other: conventional upper extremities coordination training for both arms experimental and comparator (study and control) groupsexperimental arm was recieved educational kinesiology program and conventional upper extremity coordination exercises as intervention.Respondents were explained about the Educational kinesiology program.by the therapist. The exercise program was given three times weekly for four weeks. Duration of the session was15 min ), the patients did 5 exercises, each exercise was done for 3 minutes,when patient felt fatigue during performing the exercise he or she stopped then continued after relaxation till reaching 3 min for each one . All exercises were done from sitting position. |
| control group | Active comparator | Other: conventional upper extremities coordination training for both arms experimental and comparator (study and control) groupsreceived conventional physical therapy program in form of upper extremities coordination training |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male or female aged from 18-50 years.
- Patients with relapsing remitting MS (RRMS).
- EDSS scores for (RRMS) is ranging from 2.5 to 5.5 with a pyramid function score less than 2.
- Gave their oral and written consent to participate in the training.
- Adequate vision and hearing for completion of the study protocol, as indicated by the ability to follow written and oral instructions during screening.
Key exclusion criteria (6 listed)
- Patients with communication problems.
- Patients with a history of previous neurologic diseases or disorders.
- Patients with other types of MS.
- In co-operative patients.
- Unhealed fracture, contracture, pressure sores that might interfere with training.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| educational kinesiology training program intervention for study groupAlso: brain gym exercisesThe Educational kinesiology program were included : (Cross crawl) Sit or stand and with the right-hand elbow touch the left knee and vice versa. (The owl) Bring one hand up to the opposite shoulder and hold a pinch around the trapezius muscle between the neck and shoulder. the thumb should be on one side of the muscle and the other fingers clasping around the other side. Turn the head to the same side as thehand is gripping and take a deep breath. Slowly exhale as bringing the head gently around to the other side. Repeat this movement one more time. (The arm activation) Hold one arm next to the ear. Exhale gently while activating the muscles by pushing the arm against the other hand in four directions (front, back, in and away). (The Energizer) Place the head on the desk in front exhale and inhale while coming up and try to hyperextend the neck carefully. (cook's hook-up) put the left ankle over your right knee. Next, hook the right hand around the left ankle. | Other | study group |
| conventional upper extremities coordination training for both arms experimental and comparator (study and control) groupsBimanual coordination,Hand-arm coordination ,Drinking \& Strength training | Other | control group, study group |
Primary outcome
cognition
Time frame: baseline assessment and after 12 sessions of educational kinesiology program training and conventional upper extremity coordination exercise training 3 sessions per week for 4 weaks
the rate of improvement in cognition assessed by Rehacom system V 6.10.2.0 software.
1 secondary outcome
manual dexterity and bimanual coordination
Time frame: baseline assessment and after 12 sessions of educational kinesiology training and conventional upper extremities coordination exercises training 3 sessions per week for 4 weaks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2025.
- Background: PubMed 36864515Alharthi HM, Almurdi MM. Association between cognitive impairment and motor dysfunction among patients with multiple sclerosis: a cross-sectional study. Eur J Med Res. 2023 Mar 2;28(1):110. doi: 10.1186/s40001-023-01079-6.
- Background: PubMed 28800429Lyle KB, Dombroski BA, Faul L, Hopkins RF, Naaz F, Switala AE, Depue BE. Bimanual coordination positively predicts episodic memory: A combined behavioral and MRI investigation. Brain Cogn. 2017 Nov;118:71-79. doi: 10.1016/j.bandc.2017.07.009. Epub 2017 Aug 9.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
eman s fayez, doctorate study director
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing educational kinesiology training program intervention for study group in people with Relapsing-remitting Multiple Sclerosis, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
cognition (time frame: baseline assessment and after 12 sessions of educational kinesiology program training and conventional upper extremity coordination exercise training 3 sessions per week for 4 weaks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07002151, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2025.