Myasthenia GravisGUIMAUVENCT07022028
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
An observational study of Myasthenia Gravis and Guillain-Barre Syndrome, run by Poitiers University Hospital at 1 site in France.
Trial summary
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Myasthenia Gravis, Guillain-Barre Syndrome
- How many people
- 800 participants
- Where
- 1 siteFrance
- Study dates
- 27 Feb 2024to 6 Nov 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients intubated and mechanically ventilated in ICUs for Guillain-Barré syndrome or myasthenia gravis
Inclusion Criteria: All patients mechanically ventilated for at least 48 hours for Guillain-Barré syndrome or myasthenia gravis -
Exclusion Criteria: Patients mechanically ventilated less than 48h or intubated for another reason than the neuromuscular disease.
-
Trial locations and contacts
1 site in 1 country.
About this study
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Our objective was to assess and compare for ventilator weaning modalities between patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis in a large-scale multicenter study.
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome
- Keywords
- Myasthenia Gravis, Guillain-Barre syndrome, Ventilator Weaning, Airway Extubation, Intensive Care Unit
- Medical subject headings
- Myasthenia Gravis, Guillain-Barre Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis (two groups) | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
The proportion of patients with prolonged weaning
Prolonged weaning defined as still being under mechanical ventilation at least 7 days after the initial separation attempt from the ventilator
Measured: 7 days after the initial separation attempt from the ventilator
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jun 2025
- Study start27 Feb 2024
- Primary completion6 Nov 2024
- Study completion6 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Myasthenia GravisStudies of the same condition, open and under way.
- More trials run by Poitiers University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 800 participants (actual)
Sponsor and investigators
- Lead sponsor
- Poitiers University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Arnaud W THILLE, MD, PhD, Principal investigator, Poitiers University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07022028
- Sponsor's protocol ID
- GUIMAUVE study
- Acronym
- GUIMAUVE
- Status last verified
- Jun 2025
- First submitted
- 6 Jun 2025
- Last updated
- 18 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Thille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Le Pape S, Coudroy R. Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barre syndrome. Ann Intensive Care. 2026 Jul 28;16:100124. doi: 10.1016/j.aicoj.2026.100124. eCollection 2026.
PubMed 42592412Thille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Coudroy R, Le Pape S. Characteristics of ventilator weaning in patients intubated for Guillain-Barre syndrome or myasthenia gravis: a nationwide multicenter study. Intensive Care Med. 2025 Nov;51(11):2054-2064. doi: 10.1007/s00134-025-08159-7. Epub 2025 Oct 20.
PubMed 41114833
Study at a glance
From the registry record, last updated by the sponsor on 18 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
- ClinicalTrials.gov ID
- NCT07022028
- Acronym / sponsor ID
- GUIMAUVE / GUIMAUVE study
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome
- Keywords
- Myasthenia Gravis, Guillain-Barre syndrome, Ventilator Weaning, Airway Extubation, Intensive Care Unit
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 800 participants (actual)
- Lead sponsor
- Poitiers University HospitalUniversity, hospital or other
- Study start
- 27 Feb 2024 (actual)
- Primary completion
- 6 Nov 2024 (actual)
- Study completion
- 6 Nov 2024 (actual)
- First posted
- 15 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Our objective was to assess and compare for ventilator weaning modalities between patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis in a large-scale multicenter study.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis (two groups) | – | – |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients intubated and mechanically ventilated in ICUs for Guillain-Barré syndrome or myasthenia gravis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
The proportion of patients with prolonged weaning
Time frame: 7 days after the initial separation attempt from the ventilator
Prolonged weaning defined as still being under mechanical ventilation at least 7 days after the initial separation attempt from the ventilator
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jun 2025.
- Derived from this study: PubMed 42592412Thille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Le Pape S, Coudroy R. Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barre syndrome. Ann Intensive Care. 2026 Jul 28;16:100124. doi: 10.1016/j.aicoj.2026.100124. eCollection 2026.
- Derived from this study: PubMed 41114833Thille AW, Bayon C, Gauvrit M, Saccheri C, Labruyere M, Beduneau G, Wattecamps G, Henry M, Bendiab E, Swinyard B, Gacouin A, Celier A, Foucou B, Champion S, Haudebourg AF, Dangers L, Plateker O, Daubin C, Fromont L, Guesdon C, Vivier E, Volkov L, Potier C, Bourenne J, Chiquet C, Pointurier V, Chauvelot L, Bailly P, Schnell D, Sedillot N, Reizine F, Argaud L, Reynaud F, Pelle J, Lesieur O, Auvet A, Lacave G, Kernevez M, Contou D, Grillet G, Delahaye A, Badie J, Devaquet J, Chauvin H, Beurton A, Turbil E, Rigaud JP, Ragot S, Chamblet L, Coudroy R, Le Pape S. Characteristics of ventilator weaning in patients intubated for Guillain-Barre syndrome or myasthenia gravis: a nationwide multicenter study. Intensive Care Med. 2025 Nov;51(11):2054-2064. doi: 10.1007/s00134-025-08159-7. Epub 2025 Oct 20.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Arnaud W THILLE, MD, PhD principal investigator
Poitiers University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Myasthenia Gravis and Guillain-Barre Syndrome, run by Poitiers University Hospital at 1 site in France.
The full registered description is in the About this study section and the official record.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The proportion of patients with prolonged weaning (time frame: 7 days after the initial separation attempt from the ventilator). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07022028, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jun 2025.