Post Operative PainNCT07014228
Evaluation of Post-operative Pain During Retreatment in Different Visits
A study testing single visit re-endo and multi visit re-endo in people with Post Operative Pain, run by Armed Forces Institute of Dentistry, Pakistan at 1 site in Pakistan.
Trial summary
Endodontic retreatment is performed to alleviate symptoms of recurring infection, post-treatment disease after primary endodontic therapy. Retreatment can be performed in either single or multiple visits. and have their own implications. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Post Operative Pain
- What is being tested?
- single visit re-endo and multi visit re-endo
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 116 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Apr 2022to 1 Jul 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Patients with unremarkable/ noncontributory medical history
- Age range between 15-45 years
- Cases of failed endodontic treatment resulting from inadequate root filling
- No systemic disease
- No periodontal disease
Who cannot join
- Patients having teeth with periodontal pathology
- root fractures
- Immature root apices
- Endodontic posts
- Root perforations
- Immunocompromised health were excluded from the study.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Armed Forces Institute of dentistry
Rawalpindi, Punjab Province, 64000
About this study
Official title: Evaluation of Post Operative Pain in Non-surgical Endodontic Retreatment in Single vs Multiple Visits
Endodontic retreatment is performed to alleviate symptoms of recurring infection, post-treatment disease after primary endodontic therapy. Retreatment can be performed in either single or multiple visits. and have their own implications. it is important to compare the patient response and post-op pain after single vs multi-visit reendo treatment.
Read the detailed description
Introduction:
Treating endodontic failure cases has always been a challenge for the clinician due to the complex nature of disease which includes resistant microorganisms, iatrogenic errors and cleaning and shaping of un-instrumented areas. Endodontic retreatment can be done in either single or multiple visits. Multiple visits have the added advantage of placement of intracanal medicament resulting in decreased bacterial load and reduced pain, whereas single visit endodontic retreatment reduces chances of inter appointment microbial contamination. This study aims to evaluate post operative pain among both groups.
Objective:
To evaluate frequency of post-operative pain in endodontic retreatment cases after single vs multiple (two) visits root canal therapy.
Materials and Methods:
STUDY SETTING: Department of Operative Dentistry, AFID Rawalpindi.
- Conditions
- Post Operative Pain
- Being tested
- single visit re-endo, multi visit re-endo
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
single visit re-endoProcedure or surgery
In this group, a single visit re-endodontic treatment will be performed and completed in the same visit, including all the steps.
multi visit re-endoProcedure or surgery
In this group, a multi-visit re-endodontic treatment will be performed and completed over different visits, including all the steps.
| Study group | Role | What they receive |
|---|---|---|
| Single visit group | Experimental | Endodontic retreatment in this group will be performed in a single visit. Initiated, deobturated, disinfection done and completed during the same visit. Receives: Procedure: single visit re-endo |
| Multi visit Group | Active comparator | Endodontic retreatment in this group will be performed in more than 1 visit. The retreatment will be initiated, deobturated, and disinfection done and completed in second or third visits.. Receives: Procedure: multi visit re-endo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Post operative pain after re-endo
Post-operative pain after single vs multi visit re-endo treatment to be compared. The patients will be guided in detail about the procedure and how to document their response to the treatment. The Visual Analog Scale (VAS). numbered from 0-10, with 0 being no pain, 1 - 3: mild pain, 4-6: moderate pain, and 7-10 severe pain, will be used to record pain experienced by the patients and notified to the investigator.
Measured: 6 hours - 72 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jun 2025
- Study start1 Apr 2022
- Primary completion1 May 2023
- Study completion1 Jul 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Patients will be divided into two equal groups and given two different interventions (single vs. multi-visit reendo).
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 116 participants (actual)
Sponsor and investigators
- Lead sponsor
- Armed Forces Institute of Dentistry, Pakistan
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Abdullah, Armed Forces Institute of Dentistry, Pakistan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07014228
- Sponsor's protocol ID
- Re-endo pain comparison
- Status last verified
- Jun 2025
- First submitted
- 1 Jun 2025
- Last updated
- 10 Jun 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Post Operative Pain in Non-surgical Endodontic Retreatment in Single vs Multiple Visits
- ClinicalTrials.gov ID
- NCT07014228
- Acronym / sponsor ID
- Re-endo pain comparison
- Conditions
- Post Operative Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 116 participants (actual)
- Lead sponsor
- Armed Forces Institute of Dentistry, PakistanUniversity, hospital or other
- Study start
- 1 Apr 2022 (actual)
- Primary completion
- 1 May 2023 (actual)
- Study completion
- 1 Jul 2023 (actual)
- First posted
- 10 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Endodontic retreatment is performed to alleviate symptoms of recurring infection, post-treatment disease after primary endodontic therapy. Retreatment can be performed in either single or multiple visits. and have their own implications. it is important to compare the patient response and post-op pain after single vs multi-visit reendo treatment.
Detailed description
Introduction:
Treating endodontic failure cases has always been a challenge for the clinician due to the complex nature of disease which includes resistant microorganisms, iatrogenic errors and cleaning and shaping of un-instrumented areas. Endodontic retreatment can be done in either single or multiple visits. Multiple visits have the added advantage of placement of intracanal medicament resulting in decreased bacterial load and reduced pain, whereas single visit endodontic retreatment reduces chances of inter appointment microbial contamination. This study aims to evaluate post operative pain among both groups.
Objective:
To evaluate frequency of post-operative pain in endodontic retreatment cases after single vs multiple (two) visits root canal therapy.
Materials and Methods:
STUDY SETTING: Department of Operative Dentistry, AFID Rawalpindi.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Patients will be divided into two equal groups and given two different interventions (single vs. multi-visit reendo).
| Arm | Type | Receives |
|---|---|---|
| Single visit group | Experimental | Procedure: single visit re-endoEndodontic retreatment in this group will be performed in a single visit. Initiated, deobturated, disinfection done and completed during the same visit. |
| Multi visit Group | Active comparator | Procedure: multi visit re-endoEndodontic retreatment in this group will be performed in more than 1 visit. The retreatment will be initiated, deobturated, and disinfection done and completed in second or third visits.. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Patients with unremarkable/ noncontributory medical history
- Age range between 15-45 years
- Cases of failed endodontic treatment resulting from inadequate root filling
- No systemic disease
- No periodontal disease
Key exclusion criteria (6 listed)
- Patients having teeth with periodontal pathology
- root fractures
- Immature root apices
- Endodontic posts
- Root perforations
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| single visit re-endoIn this group, a single visit re-endodontic treatment will be performed and completed in the same visit, including all the steps. | Procedure or surgery | Single visit group |
| multi visit re-endoIn this group, a multi-visit re-endodontic treatment will be performed and completed over different visits, including all the steps. | Procedure or surgery | Multi visit Group |
Primary outcome
Post operative pain after re-endo
Time frame: 6 hours - 72 hours
Post-operative pain after single vs multi visit re-endo treatment to be compared. The patients will be guided in detail about the procedure and how to document their response to the treatment. The Visual Analog Scale (VAS). numbered from 0-10, with 0 being no pain, 1 - 3: mild pain, 4-6: moderate pain, and 7-10 severe pain, will be used to record pain experienced by the patients and notified to the investigator.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing single visit re-endo and multi visit re-endo in people with Post Operative Pain, run by Armed Forces Institute of Dentistry, Pakistan at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Post operative pain after re-endo (time frame: 6 hours - 72 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2025.