Cardiac Arrest (CA)NCT07017075
Adjusting CPR Location With TEE Guidance
A study testing adjustment of CPR location in people with Cardiac Arrest (CA), run by National Taiwan University Hospital at 2 sites in Taiwan.
Trial summary
Use Transesophageal ultrasound in OHCA patients to identify the proper compression location Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- adjustment of CPR location
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 2 sitesTaiwan
- Study dates
- 21 Feb 2025to 21 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Out-of-hospital cardiac arrest patients
Who cannot join
- DNR was signed
- Age under 18
- Trauma patients
- Patients hard to establish an advanced airway
- Inavailability of ultrasound machine or operators
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan2 sites
Chang Bing Show Chawan Memorial Hospital
Changhua
National Taiwan University Hospital
Taipei
About this study
Official title: 3D Visulization The Area Of Maximal Compression And Quantitative Assessment Stroke Volume And Ejection Fraction After Adjusting CPR Location
Use Transesophageal ultrasound in OHCA patients to identify the proper compression location
Read the detailed description
For patients with cardiac arrest, high-quality cardiopulmonary resuscitation is performed according to critical care management and Advanced Cardiac Life Support (ACLS). Rapid with powerful chest compression should be performed to maintain the heart's output and blood flow. An advanced airway should be established and adjust resuscitation based on collected clinical information. Transesophageal ultrasound examination is performed after the advanced airway is established without affecting the resuscitation. The investigators use the built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)) to analyze stroke volume and cardiac output. The investigators collect the stroke volume and cardiac output at the chest compression position recommended by ACLS, as well as the stroke volume and cardiac output after adjusting the optimal chest compression position. The investigators expect it can increase the return of spontaneous circulation rate, survival rate, and neurological prognosis over time.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- adjustment of CPR location
- Keywords
- OHCA, TEE
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
adjustment of CPR locationBehavioural
Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position
| Study group | Role | What they receive |
|---|---|---|
| CPR location without adjustment | Other | If the AMC was located at the LV identified by TEE, the CPR compression site was not altered. Receives: Behavioral: adjustment of CPR location |
| CPR location with adjustment | Other | If the AMC was not located at the LV, the CPR compression site was altered. Receives: Behavioral: adjustment of CPR location |
What is being measured
The primary outcome is the main question the study is designed to answer.
stroke volume, ejection fraction, end-diastolic volume, and end-systolic volume
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)
Measured: 2 mins
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jun 2025
- Study start21 Feb 2025
- Primary completion21 Jan 2026 (estimated)
- Study completion21 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Chang Bing Show Chwan Memorial Hospital
- Responsible party
- Sponsor
- Investigators
- WANCHING LIEN, Study director, National Taiwan University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07017075
- Sponsor's protocol ID
- 202410013RINB
- Status last verified
- Jan 2025
- First submitted
- 6 May 2025
- Last updated
- 19 Nov 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: all collected IPD
Publications
Chen CC, Huang CS, Yen HT, Lien WC. A visualization of ejection fraction change after adjusting the area of maximal compression. Resuscitation. 2024 Jan;194:110097. doi: 10.1016/j.resuscitation.2023.110097. Epub 2023 Dec 20. No abstract available.
PubMed 38128870Teran F, Owyang CG, Martin-Flores M, Lao D, King A, Palasz J, Araos JD. Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography. Crit Care. 2023 Aug 19;27(1):319. doi: 10.1186/s13054-023-04575-7. No abstract available.
PubMed 37598201Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.
PubMed 19732038Olasveengen TM, Semeraro F, Ristagno G, Castren M, Handley A, Kuzovlev A, Monsieurs KG, Raffay V, Smyth M, Soar J, Svavarsdottir H, Perkins GD. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation. 2021 Apr;161:98-114. doi: 10.1016/j.resuscitation.2021.02.009. Epub 2021 Mar 24.
PubMed 33773835
Study at a glance
From the registry record, last updated by the sponsor on 19 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- 3D Visulization The Area Of Maximal Compression And Quantitative Assessment Stroke Volume And Ejection Fraction After Adjusting CPR Location
- ClinicalTrials.gov ID
- NCT07017075
- Acronym / sponsor ID
- 202410013RINB
- Conditions
- Cardiac Arrest (CA)
- Keywords
- OHCA, TEE
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Collaborators
- Chang Bing Show Chwan Memorial Hospital
- Study start
- 21 Feb 2025 (actual)
- Primary completion
- 21 Jan 2026 (estimated)
- Study completion
- 21 Jan 2027 (estimated)
- First posted
- 12 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Use Transesophageal ultrasound in OHCA patients to identify the proper compression location
Detailed description
For patients with cardiac arrest, high-quality cardiopulmonary resuscitation is performed according to critical care management and Advanced Cardiac Life Support (ACLS). Rapid with powerful chest compression should be performed to maintain the heart's output and blood flow. An advanced airway should be established and adjust resuscitation based on collected clinical information. Transesophageal ultrasound examination is performed after the advanced airway is established without affecting the resuscitation. The investigators use the built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)) to analyze stroke volume and cardiac output. The investigators collect the stroke volume and cardiac output at the chest compression position recommended by ACLS, as well as the stroke volume and cardiac output after adjusting the optimal chest compression position. The investigators expect it can increase the return of spontaneous circulation rate, survival rate, and neurological prognosis over time.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| CPR location without adjustment | Other | Behavioral: adjustment of CPR locationIf the AMC was located at the LV identified by TEE, the CPR compression site was not altered. |
| CPR location with adjustment | Other | Behavioral: adjustment of CPR locationIf the AMC was not located at the LV, the CPR compression site was altered. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Out-of-hospital cardiac arrest patients
Key exclusion criteria (5 listed)
- DNR was signed
- Age under 18
- Trauma patients
- Patients hard to establish an advanced airway
- Inavailability of ultrasound machine or operators
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| adjustment of CPR locationTransesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position | Behavioural | CPR location with adjustment, CPR location without adjustment |
Primary outcome
stroke volume, ejection fraction, end-diastolic volume, and end-systolic volume
Time frame: 2 mins
built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Nov 2025.
- Results publication: PubMed 38128870Chen CC, Huang CS, Yen HT, Lien WC. A visualization of ejection fraction change after adjusting the area of maximal compression. Resuscitation. 2024 Jan;194:110097. doi: 10.1016/j.resuscitation.2023.110097. Epub 2023 Dec 20. No abstract available.
- Results publication: PubMed 37598201Teran F, Owyang CG, Martin-Flores M, Lao D, King A, Palasz J, Araos JD. Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography. Crit Care. 2023 Aug 19;27(1):319. doi: 10.1186/s13054-023-04575-7. No abstract available.
- Results publication: PubMed 19732038Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.
- Results publication: PubMed 33773835Olasveengen TM, Semeraro F, Ristagno G, Castren M, Handley A, Kuzovlev A, Monsieurs KG, Raffay V, Smyth M, Soar J, Svavarsdottir H, Perkins GD. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation. 2021 Apr;161:98-114. doi: 10.1016/j.resuscitation.2021.02.009. Epub 2021 Mar 24.
- Individual participant dataSharing planned: Yes. all collected IPD
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
WANCHING LIEN study director
National Taiwan University Hospital
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing adjustment of CPR location in people with Cardiac Arrest (CA), run by National Taiwan University Hospital at 2 sites in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 19 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
stroke volume, ejection fraction, end-diastolic volume, and end-systolic volume (time frame: 2 mins). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07017075, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Nov 2025.