Coronary Artery Bypass Graft SurgeryNCT07006441
Cardiac Rehabilitation in Coronary Artery Bypass Graft Surgery
A study testing Preoperative Cardiac Rehabilitation and Postoperative Cardiac Rehabilitation in people with Coronary Artery Bypass Graft Surgery and Coronary Artery Disease, run by Atlas University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial investigates the comparative effects of a combined preoperative and postoperative cardiac rehabilitation program versus a postoperative-only program on functional capacity, pulmonary function, peripheral muscle strength, pain, kinesiophobia, and quality of life in patients undergoing… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Coronary Artery Bypass Graft Surgery, Coronary Artery Disease
- What is being tested?
- Preoperative Cardiac Rehabilitation and Postoperative Cardiac Rehabilitation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2024to 1 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Having undergone coronary artery bypass graft surgery
- Ejection Fraction (EF) > 40%
- Being between the ages of 18-65
- Being able to speak, read and understand in their own language
- Volunteering to participate in the study
Who cannot join
- Having an active or suspected infection
- Presence of an active tumour
- History of thrombophlebitis or pulmonary embolism within the last 3 months
- Having an orthopaedic, neurological or cardiovascular disease that may affect the assessments
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effects of Preoperative and Postoperative Cardiac Rehabilitation in Patients Undergoing Coronary Artery Bypass Graft Surgery
This randomized controlled trial investigates the comparative effects of a combined preoperative and postoperative cardiac rehabilitation program versus a postoperative-only program on functional capacity, pulmonary function, peripheral muscle strength, pain, kinesiophobia, and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery. The study aims to determine whether initiating rehabilitation prior to surgery improves short-term postoperative outcomes.
- Being tested
- Preoperative Cardiac Rehabilitation, Postoperative Cardiac Rehabilitation
- Keywords
- Coronary Artery Disease, Coronary Artery Bypass Graft Surgery, Preoperative Cardiac Rehabilitation, Postoperative Cardiac Rehabilitation
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Preoperative Cardiac RehabilitationOther
Structured exercise program, respiratory physiotherapy, and patient education
Postoperative Cardiac RehabilitationOther
Structured exercise program, respiratory physiotherapy, and patient education
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group | Experimental | Preoperative cardiac rehabilitation + postoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education) Receives: Other: Preoperative Cardiac Rehabilitation; Other: Postoperative Cardiac Rehabilitation |
| Control Group | Active comparator | Postoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education) Receives: Other: Postoperative Cardiac Rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Forced Vital Capacity (FVC)
Forced Vital Capacity will be measured before six-minute walk test according to the guideline of ERS.
Measured: 2 weeks
Forced Expiratory Volume in 1 second (FEV1)
Forced Expiratory Volume in 1 second will be measured before six-minute walk test according to the guideline of ERS.
Measured: 2 weeks
Peak Expiratory Flow (PEF)
Peak Expiratory Flow will be measured before six-minute walk test according to the guideline of ERS.
Measured: 2 weeks
Forced Expiratory Flow 25-75% (FEF25-75)
Forced Expiratory Flow 25-75% will be measured before six-minute walk test according to the guideline of ERS.
Measured: 2 weeks
6-minute Walk Test
The 6-minute Walk Test will be performed according to ATS guidelines. Walking distance, minute ventilation, respiratory rate, inspiratory capacity and breathing reserve will be recorded.
Measured: 2 weeks
M. Quadriceps Muscle Strength
The m. quadriceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.
Measured: 2 weeks
M. Biceps Muscle Strength
The m. biceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.
Measured: 2 weeks
Cough Peak Flow
Cough Peak Flow (CPF) will be measured using a peak expiratory flow meter. Participants will be instructed to take a maximal deep breath and then cough as forcefully as possible into the device; the highest value from three trials will be recorded in liters per minute (L/min). Measurements will be performed in a seated position, ensuring a tight mouth seal and consistent technique.
Measured: 2 weeks
Secondary outcomes (3)
Level of Pain
Pain assessment will be performed using the Visual Analog Scale (VAS) to evaluate chest pain levels. Participants will be asked to mark their current pain intensity on a 10 cm horizontal line, with "no pain" at one end and "worst imaginable pain" at the other. The distance in centimeters from the "no pain" end to the mark will be measured and recorded as the pain score.
Measured: 2 weeks
Level of Fear of Movement
Fear of movement (kinesiophobia) will be assessed using the Tampa Scale for Kinesiophobia (TSK). Participants will complete the 17-item questionnaire, which evaluates fear of movement and re-injury on a 4-point Likert scale. The total score, ranging from 17 to 68, will be calculated, with higher scores indicating greater fear of movement.
Measured: 2 weeks
Level of Quality of Life
Quality of life will be assessed using the Short Form-36 (SF-36) Health Survey. Participants will complete the 36-item questionnaire, which evaluates eight domains including physical functioning, bodily pain, general health, and mental well-being. Each domain will be scored from 0 to 100, with higher scores indicating better perceived quality of life.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2025
- Study start1 Aug 2024
- Primary completion1 Aug 2025
- Study completion1 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery Bypass Graft SurgeryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized, Parallel Assignment
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Atlas University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hikmet Ucgun, Atlas University
- Investigators
- Hikmet Ucgun, PT, PhD, Principal investigator, Atlas University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07006441
- Sponsor's protocol ID
- auhucgun04
- Status last verified
- Aug 2025
- First submitted
- 28 May 2025
- Last updated
- 27 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Preoperative and Postoperative Cardiac Rehabilitation in Patients Undergoing Coronary Artery Bypass Graft Surgery
- ClinicalTrials.gov ID
- NCT07006441
- Acronym / sponsor ID
- auhucgun04
- Keywords
- Coronary Artery Disease, Coronary Artery Bypass Graft Surgery, Preoperative Cardiac Rehabilitation, Postoperative Cardiac Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Atlas UniversityUniversity, hospital or other
- Study start
- 1 Aug 2024 (actual)
- Primary completion
- 1 Aug 2025 (actual)
- Study completion
- 1 Aug 2025 (actual)
- First posted
- 5 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial investigates the comparative effects of a combined preoperative and postoperative cardiac rehabilitation program versus a postoperative-only program on functional capacity, pulmonary function, peripheral muscle strength, pain, kinesiophobia, and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery. The study aims to determine whether initiating rehabilitation prior to surgery improves short-term postoperative outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Randomized, Parallel Assignment
| Arm | Type | Receives |
|---|---|---|
| Experimental Group | Experimental | Other: Preoperative Cardiac Rehabilitation, Other: Postoperative Cardiac RehabilitationPreoperative cardiac rehabilitation + postoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education) |
| Control Group | Active comparator | Other: Postoperative Cardiac RehabilitationPostoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education) |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Having undergone coronary artery bypass graft surgery
- Ejection Fraction (EF) > 40%
- Being between the ages of 18-65
- Being able to speak, read and understand in their own language
- Volunteering to participate in the study
Key exclusion criteria (4 listed)
- Having an active or suspected infection
- Presence of an active tumour
- History of thrombophlebitis or pulmonary embolism within the last 3 months
- Having an orthopaedic, neurological or cardiovascular disease that may affect the assessments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Preoperative Cardiac RehabilitationStructured exercise program, respiratory physiotherapy, and patient education | Other | Experimental Group |
| Postoperative Cardiac RehabilitationStructured exercise program, respiratory physiotherapy, and patient education | Other | Control Group, Experimental Group |
Primary outcome
Forced Vital Capacity (FVC)
Time frame: 2 weeks
Forced Vital Capacity will be measured before six-minute walk test according to the guideline of ERS.
Forced Expiratory Volume in 1 second (FEV1)
Time frame: 2 weeks
Forced Expiratory Volume in 1 second will be measured before six-minute walk test according to the guideline of ERS.
Peak Expiratory Flow (PEF)
Time frame: 2 weeks
Peak Expiratory Flow will be measured before six-minute walk test according to the guideline of ERS.
Forced Expiratory Flow 25-75% (FEF25-75)
Time frame: 2 weeks
Forced Expiratory Flow 25-75% will be measured before six-minute walk test according to the guideline of ERS.
6-minute Walk Test
Time frame: 2 weeks
The 6-minute Walk Test will be performed according to ATS guidelines. Walking distance, minute ventilation, respiratory rate, inspiratory capacity and breathing reserve will be recorded.
M. Quadriceps Muscle Strength
Time frame: 2 weeks
The m. quadriceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.
M. Biceps Muscle Strength
Time frame: 2 weeks
The m. biceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.
Cough Peak Flow
Time frame: 2 weeks
Cough Peak Flow (CPF) will be measured using a peak expiratory flow meter. Participants will be instructed to take a maximal deep breath and then cough as forcefully as possible into the device; the highest value from three trials will be recorded in liters per minute (L/min). Measurements will be performed in a seated position, ensuring a tight mouth seal and consistent technique.
3 secondary outcomes
Level of Pain
Time frame: 2 weeks
Level of Fear of Movement
Time frame: 2 weeks
Level of Quality of Life
Time frame: 2 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2025.
- Individual participant dataSharing planned: No
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Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
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Investigation of the Effects of Respiratory Muscle Training Combined With Otago Exercises in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery
Coronary Artery Bypass Graft (CABG)
Recruiting
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD)
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Comparison of Analgesic Efficacy Between Ultrasound Guided Serratus Anterior Plane Block or Thoracic Paravertebral Block Versus Intravenous Fentanyl for On-pump Coronary Artery Bypass Graft Surgery
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hikmet Ucgun, PT, PhD principal investigator
Atlas University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Preoperative Cardiac Rehabilitation and Postoperative Cardiac Rehabilitation in people with Coronary Artery Bypass Graft Surgery and Coronary Artery Disease, run by Atlas University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Forced Vital Capacity (FVC) (time frame: 2 weeks). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2025.