Cardiac Arrest (CA)NCT07002775
Which Position Is Better For CPR In OHCA Patients?
A study testing Transesophageal ultrasound in people with Cardiac Arrest (CA), run by National Taiwan University Hospital at 2 sites in Taiwan.
Trial summary
Use Transesophageal ultrasound in OHCA patients to identify the proper CPR position Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- Transesophageal ultrasound
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 2 sitesTaiwan
- Study dates
- 23 Jan 2025to 23 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Out of hospital cardiac arrest patients
Who cannot join
- DNR was signed,
- Age under 18
- Trauma patients
- Patients hard to establish advanced airway
- C spine injury patients
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan2 sites
Chang Bing Show Chawan Memorial Hospital
Changhua
National Taiwan University Hospital
Taipei
About this study
Official title: Use Transesophageal Echocardiography Comparing Head Up And Supine Cardiopulmonary Resuscitation On Cerebral And Systemic Hemodynamics In OHCA Patients
Use Transesophageal ultrasound in OHCA patients to identify the proper CPR position
- Conditions
- Cardiac Arrest (CA)
- Being tested
- Transesophageal ultrasound
- Keywords
- OHCA, TEE
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transesophageal ultrasoundDevice
Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in different position with the same person
| Study group | Role | What they receive |
|---|---|---|
| CPR position | Other | Same patient with different CPR position : head up or supine Receives: Device: Transesophageal ultrasound |
What is being measured
The primary outcome is the main question the study is designed to answer.
cardiac output
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)
Measured: check cardiac output while CPR(Periprocedural)(after TEE insertion) in head up and supine position
stroke volume
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare,
Measured: check stroke volume while CPR(Periprocedural)(after TEE insertion) in head up and supine position
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jun 2025
- Study start23 Jan 2025
- Primary completion23 Jan 2026 (estimated)
- Study completion23 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Chang Bing Show Chwan Memorial Hospital
- Responsible party
- Sponsor
- Investigators
- WANCHING LIEN, Study director, National Taiwan University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07002775
- Sponsor's protocol ID
- 202410141RINA
- Status last verified
- Jan 2025
- First submitted
- 6 May 2025
- Last updated
- 4 Jun 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: all collected IPD
Publications
Moore JC, Salverda B, Lick M, Rojas-Salvador C, Segal N, Debaty G, Lurie KG. Controlled progressive elevation rather than an optimal angle maximizes cerebral perfusion pressure during head up CPR in a swine model of cardiac arrest. Resuscitation. 2020 May;150:23-28. doi: 10.1016/j.resuscitation.2020.02.023. Epub 2020 Feb 27.
PubMed 32114071Moore JC, Holley J, Segal N, Lick MC, Labarere J, Frascone RJ, Dodd KW, Robinson AE, Lick C, Klein L, Ashton A, McArthur A, Tsangaris A, Makaretz A, Makaretz M, Debaty G, Pepe PE, Lurie KG. Consistent head up cardiopulmonary resuscitation haemodynamics are observed across porcine and human cadaver translational models. Resuscitation. 2018 Nov;132:133-139. doi: 10.1016/j.resuscitation.2018.04.009. Epub 2018 Apr 24.
PubMed 29702188Kim T, Shin SD, Song KJ, Park YJ, Ryu HH, Debaty G, Lurie K, Hong KJ. The effect of resuscitation position on cerebral and coronary perfusion pressure during mechanical cardiopulmonary resuscitation in porcine cardiac arrest model. Resuscitation. 2017 Apr;113:101-107. doi: 10.1016/j.resuscitation.2017.02.008. Epub 2017 Feb 16.
PubMed 28215591Debaty G, Shin SD, Metzger A, Kim T, Ryu HH, Rees J, McKnite S, Matsuura T, Lick M, Yannopoulos D, Lurie K. Tilting for perfusion: head-up position during cardiopulmonary resuscitation improves brain flow in a porcine model of cardiac arrest. Resuscitation. 2015 Feb;87:38-43. doi: 10.1016/j.resuscitation.2014.11.019. Epub 2014 Nov 28.
PubMed 25447353
Study at a glance
From the registry record, last updated by the sponsor on 4 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Use Transesophageal Echocardiography Comparing Head Up And Supine Cardiopulmonary Resuscitation On Cerebral And Systemic Hemodynamics In OHCA Patients
- ClinicalTrials.gov ID
- NCT07002775
- Acronym / sponsor ID
- 202410141RINA
- Conditions
- Cardiac Arrest (CA)
- Keywords
- OHCA, TEE
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Collaborators
- Chang Bing Show Chwan Memorial Hospital
- Study start
- 23 Jan 2025 (actual)
- Primary completion
- 23 Jan 2026 (estimated)
- Study completion
- 23 Jan 2027 (estimated)
- First posted
- 4 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Use Transesophageal ultrasound in OHCA patients to identify the proper CPR position
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| CPR position | Other | Device: Transesophageal ultrasoundSame patient with different CPR position : head up or supine |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Out of hospital cardiac arrest patients
Key exclusion criteria (5 listed)
- DNR was signed,
- Age under 18
- Trauma patients
- Patients hard to establish advanced airway
- C spine injury patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transesophageal ultrasoundTransesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in different position with the same person | Device | CPR position |
Primary outcome
cardiac output
Time frame: check cardiac output while CPR(Periprocedural)(after TEE insertion) in head up and supine position
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)
stroke volume
Time frame: check stroke volume while CPR(Periprocedural)(after TEE insertion) in head up and supine position
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare,
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jun 2025.
- Results publication: PubMed 32114071Moore JC, Salverda B, Lick M, Rojas-Salvador C, Segal N, Debaty G, Lurie KG. Controlled progressive elevation rather than an optimal angle maximizes cerebral perfusion pressure during head up CPR in a swine model of cardiac arrest. Resuscitation. 2020 May;150:23-28. doi: 10.1016/j.resuscitation.2020.02.023. Epub 2020 Feb 27.
- Results publication: PubMed 29702188Moore JC, Holley J, Segal N, Lick MC, Labarere J, Frascone RJ, Dodd KW, Robinson AE, Lick C, Klein L, Ashton A, McArthur A, Tsangaris A, Makaretz A, Makaretz M, Debaty G, Pepe PE, Lurie KG. Consistent head up cardiopulmonary resuscitation haemodynamics are observed across porcine and human cadaver translational models. Resuscitation. 2018 Nov;132:133-139. doi: 10.1016/j.resuscitation.2018.04.009. Epub 2018 Apr 24.
- Results publication: PubMed 28215591Kim T, Shin SD, Song KJ, Park YJ, Ryu HH, Debaty G, Lurie K, Hong KJ. The effect of resuscitation position on cerebral and coronary perfusion pressure during mechanical cardiopulmonary resuscitation in porcine cardiac arrest model. Resuscitation. 2017 Apr;113:101-107. doi: 10.1016/j.resuscitation.2017.02.008. Epub 2017 Feb 16.
- Results publication: PubMed 25447353Debaty G, Shin SD, Metzger A, Kim T, Ryu HH, Rees J, McKnite S, Matsuura T, Lick M, Yannopoulos D, Lurie K. Tilting for perfusion: head-up position during cardiopulmonary resuscitation improves brain flow in a porcine model of cardiac arrest. Resuscitation. 2015 Feb;87:38-43. doi: 10.1016/j.resuscitation.2014.11.019. Epub 2014 Nov 28.
- Individual participant dataSharing planned: Yes. all collected IPD
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
WANCHING LIEN study director
National Taiwan University Hospital
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transesophageal ultrasound in people with Cardiac Arrest (CA), run by National Taiwan University Hospital at 2 sites in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 4 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
cardiac output (time frame: check cardiac output while CPR(Periprocedural)(after TEE insertion) in head up and supine position). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07002775, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2025.