Impacted Mandibular Third MolarNCT07012564
Does Vitamin C Improve Postoperative Healing
A study testing Vitamin C in people with Impacted Mandibular Third Molar, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Impacted Mandibular Third Molar
- What is being tested?
- Vitamin C
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 56 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2024to 1 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18-35 years
- Systemically healthy
- Non-smoker
- No alcohol or substance abuse
- Bilateral impacted mandibular third molars
- Mesioangular impaction with a Pederson index of 5-6
- Voluntary participation
- Ability and willingness to attend follow-up visits
Who cannot join
- Pregnancy or lactation
- Presence of infection or pain related to third molars
- Associated pathological conditions (e.g., cysts or tumors)
- History of previous mandibular third molar extraction
- Congenital absence of third molars
- Known allergy to any drug or substance used in the study
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Hacettepe University Faculty of Dentistry
Ankara, 06100
About this study
Official title: Does Vitamin C Improve Postoperative Healing: A Randomized Split-Mouth Clinical Trial After Impacted Mandibular Third Molar Surgery
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. Fifty-six healthy patients underwent bilateral extractions, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo. The supplementation began one day before surgery and continued through postoperative day 7. The outcome measures included facial swelling assessed through linear measurements (tragus-pogonion, tragus-commissure labiorum, and lateral canthus of the eye-angulus mandible), pain using a visual analog scale (VAS), trismus based on maximum interincisal opening, and early wound healing assessed with the Landry healing index. Analgesic consumption was also recorded. Pain was evaluated using VAS on days 1, 2, and 7. Edema, trismus, and early wound healing were evaluated on postoperative days 2 and 7. The study aims to determine whether vitamin C reduces edema, pain, and trismus, and enhances early soft tissue healing compared to placebo.
Read the detailed description
This randomized, split-mouth clinical trial aimed to investigate the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. A total of 56 healthy patients requiring bilateral lower third molar extractions were included in the study. Each patient underwent two separate surgeries on both sides, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo.
Vitamin C supplementation started one day prior to surgery and continued for seven days postoperatively. The primary outcomes of the study were facial swelling, pain, trismus, and early soft tissue healing. Facial swelling was assessed using three linear measurements between specific anatomical landmarks: tragus-pogonion, tragus-labial commissure, and lateral canthus of the eye-angulus mandible. Trismus was measured based on maximum interincisal distance. Pain was evaluated using the visual analog scale (VAS) on postoperative days 1, 2, and 7. Edema, trismus, and early wound healing were assessed on postoperative days 2 and 7. Early wound healing was scored using the Landry healing index. Analgesic consumption was also recorded during the postoperative period.
This study was designed to evaluate whether vitamin C supplementation could reduce postoperative edema, pain, and trismus, and improve early soft tissue healing in comparison to placebo in the context of oral surgical procedures. The findings may provide evidence to support the use of vitamin C as an adjunctive therapy in oral surgery.
- Conditions
- Impacted Mandibular Third Molar
- Being tested
- Vitamin C, Placebo
- Keywords
- Vitamin C, Wound Healing, Third Molar Surgery, Oral Surgery, Postoperative Recovery, Trismus, Facial Swelling, Pain, Analgesic Use, Edema
- Medical subject headings
- Trismus, Pain, Edema
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin CDietary supplement
1000 mg oral vitamin C tablet taken daily from one day before surgery to postoperative day 7.
PlaceboOther
Identical-appearing oral tablet taken on the same schedule as the vitamin C group.
| Study group | Role | What they receive |
|---|---|---|
| Vitamin C | Experimental | Patients received 1000 mg of oral vitamin C daily starting one day before surgery through postoperative day 7. Receives: Dietary Supplement: Vitamin C |
| Placebo | Placebo comparator | Patients received an identical-looking placebo tablet once daily for the same duration. Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Facial Swelling
Facial swelling was measured using three linear distances: tragus-pogonion, tragus-labial commissure, and lateral canthus-mandibular angle.
Measured: Postoperative Day 2 and Day 7
Postoperative Pain Score (VAS)
Pain intensity was assessed using a 10-cm visual analog scale (VAS), with 0 = no pain and 10 = worst possible pain.
Measured: Postoperative Days 1, 2, and 7
Secondary outcomes (3)
Trismus (Maximum Interincisal Opening)
Trismus was assessed by measuring the maximum interincisal distance in millimeters using a caliper.
Measured: Postoperative Days 2 and 7
Early Wound Healing (Landry Healing Index)
Soft tissue healing was evaluated using the Landry healing index, which scores wound healing on a 5-point scale based on tissue color, bleeding, and granulation.
Measured: Postoperative Days 2 and 7
Analgesic Consumption
: The number of analgesic tablets consumed was recorded for each participant.
Measured: Postoperative Days 1,2 and 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jun 2025
- Study start1 Jun 2024
- Primary completion15 Feb 2025
- Study completion1 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Impacted Mandibular Third MolarStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study employed a split-mouth crossover design, where each participant served as their own control. Bilateral surgical extractions of impacted mandibular third molars were performed in two separate sessions. The intervention (vitamin C) and the control (placebo) were randomly assigned to either the left or right surgical site, allowing intra-individual comparison of postoperative outcomes.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alper AKTAŞ, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07012564
- Sponsor's protocol ID
- HU-ADÇC-AA-01
- Status last verified
- May 2025
- First submitted
- 31 May 2025
- Last updated
- 10 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does Vitamin C Improve Postoperative Healing: A Randomized Split-Mouth Clinical Trial After Impacted Mandibular Third Molar Surgery
- ClinicalTrials.gov ID
- NCT07012564
- Acronym / sponsor ID
- HU-ADÇC-AA-01
- Conditions
- Impacted Mandibular Third Molar
- Keywords
- Vitamin C, Wound Healing, Third Molar Surgery, Oral Surgery, Postoperative Recovery, Trismus, Facial Swelling, Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 15 Feb 2025 (actual)
- Study completion
- 1 Mar 2025 (actual)
- First posted
- 10 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. Fifty-six healthy patients underwent bilateral extractions, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo. The supplementation began one day before surgery and continued through postoperative day 7. The outcome measures included facial swelling assessed through linear measurements (tragus-pogonion, tragus-commissure labiorum, and lateral canthus of the eye-angulus mandible), pain using a visual analog scale (VAS), trismus based on maximum interincisal opening, and early wound healing assessed with the Landry healing index. Analgesic consumption was also recorded. Pain was evaluated using VAS on days 1, 2, and 7. Edema, trismus, and early wound healing were evaluated on postoperative days 2 and 7. The study aims to determine whether vitamin C reduces edema, pain, and trismus, and enhances early soft tissue healing compared to placebo.
Detailed description
This randomized, split-mouth clinical trial aimed to investigate the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. A total of 56 healthy patients requiring bilateral lower third molar extractions were included in the study. Each patient underwent two separate surgeries on both sides, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo.
Vitamin C supplementation started one day prior to surgery and continued for seven days postoperatively. The primary outcomes of the study were facial swelling, pain, trismus, and early soft tissue healing. Facial swelling was assessed using three linear measurements between specific anatomical landmarks: tragus-pogonion, tragus-labial commissure, and lateral canthus of the eye-angulus mandible. Trismus was measured based on maximum interincisal distance. Pain was evaluated using the visual analog scale (VAS) on postoperative days 1, 2, and 7. Edema, trismus, and early wound healing were assessed on postoperative days 2 and 7. Early wound healing was scored using the Landry healing index. Analgesic consumption was also recorded during the postoperative period.
This study was designed to evaluate whether vitamin C supplementation could reduce postoperative edema, pain, and trismus, and improve early soft tissue healing in comparison to placebo in the context of oral surgical procedures. The findings may provide evidence to support the use of vitamin C as an adjunctive therapy in oral surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- This study employed a split-mouth crossover design, where each participant served as their own control. Bilateral surgical extractions of impacted mandibular third molars were performed in two separate sessions. The intervention (vitamin C) and the control (placebo) were randomly assigned to either the left or right surgical site, allowing intra-individual comparison of postoperative outcomes.
| Arm | Type | Receives |
|---|---|---|
| Vitamin C | Experimental | Dietary Supplement: Vitamin CPatients received 1000 mg of oral vitamin C daily starting one day before surgery through postoperative day 7. |
| Placebo | Placebo comparator | Other: PlaceboPatients received an identical-looking placebo tablet once daily for the same duration. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Age 18-35 years
- Systemically healthy
- Non-smoker
- No alcohol or substance abuse
- Bilateral impacted mandibular third molars
Key exclusion criteria (6 listed)
- Pregnancy or lactation
- Presence of infection or pain related to third molars
- Associated pathological conditions (e.g., cysts or tumors)
- History of previous mandibular third molar extraction
- Congenital absence of third molars
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin C1000 mg oral vitamin C tablet taken daily from one day before surgery to postoperative day 7. | Dietary supplement | Vitamin C |
| PlaceboIdentical-appearing oral tablet taken on the same schedule as the vitamin C group. | Other | Placebo |
Primary outcome
Postoperative Facial Swelling
Time frame: Postoperative Day 2 and Day 7
Facial swelling was measured using three linear distances: tragus-pogonion, tragus-labial commissure, and lateral canthus-mandibular angle.
Postoperative Pain Score (VAS)
Time frame: Postoperative Days 1, 2, and 7
Pain intensity was assessed using a 10-cm visual analog scale (VAS), with 0 = no pain and 10 = worst possible pain.
3 secondary outcomes
Trismus (Maximum Interincisal Opening)
Time frame: Postoperative Days 2 and 7
Early Wound Healing (Landry Healing Index)
Time frame: Postoperative Days 2 and 7
Analgesic Consumption
Time frame: Postoperative Days 1,2 and 7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin C in people with Impacted Mandibular Third Molar, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Facial Swelling (time frame: Postoperative Day 2 and Day 7). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2025.