VV-ECMOPECURNCT07016685
Prognosis of Veno-Venous Extracorporeal Membrane Oxygenation in Emergency Thoracic Surgery
An observational study of VV-ECMO and Thoracic Surgery, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Veno-vneous extracorporeal membrane oxygenation (VV-ECMO) is an established support strategy for acute respiratory failure, but its role in the perioperative management of emergency thoracic surgery remains poorly defined. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- VV-ECMO, Thoracic Surgery, Emergency Surgery
- How many people
- 380 participants
- Where
- 1 siteFrance
- Study dates
- 1 Jun 2025to Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults ≥ 18 years, Patients undergoing emergency thoracic procedures requiring VV-ECMO and patients treated with VV-ECMO for medical respiratory failure.
Who may be able to join
- Adults ≥ 18 years
- VV-ECMO initiated during or after emergency thoracic surgery
- No opposition to data use
Who cannot join
- Pregnant women
- Veno-Arterial ECMO patients
- Patients under legal protection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHRU Amiens
Amiens, 80480
Christophe Beyls, MD, 33+3 22 08 78 66, beyls.christophe@chu-amiens.fr
Pierre Grégoire Guinot, MD
About this study
Official title: Prognostic Factors for 90-day Mortality in Patients Undergoing Veno-venous Extracorporeal Membrane Oxygenation for Emergency Thoracic Surgery
Veno-vneous extracorporeal membrane oxygenation (VV-ECMO) is an established support strategy for acute respiratory failure, but its role in the perioperative management of emergency thoracic surgery remains poorly defined. This retrospective, multicenter, observational study aims to assess the clinical outcomes and prognostic factors in this high-risk population. Patients undergoing emergency thoracic procedures requiring VV-ECMO will be compared to a control cohort of patients treated with VV-ECMO for medical respiratory failure. Data will be collected from two French academic centers (CHU Amiens-Picardie and CHU Dijon).
- Conditions
- VV-ECMO, Thoracic Surgery, Emergency Surgery, ARDS, Retrospective Cohort, Propensity Score Matching
- Keywords
- thoracic surgery, VV-ECMO, emergency surgery, ARDS, retrospective cohort, propensity score matching, mortality, ECMO outcomes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| VV-ECMO after emergency thoracic surgery | VV-ECMO after emergency thoracic surgery | |
| VV-ECMO for medical ARF | VV-ECMO for medical indication |
What is being measured
The primary outcome is the main question the study is designed to answer.
90-day all-cause mortality
Measured: 90 days
Secondary outcomes (2)
90-day mortality in oncologic vs. non-oncologic thoracic surgery
Measured: 90 days
Postoperative complication rates
Postoperative complication rates (hemorrhagic, thrombotic, infectious)
Measured: 90 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jun 2025
- Study start1 Jun 2025
- Primary completionNov 2025 (estimated)
- Study completionApr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for VV-ECMOStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Retrospective
- Enrolment
- 380 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Collaborators
- Centre Hospitalier Universitaire Dijon
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07016685
- Sponsor's protocol ID
- PI2025_843_0071
- Acronym
- PECUR
- Status last verified
- Jun 2025
- First submitted
- 29 Apr 2025
- Last updated
- 13 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Beyls C, Soulier-Zaninka Q, Georges O, Nguyen M, Dheilly T, Nicolas M, Huette P, De Dominicis F, Abou-Arab O, Guinot PG, Mahjoub Y. Perioperative Veno-Venous Extracorporeal Membrane Oxygenation in Non-Elective Thoracic Surgery: A Propensity-Matched Bicentric Comparison With Medical Indication. Interdiscip Cardiovasc Thorac Surg. 2025 Nov 6;40(11):ivaf255. doi: 10.1093/icvts/ivaf255.
PubMed 41134639
Study at a glance
From the registry record, last updated by the sponsor on 13 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prognostic Factors for 90-day Mortality in Patients Undergoing Veno-venous Extracorporeal Membrane Oxygenation for Emergency Thoracic Surgery
- ClinicalTrials.gov ID
- NCT07016685
- Acronym / sponsor ID
- PECUR / PI2025_843_0071
- Conditions
- VV-ECMO, Thoracic Surgery, Emergency Surgery, ARDS, Retrospective Cohort, Propensity Score Matching
- Keywords
- thoracic surgery, VV-ECMO, emergency surgery, ARDS, retrospective cohort, propensity score matching, mortality, ECMO outcomes
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 380 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Collaborators
- Centre Hospitalier Universitaire Dijon
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- Nov 2025 (estimated)
- Study completion
- Apr 2026 (estimated)
- First posted
- 12 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Veno-vneous extracorporeal membrane oxygenation (VV-ECMO) is an established support strategy for acute respiratory failure, but its role in the perioperative management of emergency thoracic surgery remains poorly defined. This retrospective, multicenter, observational study aims to assess the clinical outcomes and prognostic factors in this high-risk population. Patients undergoing emergency thoracic procedures requiring VV-ECMO will be compared to a control cohort of patients treated with VV-ECMO for medical respiratory failure. Data will be collected from two French academic centers (CHU Amiens-Picardie and CHU Dijon).
Study design
- Observational model
- Case only
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| VV-ECMO after emergency thoracic surgery | – | –VV-ECMO after emergency thoracic surgery |
| VV-ECMO for medical ARF | – | –VV-ECMO for medical indication |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults ≥ 18 years, Patients undergoing emergency thoracic procedures requiring VV-ECMO and patients treated with VV-ECMO for medical respiratory failure.
Key inclusion criteria (3 listed)
- Adults ≥ 18 years
- VV-ECMO initiated during or after emergency thoracic surgery
- No opposition to data use
Key exclusion criteria (3 listed)
- Pregnant women
- Veno-Arterial ECMO patients
- Patients under legal protection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
90-day all-cause mortality
Time frame: 90 days
2 secondary outcomes
90-day mortality in oncologic vs. non-oncologic thoracic surgery
Time frame: 90 days
Postoperative complication rates
Time frame: 90 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jun 2025.
- Derived from this study: PubMed 41134639Beyls C, Soulier-Zaninka Q, Georges O, Nguyen M, Dheilly T, Nicolas M, Huette P, De Dominicis F, Abou-Arab O, Guinot PG, Mahjoub Y. Perioperative Veno-Venous Extracorporeal Membrane Oxygenation in Non-Elective Thoracic Surgery: A Propensity-Matched Bicentric Comparison With Medical Indication. Interdiscip Cardiovasc Thorac Surg. 2025 Nov 6;40(11):ivaf255. doi: 10.1093/icvts/ivaf255.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of VV-ECMO and Thoracic Surgery, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Christophe Beyls, MD (33+3 22 08 78, beyls.christophe@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
90-day all-cause mortality (time frame: 90 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07016685, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jun 2025.