Neck PainPainNCT07004491
Comparison Of Different Physiotherapy Methods In People With Non-Specific Neck Pain
A study testing Conventional therapy, Conventional therapy+ Mulligan mobilization and Conventional therapy+ Graston in people with Neck Pain, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
Trial summary
The study will include 45 people between the ages of 25-55 with non-specific neck pain. The patients will be randomly divided into three groups. Group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application. Read more about this study
- Who is it for?
- Ages 25 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Neck Pain
- What is being tested?
- Conventional therapy, Conventional therapy+ Mulligan mobilization and Conventional therapy+ Graston
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 26 May 2025to 30 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients diagnosed with non-specific neck pain by a doctor
- aged between 25-55
- who have had pain in their neck for at least 2 weeks will be included in the study.
Who cannot join
- Neurological disease
- Manual therapy contraindication such as osteoporosis, spinal infection
- Spondyloarthropathy, disc herniation
- People with contraindications to the Graston technique such as neoplastic disorders, anticoagulant drug use, uncontrolled hypertension or general infection will not be included in the study
Trial locations and contacts
1 site in 1 country.
About this study
The study will include 45 people between the ages of 25-55 with non-specific neck pain. The patients will be randomly divided into three groups. Group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application. Group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to the Mulligan mobilization technique. Group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles.
Read the detailed description
The study will include 45 people between the ages of 25-55 with non-specific neck pain. The patients will be randomly divided into three groups. Group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application. Group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to the Mulligan mobilization technique. Group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles. The patients will receive treatments 3-4 times a week for 4 weeks, for a total of 10 sessions. VAS, neck joint range of motion, functional status and disability level neck pain and disability scale and SF-36 will be used as evaluation measurements.
- Conditions
- Neck Pain
- Being tested
- Conventional therapy, Conventional therapy+ Mulligan mobilization, Conventional therapy+ Graston
- Keywords
- Non specific neck pain, physiotherapy applicaitons, pain
- Medical subject headings
- Neck Pain, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional therapyOther
Ultrasound, Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application
Conventional therapy+ Mulligan mobilizationOther
Conventional therapy+ Mulligan mobilization
Conventional therapy+ GrastonOther
Conventional therapy+ Graston application
| Study group | Role | What they receive |
|---|---|---|
| First Intervention | Experimental | 5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application will be applied. Receives: Other: Conventional therapy |
| Second Intervention | Experimental | In addition to 5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application, Mulligan mobilization technique will be applied. Continuous apophyseal shifting technique will be applied as mobilization. Mobilization will be applied in 3 sets of 4-5 repetitions. Receives: Other: Conventional therapy+ Mulligan mobilization |
| Third Intervention | Experimental | In addition to 5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application, Graston treatment will be applied to the upper and lower trapezius, rhomboid major and minor muscles for 5 minutes. Receives: Other: Conventional therapy+ Graston |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visucal Analog scale
The Visual Analog Scale (VAS) (0-10 cm), which is found to be valid, reliable and sensitive in patients with neck pain, will be used to assess pain. O means no pain; 10 means severe pain.
Measured: 10 minutes
Joint range of motion
The patients' neck joint range of motion will be measured with a standard goniometer.
Measured: 20 minutes
Quality of life (SF-36)
SF-36 will be used to assess the participants' quality of life. The 36-question questionnaire is divided into 8 groups: physical role functioning, emotional role functioning, bodily pain, energy, social role functioning, mental health and general health perception. Each category is scored between 0-100 and higher scores indicate better quality of life
Measured: 15 minutes
The neck disability scale
Functional status and disability level will be assessed with the neck pain and disability scale.The neck disability scale will be used to assess how the participants' daily lives are affected by neck pain. The total score of the scale ranges from 0 to 35, with higher scores indicating higher levels of disability
Measured: 15 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jun 2025
- Study start26 May 2025
- Primary completion26 Jul 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Neck PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Medipol University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, merve yilmaz menek, Istanbul Medipol University Hospital
- Investigators
- MERVE YILMAZ MENEK, Assoc. Prof., Principal investigator, Medipol University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07004491
- Sponsor's protocol ID
- E-10840098-202.3.02-3746
- Acronym
- Pain
- Status last verified
- Sep 2026
- First submitted
- 27 May 2025
- Last updated
- 5 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We can share IPD if it is need.
Publications
Mahmood T, Afzal W, Ahmad U, Arif MA, Ahmad A. Comparative effectiveness of routine physical therapy with and without instrument assisted soft tissue mobilization in patients with neck pain due to upper crossed syndrome. J Pak Med Assoc. 2021 Oct;71(10):2304-2308. doi: 10.47391/JPMA.03-415.
PubMed 34974559
Study at a glance
From the registry record, last updated by the sponsor on 5 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Of Different Physiotherapy Methods In People With Non-Specific Neck Pain
- ClinicalTrials.gov ID
- NCT07004491
- Acronym / sponsor ID
- Pain / E-10840098-202.3.02-3746
- Conditions
- Neck Pain
- Keywords
- Non specific neck pain, physiotherapy applicaitons, pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Istanbul Medipol University HospitalUniversity, hospital or other
- Study start
- 26 May 2025 (actual)
- Primary completion
- 26 Jul 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 4 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study will include 45 people between the ages of 25-55 with non-specific neck pain. The patients will be randomly divided into three groups. Group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application. Group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to the Mulligan mobilization technique. Group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles.
Detailed description
The study will include 45 people between the ages of 25-55 with non-specific neck pain. The patients will be randomly divided into three groups. Group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application. Group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to the Mulligan mobilization technique. Group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (TENS), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles. The patients will receive treatments 3-4 times a week for 4 weeks, for a total of 10 sessions. VAS, neck joint range of motion, functional status and disability level neck pain and disability scale and SF-36 will be used as evaluation measurements.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| First Intervention | Experimental | Other: Conventional therapy5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application will be applied. |
| Second Intervention | Experimental | Other: Conventional therapy+ Mulligan mobilizationIn addition to 5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application, Mulligan mobilization technique will be applied. Continuous apophyseal shifting technique will be applied as mobilization. Mobilization will be applied in 3 sets of 4-5 repetitions. |
| Third Intervention | Experimental | Other: Conventional therapy+ GrastonIn addition to 5 minutes of Ultrasound, 20 minutes of Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application, Graston treatment will be applied to the upper and lower trapezius, rhomboid major and minor muscles for 5 minutes. |
Who may qualify
- Ages
- 25 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patients diagnosed with non-specific neck pain by a doctor
- aged between 25-55
- who have had pain in their neck for at least 2 weeks will be included in the study.
Key exclusion criteria (4 listed)
- Neurological disease
- Manual therapy contraindication such as osteoporosis, spinal infection
- Spondyloarthropathy, disc herniation
- People with contraindications to the Graston technique such as neoplastic disorders, anticoagulant drug use, uncontrolled hypertension or general infection will not be included in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional therapyUltrasound, Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application | Other | First Intervention |
| Conventional therapy+ Mulligan mobilizationConventional therapy+ Mulligan mobilization | Other | Second Intervention |
| Conventional therapy+ GrastonConventional therapy+ Graston application | Other | Third Intervention |
Primary outcome
Visucal Analog scale
Time frame: 10 minutes
The Visual Analog Scale (VAS) (0-10 cm), which is found to be valid, reliable and sensitive in patients with neck pain, will be used to assess pain. O means no pain; 10 means severe pain.
Joint range of motion
Time frame: 20 minutes
The patients' neck joint range of motion will be measured with a standard goniometer.
Quality of life (SF-36)
Time frame: 15 minutes
SF-36 will be used to assess the participants' quality of life. The 36-question questionnaire is divided into 8 groups: physical role functioning, emotional role functioning, bodily pain, energy, social role functioning, mental health and general health perception. Each category is scored between 0-100 and higher scores indicate better quality of life
The neck disability scale
Time frame: 15 minutes
Functional status and disability level will be assessed with the neck pain and disability scale.The neck disability scale will be used to assess how the participants' daily lives are affected by neck pain. The total score of the scale ranges from 0 to 35, with higher scores indicating higher levels of disability
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Oct 2026.
- Results publication: PubMed 34974559Mahmood T, Afzal W, Ahmad U, Arif MA, Ahmad A. Comparative effectiveness of routine physical therapy with and without instrument assisted soft tissue mobilization in patients with neck pain due to upper crossed syndrome. J Pak Med Assoc. 2021 Oct;71(10):2304-2308. doi: 10.47391/JPMA.03-415.
- Comparative effectiveness of routine physical therapy with and without instrument assisted soft tissue mobilization in patients with neck pain due to upper crossed syndrome.Link provided by the sponsor.
- Individual participant dataSharing planned: No. We can share IPD if it is need.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
MERVE YILMAZ MENEK, Assoc. Prof. principal investigator
Medipol University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional therapy, Conventional therapy+ Mulligan mobilization and Conventional therapy+ Graston in people with Neck Pain, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visucal Analog scale (time frame: 10 minutes). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07004491, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Oct 2026.