BalL Exercises tO Prevent FrAilty in OldeR ADults (LEOPARD)

Physical performance measures will be conducted. Upper muscle strength will be measured using the grip strength measurement. Maximum grip strength of the dominant hand (in kg) will be measured during vital signs measurements using a Jamar digital dynamometer grip. Grip strength in kilograms will be measured using a standardized protocol; participants will be seated with the ipsilateral shoulder adducted and neutrally rotated, the elbow flexed to 90 degrees, and the forearm and wrist neutrally positioned. The participants will be asked to perform three maximum force trials with their dominant hand interspersed by 1 minute and the highest measure observed will be observed.

Physical performance measures will be conducted. Lower limb strength will be measured using the Five Times Sit to Stand Test (5TSTS).Participants will be instructed to rise as quickly as possible from a seated position, with full body weight on the chair, to a standing posture, with their legs fully extended, while keeping their arms folded across their chest. The 5TSTS measures the time taken, in seconds, to complete five repeated chair stands. The test performance will be based on its duration; consequently, the shorter time taken by the patient, the better their functional condition would be.

To perform the test, a flat unobstructed course will be identified and 4 m marked out with tape. The participant will be positioned with the toes just touching the start line. The following standardized instructions will be given: "This is our walking course. I want you to walk to the other end of the course at your usual speed, just as if you were walking down the street to go to the shops. Walk all the way past the other end of the tape before you stop. Ready…begin". Timing with a stopwatch will be started when the participant begins to move, not on the command "begin". Timing will be stopped when the participant's first foot completely crosses the 4-m line. The walk test will be repeated without rest and the faster of the two times will be used to calculate the 4MGS, expressed in m·s-1. Participants will be allowed to use their normal walking aids (e.g. cane).

The participant will be asked to sit on a chair (chair height=45cm) with an upright posture, feet placed flat on the ground, and arms crossed on their chest. Next, participants will be instructed to rise from the chair, walk to, and around a cone (three meters) in front of them, walk back to the chair, and return to the starting position. Time will be recorded starting the moment the participant's back loses contact with the chair and concluded when the starting position is regained. A score of ≥ 14 seconds has been shown to indicate reduced mobility, impaired balance, and a high risk of falls.

Functional status will be assess using the Lawton's Instrumental Activities of Daily Living (IADL) Scale). The Lawton IADL Scale takes approximately 10 to 15 minutes to administer. It contains 8 items that are rated with a summary score from 0 (low functioning) to 8 (high functioning). For men, the areas of food preparation, housekeeping, and laundering will be excluded. Participants are scored according to their highest level of functioning in that category. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent) for women and 0 to 5 for men.

Cognitive function will be measured using the Montreal Cognitive Assessment (MoCA). The MoCA test is conducted over 20 minutes to measure seven cognitive domains, including executive functions, naming, verbal memory registration and learning, attention, abstraction, delay recall memory, and orientation. MoCA scores range from 0 to 30, higher scores reflect good global cognitive function.

PHQ-4 will be used to screen for depression and anxiety. PHQ-4 is a 4-item inventory rated on a 4-point Likert-type scale with response options including the following: not at all (score = 0), several days (score = 1), more than half the days (score = 2), and nearly every day (score = 3). PHQ-4 scores will be computed by adding scores on individual items. PHQ-4 scores determine 'Severe' (score range 9-12), 'Moderate' (6-8), 'Mild' (3-5), and 'Normal' (0-2) risk of anxiety or depression. On each subscale, a score of 3 or greater is considered a risk for anxiety or depression.

The 5-item World Health Organization Well-Being Index (WHO-5) is a short questionnaire covering five positively worded items, related to positive mood (good spirits, relaxation), vitality (being active and waking up fresh and rested), and general interests (being interested in things). Each of the five items in the WHO-Five is rated on a 6-point Likert scale from 0 (not present) to 5 (constantly present). The raw score ranges from 0 to 25, and the percentage final score (0-100%) can be obtained by multiplying the result by 4. A cutoff of <13 (or <50%) indicates poor psychological well-being.